POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex
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Human telomere length is controlled by a negative feedback loop based on the binding of TRF1 to double-stranded telomeric DNA. The TRF1 complex recruits POT1, a single-stranded telomeric DNA-binding protein necessary for cis-inhibition of telomerase. By mass spectrometry, we have identified a new telomeric protein, which we have named POT1-interacting protein 1 (PIP1). PIP1 bound both POT1 and the TRF1-interacting factor TIN2 and could tether POT1 to the TRF1 complex. Reduction of PIP1 or POT1 levels with shRNAs led to telomere elongation, indicating that PIP1 contributes to telomere length control through recruitment of POT1.
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TIN2 interacts with the TPP1-POT1 subcomplex that binds the single-stranded overhang.
“TRF1-interacting nuclear factor 2 also interacts with the subcomplex of shelterin that binds the single-stranded overhang-TPP1 and POT1, two oligonucleotide/ oligosaccharide binding (OB)-fold containing proteins (13)(14)(15).”
From Telomeres and telomerase in cancer (2010) · cites this paper as [14]
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Cites
Control of telomere length by the human telomeric protein TRF1
van Steensel, B., & de Lange, T. (1997) · Nature · doi:10.1038/385740a0 · Cited by 1,219 · see citing works
Pot1, the Putative Telomere End-Binding Protein in Fission Yeast and Humans
Baumann, P., & Cech, T. R. (2001) · Science · doi:10.1126/science.1060036 · Cited by 1,028 · see citing works
Structure and variability of human chromosome ends.
de Lange, T., Shiue, L., Myers, R. M., Cox, D. R., Naylor, S. L., Killery, A. M., & Varmus, H. E. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518 · Cited by 848 · see citing works
Senescence Induced by Altered Telomere State, Not Telomere Loss
Karlseder, J., Smogorzewska, A., & de Lange, T. (2002) · Science · doi:10.1126/science.1069523 · Cited by 796 · see citing works
Regulation of Telomerase by Telomeric Proteins
Smogorzewska, A., & de Lange, T. (2004) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.071403.160049 · Cited by 796 · see citing works
A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells
Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D. M., & Nakatani, Y. (2002) · Science · doi:10.1126/science.1069861 · Cited by 769 · see citing works
Control of Human Telomere Length by TRF1 and TRF2
Smogorzewska, A., van Steensel, B., Bianchi, A., Oelmann, S., Schaefer, M. R., Schnapp, G., & de Lange, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1659-1668.2000 · Cited by 768 · see citing works
POT1 as a terminal transducer of TRF1 telomere length control
Loayza, D., & de Lange, T. (2003) · Nature · doi:10.1038/nature01688 · Cited by 696 · see citing works
Self-citationChong, L., van Steensel, B., Broccoli, D., Erdjument‐Bromage, H., Hanish, J., Tempst, P., & de Lange, T. (1995) · Science · doi:10.1126/science.270.5242.1663 · Cited by 692 · see citing works
Li, B., Oestreich, S. C., & de Lange, T. (2000) · Cell · doi:10.1016/s0092-8674(00)80858-2 · Cited by 578 · see citing works
Plasma antioxidants from chocolate
Serafini, M., Bugianesi, R., Maiani, G., Valtuena, S., De Santis, S., & Crozier, A. (2003) · Nature · doi:10.1038/4241013a · Cited by 539 · see citing works
TIN2, a new regulator of telomere length in human cells
Kim, S.-H., Kaminker, P., & Campisi, J. (1999) · Nature Genetics · doi:10.1038/70508 · Cited by 525 · see citing works
A Protein-Counting Mechanism for Telomere Length Regulation in Yeast
Marcand, S., Gilson, E., & Shore, D. (1997) · Science · doi:10.1126/science.275.5302.986 · Cited by 524 · cited 1× · see citing works
“2000; Loayza and de Lange 2003), consistent with a “protein-counting” model of telomere length control (Marcand et al. 1997).”
