Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System

Structure and function of the blood–brain barrier

Abbott, N. J., Patabendige, A. A. K., Dolman, D. E. M., Yusof, S. R., & Begley, D. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.030 · Cited by 5,185 · see citing works

Pericytes regulate the blood–brain barrier

Armulik, A., Genové, G., Mäe, M., Nisancioglu, M. H., Wallgard, E., Niaudet, C., He, L., Norlin, J., Lindblom, P., Strittmatter, K., et al. (2010) · Nature · doi:10.1038/nature09522 · Cited by 2,843 · see citing works

J. Submicrosc. Cytol. Pathol.

Thomas, A. C., & Campbell, J. H. (2000) · Cited by 2,800 · see citing works

The blood-brain barrier: Bottleneck in brain drug development

Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798 · see citing works

The blood-brain barrier/neurovascular unit in health and disease

Hawkins, B. T., & Davis, T. P. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.4 · Cited by 2,661 · see citing works

Pericytes are required for blood–brain barrier integrity during embryogenesis

Daneman, R., Zhou, L., Kebede, A. A., & Barres, B. A. (2010) · Nature · doi:10.1038/nature09513 · Cited by 2,128 · see citing works

Drug Transport across the Blood–Brain Barrier

Pardridge, W. M. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.126 · Cited by 1,994 · see citing works

Astrocytes induce blood–brain barrier properties in endothelial cells

Janzer, R. C., & RAFF, M. C. (1987) · Nature · doi:10.1038/325253a0 · Cited by 1,613 · see citing works

Noninvasive MR Imaging–guided Focal Opening of the Blood-Brain Barrier in Rabbits

Hynynen, K., McDannold, N. J., Vykhodtseva, N. I., & Jolesz, F. A. (2001) · Radiology · doi:10.1148/radiol.2202001804 · Cited by 1,463 · see citing works

Intranasal delivery of biologics to the central nervous system

Lochhead, J. J., & Thorne, R. G. (2012) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2011.11.002 · Cited by 1,214 · see citing works

Transcranial Pulsed Ultrasound Stimulates Intact Brain Circuits

Tufail, Y., Matyushov, A. D., Baldwin, N. G., Tauchmann, M. L., Georges, J., Yoshihiro, A., Tillery, S. I. H., & Tyler, W. J. (2010) · Neuron · doi:10.1016/j.neuron.2010.05.008 · Cited by 958 · see citing works

Local and reversible blood–brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications

Hynynen, K., McDannold, N., Sheikov, N. A., Jolesz, F. A., & Vykhodtseva, N. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.046 · Cited by 679 · see citing works

Noninvasive localized delivery of Herceptin to the mouse brain by MRI-guided focused ultrasound-induced blood–brain barrier disruption

Kinoshita, M., McDannold, N. J., Jolesz, F. A., & Hynynen, K. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604318103 · Cited by 645 · see citing works

Intranasal Drug Delivery: How, Why and What For?

Pires, A., Fortuna, A., Alves, G., & Falcão, A. (2009) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3nc79 · Cited by 641 · see citing works

Cellular mechanisms of the blood-brain barrier opening induced by ultrasound in presence of microbubbles

Sheikov, N. A., McDannold, N. J., Vykhodtseva, N. I., Jolesz, F. A., & Hynynen, K. (2004) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2004.04.010 · Cited by 619 · see citing works

MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study

Lipsman, N., Schwartz, M. L., Huang, Y., Lee, L., Sankar, T., Chapman, M., Hynynen, K., & Lozano, A. M. (2013) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70048-6 · Cited by 604 · see citing works

Vibrating microbubbles poking individual cells: Drug transfer into cells via sonoporation

van Wamel, A. J. E. T., Kooiman, K., Harteveld, M., Emmer, M., ten Cate, F. J., Versluis, M., & de Jong, N. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.02.007 · Cited by 597 · see citing works

Temporary Disruption of the Blood–Brain Barrier by Use of Ultrasound and Microbubbles: Safety and Efficacy Evaluation in Rhesus Macaques

McDannold, N. J., Arvanitis, C., Vykhodtseva, N. I., & Livingstone, M. S. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-0128 · Cited by 588 · see citing works

Transcranial Magnetic Resonance Imaging– Guided Focused Ultrasound Surgery of Brain Tumors

