Alzheimer Disease in a Mouse Model: MR Imaging–guided Focused Ultrasound Targeted to the Hippocampus Opens the Blood-Brain Barrier and Improves Pathologic Abnormalities and Behavior

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Blood-brain barrier disruption with focused ultrasound enhances delivery of chemotherapeutic drugs for glioblastoma treatment.

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Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease

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Immature Doublecortin-Positive Hippocampal Neurons Are Important for Learning But Not for Remembering

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Short-Term Environmental Enrichment Rescues Adult Neurogenesis and Memory Deficits in APPSw,Ind Transgenic Mice

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Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats

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Disrupting the blood–brain barrier by focused ultrasound induces sterile inflammation

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Noninvasive hippocampal blood-brain barrier opening in Alzheimer's disease with focused ultrasound.

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Blood-brain barrier opening with focused ultrasound in Parkinson’s disease dementia

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Closed-loop control of targeted ultrasound drug delivery across the blood–brain/tumor barriers in a rat glioma model

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Ultrasound-mediated augmented exosome release from astrocytes alleviates amyloid-β-induced neurotoxicity

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Evaluation of permeability, doxorubicin delivery, and drug retention in a rat brain tumor model after ultrasound-induced blood-tumor barrier disruption

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Perivascular spaces and brain waste clearance systems: relevance for neurodegenerative and cerebrovascular pathology

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High-intensity focused ultrasound: past, present, and future in neurosurgery

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Non-invasive, neuron-specific gene therapy by focused ultrasound-induced blood-brain barrier opening in Parkinson's disease mouse model

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Noninvasive and targeted delivery of therapeutics to the brain using focused ultrasound

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Acoustically targeted chemogenetics for the non-invasive control of neural circuits

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Sonopermeation to improve drug delivery to tumors: from fundamental understanding to clinical translation

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Therapeutic oxygen delivery by perfluorocarbon-based colloids

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Repeated ultrasound treatment of tau transgenic mice clears neuronal tau by autophagy and improves behavioral functions

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Glymphatics visualization after focused ultrasound-induced blood-brain barrier opening in humans

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Noninvasive, Targeted and Non-Viral Ultrasound-Mediated GDNF-Plasmid Delivery for Treatment of Parkinson’s Disease

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Secondary effects on brain physiology caused by focused ultrasound-mediated disruption of the blood–brain barrier

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Cavitation-modulated inflammatory response following focused ultrasound blood-brain barrier opening

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Blood-Brain Barrier Opening with MRI-guided Focused Ultrasound Elicits Meningeal Venous Permeability in Humans with Early Alzheimer Disease

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Characterization of different bubble formulations for blood-brain barrier opening using a focused ultrasound system with acoustic feedback control

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Expression of Concern: Focused transcranial ultrasound for treatment of neurodegenerative dementia

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Enhanced delivery of paclitaxel liposomes using focused ultrasound with microbubbles for treating nude mice bearing intracranial glioblastoma xenografts

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Ultrasound responsive mesoporous silica nanoparticles for biomedical applications

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Polymeric Nanoparticles in Brain Cancer Therapy: A Review of Current Approaches

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Transcranial focused ultrasound, pulsed at 40 Hz, activates microglia acutely and reduces Aβ load chronically, as demonstrated in vivo

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Blood-brain barrier disruption: a culprit of cognitive decline?

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Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease

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Gene delivery to the spinal cord using MRI-guided focused ultrasound

Weber‐Adrian, D., Thévenot, E., O'Reilly, M. A., Oakden, W., Akens, M. K., Ellens, N. P. K., Markham-Coultes, K., Burgess, A., Finkelstein, J. A., Yee, A., et al. (2015) · Gene Therapy · doi:10.1038/gt.2015.25 · Cited by 93 · see citing works

Evaluating the safety profile of focused ultrasound and microbubble-mediated treatments to increase blood-brain barrier permeability

McMahon, D., Poon, C., & Hynynen, K. (2019) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2019.1567490 · Cited by 94 · see citing works

Clinically approved IVIg delivered to the hippocampus with focused ultrasound promotes neurogenesis in a model of Alzheimer’s disease

