Tacke, Frank

Skeletal Muscle Composition Predicts Outcome in Critically Ill Patients

Loosen, S. H., Schulze-Hagen, M., Püngel, T., Bündgens, L., Wirtz, T., Kather, J. N., Vucur, M., Paffenholz, P., Demir, M., Bruners, P., et al. (2020) · Critical Care Explorations

Nutrition and Health in AgingClinical Nutrition and Gastroenterology

Cited by 58

miR-1224 inhibits cell proliferation in acute liver failure by targeting the antiapoptotic gene Nfib

Roy, S., Bantel, H., Wandrer, F., Schneider, A. T., Gautheron, J., Vucur, M., Tacke, F., Trautwein, C., Luedde, T., & Roderburg, C. (2017) · Journal of Hepatology

MicroRNA in disease regulationLiver physiology and pathology

Cited by 56

Clinical practice guidelines of the European association for the study of the liver - advancing methodology but preserving practicability

Cornberg, M., Tacke, F., & Karlsen, T. H. (2019) · Journal of Hepatology

Clinical practice guidelines implementationHepatitis C virus research

Cited by 49

Targeting CCR2/5 in the treatment of nonalcoholic steatohepatitis (NASH) and fibrosis: opportunities and challenges

Lefere, S., Devisscher, L., & Tacke, F. (2020) · Expert Opinion on Investigational Drugs

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 47

Deciphering the Immune Microenvironment on A Single Archival Formalin-Fixed Paraffin-Embedded Tissue Section by An Immediately Implementable Multiplex Fluorescence Immunostaining Protocol

Guillot, A., Kohlhepp, M., Bruneau, A., Heymann, F., & Tacke, F. (2020) · Cancers

Cancer Immunotherapy and BiomarkersSingle-cell and spatial transcriptomics

Cited by 46

Liver macrophages revisited: The expanding universe of versatile responses in a spatiotemporal context

Guillot, A., & Tacke, F. (2024) · Hepatology Communications

Liver physiology and pathologyImmune cells in cancer

Cited by 45

Roles of CCR2 and CCR5 for hepatic macrophage polarization in mice with liver parenchymal cell-specific NEMO deletion

Bartneck, M., Koppe, C., Fech, V., Warzecha, K. T., Kohlhepp, M., Huss, S., Weiskirchen, R., Trautwein, C., Luedde, T., & Tacke, F. (2021) · Cellular and Molecular Gastroenterology and Hepatology

Liver physiology and pathologyChemokine receptors and signaling

Cited by 44

Thyroid hormones as a disease modifier and therapeutic target in nonalcoholic steatohepatitis

Wirth, E. K., Puengel, T., Spranger, J., & Tacke, F. (2022) · Expert Review of Endocrinology & Metabolism

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 42

Cholangiokines: undervalued modulators in the hepatic microenvironment

Cai, X., Tacke, F., Guillot, A., & Liu, H. (2023) · Frontiers in Immunology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 40

Spatial dimension of macrophage heterogeneity in liver diseases

Guillot, A., & Tacke, F. (2023) · eGastroenterology

Liver physiology and pathologyImmune cells in cancer

Cited by 40

CX3CR1 Mediates the Development of Monocyte-Derived Dendritic Cells during Hepatic Inflammation

Sutti, S., Bruzzì, S., Heymann, F., Liepelt, A., Krenkel, O., Toscani, A., Ramavath, N., Cotella, D., Albano, E., & Tacke, F. (2019) · Cells

Liver physiology and pathologyChemokine receptors and signaling

Cited by 34

Dissecting Acute Drug‐Induced Hepatotoxicity and Therapeutic Responses of Steatotic Liver Disease Using Primary Mouse Liver and Blood Cells in a Liver‐On‐A‐Chip Model

Liu, H., Yin, G., Kohlhepp, M. S., Schumacher, F., Hundertmark, J., Hassan, M. I. A., Heymann, F., Puengel, T., Kleuser, B., Mosig, A. S., et al. (2024) · Advanced Science

Drug-Induced Hepatotoxicity and Protection3D Printing in Biomedical Research

Cited by 30

Liver fibrosis affects the targeting properties of drug delivery systems to macrophage subsets in vivo

Ergen, C., Niemietz, P. M., Heymann, F., Baues, M., Gremse, F., Pola, R., van Bloois, L., Storm, G., Kiessling, F., Trautwein, C., et al. (2019) · Biomaterials

Nanoparticle-Based Drug DeliveryLiver physiology and pathology

Cited by 27

The contradictory roles of macrophages in non-alcoholic fatty liver disease and primary liver cancer—Challenges and opportunities

Kohlhepp, M. S., Liu, H., Tacke, F., & Guillot, A. (2023) · Frontiers in Molecular Biosciences

Immune cells in cancerLiver physiology and pathology

Cited by 27

Reactive cholangiocyte-derived ORM2 drives a pathogenic modulation of the injured biliary niche through macrophage reprogramming

Liu, H., Yin, G., Franco Leonardi, B., Lan, T., Ait Ahmed, Y., Berger, H., Kohlhepp, M. S., Amiridze, N., Martagón Calderón, N., Frau, C., et al. (2025) · Gut

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 23

Sphingosine Kinase 1 Aggravates Liver Fibrosis by Mediating Macrophage Recruitment and Polarization

Ding, X., Zhang, X., Cao, J., Chen, S., Chen, Y., Yuan, K., Chen, B., Yang, G., Li, S., Yang, J., et al. (2024) · Cellular and Molecular Gastroenterology and Hepatology

Liver physiology and pathologySphingolipid Metabolism and Signaling

Cited by 23

Telomere Shortening in Peripheral Leukocytes Is Associated With Poor Survival in Cancer Patients Treated With Immune Checkpoint Inhibitor Therapy

Rolles, B., Gorgulho, J., Tometten, M., Roderburg, C., Vieri, M., Abels, A., Vucur, M., Heymann, F., Tacke, F., Brümmendorf, T. H., et al. (2021) · Frontiers in Oncology

Telomeres, Telomerase, and SenescenceCancer Immunotherapy and Biomarkers

Cited by 12

Multiomics analyses decipher intricate changes in the cellular and metabolic landscape of steatotic livers upon dietary restriction and sleeve gastrectomy

Chen, S., Zeng, Q., Cai, X., Xue, J., Yin, G., Song, P., Tang, L., Klein, C., Tacke, F., Guillot, A., et al. (2024) · International Journal of Biological Sciences

Liver Disease Diagnosis and TreatmentBariatric Surgery and Outcomes

Cited by 8

Macrophage heterogeneity in liver fibrosis

Wang, W., Li, S., Liu, Y., Ding, X., Yang, Y., Chen, S., Cao, J., Tacke, F., Dong, W., & Lan, T. (2025) · Frontiers in Immunology

Liver physiology and pathologyImmune cells in cancer

Cited by 8