ResultPTOP interacts with POT1 and regulates its localization to telomeres
Liu, D., Safari, A., O'Connor, M. S., Chan, D. W., Laegeler, A., Qin, J., & Songyang, Z. (2004) · Nature Cell Biology · doi:10.1038/ncb1142 · Cited by 450 · see citing works
TRF1 is a dimer and bends telomeric DNA
Bianchi, A., Smith, S., Chong, L., Elias, P., & de Lange, T. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1785 · Cited by 358 · see citing works
Human telomeres are attached to the nuclear matrix.
de Lange, T. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05104.x · Cited by 333 · see citing works
Structure and Variability of Human Chromosome Ends
de Lange, T., Shiue, L., Myers, R., et al. (1990) · Molecular and Cellular Biology · doi:10.1128/mcb.10.2.518-527.1990 · Cited by 257 · see citing works
Ancelin, K., Brunori, M., Bauwens, S., Koering, C.-E., Brun, C., Ricoul, M., Pommier, J., Sabatier, L., & Gilson, É. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.10.3474-3487.2002 · Cited by 204 · see citing works
TIN2 is a tankyrase 1 PARP modulator in the TRF1 telomere length control complex
Ye, J. Z.-S., & de Lange, T. (2004) · Nature Genetics · doi:10.1038/ng1360 · Cited by 197 · see citing works
Self-citationDNA Binding Features of Human POT1
Loayza, D., Parsons, H., Donigian, J. R., Hoke, K., & de Lange, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312309200 · Cited by 196 · see citing works
Self-citationAutomatic Identification of Proteins with a MALDI-Quadrupole Ion Trap Mass Spectrometer
Krutchinsky, A. N., Kalkum, M., & Chait, B. T. (2001) · Analytical Chemistry · doi:10.1021/ac010682o · Cited by 144 · see citing works
Self-citationKrutchinsky, A. N., Zhang, W., & Chait, B. T. (2000) · Journal of the American Society for Mass Spectrometry · doi:10.1016/s1044-0305(00)00114-8 · Cited by 115 · see citing works
Self-citation
Flagged first, then by citations
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- Liu, D., Safari, A., O'Conner, M.S., Chan, D.W., Laegeler, A., Qin, L., and Songyang, Z. 2004. PTOP is a novel POT1 interacting protein that regulates POT1 telomeric localization. Nat. Cell Biol. (in press).
Cited by
Sorted by citations
Shelterin: the protein complex that shapes and safeguards human telomeres
de Lange, T. (2005) · Genes & Development · doi:10.1101/gad.1346005 · Cited by 3,056 · see citing works
How Shelterin Protects Mammalian Telomeres
Palm, W., & de Lange, T. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130350 · Cited by 1,802 · see citing works
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Denchi, E. L., & de Lange, T. (2007) · Nature · doi:10.1038/nature06065 · Cited by 880 · see citing works
G-quadruplex structures: in vivo evidence and function
Lipps, H. J., & Rhodes, D. (2009) · Trends in Cell Biology · doi:10.1016/j.tcb.2009.05.002 · Cited by 829 · see citing works
Telomeres and telomerase in cancer
Artandi, S. E., & DePinho, R. A. (2010) · Carcinogenesis · doi:10.1093/carcin/bgp268 · Cited by 823 · see citing works
Telomere length, stem cells and aging
Blasco, M. A. (2007) · Nature Chemical Biology · doi:10.1038/nchembio.2007.38 · Cited by 747 · see citing works
The POT1-TPP1 telomere complex is a telomerase processivity factor.
