Mellman, Ira

Oncology meets immunology: the cancer-immunity cycle.

Chen, D. S., & Mellman, I. (2013) · Immunity

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 6,929

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

Mariathasan, S., Turley, S. J., Nickles, D., Castiglioni, A., Yuen, K., Wang, Y., Kadel III, E. E., Koeppen, H., Astarita, J. L., Cubas, R., et al. (2018) · Nature

Cancer Immunotherapy and BiomarkersTGF-β signaling in diseases

Cited by 5,400

Elements of cancer immunity and the cancer–immune set point

Chen, D. S., & Mellman, I. (2017) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 5,352

Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients

Herbst, R. S., Soria, J.-C., Kowanetz, M., Fine, G. D., Hamid, O., Gordon, M. S., Sosman, J. A., McDermott, D. F., Powderly, J. D., Gettinger, S. N., et al. (2014) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 5,231

Cancer immunotherapy comes of age

Mellman, I., Coukos, G., & Dranoff, G. (2011) · Nature

Cancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

Cited by 3,893

Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

Lande, R., Gregorio, J., Facchinetti, V., Chatterjee, B., Wang, Y.-H., Homey, B., Cao, W., Wang, Y.-H., Su, B., Nestle, F. O., et al. (2007) · Nature

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,910

T cell costimulatory receptor CD28 is a primary target for PD-1–mediated inhibition

Hui, E., Cheung, J., Zhu, J., Su, X., Taylor, M. J., Wallweber, H. A., Sasmal, D. K., Huang, J., Kim, J. M., Mellman, I., et al. (2017) · Science

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 1,689

Personalized RNA neoantigen vaccines stimulate T cells in pancreatic cancer

Rojas, L. A., Sethna, Z., Soares, K. C., Olcese, C., Pang, N., Patterson, E., Lihm, J., Ceglia, N., Guasp, P., Chu, A., et al. (2023) · Nature

Immunotherapy and Immune ResponsesCancer Immunotherapy and Biomarkers

Cited by 1,432

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

Yadav, M., Jhunjhunwala, S., Phung, Q. T., Lupardus, P., Tanguay, J., Bumbaca, S., Franci, C., Cheung, T. K., Fritsche, J., Weinschenk, T., et al. (2014) · Nature

vaccines and immunoinformatics approachesCancer Immunotherapy and Biomarkers

Cited by 1,186

Peripheral T cell expansion predicts tumour infiltration and clinical response

Wu, T. D., Madireddi, S., de Almeida, P. E., Banchereau, R., Chen, Y.-J. J., Chitre, A. S., Chiang, E. Y., Iftikhar, H., O’Gorman, W. E., Au-Yeung, A., et al. (2020) · Nature

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 770

MAP Kinase Inhibition Promotes T Cell and Anti-tumor Activity in Combination with PD-L1 Checkpoint Blockade.

Ebert, P. J. R., Cheung, J., Yang, Y., McNamara, E., Hong, R., Moskalenko, M., Gould, S. E., Maecker, H., Irving, B. A., Kim, J. M., et al. (2016) · Immunity

Cancer Immunotherapy and BiomarkersMelanoma and MAPK Pathways

Cited by 713

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

Maurer, T., Garrenton, L. S., Oh, A., Pitts, K., Anderson, D. J., Skelton, N. J., Fauber, B. P., Pan, B., Malek, S., Stokoe, D., et al. (2012) · Proceedings of the National Academy of Sciences

Protein Kinase Regulation and GTPase SignalingProtein Tyrosine Phosphatases

Cited by 618

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines

Tahtinen, S., Tong, A.-J., Himmels, P., Oh, J., Paler-Martinez, A., Kim, L., Wichner, S., Oei, Y., McCarron, M. J., Freund, E. C., et al. (2022) · Nature Immunology

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 535

Coordinated protein sorting, targeting and distribution in polarized cells

Mellman, I., & Nelson, W. J. (2008) · Nature Reviews Molecular Cell Biology

Cellular transport and secretionCellular Mechanics and Interactions

Cited by 521

Rab4 and cellubrevin define different early endosome populations on the pathway of transferrin receptor recycling.

Daro, E., van der Sluijs, P., Galli, T., & Mellman, I. (1996) · Proceedings of the National Academy of Sciences

Cellular transport and secretionAutophagy in Disease and Therapy

Cited by 343

Endosomes are specialized platforms for bacterial sensing and NOD2 signalling

Nakamura, N., Lill, J. R., Phung, Q., Jiang, Z., Bakalarski, C., de Mazière, A., Klumperman, J., Schlatter, M., Delamarre, L., & Mellman, I. (2014) · Nature

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 313

Inflammasome-activating nanoparticles as modular systems for optimizing vaccine efficacy

Demento, S. L., Eisenbarth, S. C., Foellmer, H. G., Platt, C., Caplan, M. J., Mark Saltzman, W., Mellman, I., Ledizet, M., Fikrig, E., Flavell, R. A., et al. (2009) · Vaccine

Immunotherapy and Immune ResponsesInflammasome and immune disorders

Cited by 290

Transposable element expression in tumors is associated with immune infiltration and increased antigenicity

Kong, Y., Rose, C. M., Cass, A. A., Williams, A. G., Darwish, M., Lianoglou, S., Haverty, P. M., Tong, A.-J., Blanchette, C., Albert, M. L., et al. (2019) · Nature Communications

Epigenetics and DNA MethylationChromosomal and Genetic Variations

Cited by 285

β1 Integrin Establishes Endothelial Cell Polarity and Arteriolar Lumen Formation via a Par3-Dependent Mechanism

Zovein, A. C., Luque, A., Turlo, K. A., Hofmann, J. J., Yee, K. M., Becker, M. S., Fassler, R., Mellman, I., Lane, T. F., & Iruela-Arispe, M. L. (2010) · Developmental Cell

Cell Adhesion Molecules ResearchCellular Mechanics and Interactions

Cited by 256

Internalization and degradation of macrophage Fc receptors bound to polyvalent immune complexes.

Mellman, I., & Plutner, H. (1984) · The Journal of cell biology

Monoclonal and Polyclonal Antibodies ResearchCellular transport and secretion

Cited by 251

Polygenic risk for skin autoimmunity impacts immune checkpoint blockade in bladder cancer

Khan, Z., Di Nucci, F., Kwan, A., Hammer, C., Mariathasan, S., Rouilly, V., Carroll, J., Fontes, M., Ley Acosta, S., Guardino, E., et al. (2020) · Proceedings of the National Academy of Sciences

Cancer Immunotherapy and BiomarkersBladder and Urothelial Cancer Treatments

Cited by 91

Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers

Byrd, A. L., Liu, M., Fujimura, K. E., Lyalina, S., Nagarkar, D. R., Charbit, B., Bergstedt, J., Patin, E., Harrison, O. J., Quintana-Murci, L., et al. (2021) · Journal of Experimental Medicine

Gut microbiota and healthMicrobial Community Ecology and Physiology

Cited by 63