ATR and H2AX cooperate in maintaining genome stability under replication stress

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139

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A Third-Generation Lentivirus Vector with a Conditional Packaging System

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Sensing DNA Damage Through ATRIP Recognition of RPA-ssDNA Complexes

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DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

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Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

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A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

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ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

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Genomic Instability in Mice Lacking Histone H2AX

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Identification and characterization of a novel and specific inhibitor of the ataxia-telangiectasia mutated kinase ATM

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Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress

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ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks

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RNF8 Transduces the DNA-Damage Signal via Histone Ubiquitylation and Checkpoint Protein Assembly

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ATM and DNA-PK Function Redundantly to Phosphorylate H2AX after Exposure to Ionizing Radiation

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<i>ATR</i> disruption leads to chromosomal fragmentation and early embryonic lethality

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Choreography of the DNA Damage Response

Lisby, M., Barlow, J. H., Burgess, R. C., & Rothstein, R. (2004) · Cell · doi:10.1016/j.cell.2004.08.015 · Cited by 891 · see citing works

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880 · see citing works

Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

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Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint

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Mitotic checkpoint genes in budding yeast and the dependence of mitosis on DNA replication and repair.Preprint

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The DNA replication checkpoint response stabilizes stalled replication forks

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Regulation of DNA replication fork progression through damaged DNA by the Mec1/Rad53 checkpoint

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The cell-cycle checkpoint kinase Chk1 is required for mammalian homologous recombination repair

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ATR Regulates Fragile Site Stability

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Overexpression of a kinase‐inactive ATR protein causes sensitivity to DNA‐damaging agents and defects in cell cycle checkpoints

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Increased ionizing radiation sensitivity and genomic instability in the absence of histone H2AX

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Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance

Brown, E. J., & Baltimore, D. (2003) · Genes &amp; Development · doi:10.1101/gad.1067403 · Cited by 511 · see citing works

Histone H2AX

Bassing, C. H., Suh, H., Ferguson, D. O., Chua, K. F., Manis, J. P., Eckersdorff, M., Gleason, M., Bronson, R. T., Lee, C., & Alt, F. W. (2003) · Cell · doi:10.1016/s0092-8674(03)00566-x · Cited by 480 · see citing works

Mutation of fission yeast cell cycle control genes abolishes dependence of mitosis on DNA replication

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Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes

Furuta, T., Takemura, H., Liao, Z.-Y., Aune, G. J., Redon, C., Sedelnikova, O. A., Pilch, D. R., Rogakou, E. P., Celeste, A., Chen, H. T., et al. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300198200 · Cited by 449 · see citing works

Recovery from DNA replicational stress is the essential function of the S-phase checkpoint pathwayPreprint

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ATR Homolog Mec1 Promotes Fork Progression, Thus Averting Breaks in Replication Slow Zones

Rita, S., & Kleckner, N. E. (2002) · Science · doi:10.1126/science.1071398 · Cited by 429 · see citing works

DNA repair mutants defining G2 checkpoint pathways in Schizosaccharomyces pombe.

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A Central Role for DNA Replication Forks in Checkpoint Activation and Response

Tercero, J. A., Longhese, M. P., & Diffley, J. F. X. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00169-2 · Cited by 394 · see citing works

Fission yeast genes involved in coupling mitosis to completion of DNA replication.Preprint

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An ATR- and Cdc7-Dependent DNA Damage Checkpoint that Inhibits Initiation of DNA Replication

Costanzo, V., Shechter, D., Lupardus, P. J., Cimprich, K. A., Gottesman, M. E., & Gautier, J. (2003) · Molecular Cell · doi:10.1016/s1097-2765(02)00799-2 · Cited by 355 · see citing works

DNA polymerase stabilization at stalled replication forks requires Mec1 and the RecQ helicase Sgs1

Cobb, J. A., Bjergbæk, L., Shimada, K., Frei, C., & Gasser, S. M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg391 · Cited by 333 · see citing works

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1

Veuger, S. J., Curtin, N. J., Richardson, C. J., Smith, G. C. M., & Durkacz, B. W. (2003) · PubMed · doi:10.25405/ncl.34607331 · Cited by 332 · see citing works