Wang, F., Podell, E. R., Zaug, A. J., Yang, Y., Baciu, P., Cech, T. R., & Lei, M. (2007) · Nature · doi:10.1038/nature05454 · Cited by 704 · see citing works
The epigenetic regulation of mammalian telomeres
Blasco, M. A. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2047 · Cited by 668 · see citing works
Telomeric and extra-telomeric roles for telomerase and the telomere-binding proteins
Martínez, P., & Blasco, M. A. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3025 · Cited by 530 · see citing works
TPP1 is a homologue of ciliate TEBP-β and interacts with POT1 to recruit telomerase
Xin, H., Liu, D., Wan, M., Safari, A., Kim, H., Sun, W., O’Connor, M. S., & Songyang, Z. (2007) · Nature · doi:10.1038/nature05469 · Cited by 486 · see citing works
Lei, M., Podell, E., & Cech, T. (2004) · Nature Structural &Molecular Biology · doi:10.1038/nsmb867 · Cited by 503 · see citing works
Gilson, É., & Géli, V. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2259 · Cited by 454 · see citing works
Wu, L., Multani, A. S., He, H., Cosme-Blanco, W., Deng, Y., Deng, J. M., Bachilo, O., Pathak, S., Tahara, H., Bailey, S. M., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.037 · Cited by 422 · see citing works
Telosome, a Mammalian Telomere-associated Complex Formed by Multiple Telomeric Proteins
Liu, D., O'Connor, M. S., Qin, J., & Songyang, Z. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409293200 · Cited by 405 · see citing works
Hockemeyer, D., Daniels, J.-P., Takai, H., & de Lange, T. (2006) · Cell · doi:10.1016/j.cell.2006.04.044 · Cited by 397 · see citing works
Self-citationFinding the end: recruitment of telomerase to telomeres
Nandakumar, J., & Cech, T. R. (2013) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3505 · Cited by 378 · see citing works
The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity
Nandakumar, J., Bell, C., Weidenfeld, I., Zaug, A. J., Leinwand, L. A., & Cech, T. R. (2012) · Nature · doi:10.1038/nature11648 · Cited by 351 · see citing works
TIN2 Binds TRF1 and TRF2 Simultaneously and Stabilizes the TRF2 Complex on Telomeres
Ye, J. Z.-S., Donigian, J. R., van Overbeek, M., Loayza, D., Luo, Y., Krutchinsky, A. N., Chait, B. T., & de Lange, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409047200 · Cited by 346 · see citing works
Self-citationRegulation of human telomerase in homeostasis and disease
Roake, C. M., & Artandi, S. E. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0234-z · Cited by 341 · see citing works
Telomeres: Cancer to Human Aging
Stewart, S. A., & Weinberg, R. A. (2006) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104518 · Cited by 336 · see citing works
Chemistry in human telomere biology: structure, function and targeting of telomere DNA/RNA
Xu, Y. (2011) · Chemical Society Reviews · doi:10.1039/c0cs00134a · Cited by 322 · see citing works
Hockemeyer, D., Sfeir, A. J., Shay, J. W., Wright, W. E., & de Lange, T. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600733 · Cited by 314 · see citing works
Self-citationSurovtseva, Y. V., Churikov, D., Boltz, K. A., Song, X., Lamb, J. C., Warrington, R. T., Leehy, K. A., Heacock, M. L., Price, C. M., & Shippen, D. E. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.017 · Cited by 296 · see citing works
TPP1 OB-Fold Domain Controls Telomere Maintenance by Recruiting Telomerase to Chromosome Ends
Zhong, F. L., Batista, L. F. Z., Freund, A., Pech, M. F., Venteicher, A. S., & Artandi, S. E. (2012) · Cell · doi:10.1016/j.cell.2012.07.012 · Cited by 295 · see citing works
Hug, N., & Lingner, J. (2006) · Chromosoma · doi:10.1007/s00412-006-0067-3 · Cited by 291 · see citing works
Houghtaling, B. R., Cuttonaro, L., Chang, W., & Smith, S. H. (2004) · Current Biology · doi:10.1016/j.cub.2004.08.052 · Cited by 284 · see citing works
Functional Human Telomeres Are Recognized as DNA Damage in G2 of the Cell Cycle
Verdun, R. E., Crabbe, L., Haggblom, C., & Karlseder, J. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.024 · Cited by 284 · see citing works
Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization
Lim, C. J., & Cech, T. (2021) · Nature reviews. Molecular cell biology · doi:10.1038/s41580-021-00328-y · Cited by 228 · see citing works
Dysfunctional telomeres activate an ATM‐ATR‐dependent DNA damage response to suppress tumorigenesis
