Hynynen, Kullervo

A Randomized Trial of Focused Ultrasound Thalamotomy for Essential Tremor

Elias, W. J., Lipsman, N., Ondo, W. G., Ghanouni, P., Kim, Y. G., Lee, W., Schwartz, M., Hynynen, K., Lozano, A. M., Shah, B. B., et al. (2016) · New England Journal of Medicine

Deep Brain Stimulation and Movement DisordersUltrasound and Hyperthermia Applications

Cited by 1,167

Blood-brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound

Lipsman, N., Meng, Y., Bethune, A. J., Huang, Y., Lam, B., Masellis, M., Herrmann, N., Heyn, C., Aubert, I., Boutet, A., et al. (2018) · Nature Communications

Ultrasound and Hyperthermia ApplicationsAlzheimer's disease research and treatments

Cited by 950

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Hynynen, K., McDannold, N., Sheikov, N. A., Jolesz, F. A., & Vykhodtseva, N. (2005) · NeuroImage

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 679

MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study

Lipsman, N., Schwartz, M. L., Huang, Y., Lee, L., Sankar, T., Chapman, M., Hynynen, K., & Lozano, A. M. (2013) · The Lancet Neurology

Deep Brain Stimulation and Movement DisordersUltrasound and Hyperthermia Applications

Cited by 604

First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

Abrahao, A., Meng, Y., Llinas, M., Huang, Y., Hamani, C., Mainprize, T., Aubert, I., Heyn, C., Black, S. E., Hynynen, K., et al. (2019) · Nature Communications

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 476

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology

Ultrasound and Hyperthermia ApplicationsAlzheimer's disease research and treatments

Cited by 326

Alzheimer Disease in a Mouse Model: MR Imaging–guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior

Burgess, A., Dubey, S., Yeung, S., Hough, O., Eterman, N., Aubert, I., & Hynynen, K. (2014) · Radiology

Ultrasound and Hyperthermia ApplicationsAlzheimer's disease research and treatments

Cited by 286

Non-invasive opening of BBB by focused ultrasound

Hynynen, K., McDannold, N., Vykhodtseva, N., & Jolesz, F. A. (2003) · Brain Edema XII

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 156

The threshold for brain damage in rabbits induced by bursts of ultrasound in the presence of an ultrasound contrast agent (Optison®)

Hynynen, K., McDannold, N., Martin, H., Jolesz, F. A., & Vykhodtseva, N. (2003) · Ultrasound in Medicine & Biology

Ultrasound and Hyperthermia ApplicationsPhotoacoustic and Ultrasonic Imaging

Cited by 144

Acute effects of focused ultrasound-induced increases in blood-brain barrier permeability on rat microvascular transcriptome

McMahon, D., Bendayan, R., & Hynynen, K. (2017) · Scientific Reports

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 138

Glymphatics visualization after focused ultrasound-induced blood-brain barrier opening in humans

Meng, Y., Abrahao, A., Heyn, C. C., Bethune, A. J., Huang, Y., Pople, C. B., Aubert, I., Hamani, C., Zinman, L., Hynynen, K., et al. (2019) · Annals of Neurology

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 114

Blood–brain barrier opening of the default mode network in Alzheimer’s disease with magnetic resonance-guided focused ultrasound

Meng, Y., Goubran, M., Rabin, J. S., McSweeney, M., Ottoy, J., Pople, C. B., Huang, Y., Storace, A., Ozzoude, M., Bethune, A., et al. (2023) · Brain

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 83

Role of perivascular and meningeal macrophages in outcome following experimental subarachnoid hemorrhage.

Wan, H., Brathwaite, S., Ai, J., Hynynen, K., & Macdonald, R. L. (2021) · Journal of Cerebral Blood Flow & Metabolism

Intracerebral and Subarachnoid Hemorrhage ResearchIntracranial Aneurysms: Treatment and Complications

Cited by 65

Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System

Burgess, A., & Hynynen, K. (2016) · Advances in Experimental Medicine and Biology

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 62

Microbubble formulation influences inflammatory response to focused ultrasound exposure in the brain

McMahon, D., Lassus, A., Gaud, E., Jeannot, V., & Hynynen, K. (2020) · Scientific Reports

Ultrasound and Hyperthermia ApplicationsBarrier Structure and Function Studies

Cited by 52

Ultrasound delivery of a TrkA agonist confers neuroprotection to Alzheimer-associated pathologies

Xhima, K., Markham-Coultes, K., Hahn Kofoed, R., Saragovi, H. U., Hynynen, K., & Aubert, I. (2022) · Brain

Alzheimer's disease research and treatmentsUltrasound and Hyperthermia Applications

Cited by 43