Glucocorticoid receptor modulators decrease alcohol self-administration in male rats

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Development of mechanical hypersensitivity in rats during heroin and ethanol dependence: Alleviation by CRF1 receptor antagonism

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CRF-1 Antagonist and CRF-2 Agonist Decrease Binge-Like Ethanol Drinking in C57BL/6J Mice Independent of the HPA Axis

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Operant Behavior and Alcohol Levels in Blood and Brain of Alcohol‐Dependent Rats

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Mifepristone in the central nucleus of the amygdala reduces yohimbine stress-induced reinstatement of ethanol-seeking

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The Unique Pharmacological Characteristics of Mifepristone (RU486): From Terminating Pregnancy to Preventing Cancer Metastasis

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Corticosteroid Receptors in the Brain: Transcriptional Mechanisms for Specificity and Context-Dependent Effects

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Assessment of Safety, Tolerability, Pharmacokinetics, and Pharmacological Effect of Orally Administered CORT125134: An Adaptive, Double‐Blind, Randomized, Placebo‐Controlled Phase 1 Clinical Study

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The selective glucocorticoid receptor antagonist CORT 108297 decreases neuroendocrine stress responses and immobility in the forced swim test

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Abstinence from prolonged ethanol exposure affects plasma corticosterone, glucocorticoid receptor signaling and stress-related behaviors

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A relationship between the aldosterone-mineralocorticoid receptor pathway and alcohol drinking: preliminary translational findings across rats, monkeys and humans

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Corticosteroid Action in the Brain: The Potential of Selective Receptor Modulation

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Divergent regulation of distinct glucocorticoid systems in alcohol dependence

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Dysregulation of brain stress systems mediates compulsive alcohol drinking

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A Mixed Glucocorticoid/Mineralocorticoid Selective Modulator With Dominant Antagonism in the Male Rat Brain

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Identifying candidate drivers of alcohol dependence-induced excessive drinking by assembly and interrogation of brain-specific regulatory networks

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1H-Pyrazolo[3,4-g]hexahydro-isoquinolines as selective glucocorticoid receptor antagonists with high functional activity

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Selective glucocorticoid receptor modulation prevents and reverses non-alcoholic fatty liver disease in male mice

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Effects of the Glucocorticoid Antagonist, Mifepristone, on the Consequences of Withdrawal From Long Term Alcohol Consumption

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Resetting the Stress System with a Mifepristone Challenge

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Restraint Stress and Ethanol Consumption in Two Mouse Strains

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Mifepristone Pretreatment Reduces Ethanol Withdrawal Severity In Vivo

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Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration

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Isoform switching of steroid receptor co-activator-1 attenuates glucocorticoid-induced anxiogenic amygdala CRH expression

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A mixed glucocorticoid/mineralocorticoid receptor modulator dampens endocrine and hippocampal stress responsivity in male rats

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Binge-like ethanol consumption increases corticosterone levels and neurodegneration whereas occupancy of type II glucocorticoid receptors with mifepristone is neuroprotective

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Alcohol Vapor Inhalation as a Model of Alcohol‐Induced Organ Disease

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Targeting the glucocorticoid receptor reduces binge-like drinking in High Drinking in the Dark (HDID-1) mice

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Discovery of a novel non-steroidal GR antagonist with in vivo efficacy in the olanzapine-induced weight gain model in the rat

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11β-hydroxysteroid dehydrogenase inhibition as a new potential therapeutic target for alcohol abuse

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Compound A influences gene regulation of the Dexamethasone-activated glucocorticoid receptor by alternative cofactor recruitment

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Sex differences in the long-term effects of past stress on alcohol self-administration, glucocorticoid sensitivity and phosphodiesterase 10A expression

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Mifepristone decreases chronic voluntary ethanol consumption in Rhesus macaques

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Evaluation of mifepristone effects on alcohol-seeking and self-administration in baboons.

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Rat Models of Alcohol Use Disorder

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Alcohol Dependence Conceptualized as a Stress Disorder

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The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission

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The cortisol switch between vulnerability and resilience

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Glucagon-like peptide-1 receptor agonists, but not dipeptidyl peptidase-4 inhibitors, reduce alcohol intake

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Theoretical Frameworks and Mechanistic Aspects of Alcohol Addiction: Alcohol Addiction as a Reward Deficit/Stress Surfeit Disorder

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Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies

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Brain mineralocorticoid and glucocorticoid receptor balance in neuroendocrine regulation and stress-related psychiatric etiopathologies

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Corticosteroid sensitization drives opioid addiction

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FKBP5 inhibitors modulate alcohol drinking and trauma-related behaviors in a model of comorbid post-traumatic stress and alcohol use disorder

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Alcohol dependence and withdrawal increase sensitivity of central amygdalar GABAergic synapses to the glucocorticoid receptor antagonist mifepristone in male rats

Khom, S., Rodriguez, L., Gandhi, P., Kirson, D., Bajo, M., Oleata, C. S., Vendruscolo, L. F., Mason, B. J., & Roberto, M. (2022) · Neurobiology of Disease · doi:10.1016/j.nbd.2022.105610 · Cited by 23 · see citing works

Chemogenetic inhibition of central amygdala CRF-expressing neurons decreases alcohol intake but not trauma-related behaviors in a rat model of post-traumatic stress and alcohol use disorder

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Mifepristone as a pharmacological intervention for stress‐induced alcohol craving: A human laboratory study

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DNA methylation of the glucocorticoid receptor gene predicts substance use in adolescence: longitudinal data from over 1000 young individuals

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Coping with the multifaceted and multifunctional role of cortisol in the brain

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A conceptual framework for the intersection of hyperalgesia and hyperkatifeia in alcohol addiction

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Pairing Binge Drinking and a High-Fat Diet in Adolescence Modulates the Inflammatory Effects of Subsequent Alcohol Consumption in Mice

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Glucocorticoid feedback paradox: a homage to Mary Dallman

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Role of aldosterone and mineralocorticoid receptor (MR) in addiction: A scoping review

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Glucocorticoid receptors regulate central amygdala GABAergic synapses in Marchigian-Sardinian alcohol-preferring rats

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Alcohol Use Disorder: Stress, Negative Reinforcement, and Negative Urgency

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Mifepristone decreases nicotine intake in dependent and non-dependent adult rats

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Circulating corticosterone levels mediate the relationship between acute ethanol intoxication and markers of NF-κB activation in male rats

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Corticosterone Levels and Glucocorticoid Receptor Gene Expression in High Drinking in the Dark Mice and Their Heterogeneous Stock (HS/NPT) Founder Line

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