Guo, X., Deng, Y., Lin, Y., Cosme‐Blanco, W., Chan, S., He, H., Yuan, G., Brown, E. J., & Chang, S. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601893 · Cited by 258 · see citing works
DNA and RNA Quadruplex-Binding Proteins
Brázda, V., Hároníková, L., Liao, J. C. C., & Fojta, M. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms151017493 · Cited by 243 · see citing works
A critical role for TPP1 and TIN2 interaction in high-order telomeric complex assembly
O’Connor, M. S., Safari, A., Xin, H., Liu, D., & Songyang, Z. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605303103 · Cited by 247 · see citing works
In Vivo Stoichiometry of Shelterin Components
Takai, K., Hooper, S., Blackwood, S., Gandhi, R., & de Lange, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.038026 · Cited by 243 · see citing works
Self-citationTelomeres, chromosome instability and cancer
Bailey, S. M. (2006) · Nucleic Acids Research · doi:10.1093/nar/gkl303 · Cited by 242 · see citing works
TIN2-Tethered TPP1 Recruits Human Telomerase to Telomeres In Vivo
Abreu, E. B., Aritonovska, E., Reichenbach, P., Cristofari, G., Culp, B. R., Terns, R. M., Lingner, J., & Terns, M. P. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00240-10 · Cited by 240 · see citing works
Telomere Protection by TPP1/POT1 Requires Tethering to TIN2
Takai, K., Kibe, T., Donigian, J. R., Frescas, D., & de Lange, T. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.08.043 · Cited by 229 · see citing works
Court, R., Chapman, L., Fairall, L., & Rhodes, D. (2004) · EMBO Reports · doi:10.1038/sj.embor.7400314 · Cited by 226 · see citing works
Structural biology of telomeres and telomerase
Smith, E. M., Pendlebury, D. F., & Nandakumar, J. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03369-x · Cited by 228 · see citing works
The telosome/shelterin complex and its functions
Xin, H., Liu, D., & Songyang, Z. (2008) · Genome biology · doi:10.1186/gb-2008-9-9-232 · Cited by 224 · see citing works
A RAP1/TRF2 Complex Inhibits Nonhomologous End-Joining at Human Telomeric DNA Ends
Bae, N. S., & Baumann, P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.03.023 · Cited by 215 · see citing works
TIN2 Mediates Functions of TRF2 at Human Telomeres
Kim, S., Beausejour, C. M., Davalos, A. R., Kaminker, P. G., Heo, S., & Campisi, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408650200 · Cited by 212 · see citing works
Human Protection of Telomeres 1 (POT1) Is a Negative Regulator of Telomerase Activity In Vitro
Kelleher, C. D., Kurth, I., & Lingner, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.2.808-818.2005 · Cited by 211 · see citing works
Apollo, an Artemis-Related Nuclease, Interacts with TRF2 and Protects Human Telomeres in S Phase
van Overbeek, M., & de Lange, T. (2006) · Current Biology · doi:10.1016/j.cub.2006.05.022 · Cited by 195 · see citing works
TERT promoter mutations in telomere biology
Heidenreich, B., & Kumar, R. (2016) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2016.11.002 · Cited by 198 · see citing works
Telomeric Strategies: Means to an End
Jain, D., & Cooper, J. P. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-102108-134841 · Cited by 196 · see citing works
Telomere protection by mammalian Pot1 requires interaction with Tpp1
Hockemeyer, D. F., Palm, W., Else, T., Daniels, J., Takai, K., Ye, J. Z.-S., Keegan, C. E., de Lange, T., & Hammer, G. D. (2007) · Nature Structural & Molecular Biology · doi:10.1038/nsmb1270 · Cited by 193 · see citing works
Self-citationPathways connecting telomeres and p53 in senescence, apoptosis, and cancer
Artandi, S. E., & Attardi, L. D. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.211 · Cited by 190 · see citing works
POT1–TPP1 enhances telomerase processivity by slowing primer dissociation and aiding translocation
Latrick, C. M., & Cech, T. R. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.409 · Cited by 186 · see citing works
Nonsense Mutations in the Shelterin Complex Genes ACD and TERF2IP in Familial Melanoma
Aoude, L. G., Pritchard, A. L., Robles‐Espinoza, C. D., Wadt, K., Harland, M., Choi, J., Gartside, M. G., Quesada, V., Johansson, P. A., Palmer, J. M., et al. (2014) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/dju408 · Cited by 187 · see citing works
