Dysregulation of brain stress systems mediates compulsive alcohol drinking
Open accessAbstract
The transition from moderate to compulsive alcohol drinking is driven by increasingly dysfunctional reward and stress systems. We review behavioral and pharmacological studies of alcohol self-administration in rats that were mainly conducted within the framework of the alcohol vapor model of dependence. We discuss neurotransmitter systems that are implicated in alcohol drinking, with a focus on contrasting those neurotransmitter systems that drive behavior in the dependent vs. nondependent states. We hypothesize that the identification of systems that become increasingly dysfunctional in alcohol dependence will reveal possible targets for successful interventions to reduce the motivation that drives compulsive alcohol drinking. In our opinion, drugs that (1) normalize, rather than block, a hypofunctional reward system via restoration of the function of hypothalamic stress systems, and (2) desensitize extrahypothalamic stress systems have the potential to selectively and effectively curb compulsive alcohol drinking.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Activated GR recruits CRF signaling in the CeA.
“given that activated GR recruits CRF signaling in the CeA (Koob and Schulkin, 2019;Tunstall et al., 2017)”
From Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats (2022) · cites this paper as Tunstall et al., 2017
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Jonas, D. E., Amick, H. R., Feltner, C., Bobashev, G., Thomas, K., Wines, R., Kim, M. M., Shanahan, E., Gass, C. E., Rowe, C. J., et al. (2014) · JAMA · doi:10.1001/jama.2014.3628 · Cited by 923 · see citing works
Weiss, F., Lorang, M. T., Bloom, F. E., & Koob, G. F. (1993) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)39420-6 · Cited by 751 · see citing works
Self-citationThe role of stress in drug self-administration
Piazza, P. V., & Moal, M. L. (1998) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(97)01115-2 · Cited by 674 · see citing works
Stress and the HPA axis: role of glucocorticoids in alcohol dependence
Stephens, M. (2012) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v34.4.11 · Cited by 571 · see citing works
Endocannabinoid signalling in reward and addiction
Parsons, L. H., & Hurd, Y. L. (2015) · Nature reviews. Neuroscience · doi:10.1038/nrn4004 · Cited by 474 · see citing works
Pharmacological evidence for a motivational role of κ-opioid systems in ethanol dependence
Walker, B. M., & Koob, G. F. (2008) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301438 · Cited by 392 · see citing works
Self-citationValdez, G. R., Roberts, A. J., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2002.tb02448.x · Cited by 387 · see citing works
Self-citationFunk, C. K., O'Dell, L. E., Crawford, E. F., & Koob, G. F. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3096-06.2006 · Cited by 381 · see citing works
Self-citationDecreased brain reward produced by ethanol withdrawal
Schulteis, G., Markou, A., Cole, M., & Koob, G. F. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.13.5880 · Cited by 345 · see citing works
Self-citationIntra-amygdala muscimol decreases operant ethanol self-administration in dependent rats
Roberts, A. J., Cole, M., & Koob, G. F. (1996) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.1996.tb01125.x · Cited by 340 · see citing works
Self-citationGabapentin Treatment for Alcohol Dependence: A Randomized Clinical Trial
Mason, B. J., Quello, S., Goodell, V., Shadan, F., Kyle, M., & Begovic, A. (2014) · JAMA Internal Medicine · doi:10.1001/jamainternmed.2013.11950 · Cited by 340 · see citing works
Rimondini, R., Arlinde, C., Sommer, W. H., & Heilig, M. A. (2002) · The FASEB Journal · doi:10.1096/fj.01-0593com · Cited by 320 · see citing works
Corticosteroid-dependent plasticity mediates compulsive alcohol drinking in rats
Vendruscolo, L. F., Barbier, E., Schlosburg, J. E., Misra, K. K., Whitfield, T. W., Logrip, M. L., Rivier, C., Repunte-Canonigo, V., Zorrilla, E. P., Sanna, P. P., et al. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0069-12.2012 · Cited by 319 · see citing works