Functional Interaction of Monoubiquitinated FANCD2 and BRCA2/FANCD1 in Chromatin

Wang, X., Andreassen, P. R., & D’Andrea, A. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.13.5850-5862.2004 · Cited by 332 · see citing works

ATR inhibition selectively sensitizes G ₁ checkpoint-deficient cells to lethal premature chromatin condensation

Nghiem, P., Park, P. K., Kim, Y.-S., Vaziri, C., & Schreiber, S. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.161281798 · Cited by 290 · see citing works

Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis

Guo, X., Deng, Y., Lin, Y., Cosme‐Blanco, W., Chan, S., He, H., Yuan, G., Brown, E. J., & Chang, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601893 · Cited by 258 · see citing works

The ATR pathway: Fine-tuning the fork

PAULSEN, R., & Cimprich, K. A. (2007) · DNA repair · doi:10.1016/j.dnarep.2007.02.015 · Cited by 256 · see citing works

Chk1‐deficient tumour cells are viable but exhibit multiple checkpoint and survival defects

Zachos, G., Rainey, M. D., & Gillespie, D. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg060 · Cited by 247 · see citing works

ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

Trenz, K., Smith, E., Smith, S. J., & Costanzo, V. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601045 · Cited by 219 · see citing works

A Critical Role for the Ubiquitin-Conjugating Enzyme Ubc13 in Initiating Homologous Recombination

Zhao, G., Sonoda, E., Barber, L. J., Oka, H., Murakawa, Y., Yamada, K., Ikura, T., Wang, X., Kobayashi, M., Yamamoto, K., et al. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.029 · Cited by 218 · see citing works

Control of Sister Chromatid Recombination by Histone H2AX

Xie, A., Puget, N., Shim, I., Odate, S., Jarzyna, I., Bassing, C. H., Alt, F. W., & Scully, R. (2004) · Molecular Cell · doi:10.1016/j.molcel.2004.12.007 · Cited by 208 · see citing works

Phosphorylation of the Bloom's Syndrome Helicase and Its Role in Recovery from S-Phase Arrest

Davies, S. L., North, P. S., Dart, D. A., Lakin, N. D., & Hickson, I. D. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.1279-1291.2004 · Cited by 208 · see citing works

Replisome instability, fork collapse, and gross chromosomal rearrangements arise synergistically from Mec1 kinase and RecQ helicase mutationsPreprint

Cobb, J. A., Schleker, T., Rojas, V., Bjergbæk, L., Tercero, J. A., & Gasser, S. M. (2005) · Genes & Development · doi:10.1101/gad.361805 · Cited by 197 · see citing works

Somatic mutations in the DNA damage-response genes ATR and CHK1 in sporadic stomach tumors with microsatellite instability.

Menoyo, A., Alazzouzi, H., Espín, E., Armengol, M., Yamamoto, H., & Schwartz, S. (2001) · PubMed · Cited by 151 · see citing works

A conserved pathway to activate BRCA1‐dependent ubiquitylation at DNA damage sites

Polanowska, J., Martin, J. S., García‐Muse, T., Petalcorin, M. I. R., & Boulton, S. J. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601102 · Cited by 143 · see citing works

Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest

Sengupta, S., Robles, A. I., Linke, S. P., Sinogeeva, N. I., Zhang, R., Pedeux, R., Ward, I. M., Celeste, A., Nussenzweig, A., Chen, J., et al. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200405128 · Cited by 130 · see citing works

ATR Affecting Cell Radiosensitivity Is Dependent on Homologous Recombination Repair but Independent of Nonhomologous End Joining

Wang, H., Wang, H., Powell, S. N., Iliakis, G., & Wang, Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1289 · Cited by 130 · see citing works

Histone H2AX and Fanconi anemia FANCD2 function in the same pathway to maintain chromosome stability

Bogliolo, M., Lyakhovich, A., Callén, E., Castellà, M., Cappelli, E., Ramı́rez, M. J., Creus, A., Marcos, R., Kalb, R., Neveling, K., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601574 · Cited by 128 · see citing works

Depletion of CHK1, but not CHK2, induces chromosomal instability and breaks at common fragile sites

