Scadden, David T.

The bone marrow niche for haematopoietic stem cells

Morrison, S. J., & Scadden, D. T. (2014) · Nature

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 2,451

AZD2171, a Pan-VEGF Receptor Tyrosine Kinase Inhibitor, Normalizes Tumor Vasculature and Alleviates Edema in Glioblastoma Patients

Batchelor, T. T., Sorensen, A. G., di Tomaso, E., Zhang, W.-T., Duda, D. G., Cohen, K. S., Kozak, K. R., Cahill, D. P., Chen, P.-J., Zhu, M., et al. (2007) · Cancer Cell

Angiogenesis and VEGF in CancerGlioma Diagnosis and Treatment

Cited by 1,769

Bayesian approach to single-cell differential expression analysis

Kharchenko, P. V., Silberstein, L., & Scadden, D. T. (2014) · Nature Methods

Single-cell and spatial transcriptomicsGene expression and cancer classification

Cited by 1,348

Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science

Hematopoietic Stem Cell TransplantationMesenchymal stem cell research

Cited by 1,339

Direct measurement of local oxygen concentration in the bone marrow of live animals

Spencer, J. A., Ferraro, F., Roussakis, E., Klein, A., Wu, J., Runnels, J. M., Zaher, W., Mortensen, L. J., Alt, C., Turcotte, R., et al. (2014) · Nature

Hematopoietic Stem Cell TransplantationAdvanced Fluorescence Microscopy Techniques

Cited by 1,167

Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia

Raaijmakers, M. H. G. P., Mukherjee, S., Guo, S., Zhang, S., Kobayashi, T., Schoonmaker, J. A., Ebert, B. L., Al-Shahrour, F., Hasserjian, R. P., Scadden, E. O., et al. (2010) · Nature

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 1,115

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature

Hematopoietic Stem Cell TransplantationTelomeres, Telomerase, and Senescence

Cited by 1,106

Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis

Demers, M., Krause, D. S., Schatzberg, D., Martinod, K., Voorhees, J. R., Fuchs, T. A., Scadden, D. T., & Wagner, D. D. (2012) · Proceedings of the National Academy of Sciences

Neutrophil, Myeloperoxidase and Oxidative MechanismsVenous Thromboembolism Diagnosis and Management

Cited by 883

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

Orford, K. W., & Scadden, D. T. (2008) · Nature Reviews Genetics

Developmental Biology and Gene RegulationPluripotent Stem Cells Research

Cited by 851

Inhibition of dihydroorotate dehydrogenase overcomes differentiation blockade in acute myeloid leukemia

Sykes, D. B., Kfoury, Y. S., Mercier, F. E., Wawer, M. J., Law, J. M., Haynes, M. K., Lewis, T. A., Schajnovitz, A., Jain, E., Lee, D., et al. (2016) · Cell

Acute Myeloid Leukemia ResearchBiochemical and Molecular Research

Cited by 500

CCAAT/Enhancer Binding Protein α Is a Regulatory Switch Sufficient for Induction of Granulocytic Development from Bipotential Myeloid Progenitors

Radomska, H. S., Huettner, C. S., Zhang, P., Cheng, T., Scadden, D. T., & Tenen, D. G. (1998) · Molecular and Cellular Biology

Acute Myeloid Leukemia ResearchGenomics and Chromatin Dynamics

Cited by 466

SIRT3 Reverses Aging-Associated Degeneration

Brown, K., Xie, S., Qiu, X., Mohrin, M., Shin, J., Liu, Y., Zhang, D., Scadden, D. T., & Chen, D. (2013) · Cell Reports

Sirtuins and Resveratrol in MedicineGenetics, Aging, and Longevity in Model Organisms

Cited by 436

C9orf72 suppresses systemic and neural inflammation induced by gut bacteria

Burberry, A., Wells, M. F., Limone, F., Couto, A., Smith, K. S., Keaney, J., Gillet, G., van Gastel, N., Wang, J.-Y., Pietilainen, O., et al. (2020) · Nature

