Tacke, Frank

RIPK1 Suppresses a TRAF2-Dependent Pathway to Liver Cancer

Schneider, A. T., Gautheron, J., Feoktistova, M., Roderburg, C., Loosen, S. H., Roy, S., Benz, F., Schemmer, P., Büchler, M. W., Nachbur, U., et al. (2017) · Cancer Cell

Cell death mechanisms and regulationNF-κB Signaling Pathways

Cited by 155

Acquisition of epithelial plasticity in human chronic liver disease

Gribben, C., Galanakis, V., Calderwood, A., Williams, E. C., Chazarra-Gil, R., Larraz, M., Frau, C., Puengel, T., Guillot, A., Rouhani, F. J., et al. (2024) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 142

Fluorescent cell-traceable dexamethasone-loaded liposomes for the treatment of inflammatory liver diseases

Bartneck, M., Scheyda, K. M., Warzecha, K. T., Rizzo, L. Y., Hittatiya, K., Luedde, T., Storm, G., Trautwein, C., Lammers, T., & Tacke, F. (2015) · Biomaterials

Nanoparticle-Based Drug DeliveryLiver physiology and pathology

Cited by 141

Hepatic stellate cells control liver zonation, size and functions via R-spondin 3

Sugimoto, A., Saito, Y., Wang, G., Sun, Q., Yin, C., Lee, K. H., Geng, Y., Rajbhandari, P., Hernandez, C., Steffani, M., et al. (2025) · Nature

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 133

Kupffer cell–like syncytia replenish resident macrophage function in the fibrotic liver

Peiseler, M., Araujo David, B., Zindel, J., Surewaard, B. G. J., Lee, W.-Y., Heymann, F., Nusse, Y., Castanheira, F. V. S., Shim, R., Guillot, A., et al. (2023) · Science

Liver physiology and pathologyImmune cells in cancer

Cited by 123

Mapping the hepatic immune landscape identifies monocytic macrophages as key drivers of steatohepatitis and cholangiopathy progression

Guillot, A., Winkler, M., Silva Afonso, M., Aggarwal, A., Lopez, D., Berger, H., Kohlhepp, M. S., Liu, H., Özdirik, B., Eschrich, J., et al. (2023) · Hepatology

Liver Diseases and ImmunityLiver Disease Diagnosis and Treatment

Cited by 116

Understanding the cellular interactome of non-alcoholic fatty liver disease

Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 116

Intestinal B cells license metabolic T-cell activation in NASH microbiota/antigen-independently and contribute to fibrosis by IgA-FcR signalling

Kotsiliti, E., Leone, V., Schuehle, S., Govaere, O., Li, H., Wolf, M. J., Horvatic, H., Bierwirth, S., Hundertmark, J., Inverso, D., et al. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 108

Histidine‐rich glycoprotein promotes macrophage activation and inflammation in chronic liver disease

Bartneck, M., Fech, V., Ehling, J., Govaere, O., Warzecha, K. T., Hittatiya, K., Vucur, M., Gautheron, J., Luedde, T., Trautwein, C., et al. (2016) · Hepatology

Liver physiology and pathologyImmune cells in cancer

Cited by 101

The NLRP3 inflammasome in alcoholic and nonalcoholic steatohepatitis

Knorr, J., Wree, A., Tacke, F., & Feldstein, A. E. (2020) · Seminars in Liver Disease

Inflammasome and immune disordersLiver Disease Diagnosis and Treatment

Cited by 99

Pharmacological intervention in hepatic stellate cell activation and hepatic fibrosis

Schon, H.-T., Bartneck, M., Borkham-Kamphorst, E., Nattermann, J., Lammers, T., Tacke, F., & Weiskirchen, R. (2016) · Frontiers in Pharmacology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 97

The Multifaceted Roles of Macrophages in NAFLD Pathogenesis

Vonderlin, J., Chavakis, T., Sieweke, M., & Tacke, F. (2023) · Cellular and Molecular Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 96

Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease

Puengel, T., Liu, H., Guillot, A., Heymann, F., Tacke, F., & Peiseler, M. (2022) · International Journal of Molecular Sciences

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 95

Portal fibroblasts with mesenchymal stem cell features form a reservoir of proliferative myofibroblasts in liver fibrosis

Lei, L., Bruneau, A., El Mourabit, H., Guégan, J., Folseraas, T., Lemoinne, S., Karlsen, T. H., Hoareau, B., Morichon, R., Gonzalez‐Sanchez, E., et al. (2022) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 94

Monocyte-derived macrophages orchestrate multiple cell-type interactions to repair necrotic liver lesions in disease models

Feng, D., Xiang, X., Guan, Y., Guillot, A., Lu, H., Chang, C., He, Y., Wang, H., Pan, H., Ju, C., et al. (2023) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 93

Distinct histopathological phenotypes of severe alcoholic hepatitis suggest different mechanisms driving liver injury and failure

Ma, J., Guillot, A., Yang, Z., Mackowiak, B., Hwang, S., Park, O., Peiffer, B. J., Ahmadi, A. R., Melo, L., Kusumanchi, P., et al. (2022) · Journal of Clinical Investigation

Alcohol Consumption and Health EffectsLiver physiology and pathology

Cited by 90

Angiocrine signaling in sinusoidal homeostasis and liver diseases

Gao, J., Lan, T., Kostallari, E., Guo, Y., Lai, E., Guillot, A., Ding, B., Tacke, F., Tang, C., & Shah, V. H. (2024) · Journal of Hepatology

Liver physiology and pathologyLiver Disease and Transplantation

Cited by 90

Bile acid–activated macrophages promote biliary epithelial cell proliferation through integrin αvβ6 upregulation following liver injury

Guillot, A., Guerri, L., Feng, D., Kim, S.-J., Ahmed, Y. A., Paloczi, J., He, Y., Schuebel, K., Dai, S., Liu, F., et al. (2021) · Journal of Clinical Investigation

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 86

Immunopathogenic mechanisms and immunoregulatory therapies in MASLD

He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 81

Macrophages in nonalcoholic fatty liver disease: a role model of pathogenic immunometabolism

Krenkel, O., & Tacke, F. (2017) · Seminars in Liver Disease

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 66

GLP-1 Levels Predict Mortality in Patients with Critical Illness as Well as End-Stage Renal Disease

Lebherz, C., Schlieper, G., Möllmann, J., Kahles, F., Schwarz, M., Brünsing, J., Dimkovic, N., Koch, A., Trautwein, C., Flöge, J., et al. (2017) · The American Journal of Medicine

Sepsis Diagnosis and TreatmentDiabetes Treatment and Management

Cited by 65

Implementation of a liver health check in people with type 2 diabetes

Abeysekera, K. W. M., Valenti, L., Younossi, Z., Dillon, J. F., Allen, A. M., Noureddin, M., Rinella, M. E., Tacke, F., Francque, S., Ginès, P., et al. (2024) · The Lancet Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentLiver Disease and Transplantation

Cited by 63

The Potential Role of Cellular Senescence in Non-Alcoholic Fatty Liver Disease

Engelmann, C., & Tacke, F. (2022) · International Journal of Molecular Sciences

Liver Disease Diagnosis and TreatmentTelomeres, Telomerase, and Senescence

Cited by 61

Combined therapy with a CCR2/CCR5 antagonist and FGF21 analogue synergizes in ameliorating steatohepatitis and fibrosis

Puengel, T., Lefere, S., Hundertmark, J., Kohlhepp, M., Penners, C., Van de Velde, F., Lapauw, B., Hoorens, A., Devisscher, L., Geerts, A., et al. (2022) · International Journal of Molecular Sciences

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 59