Durkin, S. G., Arlt, M. F., Howlett, N. G., & Glover, T. W. (2006) · Oncogene · doi:10.1038/sj.onc.1209466 · Cited by 127 · see citing works

ATR functions as a gene dosage‐dependent tumor suppressor on a mismatch repair‐deficient background

Fang, Y., Tsao, C., Goodman, B. K., Furumai, R., Tirado, C. A., Abraham, R. T., & Wang, X.-F. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600315 · Cited by 113 · see citing works

Replication and recombination intersect

Marians, K. J. (2000) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00059-9 · Cited by 91 · see citing works

Phosphorylation of BLM, Dissociation from Topoisomerase IIIα, and Colocalization with γ-H2AX after Topoisomerase I-Induced Replication Damage

Rao, V. A., Fan, A. M., Meng, L., Doe, C. F., North, P. S., Hickson, I. D., & Pommier, Y. G. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.20.8925-8937.2005 · Cited by 87 · see citing works

Temporal separation of replication and recombination requires the intra-S checkpoint

Meister, P., Taddei, A., Vernis, L., Poidevin, M., Gasser, S. M., & Baldacci, G. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200410006 · Cited by 84 · see citing works

ATR and ATM-Dependent Movement of BLM Helicase during Replication Stress Ensures Optimal ATM Activation and 53BP1 Focus Formation

Davalos, A. R., Kaminker, P. G., Hansen, R. K., & Campisi, J. (2004) · Cell Cycle · doi:10.4161/cc.3.12.1286 · Cited by 58 · see citing works

Heterozygous ATR Mutations in Mismatch Repair–Deficient Cancer Cells Have Functional Significance

Lewis, K. A., Mullany, S. A., Thomas, B., CHIEN, J. R., Loewen, R. T., Shridhar, V., & Cliby, W. A. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-1019 · Cited by 58 · see citing works

Collaborative roles of γH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair

Sonoda, E., Zhao, G. Y., Kohzaki, M., Dhar, P. K., Kikuchi, K., Redon, C., Pilch, D. R., Bonner, W. M., Nakano, A., Watanabe, M., et al. (2007) · DNA Repair · doi:10.1016/j.dnarep.2006.10.025 · Cited by 47 · see citing works

Collaborative roles of gammaH2AX and the Rad51 paralog Xrcc3 in homologous recombinational repair

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Increased Common Fragile Site Expression, Cell Proliferation Defects, and Apoptosis following Conditional Inactivation of MouseHus1in Primary Cultured Cells

Zhu, M., & Weiss, R. S. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-10-0957 · Cited by 34 · see citing works

Causes and consequences of replication stress

Zeman, M. K., & Cimprich, K. A. (2014) · Nature Cell Biology · doi:10.1038/ncb2897 · Cited by 2,079 · see citing works

DNA Damage Sensing by the ATM and ATR Kinases

Marechal, A., & Zou, L. (2013) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a012716 · Cited by 1,514 · see citing works

The essential kinase ATR: ensuring faithful duplication of a challenging genome

Saldivar, J. C., Cortez, D., & Cimprich, K. A. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.67 · Cited by 829 · see citing works

Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase

Buisson, R., Boisvert, J. L., Benes, C. H., & Zou, L. (2015) · Molecular Cell · doi:10.1016/j.molcel.2015.07.029 · Cited by 316 · see citing works

Replication Catastrophe: When a Checkpoint Fails because of Exhaustion

Toledo, L. I., Neelsen, K. J., & Lukas, J. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.05.001 · Cited by 228 · see citing works

Combining ATR Suppression with Oncogenic Ras Synergistically Increases Genomic Instability, Causing Synthetic Lethality or Tumorigenesis in a Dosage-Dependent Manner

Gilad, O., Nabet, B. Y., Ragland, R. L., Schoppy, D. W., Smith, K. D., Durham, A. C., & Brown, E. J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2286 · Cited by 225 · see citing works

Human CST promotes telomere duplex replication and general replication restart after fork stalling

Stewart, J. A., Wang, F., Fedor‐Chaiken, M., Kasbek, C., Chastain, P. D., Wright, W. E., & Price, C. M. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.215 · Cited by 206 · see citing works

Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

Hall, A. B., Newsome, D., Wang, Y., Boucher, D. M., Eustace, B. K., Gu, Y., Hare, B. J., Johnson, M., Li, H. Y., Milton, S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2158 · Cited by 198 · see citing works

Targeting ATR in DNA damage response and cancer therapeutics

Fokas, E., Prevo, R., Hammond, E. M., Brunner, T. B., McKenna, W. G., & Muschel, R. J. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.03.002 · Cited by 192 · see citing works

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

Schoppy, D. W., Ragland, R. L., Gilad, O., Shastri, N., Peters, A. A., Murga, M., Fernández-Capetillo, Ó., Diehl, J. A., & Brown, E. J. (2011) · Journal of Clinical Investigation · doi:10.1172/jci58928 · Cited by 180 · see citing works

ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses

Jossé, R., Martin, S. E., Guha, R., Ormanoglu, P., Pfister, T. D., Reaper, P. M., Barnes, C. S., Jones, J. L., Charlton, P., Pollard, J. R., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3369 · Cited by 173 · see citing works

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

Ammazzalorso, F., Pirzio, L. M., Bignami, M., Franchitto, A., & Pichierri, P. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.205 · Cited by 171 · see citing works

Histone Modifiers in Cancer: Friends or Foes?

Cohen, I., Poręba, E., Kamieniarz-Gdula, K., & Schneider, R. (2011) · Genes & Cancer · doi:10.1177/1947601911417176 · Cited by 171 · see citing works

Glutamine Synthetase Promotes Radiation Resistance via Facilitating Nucleotide Metabolism and Subsequent DNA Damage Repair

Fu, S., Li, Z., Xiao, L., Hu, W., Zhang, L., Xie, B., Zhou, Q., He, J., Qiu, Y., Wen, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.07.002 · Cited by 169 · see citing works

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression

An, J., Huang, Y.-C., Xu, Q.-Z., Zhou, L.-J., Shang, Z., Huang, B., Wang, Y., Liu, X.-D., Wu, D.-C., & Zhou, P. (2010) · BMC Molecular Biology · doi:10.1186/1471-2199-11-18 · Cited by 163 · see citing works

Wip1 Directly Dephosphorylates γ-H2AX and Attenuates the DNA Damage Response

Cha, H., Lowe, J. M., Li, H., Lee, J., Belova, G. I., Bulavin, D. V., & Fornace, A. J. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-4244 · Cited by 151 · see citing works

Trial Watch: Targeting ATM–CHK2 and ATR–CHK1 pathways for anticancer therapy

Manic, G., Obrist, F., Sistigu, A., & Vitale, I. (2015) · Molecular & Cellular Oncology · doi:10.1080/23723556.2015.1012976 · Cited by 147 · see citing works

More forks on the road to replication stress recovery

Allen, C., Ashley, A. K., Hromas, R., & Nickoloff, J. A. (2011) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjq049 · Cited by 147 · see citing works

H2AX phosphorylation at the sites of DNA double-strand breaks in cultivated mammalian cells and tissues

Firsanov, D., Solovjeva, L. V., & Svetlova, M. (2011) · Clinical Epigenetics · doi:10.1007/s13148-011-0044-4 · Cited by 139 · see citing works

Efficacy of CHK inhibitors as single agents in MYC-driven lymphoma cells

Ferrao, P. T., Bukczynska, E. P., Johnstone, R. W., & McArthur, G. A. (2012) · Oncogene · doi:10.1038/onc.2011.358 · Cited by 133 · see citing works

Identification of the First ATRIP–Deficient Patient and Novel Mutations in ATR Define a Clinical Spectrum for ATR–ATRIP Seckel Syndrome

Ogi, T., Walker, S., Stiff, T., Hobson, E., Limsirichaikul, S., Carpenter, G., Prescott, K., Suri, M., Byrd, P. J., Matsuse, M., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002945 · Cited by 117 · see citing works

RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cellsPreprint

Ragland, R. L., Patel, S., Rivard, R. S., Smith, K. D., Peters, A. A., Bielinsky, A., & Brown, E. J. (2013) · Genes & Development · doi:10.1101/gad.223180.113 · Cited by 113 · see citing works