McDannold, N. J., Clement, G. T., Black, P. M., Jolesz, F. A., & Hynynen, K. (2010) · Neurosurgery · doi:10.1227/01.neu.0000360379.95800.2f · Cited by 555 · see citing works

Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI‐guided focused ultrasound

Treat, L. H., McDannold, N. J., Vykhodtseva, N. I., Zhang, Y., Tam, K., & Hynynen, K. (2007) · International Journal of Cancer · doi:10.1002/ijc.22732 · Cited by 543 · see citing works

Tight Junctions of the Blood–Brain Barrier

Kniesel, U., & Wolburg, H. (2000) · Cellular and Molecular Neurobiology · doi:10.1023/a:1006995910836 · Cited by 525 · see citing works

Effect of Focused Ultrasound Applied With an Ultrasound Contrast Agent on the Tight Junctional Integrity of the Brain Microvascular Endothelium

Sheikov, N. A., McDannold, N. J., Sharma, S., & Hynynen, K. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.12.015 · Cited by 494 · see citing works

Ultrasound and Microbubble-Targeted Delivery of Macromolecules Is Regulated by Induction of Endocytosis and Pore Formation

Meijering, B. D. M., Juffermans, L. J. M., van Wamel, A. J. E. T., Henning, R. H., Zuhorn, I. S., Emmer, M., Versteilen, A. M. G., Paulus, W. J., van Gilst, W. H., Kooiman, K., et al. (2009) · Circulation Research · doi:10.1161/circresaha.108.183806 · Cited by 484 · see citing works

Targeted disruption of the blood–brain barrier with focused ultrasound: association with cavitation activity

McDannold, N. J., Vykhodtseva, N. I., & Hynynen, K. (2006) · Physics in Medicine and Biology · doi:10.1088/0031-9155/51/4/003 · Cited by 449 · see citing works

Demonstration of Potential Noninvasive Ultrasound Brain Therapy Through an Intact Skull

Hynynen, K., & Jolesz, F. A. (1998) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(97)00269-x · Cited by 445 · see citing works

Blood-Brain Barrier: Real-time Feedback-controlled Focused Ultrasound Disruption by Using an Acoustic Emissions–based Controller

O’Reilly, M. A., & Hynynen, K. (2012) · Radiology · doi:10.1148/radiol.11111417 · Cited by 404 · see citing works

Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

Liu, H.-L., Hua, M., Chen, P.-Y., Chu, P.-C., Pan, C.-H., Yang, H.-W., Huang, C.-Y., Wang, J.-J., Yen, T., & Wei, K.-C. (2010) · Radiology · doi:10.1148/radiol.10090699 · Cited by 387 · see citing works

Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

Jordão, J. F., Ayala‐Grosso, C. A., Markham, K. A., Huang, Y., Chopra, R., McLaurin, J., Hynynen, K., & Aubert, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010549 · Cited by 378 · see citing works

Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice

Choi, J. J., Pernot, M., Small, S. A., & Konofagou, E. E. (2006) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.07.018 · Cited by 356 · see citing works

Ultrasound-induced cell membrane porosity

Deng, C. X., Sieling, F. H., Pan, H., & Cui, J. (2004) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2004.01.005 · Cited by 354 · see citing works

500‐element ultrasound phased array system for noninvasive focal surgery of the brain: A preliminary rabbit study with ex vivo human skulls

Hynynen, K., Clement, G. T., McDannold, N. J., Vykhodtseva, N. I., King, R. L., White, P. J., Vitek, S., & Jolesz, F. A. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20118 · Cited by 340 · see citing works

Amyloid-β plaque reduction, endogenous antibody delivery and glial activation by brain-targeted, transcranial focused ultrasound

Jordão, J. F., Thévenot, E., Markham-Coultes, K., Scarcelli, T., Weng, Y.-Q., Xhima, K., O'Reilly, M., Huang, Y., McLaurin, J., Hynynen, K., et al. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.05.008 · Cited by 326 · see citing works

MRI-guided targeted blood-brain barrier disruption with focused ultrasound: Histological findings in rabbits

McDannold, N. J., Vykhodtseva, N. I., Raymond, S. B., Jolesz, F. A., & Hynynen, K. (2005) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2005.07.010 · Cited by 323 · see citing works

