Moore, David D.

Comprehensive and Integrative Genomic Characterization of Hepatocellular Carcinoma

Ally, A., Balasundaram, M., Carlsen, R., Chuah, E., Clarke, A., Dhalla, N., Holt, R. A., Jones, S. J. M., Lee, D., Ma, Y., et al. (2017) · Cell

Cancer Genomics and DiagnosticsHepatocellular Carcinoma Treatment and Prognosis

Cited by 2,490

Bile Acids: Natural Ligands for an Orphan Nuclear Receptor

Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., et al. (1999) · Science

Cholesterol and Lipid MetabolismDrug Transport and Resistance Mechanisms

Cited by 2,274

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism

Wei, P., Zhang, J., Egan-Hafley, M., Liang, S., & Moore, D. D. (2000) · Nature

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 654

Nuclear Receptor-Dependent Bile Acid Signaling Is Required for Normal Liver Regeneration

Huang, W., Ma, K., Zhang, J., Qatanani, M., Cuvillier, J., Liu, J., Dong, B., Huang, X., & Moore, D. D. (2006) · Science

Liver physiology and pathologyDrug Transport and Resistance Mechanisms

Cited by 645

Asprosin, a Fasting-Induced Glucogenic Protein Hormone

Romere, C., Duerrschmid, C., Bournat, J., Constable, P., Jain, M., Xia, F., Saha, P. K., Del Solar, M., Zhu, B., York, B., et al. (2016) · Cell

Adipokines, Inflammation, and Metabolic DiseasesPancreatic function and diabetes

Cited by 591

Circadian Homeostasis of Liver Metabolism Suppresses Hepatocarcinogenesis

Kettner, N. M., Voicu, H., Finegold, M. J., Coarfa, C., Sreekumar, A., Putluri, N., Katchy, C. A., Lee, C., Moore, D. D., & Fu, L. (2016) · Cancer Cell

Circadian rhythm and melatoninLiver physiology and pathology

Cited by 508

Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor

Yang, F., Huang, X., Yi, T., Yen, Y., Moore, D. D., & Huang, W. (2007) · Cancer Research

Liver physiology and pathologyDrug Transport and Resistance Mechanisms

Cited by 488

Ikaros, an Early Lymphoid-Specific Transcription Factor and a Putative Mediator for T Cell Commitment

Georgopoulos, K., Moore, D. D., & Derfler, B. (1992) · Science

T-cell and B-cell ImmunologyGenomics and Chromatin Dynamics

Cited by 464

FXR: a metabolic regulator and cell protector

Wang, Y.-D., Chen, W.-D., Moore, D. D., & Huang, W. (2008) · Cell Research

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 389

Asprosin is a centrally acting orexigenic hormone

Duerrschmid, C., He, Y., Wang, C., Li, C., Bournat, J. C., Romere, C., Saha, P. K., Lee, M. E., Phillips, K. J., Jain, M., et al. (2017) · Nature Medicine

Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic Diseases

Cited by 357

Mutations in the nuclear bile acid receptor FXR cause progressive familial intrahepatic cholestasis

Gomez-Ospina, N., Potter, C. J., Xiao, R., Manickam, K., Kim, M.-S., Kim, K. H., Shneider, B. L., Picarsic, J. L., Jacobson, T. A., Zhang, J., et al. (2016) · Nature Communications

Drug Transport and Resistance MechanismsPediatric Hepatobiliary Diseases and Treatments

Cited by 300

Disrupting Circadian Homeostasis of Sympathetic Signaling Promotes Tumor Development in Mice

Lee, S., Donehower, L. A., Herron, A. J., Moore, D. D., & Fu, L. (2010) · PLoS ONE

Circadian rhythm and melatoninCancer-related Molecular Pathways

Cited by 286

Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor

Huang, W., Zhang, J., Washington, M., Liu, J., Parant, J. M., Lozano, G., & Moore, D. D. (2005) · Molecular Endocrinology