Estrogen receptor α-mediated transcription induces cell cycle-dependent DNA double-strand breaks

Williamson, L. M., & Lees‐Miller, S. P. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq255 · Cited by 111 · see citing works

Single-molecule imaging reveals replication fork coupled formation of G-quadruplex structures hinders local replication stress signaling

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TopBP1/Dpb11 binds DNA anaphase bridges to prevent genome instability

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DNA damage response curtails detrimental replication stress and chromosomal instability induced by the dietary carcinogen PhIP

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ATR Mutations Promote the Growth of Melanoma Tumors by Modulating the Immune Microenvironment

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Excision of mutagenic replication-blocking lesions suppresses cancer but promotes cytotoxicity and lethality in nitrosamine-exposed mice

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The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells

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Evaluation of ATM Kinase Inhibitor KU-55933 as Potential Anti-Toxoplasma gondii Agent

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DNA Damage Response and Repair in Boron Neutron Capture Therapy

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Loss of INPP4B causes a DNA repair defect through loss of BRCA1, ATM and ATR and can be targeted with PARP inhibitor treatment

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S phase entry causes homocysteine-induced death while ataxia telangiectasia and Rad3 related protein functions anti-apoptotically to protect neurons

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Targeting DNA Damage Response as a Strategy to Treat HPV Infections

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DNA polymerase η modulates replication fork progression and DNA damage responses in platinum-treated human cells

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Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans

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Paths from DNA damage and signaling to genome rearrangements via homologous recombination

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The relationship between histone posttranslational modification and DNA damage signaling and repair

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Age-Dependent Changes in DNA Repair in Radiation-Exposed Mice

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A site-selective, irreversible inhibitor of the DNA replication auxiliary factor proliferating cell nuclear antigen (PCNA)

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ATR limits Rad18-mediated PCNA monoubiquitination to preserve replication fork and telomerase-independent telomere stability

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XLF and H2AX function in series to promote replication fork stability

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Quantitative profiling of adaptation to cyclin E overproduction

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Translating pharmacodynamic biomarkers from bench to bedside: analytical validation and fit-for-purpose studies to qualify multiplex immunofluorescent assays for use on clinical core biopsy specimens

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Chromatin as a Platform for Modulating the Replication Stress Response

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ATR Suppresses Endogenous DNA Damage and Allows Completion of Homologous Recombination Repair

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The genetic depletion or the triptolide inhibition of TFIIH in p53 deficient cells induce a JNK-dependent cell death in Drosophila

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SAF-A promotes origin licensing and replication fork progression to ensure robust DNA replication

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ATM and ATR homologes of Neurospora crassa are essential for normal cell growth and maintenance of chromosome integrity

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Guggulsterone-Mediated Enhancement of Radiosensitivity in Human Tumor Cell Lines

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Irradiation with heavy-ion particles changes the cellular distribution of human histone acetyltransferase HAT1

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Core and Linker Histone Modifications Involved in the DNA Damage Response

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Redundant and Nonredundant Functions of ATM and H2AX in αβ T-Lineage Lymphocytes

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New human ATM variants are able to regain ATM functions in ataxia telangiectasia disease

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ATRX loss inhibits DDR to strengthen radio-sensitization in p53-deficent HCT116 cells

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Targeting extracellular matrix remodeling sensitizes glioblastoma to ionizing radiation

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Structural insights into γH2Ax containing nucleosomes

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Targeting DNA Repair and Chromatin Crosstalk in Cancer Therapy

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Evaluation of topotecan and 10-hydroxycamptothecin on Toxoplasma gondii: Implications on baseline DNA damage and repair efficiency

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Pesticide avermectin B1a exerts cytotoxicity by blocking the interaction between mini-chromosome maintenance 6 protein (MCM6) and chromatin licensing and DNA replication factor 1 (CDT1)

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ATM and ATR promote Mre11 dependent restart of collapsed replication forks and prevent accumulation of DNA breaks

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ATR Signaling Uncouples the Role of RAD51 Paralogs in Homologous Recombination and Replication Stress Response

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ATM and ATR Activities Maintain Replication Fork Integrity during SV40 Chromatin Replication

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Mechanisms for Maintaining Genome Stability at the Replication Fork

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