POT1 and TRF2 Cooperate To Maintain Telomeric Integrity
Yang, Q., Zheng, Y., & Harris, C. C. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.1070-1080.2005 · Cited by 180 · see citing works
Oligonucleotide/oligosaccharide-binding fold proteins: a growing family of genome guardians
Flynn, R. L., & Zou, L. (2010) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2010.488216 · Cited by 178 · see citing works
DNA damage response at functional and dysfunctional telomeresPreprint
Longhese, M. P. (2008) · Genes & Development · doi:10.1101/gad.1626908 · Cited by 180 · see citing works
Switching Human Telomerase On and Off with hPOT1 Protein in Vitro
Lei, M., Zaug, A. J., Podell, E. R., & Cech, T. R. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502212200 · Cited by 175 · see citing works
Stop pulling my strings — what telomeres taught us about the DNA damage response
Denchi, E. L., & Sfeir, A. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.43 · Cited by 166 · see citing works
Role of shelterin in cancer and aging
Martínez, P., & Blasco, M. A. (2010) · Aging Cell · doi:10.1111/j.1474-9726.2010.00596.x · Cited by 162 · see citing works
Genetics of familial melanoma: 20 years after CDKN 2 A
Aoude, L. G., Wadt, K., Pritchard, A. L., & Hayward, N. K. (2014) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12333 · Cited by 165 · see citing works
The Role of Telomere Biology in Cancer
Xu, L., Li, S., & Stohr, B. A. (2013) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-020712-164030 · Cited by 160 · see citing works
How Shelterin Solves the Telomere End-Protection ProblemPreprint
de Lange, T. (2010) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2010.75.017 · Cited by 157 · see citing works
How Telomerase Reaches Its End: Mechanism of Telomerase Regulation by the Telomeric Complex
Bianchi, A., & Shore, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.013 · Cited by 157 · see citing works
Revisiting Telomere Shortening in Cancer
Okamoto, K., & Seimiya, H. (2019) · Cells · doi:10.3390/cells8020107 · Cited by 153 · see citing works
Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging
Blasco, M. A. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600598 · Cited by 147 · see citing works
Familial Clonal Hematopoiesis in a Long Telomere Syndrome
DeBoy, E. A., Tassia, M. G., Schratz, K. E., Yan, S. M., Cosner, Z. L., McNally, E. J., Gable, D. L., Xiang, Z., Lombard, D. B., Antonarakis, E. S., et al. (2023) · New England Journal of Medicine · doi:10.1056/nejmoa2300503 · Cited by 147 · see citing works
Loss of hPot1 Function Leads to Telomere Instability and a cut-like Phenotype
Veldman, T., Etheridge, K. T., & Counter, C. M. (2004) · Current Biology · doi:10.1016/j.cub.2004.12.031 · Cited by 144 · see citing works
Unraveling the pathogenesis of Hoyeraal–Hreidarsson syndrome, a complex telomere biology disorder
Glousker, G., Touzot, F., Revy, P., Tzfati, Y., & Savage, S. A. (2015) · British Journal of Haematology · doi:10.1111/bjh.13442 · Cited by 141 · see citing works
Human telomeric proteins occupy selective interstitial sites
Yang, D., Xiong, Y., Kim, H., He, Q., Li, Y., Chen, R., & Songyang, Z. (2011) · Cell Research · doi:10.1038/cr.2011.39 · Cited by 141 · see citing works
ATM and ATR Signaling Regulate the Recruitment of Human Telomerase to Telomeres
Tong, A. S., Stern, J. L., Sfeir, A. J., Kartawinata, M., de Lange, T., Zhu, X., & Bryan, T. M. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.041 · Cited by 136 · see citing works
Paeschke, K., Juranek, S., Simonsson, T., Hempel, A., Rhodes, D., & Lipps, H. J. (2008) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1422 · Cited by 141 · see citing works
Wan, M., Qin, J., Songyang, Z., & Liu, D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.021105 · Cited by 136 · see citing works
Cancer and aging: the importance of telomeres in genome maintenance
Rodier, F., Kim, S.-H., Nijjar, T., Yaswen, P., & Campisi, J. (2005) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2004.10.012 · Cited by 132 · see citing works
Shakirov, E. V., Surovtseva, Y. V., Osbun, N. C., & Shippen, D. E. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.17.7725-7733.2005 · Cited by 130 · see citing works
