Tacke, Frank

Metabolic reprogramming in liver fibrosis

Horn, P., & Tacke, F. (2024) · Cell Metabolism

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 432

Platelet GPIbα is a mediator and potential interventional target for NASH and subsequent liver cancer

Malehmir, M., Pfister, D., Gallage, S., Szydlowska, M., Inverso, D., Kotsiliti, E., Leone, V., Peiseler, M., Surewaard, B. G. J., Rath, D., et al. (2019) · Nature Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 398

Inflammatory Pathways in Liver Homeostasis and Liver Injury

Tacke, F., Luedde, T., & Trautwein, C. (2009) · Clinical Reviews in Allergy & Immunology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 393

Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

Seidler, S., Zimmermann, H. W., Bartneck, M., Trautwein, C., & Tacke, F. (2010) · BMC Immunology

Immune cells in cancerImmune Response and Inflammation

Cited by 390

Cenicriviroc Treatment for Adults With Nonalcoholic Steatohepatitis and Fibrosis: Final Analysis of the Phase 2b CENTAUR Study

Ratziu, V., Sanyal, A., Harrison, S. A., Wong, V. W., Francque, S., Goodman, Z., Aithal, G. P., Kowdley, K. V., Seyedkazemi, S., Fischer, L., et al. (2020) · Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 378

Chemokine (C‐C motif) receptor 2–positive monocytes aggravate the early phase of acetaminophen‐induced acute liver injury

Mossanen, J. C., Krenkel, O., Ergen, C., Govaere, O., Liepelt, A., Puengel, T., Heymann, F., Kalthoff, S., Lefebvre, E., Eulberg, D., et al. (2016) · Hepatology

Drug-Induced Hepatotoxicity and ProtectionLiver physiology and pathology

Cited by 325

An integrated view of anti-inflammatory and antifibrotic targets for the treatment of NASH

Tacke, F., Puengel, T., Loomba, R., & Friedman, S. L. (2023) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 321

Nonalcoholic steatohepatitis: the role of peroxisome proliferator-activated receptors

Francque, S., Szabo, G., Abdelmalek, M. F., Byrne, C. D., Cusi, K., Dufour, J.-F., Roden, M., Sacks, F., & Tacke, F. (2021) · Nature Reviews Gastroenterology & Hepatology

Liver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated Receptors

Cited by 316

A positive feedback loop between RIP3 and JNK controls non‐alcoholic steatohepatitis

Gautheron, J., Vucur, M., Reisinger, F., Cardenas, D. V., Roderburg, C., Koppe, C., Kreggenwinkel, K., Schneider, A. T., Bartneck, M., Neumann, U. P., et al. (2014) · EMBO Molecular Medicine

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 314

Differential Effects of Selective- and Pan-PPAR Agonists on Experimental Steatohepatitis and Hepatic Macrophages(☆)

Lefere, S., Puengel, T., Hundertmark, J., Penners, C., Frank, A. K., Guillot, A., de Muynck, K., Heymann, F., Adarbes, V., Defrêne, E., et al. (2020) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentPeroxisome Proliferator-Activated Receptors

Cited by 310

Macrophages in obesity and non-alcoholic fatty liver disease: crosstalk with metabolism

Lefere, S., & Tacke, F. (2019) · JHEP Reports

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 278

CCL2-dependent infiltrating macrophages promote angiogenesis in progressive liver fibrosis

Ehling, J., Bartneck, M., Wei, X., Gremse, F., Fech, V., Möckel, D., Baeck, C., Hittatiya, K., Eulberg, D., Luedde, T., et al. (2014) · Gut

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 273

Pharmacological inhibition of the chemokine C-C motif chemokine ligand 2 (monocyte chemoattractant protein 1) accelerates liver fibrosis regression by suppressing Ly-6C+ macrophage infiltration in mice

Baeck, C., Wei, X., Bartneck, M., Fech, V., Heymann, F., Gassler, N., Hittatiya, K., Eulberg, D., Luedde, T., Trautwein, C., et al. (2014) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 270