Dubey, S., Heinen, S., Krantic, S. M., McLaurin, J., Branch, D. R., Hynynen, K., & Aubert, I. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1908658117 · Cited by 91 · see citing works

Safety Validation of Repeated Blood–Brain Barrier Disruption Using Focused Ultrasound

Kobus, T., Vykhodtseva, N. I., Pilatou, M. C., Zhang, Y., & McDannold, N. J. (2015) · Ultrasound in Medicine & Biology · doi:10.1016/j.ultrasmedbio.2015.10.009 · Cited by 94 · see citing works

Rapid Short-pulse Ultrasound Delivers Drugs Uniformly across the Murine Blood-Brain Barrier with Negligible Disruption

Morse, S. V., Pouliopoulos, A. N., Chan, T. G., Copping, M. J., Lin, J., Long, N. J., & Choi, J. J. (2019) · Radiology · doi:10.1148/radiol.2019181625 · Cited by 91 · see citing works

Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model

Shin, J., Kong, C., Lee, J., Choi, B. Y., Sim, J., Koh, C. S., Park, M., Na, Y. C., Suh, S. W., Chang, W. S., et al. (2019) · Alzheimer s Research & Therapy · doi:10.1186/s13195-019-0569-x · Cited by 91 · see citing works

β-Amyloid Plaque Reduction in the Hippocampus After Focused Ultrasound-Induced Blood–Brain Barrier Opening in Alzheimer’s Disease

D’Haese, P.-F., Ranjan, M., Song, A., Haut, M. W., Carpenter, J., Dieb, G., Najib, U., Wang, P., Mehta, R. I., Chazen, J. L., et al. (2020) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2020.593672 · Cited by 94 · see citing works

A pilot clinical study of low-intensity transcranial focused ultrasound in Alzheimer’s disease

Jeong, H. S., Im, J. J., Park, J., Na, S., Lee, W., Yoo, S., Song, I., & Chung, Y. (2021) · ULTRASONOGRAPHY · doi:10.14366/usg.20138 · Cited by 89 · see citing works

Blood–brain barrier opening of the default mode network in Alzheimer’s disease with magnetic resonance-guided focused ultrasound

Meng, Y., Goubran, M., Rabin, J. S., McSweeney, M., Ottoy, J., Pople, C. B., Huang, Y., Storace, A., Ozzoude, M., Bethune, A., et al. (2023) · Brain · doi:10.1093/brain/awac459 · Cited by 83 · see citing works

Safety evaluation of a clinical focused ultrasound system for neuronavigation guided blood-brain barrier opening in non-human primates

Pouliopoulos, A. N., Kwon, N., Jensen, G., Meaney, A., Niimi, Y., Burgess, M. T., Ji, R., McLuckie, A. J., Muñoz, F., Kamimura, H. A. S., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-94188-3 · Cited by 83 · see citing works

Drug delivery system based on nanobubbles

Jin, J., Yang, L., Chen, F., & Gu, N. (2022) · Interdisciplinary materials · doi:10.1002/idm2.12050 · Cited by 87 · see citing works

Recent Advances on Ultrasound Contrast Agents for Blood-Brain Barrier Opening with Focused Ultrasound

Dauba, A., Delalande, A., Kamimura, H. A. S., Conti, A., Larrat, B., Tsapis, N., & Novell, A. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111125 · Cited by 83 · see citing works

Noninvasive delivery of an α‐synuclein gene silencing vector with magnetic resonance–guided focused ultrasound

Xhima, K., Nabbouh, F., Hynynen, K., Aubert, I., & Tandon, A. (2018) · Movement Disorders · doi:10.1002/mds.101 · Cited by 81 · see citing works

Ultrasound-mediated blood–brain barrier opening uncovers an intracerebral perivenous fluid network in persons with Alzheimer’s disease

Mehta, R. I., Carpenter, J. S., Mehta, R. I., Haut, M. W., Wang, P., Ranjan, M., Najib, U., D’Haese, P.-F., & Rezai, A. R. (2023) · Fluids and Barriers of the CNS · doi:10.1186/s12987-023-00447-y · Cited by 74 · see citing works