Blood Vessel Deformations on Microsecond Time Scales by Ultrasonic Cavitation

Chen, H., Kreider, W., Brayman, A. A., Bailey, M. R., & Matula, T. J. (2011) · Physical Review Letters · doi:10.1103/physrevlett.106.034301 · Cited by 315 · see citing works

Focal disruption of the blood–brain barrier due to 260-kHz ultrasound bursts: a method for molecular imaging and targeted drug delivery

Hynynen, K., McDannold, N. J., Vykhodtseva, N. I., Raymond, S. B., Weissleder, R., Jolesz, F. A., & Sheikov, N. A. (2006) · Journal of neurosurgery · doi:10.3171/jns.2006.105.3.445 · Cited by 313 · see citing works

Biological effects of ultrasound: Development of safety guidelines. Part II: General review

Nyborg, W. L. (2001) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(00)00333-1 · Cited by 306 · see citing works

Improved Anti-Tumor Effect of Liposomal Doxorubicin After Targeted Blood-Brain Barrier Disruption by MRI-Guided Focused Ultrasound in Rat Glioma

Treat, L. H., McDannold, N. J., Zhang, Y., Vykhodtseva, N. I., & Hynynen, K. (2012) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2012.04.015 · Cited by 296 · see citing works

Blood-Brain Barrier Disruption Induced by Focused Ultrasound and Circulating Preformed Microbubbles Appears to Be Characterized by the Mechanical Index

McDannold, N. J., Vykhodtseva, N. I., & Hynynen, K. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.10.016 · Cited by 289 · see citing works

Alzheimer Disease in a Mouse Model: MR Imaging–guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior

Burgess, A., Dubey, S., Yeung, S., Hough, O., Eterman, N., Aubert, I., & Hynynen, K. (2014) · Radiology · doi:10.1148/radiol.14140245 · Cited by 286 · see citing works

Concurrent blood–brain barrier opening and local drug delivery using drug-carrying microbubbles and focused ultrasound for brain glioma treatment

Ting, C.-Y., Fan, C., Liu, H.-L., Huang, C.-Y., Hsieh, H.-Y., Yen, T., Wei, K., & Yeh, C. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.09.096 · Cited by 283 · see citing works

Targeted Delivery of Neural Stem Cells to the Brain Using MRI-Guided Focused Ultrasound to Disrupt the Blood-Brain Barrier

Burgess, A., Ayala‐Grosso, C. A., Ganguly, M., Jordão, J. F., Aubert, I., & Hynynen, K. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027877 · Cited by 279 · see citing works

High-intensity focused ultrasound selectively disrupts the blood-brain barrier in vivo

Mesiwala, A. H., Farrell, L., Wenzel, H. J., Silbergeld, D. L., Crum, L. A., Winn, H. R., & Mourad, P. D. (2002) · Ultrasound in Medicine & Biology · doi:10.1016/s0301-5629(01)00521-x · Cited by 272 · see citing works

The Size of Blood–Brain Barrier Opening Induced by Focused Ultrasound is Dictated by the Acoustic Pressure

Chen, H., & Konofagou, E. E. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2014.71 · Cited by 265 · see citing works

Effects of Acoustic Parameters and Ultrasound Contrast Agent Dose on Focused-Ultrasound Induced Blood-Brain Barrier Disruption

McDannold, N. J., Vykhodtseva, N. I., & Hynynen, K. (2008) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2007.11.009 · Cited by 264 · see citing works

Multiple treatments with liposomal doxorubicin and ultrasound-induced disruption of blood–tumor and blood–brain barriers improve outcomes in a rat glioma model

Aryal, M., Vykhodtseva, N. I., Zhang, Y., Park, J., & McDannold, N. J. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.04.007 · Cited by 261 · see citing works

Microbubble-Size Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening in MiceIn Vivo

Choi, J. J., Feshitan, J. A., Baseri, B., Wang, S., Tung, Y., Borden, M. A., & Konofagou, E. E. (2009) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2009.2034533 · Cited by 258 · see citing works

Progress and problems in the application of focused ultrasound for blood–brain barrier disruption