Self-citationFunk, C. K., Zorrilla, E. P., Lee, M.-J., Rice, K. C., & Koob, G. F. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.03.063 · Cited by 276 · see citing works
Self-citationGlucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals
Vendruscolo, L. F., Estey, D., Goodell, V., Macshane, L. G., Logrip, M. L., Schlosburg, J. E., McGinn, M. A., Zamora-Martinez, E. R., Belanoff, J. K., Hunt, H. J., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79828 · Cited by 218 · see citing works
Self-citationNeurokinin 1 Receptor Antagonism as a Possible Therapy for Alcoholism
George, D. T., Gilman, J. M., Hersh, J., Thorsell, A., Herion, D. W., Geyer, C., Peng, X., Kielbasa, W., Rawlings, R. R., Brandt, J., et al. (2008) · Science · doi:10.1126/science.1153813 · Cited by 213 · see citing works
Rassnick, S., Stinus, L., & Koob, G. F. (1993) · Brain Research · doi:10.1016/0006-8993(93)90004-7 · Cited by 205 · see citing works
Self-citationWalker, B. M., Zorrilla, E. P., & Koob, G. F. (2010) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00226.x · Cited by 202 · see citing works
Self-citationWalker, B. M., & Koob, G. F. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00259.x · Cited by 196 · see citing works
Self-citationValdez, G. R., Roberts, A., Chan, K., Davis, H., Brennan, M., Zorrilla, E. P., & Koob, G. F. (2002) · PubMed · doi:10.1097/01.alc.0000033120.51856.f0 · Cited by 187 · see citing works
Self-citationα1-noradrenergic receptor antagonism blocks dependence-induced increases in responding for ethanol
Walker, B. M., Rasmussen, D. D., Raskind, M. A., & Koob, G. F. (2008) · Alcohol · doi:10.1016/j.alcohol.2007.12.002 · Cited by 167 · see citing works
Self-citationOperant alcohol self-administration in dependent rats: Focus on the vapor model
Vendruscolo, L. F., & Roberts, A. J. (2014) · Alcohol · doi:10.1016/j.alcohol.2013.08.006 · Cited by 166 · see citing works
Self-citationKwako, L. E., Spagnolo, P. A., Schwandt, M. L., Thorsell, A., George, D. T., Momenan, R., Rio, D. E., Huestis, M. A., Anizan, S., Concheiro, M., et al. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.306 · Cited by 160 · see citing works
Schwandt, M. L., Cortes, C. R., Kwako, L. E., George, D. T., Momenan, R., Sinha, R., Grigoriadis, D. E., Pich, E. M., Leggio, L., & Heilig, M. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.61 · Cited by 159 · see citing works
Acamprosate Produces Its Anti-Relapse Effects Via Calcium
Spanagel, R., Vengeliene, V., Jandeleit, B., Fischer, W.-N., Grindstaff, K. K., Zhang, X., Gallop, M. A., Krstew, E., Lawrence, A. J., & Kiefer, F. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2013.264 · Cited by 141 · see citing works
Nealey, K. A., Smith, A. W., Davis, S. M., Smith, D. G., & Walker, B. M. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.02.012 · Cited by 133 · see citing works
Cellular and behavioral interactions of gabapentin with alcohol dependence
Roberto, M., Gilpin, N. W., O'Dell, L. E., Cruz, M. T., Morse, A. C., Siggins, G. R., & Koob, G. F. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0575-08.2008 · Cited by 126 · see citing works
Self-citationExisting and future drugs for the treatment of the dark side of addiction
Koob, G. F., & Mason, B. J. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010715-103143 · Cited by 121 · see citing works
Self-citationGlucocorticoid feedback increases the sensitivity of the limbic system to stress
Cook, C. J. (2002) · Physiology & Behavior · doi:10.1016/s0031-9384(02)00650-9 · Cited by 110 · see citing works
Fahlke, C., Hȧrd, E., Hansen, S., Eriksson, C. J. P., & Engel, J. (1995) · Psychopharmacology · doi:10.1007/bf02245190 · Cited by 106 · see citing works
Edwards, S., Guerrero, M. A., Ghoneim, O. M., Roberts, E., & Koob, G. F. (2011) · Addiction Biology · doi:10.1111/j.1369-1600.2010.00291.x · Cited by 103 · see citing works
Self-citationde Fonseca, F. R., Roberts, A. J., Bilbao, A., Koob, G. F., & Navarro, M. (1999) · PubMed · Cited by 103 · see citing works
Self-citationEffects of β-adrenoceptor antagonists on alcohol drinking by alcohol-dependent rats
Gilpin, N. W., & Koob, G. F. (2010) · Psychopharmacology · doi:10.1007/s00213-010-1967-8 · Cited by 99 · see citing works
