Brown, Eric J.

A mammalian protein targeted by G1-arresting rapamycin–receptor complex

Brown, E. J., Albers, M. W., Bum Shin, T., ichikawa, K., Keith, C. T., Lane, W. S., & Schreiber, S. L. (1994) · Nature

PI3K/AKT/mTOR signaling in cancerSignaling Pathways in Disease

Cited by 2,053

The DNA damage pathway regulates innate immune system ligands of the NKG2D receptor

Gasser, S., Orsulic, S., Brown, E. J., & Raulet, D. H. (2005) · Nature

Immune Cell Function and Interactioninterferon and immune responses

Cited by 1,308

ATR disruption leads to chromosomal fragmentation and early embryonic lethality

Brown, E. J., & Baltimore, D. (2000) · Genes & Development

DNA Repair MechanismsDevelopmental Biology and Gene Regulation

Cited by 951

Identification of an 11-kDa FKBP12-rapamycin-binding domain within the 289-kDa FKBP12-rapamycin-associated protein and characterization of a critical serine residue.

Chen, J., Zheng, X. F., Brown, E. J., & Schreiber, S. L. (1995) · Proceedings of the National Academy of Sciences

PI3K/AKT/mTOR signaling in cancerSignaling Pathways in Disease

Cited by 556

Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Brown, E. J., & Baltimore, D. (2003) · Genes & Development

DNA Repair MechanismsCancer-related Molecular Pathways

Cited by 511

Disruption of the Mouse mTOR Gene Leads to Early Postimplantation Lethality and Prohibits Embryonic Stem Cell Development

Gangloff, Y.-G., Mueller, M., Dann, S. G., Svoboda, P., Sticker, M., Spetz, J.-F., Um, S. H., Brown, E. J., Cereghini, S., Thomas, G., et al. (2004) · Molecular and Cellular Biology

PI3K/AKT/mTOR signaling in cancerDevelopmental Biology and Gene Regulation

Cited by 485

Acute postnatal ablation of Hif-2 α results in anemia

Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C. (2007) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 457

Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis

Guo, X., Deng, Y., Lin, Y., Cosme‐Blanco, W., Chan, S., He, H., Yuan, G., Brown, E. J., & Chang, S. (2007) · The EMBO Journal

Telomeres, Telomerase, and SenescenceDNA Repair Mechanisms

Cited by 258

HIF2α inhibition promotes p53 pathway activity, tumor cell death, and radiation responses

Bertout, J. A., Majmundar, A. J., Gordan, J. D., Lam, J. C., Ditsworth, D., Keith, B., Brown, E. J., Nathanson, K. L., & Simon, M. C. (2009) · Proceedings of the National Academy of Sciences

Cancer, Hypoxia, and MetabolismCancer-related Molecular Pathways

Cited by 196

FKBP-rapamycin inhibits a cyclin-dependent kinase activity and a cyclin D1-Cdk association in early G1 of an osteosarcoma cell line

Albers, M. W., Williams, R. T., Brown, E. J., Tanaka, A., Hall, F. L., & Schreiber, S. L. (1993) · Journal of Biological Chemistry

PI3K/AKT/mTOR signaling in cancerCancer-related Molecular Pathways

Cited by 145

ATR and H2AX cooperate in maintaining genome stability under replication stress

Chanoux, R. A., Yin, B., Urtishak, K. A., Asare, A., Bassing, C. H., & Brown, E. J. (2009) · Journal of Biological Chemistry

DNA Repair MechanismsEffects of Radiation Exposure

Cited by 130

Removing all obstacles: A critical role for p53 in promoting tissue renewal

Schoppy, D. W., Ruzankina, Y., & Brown, E. J. (2010) · Cell Cycle

Cancer-related Molecular PathwaysDNA Repair Mechanisms

Cited by 32

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

Mackay, H. L., Stone, H. R., Ronson, G. E., Ellis, K., Lanz, A., Aghabi, Y., Walker, A. K., Starowicz, K., Garvin, A. J., Van Eijk, P., et al. (2024) · Nature Communications

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 4

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication

Mackay, H. L., Stone, H. R., Ellis, K., Ronson, G. E., Walker, A. K., Starowicz, K., Garvin, A. J., van Eijk, P., Vaitsiankova, A., Vijayendran, S., et al. (2024) · Nature Communications

DNA Repair MechanismsUbiquitin and proteasome pathways

Cited by 4