Therapeutic Agent Delivery Across the Blood–Brain Barrier Using Focused Ultrasound

McMahon, D., O’Reilly, M. A., & Hynynen, K. (2021) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-062117-121238 · Cited by 80 · see citing works

Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease

Poon, C., Shah, K., Lin, C., Tse, R., Kim, K. K., Mooney, S. J., Aubert, I., Stefanovic, B., & Hynynen, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-32250-3 · Cited by 80 · see citing works

Analysis of focused ultrasound-induced blood–brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy

Burgess, A., Nhan, T., Moffatt, C., Klibanov, A. L., & Hynynen, K. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.051 · Cited by 79 · see citing works

Focused Ultrasound-Induced Neurogenesis Requires an Increase in Blood-Brain Barrier Permeability

Mooney, S. J., Shah, K., Yeung, S., Burgess, A., Aubert, I., & Hynynen, K. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159892 · Cited by 78 · see citing works

Focused ultrasound with microbubbles induces sterile inflammatory response proportional to the blood brain barrier opening: Attention to experimental conditions

Kovacs‐Balint, Z., Burks, S. R., & Frank, J. A. (2018) · Theranostics · doi:10.7150/thno.24181 · Cited by 77 · see citing works

Focused Ultrasound: An Emerging Therapeutic Modality for Neurologic Disease

Fishman, P. S., & Frenkel, V. (2017) · Neurotherapeutics · doi:10.1007/s13311-017-0515-1 · Cited by 76 · see citing works

Striatal Blood–Brain Barrier Opening in Parkinson's Disease Dementia: A Pilot Exploratory Study

Pineda‐Pardo, J. A., Gasca‐Salas, C., Fernández‐Rodríguez, B., Rodríguez‐Rojas, R., del Álamo, M., Obeso, I., Hernández‐Fernández, F., Trompeta, C., Martínez‐Fernández, R., Matarazzo, M., et al. (2022) · Movement Disorders · doi:10.1002/mds.29134 · Cited by 75 · see citing works

Receptor specific, stimuli responsive and subcellular targeted approaches for effective therapy of Alzheimer: Role of surface engineered nanocarriers

Gopalan, D., Pandey, A. P., Udupa, N., & Mutalik, S. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.12.034 · Cited by 74 · see citing works

Non-invasive transcranial brain modulation for neurological disorders treatment: A narrative review

Mosilhy, E. A., Alshial, E. E., Eltaras, M. M., Rahman, M. M. A., Helmy, H. I., Elazoul, A. H., Hamdy, O., & Mohammed, H. S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120869 · Cited by 76 · see citing works

Blood–brain barrier opening by intracarotid artery hyperosmolar mannitol induces sterile inflammatory and innate immune responses

Burks, S. R., Kersch, C. N., Witko, J. A., Pagel, M. A., Sundby, M., Muldoon, L. L., Neuwelt, E. A., & Frank, J. A. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021915118 · Cited by 73 · see citing works

Acoustic Holograms for Bilateral Blood-Brain Barrier Opening in a Mouse Model

Jimenez-Gambin, S., Jiménez, N., Pouliopoulos, A. N., Benlloch, J., Konofagou, E., & Camarena, F. (2021) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2021.3115553 · Cited by 72 · see citing works

MRI and histological evaluation of pulsed focused ultrasound and microbubbles treatment effects in the brain

Kovacs‐Balint, Z., Tu, T., Sundby, M., Qureshi, F. M., Lewis, B. K., Jikaria, N. R., Burks, S. R., & Frank, J. A. (2018) · Theranostics · doi:10.7150/thno.24512 · Cited by 71 · see citing works

Focused Ultrasound Combined with Microbubbles in Central Nervous System Applications

Chen, K., Wei, K., & Liu, H. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13071084 · Cited by 72 · see citing works

Focused Ultrasound-Induced Blood-Brain Barrier Opening Enhances GSK-3 Inhibitor Delivery for Amyloid-Beta Plaque Reduction