Amyotrophic Lateral Sclerosis ResearchGut microbiota and health

Cited by 314

Exercise reduces inflammatory cell production and cardiovascular inflammation via instruction of hematopoietic progenitor cells

Frodermann, V., Rohde, D., Courties, G., Severe, N., Schloss, M. J., Amatullah, H., McAlpine, C. S., Cremer, S., Hoyer, F. F., Ji, F., et al. (2019) · Nature Medicine

Hematopoietic Stem Cell TransplantationExercise and Physiological Responses

Cited by 292

A protocol for phenotypic detection and enumeration of circulating endothelial cells and circulating progenitor cells in human blood

Duda, D. G., Cohen, K. S., Scadden, D. T., & Jain, R. K. (2007) · Nature Protocols

Angiogenesis and VEGF in CancerMesenchymal stem cell research

Cited by 275

Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1

Schiroli, G., Ferrari, S., Conway, A., Jacob, A., Capo, V., Albano, L., Plati, T., Castiello, M. C., Sanvito, F., Gennery, A. R., et al. (2017) · Science Translational Medicine

Virus-based gene therapy researchCRISPR and Genetic Engineering

Cited by 214

Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation

Steinbicker, A. U., Sachidanandan, C., Vonner, A. J., Yusuf, R. Z., Deng, D. Y., Lai, C. S., Rauwerdink, K. M., Winn, J. C., Saez, B., Cook, C. M., et al. (2011) · Blood

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 173

Temporal mapping of gene expression levels during the differentiation of individual primary hematopoietic cells

Cheng, T., Shen, H., Giokas, D., Gere, J., Tenen, D. G., & Scadden, D. T. (1996) · Proceedings of the National Academy of Sciences

Hematopoietic Stem Cell TransplantationAcute Myeloid Leukemia Research

Cited by 163

PHD3 Loss in Cancer Enables Metabolic Reliance on Fatty Acid Oxidation via Deactivation of ACC2

German, N. J., Yoon, H., Yusuf, R. Z., Murphy, J. P., Finley, L. W. S., Laurent, G., Haas, W., Satterstrom, F. K., Guarnerio, J., Zaganjor, E., et al. (2016) · Molecular Cell

Cancer, Lipids, and MetabolismCancer, Hypoxia, and Metabolism

Cited by 156

Lineage Tracing Reveals a Subset of Reserve Muscle Stem Cells Capable of Clonal Expansion under Stress

Scaramozza, A., Park, D., Kollu, S., Beerman, I., Sun, X., Rossi, D. J., Lin, C. P., Scadden, D. T., Crist, C., & Brack, A. S. (2019) · Cell Stem Cell

Muscle Physiology and DisordersMesenchymal stem cell research

Cited by 93

Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow

Yu, V. W. C., Lymperi, S., Oki, T., Jones, A., Swiatek, P., Vasic, R., Ferraro, F., & Scadden, D. T. (2016) · Stem Cell Reports

Hematopoietic Stem Cell TransplantationT-cell and B-cell Immunology

Cited by 52

Chromatin-state barriers enforce an irreversible mammalian cell fate decision

Blanco, M. A., Sykes, D. B., Gu, L., Wu, M., Petroni, R., Karnik, R., Wawer, M., Rico, J., Li, H., Jacobus, W. D., et al. (2021) · Cell Reports

Genomics and Chromatin DynamicsHematopoietic Stem Cell Transplantation

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Cyclophilin A supports translation of intrinsically disordered proteins and affects haematopoietic stem cell ageing

Maneix, L., Iakova, P., Lee, C. G., Moree, S. E., Lu, X., Datar, G. K., Hill, C. T., Spooner, E., King, J. C. K., Sykes, D. B., et al. (2024) · Nature Cell Biology

Heat shock proteins researchSignaling Pathways in Disease

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The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Shao, L., Chang, J., Feng, W., Wang, X., Williamson, E. A., Li, Y., Schajnovitz, A., Scadden, D., Mortensen, L. J., Lin, C. P., et al. (2018) · Nature Communications

Hematopoietic Stem Cell TransplantationBlood disorders and treatments

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