Finnemann, Silvia C.

Phagocytosis of rod outer segments by retinal pigment epithelial cells requires αvβ5 integrin for binding but not for internalization

Finnemann, S. C., Bonilha, V. L., Marmorstein, A. D., & Rodriguez-Boulan, E. (1997) · Proceedings of the National Academy of Sciences

Cell Adhesion Molecules ResearchRetinal Diseases and Treatments

Cited by 382

Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking αvβ5 integrin

Nandrot, E. F., Kim, Y., Brodie, S. E., Huang, X., Sheppard, D., & Finnemann, S. C. (2004) · The Journal of Experimental Medicine

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 319

The lipofuscin component A2E selectively inhibits phagolysosomal degradation of photoreceptor phospholipid by the retinal pigment epithelium

Finnemann, S. C., Leung, L. W., & Rodriguez-Boulan, E. (2002) · Proceedings of the National Academy of Sciences

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 283

Essential role for MFG-E8 as ligand for αvβ5 integrin in diurnal retinal phagocytosis

Nandrot, E. F., Anand, M., Almeida, D., Atabai, K., Sheppard, D., & Finnemann, S. C. (2007) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 241

Understanding photoreceptor outer segment phagocytosis: use and utility of RPE cells in culture

Mazzoni, F., Safa, H., & Finnemann, S. C. (2014) · Experimental Eye Research

Retinal Diseases and TreatmentsPhagocytosis and Immune Regulation

Cited by 221

Focal adhesion kinase signaling promotes phagocytosis of integrin‐bound photoreceptors

Finnemann, S. C. (2003) · The EMBO Journal

Cell Adhesion Molecules ResearchPhagocytosis and Immune Regulation

Cited by 208

Light-induced Oxidation of Photoreceptor Outer Segment Phospholipids Generates Ligands for CD36-mediated Phagocytosis by Retinal Pigment Epithelium

Sun, M., Finnemann, S. C., Febbraio, M., Shan, L., Annangudi, S. P., Podrez, E. A., Hoppe, G., Darrow, R., Organisciak, D. T., Salomon, R. G., et al. (2006) · Journal of Biological Chemistry

Retinal Diseases and TreatmentsAntioxidant Activity and Oxidative Stress

Cited by 165

The lipofuscin fluorophore A2E perturbs cholesterol metabolism in retinal pigment epithelial cells

Lakkaraju, A., Finnemann, S. C., & Rodriguez-Boulan, E. (2007) · Proceedings of the National Academy of Sciences

Cholesterol and Lipid MetabolismRetinal Diseases and Treatments

Cited by 162

Expression of ABCA4 in the retinal pigment epithelium and its implications for Stargardt macular degeneration

Lenis, T. L., Hu, J., Ng, S. Y., Jiang, Z., Sarfare, S., Lloyd, M. B., Esposito, N. J., Samuel, W., Jaworski, C., Bok, D., et al. (2018) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 158

Diurnal, localized exposure of phosphatidylserine by rod outer segment tips in wild-type but not Itgb5 −/− or Mfge8 −/− mouse retina

Ruggiero, L., Connor, M. P., Chen, J., Langen, R., & Finnemann, S. C. (2012) · Proceedings of the National Academy of Sciences

Retinal Development and DisordersPhagocytosis and Immune Regulation

Cited by 156

The Age Lipid A2E and Mitochondrial Dysfunction Synergistically Impair Phagocytosis by Retinal Pigment Epithelial Cells

Vives-Bauza, C., Anand, M., Shirazi, A. K., Magrane, J., Gao, J., Vollmer-Snarr, H. R., Manfredi, G., & Finnemann, S. C. (2008) · Journal of Biological Chemistry

Retinal Diseases and TreatmentsAutophagy in Disease and Therapy

Cited by 155

Tetraspanin CD81 is required for the αvβ5-integrin-dependent particle-binding step of RPE phagocytosis

Chang, Y., & Finnemann, S. C. (2007) · Journal of Cell Science

Cell Adhesion Molecules ResearchPhagocytosis and Immune Regulation

Cited by 88

Novel role for α v β 5 -integrin in retinal adhesion and its diurnal peak

Nandrot, E. F., Anand, M., Sircar, M., & Finnemann, S. C. (2006) · American Journal of Physiology-Cell Physiology

Retinal Development and DisordersCell Adhesion Molecules Research

Cited by 72

Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture

Mao, Y., & Finnemann, S. C. (2012) · Methods in Molecular Biology

Retinal Diseases and TreatmentsRetinal Development and Disorders

Cited by 70

Quantified F-actin morphology is predictive of phagocytic capacity of stem cell-derived retinal pigment epithelium

Müller, C., Charniga, C., Temple, S., & Finnemann, S. C. (2018) · Stem Cell Reports

Retinal Development and DisordersRetinal Diseases and Treatments

Cited by 61

Regulation of phagolysosomal digestion by caveolin-1 of the retinal pigment epithelium is essential for vision

Sethna, S., Chamakkala, T., Gu, X., Thompson, T. C., Cao, G., Elliott, M. H., & Finnemann, S. C. (2016) · Journal of Biological Chemistry

Caveolin-1 and cellular processesRetinal Development and Disorders

Cited by 53

Retinal pigment epithelial cells use a MerTK‐dependent mechanism to limit the phagocytic particle binding activity of αvβ5 integrin

Nandrot, E. F., Silva, K. E., Scelfo, C., & Finnemann, S. C. (2012) · Biology of the Cell

Cell Adhesion Molecules ResearchPhagocytosis and Immune Regulation

Cited by 52

PI 3-kinase independent role for AKT in F-actin regulation during outer segment phagocytosis by RPE cells

Bulloj, A., Duan, W., & Finnemann, S. C. (2013) · Experimental Eye Research

Phagocytosis and Immune RegulationRetinal Diseases and Treatments

Cited by 39