POT1-TPP1 Regulates Telomeric Overhang Structural Dynamics
Hwang, H. H., Buncher, N. A., Opresko, P. L., & Myong, S. (2012) · Structure · doi:10.1016/j.str.2012.08.018 · Cited by 129 · see citing works
Koçak, H., Ballew, B. J., Bisht, K. K., Eggebeen, R., Hicks, B. D., Suman, S., O’Neil, A., Giri, N., NCI DCEG Cancer Sequencing Working Group, Maillard, I. P., et al. (2014) · Genes & Development · doi:10.1101/gad.248567.114 · Cited by 129 · see citing works
Functional interaction between telomere protein TPP1 and telomerasePreprint
Zaug, A. J., Podell, E. R., Nandakumar, J., & Cech, T. R. (2010) · Genes & Development · doi:10.1101/gad.1881810 · Cited by 129 · see citing works
RAP1 Protects from Obesity through Its Extratelomeric Role Regulating Gene Expression
Martínez, P., Goméz-López, G., Garcı́a, F., Mercken, E. M., Mitchell, S. J., Flores, J. M., de Cabo, R., & Blasco, M. A. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.05.030 · Cited by 125 · see citing works
POT1b protects telomeres from end‐to‐end chromosomal fusions and aberrant homologous recombination
He, H., Multani, A. S., Cosme‐Blanco, W., Tahara, H., Ma, J., Pathak, S., Deng, Y., & Chang, S. S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601294 · Cited by 125 · see citing works
The short and long telomere syndromes: paired paradigms for molecular medicine
Stanley, S. E., & Armanios, M. Y. (2015) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2015.06.004 · Cited by 123 · see citing works
Replicating through telomeres: a means to an end
Martínez, P., & Blasco, M. A. (2015) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2015.06.003 · Cited by 124 · see citing works
Telomeres and telomerase in prostate cancer development and therapy
Graham, M. K., & Meeker, A. K. (2017) · Nature Reviews Urology · doi:10.1038/nrurol.2017.104 · Cited by 122 · see citing works
Functional Dissection of Human and Mouse POT1 Proteins
Palm, W., Hockemeyer, D. F., Kibe, T., & de Lange, T. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01352-08 · Cited by 121 · see citing works
Self-citationSpeedy, H. E., Kinnersley, B., Chubb, D., Broderick, P., Law, P., Litchfield, K., Jayne, S., Dyer, M. J. S., Dearden, C. E., Follows, G., et al. (2016) · Blood · doi:10.1182/blood-2016-01-695692 · Cited by 121 · see citing works
ArabidopsisPOT1A interacts with TERT-V(I8), an N-terminal splicing variant of telomerase
Rossignol, P., Collier, S., Bush, M., Shaw, P., & Doonan, J. H. (2007) · Journal of Cell Science · doi:10.1242/jcs.004119 · Cited by 122 · see citing works
Telomere Protection by TPP1 Is Mediated by POT1a and POT1b
Kibe, T., Osawa, G. A., Keegan, C. E., & de Lange, T. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.01498-09 · Cited by 121 · see citing works
Guo, Y., Kartawinata, M., Li, J., Pickett, H. A., Teo, J., Kilo, T., Barbaro, P., Keating, B. J., Chen, Y., Tian, L., et al. (2014) · Blood · doi:10.1182/blood-2014-08-596445 · Cited by 119 · see citing works
The Role of the Nonhomologous End-Joining DNA Double-Strand Break Repair Pathway in Telomere Biology
Říha, K., Heacock, M. L., & Shippen, D. E. (2006) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095755 · Cited by 118 · see citing works
Telomere uncapping and alternative lengthening of telomeres
Cesare, A. J., & Reddel, R. R. (2007) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2007.11.006 · Cited by 119 · see citing works
Control of telomerase action at human telomeres
Hockemeyer, D. F., & Collins, K. (2015) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.3083 · Cited by 118 · see citing works
Self-citationTelomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis
Pinzaru, A. M., Hom, R. A., Beal, A., Phillips, A. F., Ni, E., Cardozo, T. J., Nair, N., Choi, J., Wuttke, D. S., Sfeir, A. J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.05.008 · Cited by 114 · see citing works
Human single-stranded DNA binding proteins are essential for maintaining genomic stability
Ashton, N. W., Bolderson, E., Cubeddu, L., O'Byrne, K. J., & Richard, D. J. (2013) · BMC Molecular Biology · doi:10.1186/1471-2199-14-9 · Cited by 113 · see citing works
Structural and functional analysis of the human POT1-TPP1 telomeric complex
