The bone marrow niche for haematopoietic stem cells
Open accessAbstract
Niches are local tissue microenvironments that maintain and regulate stem cells. Haematopoiesis provides a model for understanding mammalian stem cells and their niches, but the haematopoietic stem cell (HSC) niche remains incompletely defined and beset by competing models. Recent progress has been made in elucidating the location and cellular components of the HSC niche in the bone marrow. The niche is perivascular, created partly by mesenchymal stromal cells and endothelial cells and often, but not always, located near trabecular bone. Outstanding questions concern the cellular complexity of the niche, the role of the endosteum and functional heterogeneity among perivascular microenvironments.
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Non-haematopoietic stromal cells, including osteoblasts and osteoprogenitor cells, promote the maintenance of haematopoietic stem cells.
“Non-haematopoietic stromal cells, including osteoblasts and osteoprogenitor cells, promote the maintenance of haematopoietic stem cells.95”
From The costs and benefits of senotherapeutics for human health (2022) · cites this paper as [95]
Other cell types that regulate HSC niches include osteoclasts, extracellular matrix, megakaryocytes, and calcium.
“Other cell types that regulate HSC niches include osteoclasts, extracellular matrix, megakaryocytes, and calcium.9”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [9]
Perivascular mesenchymal cells that express CD146 in humans and Cxcl12-GFP, Nestin-GFP, full-length Leptin receptor, Prx-1-Cre, Osterix-Cre, and inducible Mx-1-Cre in mice generate osteoblastic cells and express factors that promote the maintenance of HSPCs.
“Although MSCs are a heterogeneous population and still require better characterization by surface markers, perivascular mesenchymal cells that express CD146 in humans and Cxcl12-green fluorescent protein, Nestin-green fluorescent protein, full-length Leptin receptor, Prx-1-Cre, Osterix-Cre, and inducible Mx-1-Cre in mice generate osteoblastic cells and express factors that promote the maintenance”
From Inflammatory bone marrow microenvironment (2019) · cites this paper as [9]
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- Authors
- Morrison, S. J., & Scadden, D. T.
- Affiliations
- Howard Hughes Medical Institute (US)
- Harvard University (US)
- Corresponding author
- Morrison, Sean J.
- Scadden, David T.
- Venue
- Nature
- Published
- 2014-01
- Volume
- 505
- Issue
- 7483
- Pages
- 327-334
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- PMC
- PMC4514480
- OpenAlex
- W2149053153
- Semantic Scholar
- 63cdd906a38c49f8d452a64cb77d5a597cfbfb38
- Cited by
- 2,451
- References
- 130
- Citations by year
- 2026: 139 · 2025: 176 · 2024: 141 · 2023: 177 · 2022: 194 · 2021: 210 · 2020: 226 · 2019: 225 · 2018: 240 · 2017: 223 · 2016: 225 · 2015: 184 · 2014: 89
- FWCI
- 36.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Funders
- Howard Hughes Medical Institute
- National Heart, Lung, and Blood Institute (HL096372, R01HL044851, R03HL096372, HL044851, HL097760, R01HL097760)
- National Institute of Biomedical Imaging and Bioengineering (R01EB014703, EB014703)
- Topics
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Health Sciences › Medicine › Genetics › Mesenchymal stem cell research
- Health Sciences › Medicine › Hematology › Multiple Myeloma Research and Treatments
- Keywords
- hematopoietic stem cells, bone marrow microenvironment, hematopoiesis, perivascular niche, mesenchymal stem cells, endothelial cells, trabecular bone, endosteum, stem cell niche
- MeSH terms
- Animals, Bone and Bones, Bone Marrow, Hematopoietic Stem Cells, Humans, Osteoblasts, Endothelial Cells, Stem Cell Niche, Mesenchymal Stem Cells
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