Vykhodtseva, N. I., McDannold, N. J., & Hynynen, K. (2008) · Ultrasonics · doi:10.1016/j.ultras.2008.04.004 · Cited by 245 · see citing works

A super‐resolution ultrasound method for brain vascular mapping

O’Reilly, M. A., & Hynynen, K. (2013) · Medical Physics · doi:10.1118/1.4823762 · Cited by 244 · see citing works

Histologic effects of high intensity pulsed ultrasound exposure with subharmonic emission in rabbit brain in vivo

Vykhodtseva, N. I., Hynynen, K., & Damianou, C. (1995) · Ultrasound in Medicine & Biology · doi:10.1016/0301-5629(95)00038-s · Cited by 230 · see citing works

Ultrasound Enhanced Delivery of Molecular Imaging and Therapeutic Agents in Alzheimer's Disease Mouse Models

Raymond, S. B., Treat, L. H., Dewey, J. D., McDannold, N. J., Hynynen, K., & Bacskai, B. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002175 · Cited by 227 · see citing works

SPIO-conjugated, doxorubicin-loaded microbubbles for concurrent MRI and focused-ultrasound enhanced brain-tumor drug delivery

Fan, C.-H., Ting, C.-Y., Lin, H.-J., Wang, C.-H., Liu, H.-L., Yen, T.-C., & Yeh, C.-K. (2013) · Biomaterials · doi:10.1016/j.biomaterials.2013.01.099 · Cited by 225 · see citing works

Ultrasound-mediated blood‐brain/blood-tumor barrier disruption improves outcomes with trastuzumab in a breast cancer brain metastasis model

Park, E.-J., Zhang, Y., Vykhodtseva, N. I., & McDannold, N. J. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.09.007 · Cited by 223 · see citing works

Fundamental Neurological Research and Human Neurosurgery Using Intense Ultrasound

Fry, W. J., & Fry, F. J. (1960) · IRE Transactions on Medical Electronics · doi:10.1109/iret-me.1960.5008041 · Cited by 205 · see citing works

Targeted Delivery of Self-Complementary Adeno-Associated Virus Serotype 9 to the Brain, Using Magnetic Resonance Imaging-Guided Focused Ultrasound

Thévenot, E., Jordão, J. F., O’Reilly, M. A., Markham, K. A., Weng, Y., Foust, K. D., Kaspar, B. K., Hynynen, K., & Aubert, I. (2012) · Human Gene Therapy · doi:10.1089/hum.2012.013 · Cited by 202 · see citing works

Reengineering Biopharmaceuticals for Targeted Delivery Across the Blood–Brain Barrier

Pardridge, W. M., & Boado, R. J. (2012) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/b978-0-12-396962-0.00011-2 · Cited by 199 · see citing works

Focused Ultrasound Delivers Targeted Immune Cells to Metastatic Brain Tumors

Alkins, R. D., Burgess, A., Ganguly, M., Francia, G., Kerbel, R. S., Wels, W. S., & Hynynen, K. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2609 · Cited by 197 · see citing works

Controlled Ultrasound-Induced Blood-Brain Barrier Disruption Using Passive Acoustic Emissions Monitoring

Arvanitis, C., Livingstone, M. S., Vykhodtseva, N. I., & McDannold, N. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045783 · Cited by 194 · see citing works

MRI investigation of the threshold for thermally induced blood–brain barrier disruption and brain tissue damage in the rabbit brain

McDannold, N. J., Vykhodtseva, N. I., Jolesz, F. A., & Hynynen, K. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20060 · Cited by 185 · see citing works

Multiphoton Imaging of Ultrasound/Optison Mediated Cerebrovascular Effects in vivo

Raymond, S. B., Skoch, J. M., Hynynen, K., & Bacskai, B. J. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600336 · Cited by 174 · see citing works

A quantitative pressure and microbubble‐size dependence study of focused ultrasound‐induced blood‐brain barrier opening reversibility in vivo using MRI

Samiotaki, G., Vlachos, F., Tung, Y., & Konofagou, E. E. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.23063 · Cited by 173 · see citing works

Structural and Functional Variations in Capillary Systems within the Braina

Fenstermacher, J. D., Gross, P. M., Sposito, N. M., Acuff, V., Pettersen, S. E., & Gruber, K. (1988) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1988.tb51416.x · Cited by 162 · see citing works