Rice, C., Shastrula, P. K., Kossenkov, A. V., Hills, R., Baird, D. M., Showe, L. C., Doukov, T. I., Janicki, S. M., & Skordalakes, E. (2017) · Nature Communications · doi:10.1038/ncomms14928 · Cited by 109 · see citing works
Telomere Maintenance through Spatial Control of Telomeric Proteins
Chen, L., Liu, D., & Songyang, Z. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00603-07 · Cited by 111 · see citing works
Sexton, A. N., Regalado, S. G., Lai, C. S., Cost, G. J., O’Neil, C. M., Urnov, F. D., Gregory, P. D., Jaenisch, R., Collins, K., & Hockemeyer, D. F. (2014) · Genes & Development · doi:10.1101/gad.246819.114 · Cited by 109 · see citing works
Self-citationA POT1 mutation implicates defective telomere end fill-in and telomere truncations in Coats plusPreprint
Takai, H., Jenkinson, E. M., Kabir, S., Babul‐Hirji, R., Najm-Tehrani, N., Chitayat, D. A., Crow, Y. J., & de Lange, T. (2016) · Genes & Development · doi:10.1101/gad.276873.115 · Cited by 105 · see citing works
Human UPF1 interacts with TPP1 and telomerase and sustains telomere leading‐strand replication
Chawla, R., Redon, S., Raftopoulou, C., Wischnewski, H., Gagos, S., & Azzalin, C. M. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.280 · Cited by 105 · see citing works
Lee, O.-H., Kim, H., He, Q., Baek, H. J., Yang, D., Chen, L., Liang, J., Chae, H. K., Safari, A., Liu, D., et al. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.001628 · Cited by 106 · see citing works
Genetic analysis of adrenal absence: agenesis and aplasia
Else, T., & Hammer, G. D. (2005) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2005.10.004 · Cited by 104 · see citing works
Protein requirements for sister telomere association in human cells
Canudas, S., Houghtaling, B. R., Kim, J. Y., Dynek, J. N., Chang, W., & Smith, S. H. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601903 · Cited by 104 · see citing works
Telomerase and Telomere-Associated Proteins: Structural Insights into Mechanism and Evolution
Lewis, K. A., & Wuttke, D. S. (2012) · Structure · doi:10.1016/j.str.2011.10.017 · Cited by 101 · see citing works
Lee, T. H., Perrem, K., Harper, J. W., Lu, K. P., & Zhou, X. Z. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509855200 · Cited by 103 · see citing works
Structural basis of human telomerase recruitment by TPP1-POT1
Sekne, Z., Ghanim, G. E., van Roon, A. M., & Nguyen, T. H. D. (2022) · Science · doi:10.1126/science.abn6840 · Cited by 100 · see citing works
Boeck, G. D., Forsyth, R. G., Praet, M. M., & Hogendoorn, P. C. W. (2008) · The Journal of Pathology · doi:10.1002/path.2500 · Cited by 98 · see citing works
A role for heterochromatin protein 1γ at human telomeresPreprint
Canudas, S., Houghtaling, B. R., Bhanot, M., Sasa, G., Savage, S. A., Bertuch, A. A., & Smith, S. H. (2011) · Genes & Development · doi:10.1101/gad.17325211 · Cited by 99 · see citing works
- Authors
- Ye, J. Z.-S., Hockemeyer, D., Krutchinsky, A. N., Loayza, D., Hooper, S. M., Chait, B. T., & de Lange, T.
- Affiliations
- Memorial Sloan Kettering Cancer Center (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-07-01
- Volume
- 18
- Issue
- 14
- Pages
- 1649-1654
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC478187
- OpenAlex
- W2155983703
- Cited by
- 459
- References
- 21
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 15 · 2023: 18 · 2022: 6 · 2021: 21 · 2020: 12 · 2019: 15 · 2018: 15 · 2017: 16 · 2016: 30 · 2015: 21 · 2014: 34 · 2013: 17 · 2012: 24
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (RR00862)
- National Cancer Institute (K08 CA93604, K08CA093604, T32 CA09673-26A1, T32CA009673)
- National Center for Research Resources (RR00862, P41RR000862)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA and Nucleic Acid Chemistry
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- PIP1, POT1, TIN2, TRF1, telomere length regulation, telomeric proteins, telomerase inhibition, telomere elongation, protein-protein interaction, telomeric DNA
- MeSH terms
- Shelterin Complex, Carrier Proteins, Cloning, Molecular, Fluorescent Antibody Technique, HeLa Cells, Humans, Mass Spectrometry, Telomere, Two-Hybrid System Techniques, Telomere-Binding Proteins, RNA Interference, Telomeric Repeat Binding Protein 1, Intracellular Signaling Peptides and Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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