Chemokine receptor CXCR6-dependent hepatic NK T Cell accumulation promotes inflammation and liver fibrosis

Wehr, A., Baeck, C., Heymann, F., Niemietz, P. M., Hammerich, L., Martin, C., Zimmermann, H. W., Pack, O., Gassler, N., Hittatiya, K., et al. (2013) · The Journal of Immunology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 268

The Fractalkine Receptor CX3CR1 Protects Against Liver Fibrosis by Controlling Differentiation and Survival of Infiltrating Hepatic Monocytes

Karlmark, K. R., Zimmermann, H. W., Roderburg, C., Gassler, N., Wasmuth, H. E., Luedde, T., Trautwein, C., & Tacke, F. (2010) · Hepatology

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 249

Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis

Krenkel, O., Hundertmark, J., Ritz, T., Weiskirchen, R., & Tacke, F. (2019) · Cells

Liver physiology and pathologyLiver Disease Diagnosis and Treatment

Cited by 241

Myeloid cells in liver and bone marrow acquire a functionally distinct inflammatory phenotype during obesity-related steatohepatitis

Krenkel, O., Hundertmark, J., Abdallah, A. T., Kohlhepp, M., Puengel, T., Roth, T., Branco, D. P. P., Mossanen, J. C., Luedde, T., Trautwein, C., et al. (2020) · Gut

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 220

GLP-1 Secretion Is Increased by Inflammatory Stimuli in an IL-6–Dependent Manner, Leading to Hyperinsulinemia and Blood Glucose Lowering

Kahles, F., Meyer, C., Möllmann, J., Diebold, S., Findeisen, H. M., Lebherz, C., Trautwein, C., Koch, A., Tacke, F., Marx, N., et al. (2014) · Diabetes

Diabetes Treatment and ManagementPancreatic function and diabetes

Cited by 212

Report on the AASLD/EASL joint workshop on clinical trial endpoints in NAFLD

Rinella, M. E., Tacke, F., Sanyal, A. J., & Anstee, Q. M. (2019) · Journal of Hepatology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 209

Therapeutic depletion of CCR8 + tumor-infiltrating regulatory T cells elicits antitumor immunity and synergizes with anti-PD-1 therapy

Van Damme, H., Dombrecht, B., Kiss, M., Roose, H., Allen, E., Van Overmeire, E., Kancheva, D., Martens, L., Murgaski, A., Bardet, P. M. R., et al. (2021) · Journal for ImmunoTherapy of Cancer

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 205

The fecal mycobiome in non-alcoholic fatty liver disease

Demir, M., Lang, S., Hartmann, P., Duan, Y., Martin, A., Miyamoto, Y., Bondareva, M., Zhang, X., Wang, Y., Kasper, P., et al. (2022) · Journal of Hepatology

Gut microbiota and healthLiver Disease Diagnosis and Treatment

Cited by 197

Global Consensus Recommendations for Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis

Younossi, Z. M., Zelber-Sagi, S., Lazarus, J. V., Wong, V. W.-S., Yilmaz, Y., Duseja, A., Eguchi, Y., Castera, L., Pessoa, M. G., Oliveira, C. P., et al. (2025) · Gastroenterology

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 194

Chemokine receptor CCR6-dependent accumulation of γδ T cells in injured liver restricts hepatic inflammation and fibrosis

Hammerich, L., Bangen, J. M., Govaere, O., Zimmermann, H. W., Gassler, N., Huss, S., Liedtke, C., Prinz, I., Lira, S. A., Luedde, T., et al. (2014) · Hepatology

Liver physiology and pathologyLiver Diseases and Immunity

Cited by 190

Cenicriviroc lacked efficacy to treat liver fibrosis in nonalcoholic steatohepatitis: AURORA phase III randomized study

Anstee, Q. M., Neuschwander-Tetri, B. A., Wai-Sun Wong, V., Abdelmalek, M. F., Rodriguez-Araujo, G., Landgren, H., Park, G. S., Bedossa, P., Alkhouri, N., Tacke, F., et al. (2024) · Clinical Gastroenterology and Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 179