Self-citationMPZP: A novel small molecule corticotropin-releasing factor type 1 receptor (CRF1) antagonist
RICHARDSON, H., ZHAO, Y., Fekete, É. M., FUNK, C., Wirsching, P., Janda, K. D., Zorrilla, E. P., & Koob, G. F. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.10.008 · Cited by 95 · see citing works
Self-citationFunk, C. K., & Koob, G. F. (2007) · Brain Research · doi:10.1016/j.brainres.2007.04.009 · Cited by 94 · see citing works
Self-citationThorsell, A., Slawecki, C. J., & Ehlers, C. L. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.016 · Cited by 83 · see citing works
Rohn, M. C. H., Lee, M. R., Kleuter, S. B., Schwandt, M. L., Falk, D. E., & Leggio, L. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13304 · Cited by 80 · see citing works
Sabino, V., Cottone, P., Zhao, Y., Iyer, M. R., Steardo, L., Steardo, L., Rice, K. C., Conti, B., Koob, G. F., & Zorrilla, E. P. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.192 · Cited by 74 · see citing works
Self-citationHippocrates (2018) · Medical Entomology and Zoology · Cited by 73 · see citing works
Role of the α1blocker doxazosin in alcoholism: a proof-of-concept randomized controlled trial
Kenna, G. A., Haass‐Koffler, C. L., Zywiak, W. H., Edwards, S. M., Brickley, M., Swift, R. M., & Leggio, L. (2015) · Addiction Biology · doi:10.1111/adb.12275 · Cited by 68 · see citing works
Acamprosate in Alcohol Dependence: Implications of a Unique Mechanism of Action
Littleton, J. M. (2007) · Journal of Addiction Medicine · doi:10.1097/adm.0b013e318156c26f · Cited by 68 · see citing works
Roles for the endocannabinoid system in ethanol-motivated behavior
Henderson, A. N., Guindon, J., & Morgan, D. J. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.06.011 · Cited by 63 · see citing works
Divergent regulation of distinct glucocorticoid systems in alcohol dependence
Edwards, S., Little, H. J., Richardson, H. N., & Vendruscolo, L. F. (2015) · Alcohol · doi:10.1016/j.alcohol.2015.04.004 · Cited by 56 · see citing works
Self-citationRepunte-Canonigo, V., Shin, W., Vendruscolo, L. F., Lefebvre, C., van der Stap, L., Kawamura, T., Schlosburg, J. E., Alvarez, M., Koob, G. F., Califano, A., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0593-5 · Cited by 52 · see citing works
Self-citationKissler, J. L., & Walker, B. M. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.183 · Cited by 43 · see citing works
An Animal Model of Alcohol Dependence to Screen Medications for Treating Alcoholism
Becker, H. C., & Lopez, M. F. (2016) · International review of neurobiology · doi:10.1016/bs.irn.2016.02.006 · Cited by 32 · see citing works
Memantine reduces alcohol drinking but not relapse in alcohol‐dependent rats
Alaux‐Cantin, S., Buttolo, R., Houchi, H., Jeanblanc, J., & Naassïla, M. (2014) · Addiction Biology · doi:10.1111/adb.12177 · Cited by 29 · see citing works
11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse
Sanna, P. P., Kawamura, T., Chen, J., Koob, G. F., Roberts, A. J., Vendruscolo, L. F., & Repunte‐Canonigo, V. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.13 · Cited by 25 · see citing works
Self-citationMann, K. F., Hoffmann, S., & Pawlak, C. R. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.175 · Cited by 19 · see citing works
Flagged first, then by citations
2 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Advances in the science and treatment of alcohol use disorder
Witkiewitz, K. A., Litten, R. Z., & Leggio, L. (2019) · Science Advances · doi:10.1126/sciadv.aax4043 · Cited by 599 · see citing works
Tunstall, B. J., Kirson, D., Zallar, L. J., McConnell, S. A., Vendruscolo, J. C. M., Ho, C. P., Oleata, C. S., Khom, S., Manning, M., Lee, M. R., et al. (2019) · PLOS Biology · doi:10.1371/journal.pbio.2006421 · Cited by 104 · see citing works
Self-citationTolerance to alcohol: A critical yet understudied factor in alcohol addiction
Elvig, S. K., McGinn, M. A., Smith, C. C., Arends, M. A., Koob, G. F., & Vendruscolo, L. F. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173155 · Cited by 85 · see citing works
Self-citationMale and female mice develop escalation of heroin intake and dependence following extended access
