Vendruscolo, Leandro F.

Addiction as a stress surfeit disorder

Koob, G. F., Buck, C. L., Cohen, A., Edwards, S., Park, P. E., Schlosburg, J. E., Schmeichel, B., Vendruscolo, L. F., Wade, C. L., Whitfield, T. W., et al. (2014) · Neuropharmacology

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 483

Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats

Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., et al. (2012) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

Cited by 319

Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals

Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., et al. (2015) · Journal of Clinical Investigation

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 218

The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

Chuong, V., Farokhnia, M., Khom, S., Pince, C. L., Elvig, S. K., Vlkolinsky, R., Marchette, R. C. N., Koob, G. F., Roberto, M., Vendruscolo, L. F., et al. (2023) · JCI Insight

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 214

Operant alcohol self-administration in dependent rats: Focus on the vapor model

Vendruscolo, L. F., & Roberts, A. J. (2014) · Alcohol

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 166

Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake

Schlosburg, J. E., Whitfield, T. W., Park, P. E., Crawford, E. F., George, O., Vendruscolo, L. F., & Koob, G. F. (2013) · The Journal of Neuroscience

Neuropeptides and Animal PhysiologyNeurotransmitter Receptor Influence on Behavior

Cited by 119

Recruitment of a neuronal ensemble in the central nucleus of the amygdala is required for alcohol dependence

de Guglielmo, G., Crawford, E., Kim, S., Vendruscolo, L. F., Hope, B. T., Brennan, M., Cole, M., Koob, G. F., & George, O. (2016) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Cited by 106

Oxytocin blocks enhanced motivation for alcohol in alcohol dependence and blocks alcohol effects on GABAergic transmission in the central amygdala

Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., et al. (2019) · PLOS Biology

Neuroendocrine regulation and behaviorNeurotransmitter Receptor Influence on Behavior

Cited by 104

Hypocretin receptor 2 antagonism dose-dependently reduces escalated heroin self-administration in rats

Schmeichel, B. E., Barbier, E., Misra, K. K., Contet, C., Schlosburg, J. E., Grigoriadis, D., Williams, J. P., Karlsson, C., Pitcairn, C., Heilig, M., et al. (2015) · Neuropsychopharmacology

Neurotransmitter Receptor Influence on BehaviorSleep and Wakefulness Research

Cited by 79

κ opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake

Whitfield, T. W., Schlosburg, J. E., Wee, S., Gould, A., George, O., Grant, Y., Zamora-Martinez, E. R., Edwards, S., Crawford, E., Vendruscolo, L. F., et al. (2015) · The Journal of Neuroscience

Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal Physiology

Cited by 75

Chronic CRF1receptor blockade reduces heroin intake escalation and dependence‐induced hyperalgesia

Park, P. E., Schlosburg, J. E., Vendruscolo, L. F., Schulteis, G., Edwards, S., & Koob, G. F. (2015) · Addiction Biology

Neuropeptides and Animal PhysiologyOpioid Use Disorder Treatment

Cited by 69

Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors

Somkuwar, S. S., Vendruscolo, L. F., Fannon, M. J., Schmeichel, B. E., Nguyen, T. B., Guevara, J., Sidhu, H., Contet, C., Zorrilla, E. P., & Mandyam, C. D. (2017) · Psychoneuroendocrinology

Stress Responses and CortisolAlcohol Consumption and Health Effects

Cited by 64

A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans

Aoun, E. G., Jimenez, V. A., Vendruscolo, L. F., Walter, N. A. R., Barbier, E., Ferrulli, A., Haass-Koffler, C. L., Darakjian, P., Lee, M. R., Addolorato, G., et al. (2018) · Molecular Psychiatry

Alcohol Consumption and Health EffectsNeurotransmitter Receptor Influence on Behavior

Cited by 60

Dysregulation of brain stress systems mediates compulsive alcohol drinking

Tunstall, B. J., Carmack, S. A., Koob, G. F., & Vendruscolo, L. F. (2017) · Current Opinion in Behavioral Sciences

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 55

Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

Repunte-Canonigo, V., Shin, W., Vendruscolo, L. F., Lefebvre, C., van der Stap, L., Kawamura, T., Schlosburg, J. E., Alvarez, M., Koob, G. F., Califano, A., et al. (2015) · Genome Biology

Neurotransmitter Receptor Influence on BehaviorGene Regulatory Network Analysis

Cited by 52

Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies

Farokhnia, M., Rentsch, C. T., Chuong, V., McGinn, M. A., Elvig, S. K., Douglass, E. A., Gonzalez, L. A., Sanfilippo, J. E., Marchette, R. C. N., Tunstall, B. J., et al. (2022) · Molecular Psychiatry

Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

Cited by 41

Glucocorticoid receptor modulators decrease alcohol self-administration in male rats

McGinn, M. A., Tunstall, B. J., Schlosburg, J. E., Gregory-Flores, A., George, O., de Guglielmo, G., Mason, B. J., Hunt, H. J., Koob, G. F., & Vendruscolo, L. F. (2021) · Neuropharmacology

Neurotransmitter Receptor Influence on BehaviorSubstance Abuse Treatment and Outcomes

Cited by 35

PCSK9 inhibition attenuates alcohol-associated neuronal oxidative stress and cellular injury

Wagner, J., Park, L. M., Mukhopadhyay, P., Matyas, C., Trojnar, E., Damadzic, R., Jung, J., Bell, A. S., Mavromatis, L. A., Hamandi, A. M., et al. (2024) · Brain, Behavior, and Immunity

Neuroinflammation and Neurodegeneration MechanismsAlcohol Consumption and Health Effects

Cited by 26

Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats

Khom, S., Rodriguez, L., Gandhi, P., Kirson, D., Bajo, M., Oleata, C. S., Vendruscolo, L. F., Mason, B. J., & Roberto, M. (2022) · Neurobiology of Disease

Neuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Cited by 23

The Role of Brain Glucocorticoid Systems in Alcohol Dependence

Whitaker, A. M., Priddy, B. M., Edwards, S., & Vendruscolo, L. F. (2016) · Neuropathology of Drug Addictions and Substance Misuse

Stress Responses and CortisolNeurotransmitter Receptor Influence on Behavior

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