Hsu, P.-H., Lin, Y.-T., Chung, Y.-H., Lin, K.-J., Yang, L.-Y., Yen, T.-C., & Liu, H.-L. (2018) · Scientific Reports · doi:10.1038/s41598-018-31071-8 · Cited by 70 · see citing works

Magnetic Resonance-Guided Focused Ultrasound : Current Status and Future Perspectives in Thermal Ablation and Blood-Brain Barrier Opening

Lee, E., Fomenko, A., & Lozano, A. M. (2019) · Journal of Korean Neurosurgical Society · doi:10.3340/jkns.2018.0180 · Cited by 68 · see citing works

Focused ultrasound delivery of a selective TrkA agonist rescues cholinergic function in a mouse model of Alzheimer’s disease

Xhima, K., Markham-Coultes, K., Nedev, H., Heinen, S., Saragovi, H. U., Hynynen, K., & Aubert, I. (2020) · Science Advances · doi:10.1126/sciadv.aax6646 · Cited by 69 · see citing works

The emerging role of transcranial magnetic resonance imaging–guided focused ultrasound in functional neurosurgery

Weintraub, D., & Elias, W. J. (2016) · Movement Disorders · doi:10.1002/mds.26599 · Cited by 68 · see citing works

Neutrophil recruitment and leukocyte response following focused ultrasound and microbubble mediated blood-brain barrier treatments

Poon, C., Pellow, C., & Hynynen, K. (2020) · Theranostics · doi:10.7150/thno.52710 · Cited by 68 · see citing works

Ultrasound frequency-controlled microbubble dynamics in brain vessels regulate the enrichment of inflammatory pathways in the blood-brain barrier

Guo, Y., Lee, H., Kim, C., Park, C., Yamamichi, A., Chuntova, P., Gallus, M., Bernabéu, M. O., Okada, H., Jo, H., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-52329-y · Cited by 68 · see citing works

Facilitation of Drug Transport across the Blood–Brain Barrier with Ultrasound and Microbubbles

Meairs, S. P. (2015) · Pharmaceutics · doi:10.3390/pharmaceutics7030275 · Cited by 67 · see citing works

Investigation of the Safety of Focused Ultrasound-Induced Blood-Brain Barrier Opening in a Natural Canine Model of Aging

O’Reilly, M. A., Jones, R. M., Barrett, E. G., Schwab, A., Head, E., & Hynynen, K. (2017) · Theranostics · doi:10.7150/thno.20621 · Cited by 66 · see citing works

Characterizing Focused-Ultrasound Mediated Drug Delivery to the Heterogeneous Primate Brain In Vivo with Acoustic Monitoring

Wu, S.-Y., Sánchez, C. S., Samiotaki, G., Buch, A., Ferrera, V. P., & Konofagou, E. E. (2016) · Scientific Reports · doi:10.1038/srep37094 · Cited by 67 · see citing works

Construction of Silica‐Based Micro/Nanoplatforms for Ultrasound Theranostic Biomedicine

Zhou, Y., Han, X., Jing, X., & Chen, Y. (2017) · Advanced Healthcare Materials · doi:10.1002/adhm.201700646 · Cited by 67 · see citing works

Cavitation dose painting for focused ultrasound-induced blood-brain barrier disruption

Yang, Y., Zhang, X., Ye, D., Laforest, R. A., Williamson, J. F., Liu, Y., & Chen, H. (2019) · Scientific Reports · doi:10.1038/s41598-019-39090-9 · Cited by 63 · see citing works

Microbubble-Assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System

Burgess, A., & Hynynen, K. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-22536-4_16 · Cited by 62 · see citing works

Brain Mechanisms of COVID-19-Sleep Disorders

Semyachkina-Glushkovskaya, O. V., Mamedova, A., Telnova, V., Klimova, M., Saranceva, E. I., Ageev, V., Yu, T., Zhu, D. Y., Penzel, T., & Kurths, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22136917 · Cited by 62 · see citing works

In vivo imaging of sterile microglial activation in rat brain after disrupting the blood-brain barrier with pulsed focused ultrasound: [18F]DPA-714 PET study