Pharmacogenetics and Drug MetabolismDrug-Induced Hepatotoxicity and Protection

Cited by 284

Circadian dysfunction induces leptin resistance in mice

Kettner, N. M., Mayo, S. A., Hua, J., Lee, C., Moore, D. D., & Fu, L. (2015) · Cell Metabolism

Circadian rhythm and melatoninRegulation of Appetite and Obesity

Cited by 260

The Constitutive Androstane Receptor and Pregnane X Receptor Function Coordinately to Prevent Bile Acid-induced Hepatotoxicity

Zhang, J., Huang, W., Qatanani, M., Evans, R. M., & Moore, D. D. (2004) · Journal of Biological Chemistry

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 246

Bile Acids Activate YAP to Promote Liver Carcinogenesis

Anakk, S., Bhosale, M., Schmidt, V. A., Johnson, R. L., Finegold, M. J., & Moore, D. D. (2013) · Cell Reports

Hippo pathway signaling and YAP/TAZLiver physiology and pathology

Cited by 196

C‐Myc and its target FoxM1 are critical downstream effectors of constitutive androstane receptor (CAR) mediated direct liver hyperplasia†

Blanco‐Bose, W. E., Murphy, M. J., Ehninger, A., Offner, S., Dubey, C., Huang, W., Moore, D. D., & Trumpp, A. (2008) · Hepatology

Liver physiology and pathologyDrug-Induced Hepatotoxicity and Protection

Cited by 138

Alterations in xenobiotic metabolism in the long‐lived Little mice

Amador‐Noguez, D., Dean, A., Huang, W., Setchell, K., Moore, D., & Darlington, G. (2007) · Aging Cell

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 134

Meclizine is an agonist ligand for mouse constitutive androstane receptor (CAR) and an inverse agonist for human CAR

Huang, W., Zhang, J., Wei, P., Schrader, W. T., & Moore, D. D. (2004) · Molecular Endocrinology

Pharmacogenetics and Drug MetabolismDrug Transport and Resistance Mechanisms

Cited by 110

Hepatic FXR/SHP axis modulates systemic glucose and fatty acid homeostasis in aged mice

Kim, K. H., Choi, S., Zhou, Y., Kim, E. Y., Lee, J. M., Saha, P. K., Anakk, S., & Moore, D. D. (2017) · Hepatology

Drug Transport and Resistance MechanismsCholesterol and Lipid Metabolism

Cited by 107

Activating CAR and β-catenin induces uncontrolled liver growth and tumorigenesis

Dong, B., Lee, J.-S., Park, Y.-Y., Yang, F., Xu, G., Huang, W., Finegold, M. J., & Moore, D. D. (2015) · Nature Communications

Wnt/β-catenin signaling in development and cancerLiver physiology and pathology

Cited by 97

Loss of orphan receptor small heterodimer partner sensitizes mice to liver injury from obstructive cholestasis

Park, Y. J., Qatanani, M., Chua, S. S., LaRey, J. L., Johnson, S. A., Watanabe, M., Moore, D. D., & Lee, Y. K. (2008) · Hepatology

Liver physiology and pathologyDrug Transport and Resistance Mechanisms

Cited by 68

The environmental estrogen, nonylphenol, activates the constitutive androstane receptor

Hernandez, J. P., Huang, W., Chapman, L. M., Chua, S., Moore, D. D., & Baldwin, W. S. (2007) · Toxicological Sciences

Effects and risks of endocrine disrupting chemicalsPharmacogenetics and Drug Metabolism

Cited by 52

A human liver chimeric mouse model for non-alcoholic fatty liver disease

Bissig-Choisat, B., Alves-Bezerra, M., Zorman, B., Ochsner, S. A., Barzi, M., Legras, X., Yang, D., Borowiak, M., Dean, A. M., York, R. B., et al. (2021) · JHEP Reports

Liver Disease Diagnosis and TreatmentDiet, Metabolism, and Disease

Cited by 49