Stimulation of Hippocampal Neurogenesis by Transcranial Focused Ultrasound and Microbubbles in Adult Mice

Scarcelli, T., Jordão, J. F., O’Reilly, M. A., Ellens, N. P. K., Hynynen, K., & Aubert, I. (2014) · Brain stimulation · doi:10.1016/j.brs.2013.12.012 · Cited by 156 · see citing works

Noninvasive and Localized Blood—Brain Barrier Disruption using Focused Ultrasound can be Achieved at Short Pulse Lengths and Low Pulse Repetition Frequencies

Choi, J. J., Selert, K., Gao, Z., Samiotaki, G., Baseri, B., & Konofagou, E. E. (2010) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2010.155 · Cited by 153 · see citing works

Roles of ZO-1, occludin, and actin in oxidant-induced barrier disruption

Musch, M. W., Walsh-Reitz, M. M., & Chang, E. B. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00301.2005 · Cited by 152 · see citing works

Noninvasive, Transient and Selective Blood-Brain Barrier Opening in Non-Human Primates In Vivo

Marquet, F., Tung, Y., Teichert, T., Ferrera, V. P., & Konofagou, E. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022598 · Cited by 152 · see citing works

Use of Ultrasound Pulses Combined with Definity for Targeted Blood-Brain Barrier Disruption: A Feasibility Study

McDannold, N. J., Vykhodtseva, N. I., & Hynynen, K. (2007) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2006.10.004 · Cited by 150 · see citing works

Advances in osmotic opening of the blood-brain barrier to enhance CNS chemotherapy

Rapoport, S. I. (2001) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.10.10.1809 · Cited by 147 · see citing works

Antiangiogenic-targeting drug-loaded microbubbles combined with focused ultrasound for glioma treatment

Fan, C., Ting, C.-Y., Liu, H.-L., Huang, C.-Y., Hsieh, H.-Y., Yen, T., Wei, K., & Yeh, C. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.11.048 · Cited by 145 · see citing works

Ultrasonically Produced Changes in the Blood-Brain Barrier

Bakay, L. (1956) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1956.02330290001001 · Cited by 144 · see citing works

Two-Photon Fluorescence Microscopy Study of Cerebrovascular Dynamics in Ultrasound-Induced Blood—Brain Barrier Opening

Cho, E. E., Drazic, J., Ganguly, M., Stefanovic, B., & Hynynen, K. (2011) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2011.59 · Cited by 139 · see citing works

Expression and adhesive properties of basement membrane proteins in cerebral capillary endothelial cell cultures

Tilling, T., Engelbertz, C. M., Decker, S., Korte, D., Hüwel, S., & Galla, H. (2002) · Cell and Tissue Research · doi:10.1007/s00441-002-0604-1 · Cited by 138 · see citing works

Noninvasive and Targeted Gene Delivery into the Brain Using Microbubble-Facilitated Focused Ultrasound

Hsu, P.-H., Wei, K.-C., Huang, C.-Y., Wen, C.-J., Yen, T.-C., Liu, C.-L., Lin, Y.-T., Chen, J.-C., Shen, C.-R., & Liu, H.-L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057682 · Cited by 136 · see citing works

Novel magnetic/ultrasound focusing system enhances nanoparticle drug delivery for glioma treatment.

Chen, P.-Y., Liu, H.-L., Hua, M., Yang, H.-W., Huang, C.-Y., Chu, P.-C., Lyu, L.-A., Tseng, I.-C., Feng, L.-Y., Tsai, H.-C., et al. (2010) · Neuro-Oncology · doi:10.1093/neuonc/noq054 · Cited by 136 · see citing works

Activation of signaling pathways following localized delivery of systemically administered neurotrophic factors across the blood–brain barrier using focused ultrasound and microbubbles

Baseri, B., Choi, J. J., Deffieux, T., Samiotaki, G., Tung, Y., Olumolade, O., Small, S. A., Morrison, B., & Konofagou, E. E. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/7/n65 · Cited by 131 · see citing works

Drug delivery to the brain by focused ultrasound induced blood–brain barrier disruption: Quantitative evaluation of enhanced permeability of cerebral vasculature using two-photon microscopy