Towers, E. B., Tunstall, B. J., McCracken, M. L., Vendruscolo, L. F., & Koob, G. F. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.019 · Cited by 76 · see citing works
Self-citationKim, S. W., Wiers, C. E., Tyler, R., Kojori, E. S., Jang, Y. J., Zehra, A., Freeman, C. R., Ramirez, V., Lindgren, E., Miller, G., et al. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0085-x · Cited by 73 · see citing works
Self-citationPantazis, C. B., Gonzalez, L. A., Tunstall, B. J., Carmack, S. A., Koob, G. F., & Vendruscolo, L. F. (2021) · Science Advances · doi:10.1126/sciadv.abf0364 · Cited by 73 · see citing works
Self-citationEmerging pharmacotherapies for alcohol use disorder
Mason, B. J. (2017) · Neuropharmacology · doi:10.1016/j.neuropharm.2017.04.032 · Cited by 46 · see citing works
Evaluation of N-acetylcysteine on ethanol self-administration in ethanol-dependent rats
Lebourgeois, S., González‐Marín, M. C., Antol, J., Naassïla, M., & Vilpoux, C. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.03.010 · Cited by 37 · see citing works
Glucocorticoid receptor modulators decrease alcohol self-administration in male rats
McGinn, M. A., Tunstall, B. J., Schlosburg, J. E., Gregory-Flores, A., George, O., de Guglielmo, G., Mason, B. J., Hunt, H. J., Koob, G. F., & Vendruscolo, L. F. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108510 · Cited by 35 · see citing works
Self-citationMatzeu, A., & Martin‐Fardon, R. (2020) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2020.599710 · Cited by 34 · see citing works
Targeting the subthalamic nucleus in a preclinical model of alcohol use disorder
Pelloux, Y., & Baunez, C. (2017) · Psychopharmacology · doi:10.1007/s00213-017-4618-5 · Cited by 34 · see citing works
Mechanisms of Alcohol Addiction: Bridging Human and Animal Studies
Kramer, J., Dick, D. M., King, A. C., Ray, L. A., Sher, K. J., Vena, A. A., Vendruscolo, L. F., & Ación, L. (2020) · Alcohol and Alcoholism · doi:10.1093/alcalc/agaa068 · Cited by 32 · see citing works
Self-citationJimenez, V. A., Herman, M. A., Cuzon Carlson, V. C., Walter, N. A., Grant, K. A., & Roberto, M. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-018-0290-7 · Cited by 29 · see citing works
Patel, R. R., Varodayan, F. P., Herman, M. A., Jiménez, V., Agnore, R., Gao, L., Bajo, M., Carlson, V. C. C., Walter, N. A. R., Fei, S. S., et al. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01231-y · Cited by 30 · see citing works
Alcohol Binge Drinking and Anxiety‐Like Behavior in Socialized Versus Isolated C57BL/6J Mice
Evans, O., Rodríguez‐Borillo, O., Font, L., Currie, P. J., & Pastor, R. (2019) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.14236 · Cited by 29 · see citing works
Lee, K. M., Coelho, M. A., Class, M. A., Sern, K. R., Bocz, M. D., & Szumlinski, K. K. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01306 · Cited by 24 · see citing works
Khom, S., Rodriguez, L., Gandhi, P., Kirson, D., Bajo, M., Oleata, C. S., Vendruscolo, L. F., Mason, B. J., & Roberto, M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105610 · Cited by 23 · see citing works
Self-citationZhou, Y., Rubinstein, M., Low, M. J., & Kreek, M. J. (2017) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13544 · Cited by 22 · see citing works
Effect of chronic alcohol vapor exposure on reinstatement of alcohol seeking induced by U50,488
Funk, D. R., Coen, K. M., Tamadon, S., & Lê, A. D. (2019) · Neuropharmacology · doi:10.1016/j.neuropharm.2019.01.017 · Cited by 21 · see citing works
Benvenuti, F., Cannella, N., Stopponi, S., Soverchia, L., Ubaldi, M., Lunerti, V., Vozella, V., Cruz, B., Roberto, M., & Ciccocioppo, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084184 · Cited by 20 · see citing works
Zhou, Y., & Kreek, M. J. (2018) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.245621 · Cited by 19 · see citing works
Advancing Pharmacotherapy Development from Preclinical Animal Studies
Egli, M. (2018) · Handbook of experimental pharmacology · doi:10.1007/164_2017_85 · Cited by 19 · see citing works
Prajapati, S. K., Bhaseen, S., Krishnamurthy, S., & Sahu, A. N. (2020) · Neurochemical Research · doi:10.1007/s11064-019-02944-9 · Cited by 17 · see citing works