Sinharay, S., Tu, T., Kovacs‐Balint, Z., Schreiber-Stainthorp, W., Sundby, M., Zhang, X., Papadakis, G. Z., Reid, W. C., Frank, J. A., & Hammoud, D. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1543-z · Cited by 60 · see citing works

Short-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer’s Disease: A Preliminary Study

Jeong, H. S., Song, I., Chung, Y., Park, J., Na, S., Im, J. J., Bikson, M., Lee, W., & Yoo, S. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12020250 · Cited by 60 · see citing works

Establishing sheep as an experimental species to validate ultrasound-mediated blood-brain barrier opening for potential therapeutic interventions

Pelekanos, M., Leinenga, G., Odabaee, M., Odabaee, M., Saifzadeh, S., Steck, R., & Götz, J. (2018) · Theranostics · doi:10.7150/thno.22852 · Cited by 58 · see citing works

Sleep as a Novel Biomarker and a Promising Therapeutic Target for Cerebral Small Vessel Disease: A Review Focusing on Alzheimer’s Disease and the Blood-Brain Barrier

Semyachkina-Glushkovskaya, O. V., Postnov, D. E., Penzel, T., & Kurths, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21176293 · Cited by 60 · see citing works

Investigating the effects of dexamethasone on blood-brain barrier permeability and inflammatory response following focused ultrasound and microbubble exposure

McMahon, D., Oakden, W., & Hynynen, K. (2020) · Theranostics · doi:10.7150/thno.40908 · Cited by 57 · see citing works

Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping

Bae, S., Liu, K., Pouliopoulos, A. N., Ji, R., Jiménez-Gambín, S., Yousefian, O., Kline-Schoder, A. R., Batts, A. J., Tsitsos, F. N., Kokossis, D., et al. (2024) · Theranostics · doi:10.7150/thno.94206 · Cited by 70 · see citing works

Focused ultrasound for opening blood-brain barrier and drug delivery monitored with positron emission tomography

Arif, W. M., Elsinga, P. H., Gasca‐Salas, C., Versluis, M., Martínez‐Fernández, R., Dierckx, R., Borra, R., & Luurtsema, G. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.05.020 · Cited by 57 · see citing works

Overview of Therapeutic Ultrasound Applications and Safety Considerations: 2024 Update

Bader, K. B., Padilla, F. R., Haworth, K. J., Ellens, N. P. K., Dalecki, D., Miller, D. L., & Wear, K. A. (2024) · Journal of Ultrasound in Medicine · doi:10.1002/jum.16611 · Cited by 60 · see citing works

Amyloid-β and Tau in Alzheimer’s Disease: Novel Pathomechanisms and Non-Pharmacological Treatment Strategies

Nisbet, R. M., & Götz, J. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-179907 · Cited by 55 · see citing works

P1‐090: EFFECT OF REPEATED FOCUSED ULTRASOUND TREATMENTS ON THE DAILY LIVING ACTIVITIES OF THE TGCRND8 MOUSE MODEL OF ALZHEIMER'S DISEASE

Poon, C., Shah, K., & Hynynen, K. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.092

Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients

Karakatsani, M. E., Ji, R., Murillo, M. F., Kugelman, T., Kwon, N., Lao, Y., Liu, K., Pouliopoulos, A. N., Honig, L. S., Duff, K., et al. (2023) · Theranostics · doi:10.7150/thno.79898 · Cited by 43 · see citing works

Effects of Transcranial Focused Ultrasound on Hippocampal Neurogenesis and Astrogenesis

Scarcelli, T. (2013) · TSpace (University of Toronto)

Time course of focused ultrasound effects on β-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer’s disease

Poon, C., Shah, K., Lin, C., Tse, R., Kim, K. K., Mooney, S. J., Aubert, I., Stefanovic, B., & Hynynen, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-32250-3 · Cited by 80 · see citing works

Time course of focused ultrasound effects on beta-amyloid plaque pathology in the TgCRND8 mouse model of Alzheimer's disease

Poon, C., Shah, K., Lin, C., Tse, R., Kim, K. K., Mooney, S. J., Aubert, I., Stefanovic, B., & Hynynen, K. (2018) · UEF eRepo (University of Eastern Finland)