Nhan, T., Burgess, A., Cho, E. E., Stefanovic, B., Lilge, L. D., & Hynynen, K. (2013) · Journal of Controlled Release · doi:10.1016/j.jconrel.2013.08.029 · Cited by 124 · see citing works

Enhanced Delivery of Gold Nanoparticles with Therapeutic Potential into the Brain using MRI-Guided Focused Ultrasound

Etame, A., Diaz, R., O'Reilly, M., Smith, C. A., Mainprize, T., Hynynen, K., & Rutka, J. (2012) · Nanomedicine: Nanotechnology, Biology and Medicine · doi:10.1016/j.nano.2012.02.003 · Cited by 122 · see citing works

Focused-Ultrasound Disruption of the Blood-Brain Barrier Using Closely-Timed Short Pulses: Influence of Sonication Parameters and Injection Rate

O’Reilly, M. A., Waspe, A. C., Ganguly, M., & Hynynen, K. (2011) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2011.01.008 · Cited by 121 · see citing works

Feasibility of noninvasive cavitation-guided blood-brain barrier opening using focused ultrasound and microbubbles in nonhuman primates

Tung, Y.-S., Marquet, F., Teichert, T., Ferrera, V., & Konofagou, E. E. (2011) · Applied Physics Letters · doi:10.1063/1.3580763 · Cited by 119 · see citing works

Focused ultrasound for targeted delivery of siRNA and efficient knockdown of Htt expression

Burgess, A., Huang, Y., Querbes, W., Sah, D. W. Y., & Hynynen, K. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.08.012 · Cited by 118 · see citing works

The Role of Caveolin-1 in Blood–Brain Barrier Disruption Induced by Focused Ultrasound Combined with Microbubbles

Deng, J., Huang, Q., Wang, F., Liu, Y., Wang, Z.-B., Wang, Z.-G., Zhang, Q., Lei, B., & Cheng, Y. (2011) · Journal of Molecular Neuroscience · doi:10.1007/s12031-011-9629-9 · Cited by 117 · see citing works

Experimental Study on Targeted Methotrexate Delivery to the Rabbit Brain via Magnetic Resonance Imaging–Guided Focused Ultrasound

Mei, J., Cheng, Y., Song, Y., Yang, Y.-Q., Wang, F., Liu, Y., & Wang, Z.-B. (2009) · Journal of ultrasound in medicine · doi:10.7863/jum.2009.28.7.871 · Cited by 111 · see citing works

Permeability dependence study of the focused ultrasound‐induced blood–brain barrier opening at distinct pressures and microbubble diameters using DCE‐MRI

Vlachos, F., Tung, Y., & Konofagou, E. E. (2011) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22848 · Cited by 110 · see citing works

Microbubble Type and Distribution Dependence of Focused Ultrasound-Induced Blood–Brain Barrier Opening

Wang, S., Samiotaki, G., Olumolade, O., Feshitan, J. A., & Konofagou, E. E. (2013) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2013.09.015 · Cited by 108 · see citing works

Dependence of the reversibility of focused- ultrasound-induced blood-brain barrier opening on pressure and pulse length in vivo

Samiotaki, G., & Konofagou, E. E. (2013) · IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control · doi:10.1109/tuffc.2013.6644731 · Cited by 104 · see citing works

Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats

Jalali, S., Huang, Y., Dumont, D., & Hynynen, K. (2010) · BMC Neurology · doi:10.1186/1471-2377-10-114 · Cited by 97 · see citing works

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Noninvasive delivery of an α‐synuclein gene silencing vector with magnetic resonance–guided focused ultrasound

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Boron Neutron Capture Therapy: Clinical Application and Research Progress

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Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia

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Increasing of Blood-Brain Tumor Barrier Permeability through Transcellular and Paracellular Pathways by Microbubble-Enhanced Diagnostic Ultrasound in a C6 Glioma Model

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Scanning ultrasound in the absence of blood-brain barrier opening is not sufficient to clear β-amyloid plaques in the APP23 mouse model of Alzheimer's disease

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Focused Ultrasound Improves NK-92MI Cells Infiltration Into Tumors

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Perfluorocarbon Nanodroplets as Potential Nanocarriers for Brain Delivery Assisted by Focused Ultrasound-Mediated Blood–Brain Barrier Disruption

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