Tunstall, B. J., Lorrai, I., McConnell, S. A., Gazo, K. L., Zallar, L. J., de Guglielmo, G., Hoang, I. B., Haass‐Koffler, C. L., Repunte‐Canonigo, V., Koob, G. F., et al. (2019) · Alcohol and Alcoholism · doi:10.1093/alcalc/agz054 · Cited by 15 · see citing works
Self-citationInvestigational drugs for alcohol use disorders: a review of preclinical data
Ch’ng, S. S., & Lawrence, A. J. (2018) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2018.1472763 · Cited by 14 · see citing works
Withdrawal from Brief Repeated Alcohol Treatment in Adolescent and Adult Male and Female Rats
Fleming, W., Jones, Q., Chandra, U., Saini, A., Walker, D. W., Francis, R., Ocampo, G., & Kuhn, C. M. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13936 · Cited by 14 · see citing works
Lopez, M. F., Davis, E. C., Cucinello‐Ragland, J. A., Regunathan, S., Edwards, S., & Becker, H. C. (2023) · Alcohol · doi:10.1016/j.alcohol.2023.01.003 · Cited by 13 · see citing works
Zhou, Y., Liang, Y., Low, M. J., & Kreek, M. J. (2019) · Genes Brain & Behavior · doi:10.1111/gbb.12600 · Cited by 13 · see citing works
Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review
Pince, C. L., Whiting, K. E., Wang, T., Lékó, A. H., Farinelli, L. A., Cooper, D., Farokhnia, M., Vendruscolo, L. F., & Leggio, L. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105427 · Cited by 12 · see citing works
Self-citationMartinez, C. A., Pantazopoulos, H., Gisabella, B., Stephens, E. T., Garteiser, J., & Arco, A. D. (2024) · Scientific Reports · doi:10.1038/s41598-024-57599-6 · Cited by 11 · see citing works
Vlkolinský, R., Khom, S., Vozella, V., Bajo, M., & Roberto, M. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106590 · Cited by 12 · see citing works
Rat Models of Alcohol Use Disorder
Tunstall, B. J., Vendruscolo, L. F., & Allen‐Worthington, K. H. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814338-4.00026-x · Cited by 12 · see citing works
Self-citationKhom, S., Borgonetti, V., Vozella, V., Kirson, D., Rodriguez, L., Gandhi, P. J., Bianchi, P., Snyder, A. E., Vlkolinský, R., Bajo, M., et al. (2023) · Neurobiology of Stress · doi:10.1016/j.ynstr.2023.100547 · Cited by 12 · see citing works
Céspedes, I. C., Ota, V., Mazzotti, D. R., Wscieklica, T., Conte, R., Galduróz, J. C. F., Varela, P., Pesquero, J. B., & Formigoni, M. L. O. D. S. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113563 · Cited by 11 · see citing works
Brain proteomic atlas of alcohol use disorder in adult males
Teng, P.-N., Barakat, W., Tran, S. M., Tran, Z. M., Bateman, N. W., Conrads, K. A., Wilson, K. N., Oliver, J., Gist, G. D., Hood, B. L., et al. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02605-0 · Cited by 11 · see citing works
Charlton, A. J., & Perry, C. J. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.836827 · Cited by 11 · see citing works
Palombo, P., Engi, S. A., Yokoyama, T. S., Bezerra, A. G., Curado, D. F., Anésio, A., Leão, R. M., Santos, P. C. J. L., Cruz, F. C., & Galduróz, J. C. F. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135551 · Cited by 11 · see citing works
Drug addiction co-morbidity with alcohol: Neurobiological insights
McGinn, M. A., Pantazis, C. B., Tunstall, B. J., Marchette, R. C. N., Carlson, E. R., Said, N., Koob, G. F., & Vendruscolo, L. F. (2021) · International review of neurobiology · doi:10.1016/bs.irn.2020.11.002 · Cited by 9 · see citing works
Self-citationAssociation between RMTg Neuropeptide Genes and Negative Effect during Alcohol Withdrawal in Mice
Fu, Y., Li, W., Mai, Y., Guan, J., Ding, R., Hou, J., Chen, B., Cao, G., Sun, S., Tang, Y., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25052933 · Cited by 7 · see citing works
Jones, M., Brandner, A. J., Vendruscolo, L. F., Vendruscolo, J. C. M., Koob, G. F., & Schmeichel, B. E. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.838486 · Cited by 7 · see citing works
Self-citationGardner, E. L. (2020) · Springer eBooks · doi:10.1007/978-3-030-36391-8_4 · Cited by 7 · see citing works
Lemon, C., & Arco, A. D. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113613 · Cited by 6 · see citing works
The Mineralocorticoid Receptor: An Emerging Pharmacotherapeutic Target for Alcohol Use Disorder?
Lékó, A. H., McGinn, M. A., & Farokhnia, M. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00326 · Cited by 5 · see citing works
Carpio, M. J., Gao, R., Wooner, E., Cayton, C. A., & Richard, J. M. (2022) · Psychopharmacology · doi:10.1007/s00213-022-06192-8 · Cited by 4 · see citing works
Funk, D. R., Mak, D., Coen, K. M., & Lê, A. D. (2022) · Behavioural Brain Research · doi:10.1016/j.bbr.2022.114032 · Cited by 3 · see citing works
Nisbett, K. E. (2024) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2024.100244 · Cited by 3 · see citing works
Neurobiological theories of addiction
Koob, G. F., Arends, M. A., McCracken, M. L., & Moal, M. L. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-816863-9.00003-0 · Cited by 3 · see citing works
Self-citationThe analgesic effect of neuropeptide S (NPS) in alcohol-dependent male and female rats
Marendes, J., Young, C. L., & Tunstall, B. J. (2026) · Alcohol · doi:10.1016/j.alcohol.2026.01.159 · Cited by 1 · see citing works
Self-citationHua, C. (2023) · Frontiers in clinical drug research. CNS and neurological disorders · doi:10.2174/9789815123319123110004 · Cited by 1 · see citing works
Lopez, M. F., Davis, E. C., Cucinello‐Ragland, J. A., Regunathan, S., Edwards, S., & Becker, H. C. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4201510 · Cited by 1 · see citing works
Central Role of Amygdala and Hypothalamus Neural Circuits in Alcohol Withdrawal Symptom
Wininger, K. M., Karpyak, V. M., Kang, S., & Choi, D. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813125-1.00026-x
Neurobiology of Substance Use Disorders
Palombo, P. (2025) · Springer eBooks · doi:10.1007/978-3-031-82614-6_5
Gashi, L., & Khom, S. (2025) · Biological Psychiatry Global Open Science · doi:10.1016/j.bpsgos.2025.100621
Gashi, L., Lubec, J., Daneyshar, B. H., Steinkellner, T., & Khom, S. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110927
Rojas-Pirela, M., Lesmes, S. P. G., Salete-Granado, D., Llorente, H., Pérez-Nieto, M.-Á., Novo-Veleiro, I., Cieza-Borrella, C., Pastor, I., Fernández-Mateos, J., Ines, S. M., et al. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27125376
- Authors
- Tunstall, B. J., Carmack, S. A., Koob, G. F., & Vendruscolo, L. F.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Vendruscolo, Leandro F
- Venue
- Current Opinion in Behavioral Sciences
- Publisher
- Elsevier BV
- Published
- 2017-02
- Volume
- 13
- Pages
- 85-90
- ISSN
- 2352-1546 (ISSN-L)
- PMC
- PMC5461929
- OpenAlex
- W2553162569
- Cited by
- 55
- References
- 51
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 7 · 2020: 6 · 2019: 11 · 2018: 7 · 2017: 3
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Behavioral Sciences (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (NIDA) Intramural Research Program
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- alcoholism, alcohol self-administration, reward systems, stress system, hypothalamic-pituitary-adrenal axis, neurotransmitter systems, drinking motives, pharmacological treatment of alcoholism
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
