Deane, Rashid

A Paravascular Pathway Facilitates CSF Flow Through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid β

Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 5,824

Sleep Drives Metabolite Clearance from the Adult Brain

Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science

Sleep and Wakefulness ResearchCerebrospinal fluid and hydrocephalus

Cited by 5,411

Impairment of paravascular clearance pathways in the aging brain

Kress, B. T., Iliff, J. J., Xia, M., Wang, M., Wei, H. S., Zeppenfeld, D., Xie, L., Kang, H., Xu, Q., Liew, J. A., et al. (2014) · Annals of Neurology

Cerebrospinal fluid and hydrocephalusIon Transport and Channel Regulation

Cited by 1,521

Pericytes Control Key Neurovascular Functions and Neuronal Phenotype in the Adult Brain and during Brain Aging

Bell, R. D., Winkler, E. A., Sagare, A. P., Singh, I., LaRue, B., Deane, R., & Zlokovic, B. V. (2010) · Neuron

Barrier Structure and Function StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 1,448

RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain

Deane, R., Du Yan, S., Submamaryan, R. K., LaRue, B., Jovanovic, S., Hogg, E., Welch, D., Manness, L., Lin, C., Yu, J., et al. (2003) · Nature Medicine

Alzheimer's disease research and treatmentsAdvanced Glycation End Products research

Cited by 1,426

Cerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain

Iliff, J. J., Wang, M., Zeppenfeld, D. M., Venkataraman, A., Plog, B. A., Liao, Y., Deane, R., & Nedergaard, M. (2013) · The Journal of Neuroscience

Cerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances

Cited by 1,319

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 1,293

Impairment of Glymphatic Pathway Function Promotes Tau Pathology after Traumatic Brain Injury

Iliff, J. J., Chen, M. J., Plog, B. A., Zeppenfeld, D. M., Soltero, M., Yang, L., Singh, I., Deane, R., & Nedergaard, M. (2014) · The Journal of Neuroscience

Cerebrospinal fluid and hydrocephalusTraumatic Brain Injury and Neurovascular Disturbances

Cited by 1,159

LRP/Amyloid β-Peptide Interaction Mediates Differential Brain Efflux of Aβ Isoforms

Deane, R., Wu, Z., Sagare, A., Davis, J., Du Yan, S., Hamm, K., Xu, F., Parisi, M., LaRue, B., Hu, H. W., et al. (2004) · Neuron

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 828

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

Deane, R., Sagare, A., Hamm, K., Parisi, M., Lane, S., Finn, M. B., Holtzman, D. M., & Zlokovic, B. V. (2008) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 771

Transport Pathways for Clearance of Human Alzheimer's Amyloid β-Peptide and Apolipoproteins E and J in the Mouse Central Nervous System

Bell, R. D., Sagare, A. P., Friedman, A. E., Bedi, G. S., Holtzman, D. M., Deane, R., & Zlokovic, B. V. (2007) · Journal of Cerebral Blood Flow & Metabolism

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 670

A multimodal RAGE-specific inhibitor reduces amyloid β–mediated brain disorder in a mouse model of Alzheimer disease

Deane, R., Singh, I., Sagare, A. P., Bell, R. D., Ross, N. T., LaRue, B., Love, R., Perry, S., Paquette, N., Deane, R. J., et al. (2012) · Journal of Clinical Investigation

Alzheimer's disease research and treatmentsAdvanced Glycation End Products research

Cited by 619

Suppression of glymphatic fluid transport in a mouse model of Alzheimer's disease

Peng, W., Achariyar, T. M., Li, B., Liao, Y., Mestre, H., Hitomi, E., Regan, S., Kasper, T., Peng, S., Ding, F., et al. (2016) · Neurobiology of Disease

Cerebrospinal fluid and hydrocephalusAlzheimer's disease research and treatments

Cited by 580

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.

Plog, B. A., Dashnaw, M. L., Hitomi, E., Peng, W., Liao, Y., Lou, N., Deane, R., & Nedergaard, M. (2015) · The Journal of Neuroscience

Traumatic Brain Injury and Neurovascular DisturbancesCerebrospinal fluid and hydrocephalus

Cited by 525

ALS-causing SOD1 mutants generate vascular changes prior to motor neuron degeneration

Zhong, Z., Deane, R., Ali, Z., Parisi, M., Shapovalov, Y., O'Banion, M. K., Stojanovic, K., Sagare, A., Boillee, S., Cleveland, D. W., et al. (2008) · Nature Neuroscience

Amyotrophic Lateral Sclerosis ResearchBarrier Structure and Function Studies

Cited by 476

The Effect of Body Posture on Brain Glymphatic Transport

Lee, H., Xie, L., Yu, M., Kang, H., Feng, T., Deane, R., Logan, J., Nedergaard, M., & Benveniste, H. (2015) · Journal of Neuroscience

Cerebrospinal fluid and hydrocephalusSleep and Wakefulness Research

Cited by 456

RAGE (Yin) Versus LRP (Yang) Balance Regulates Alzheimer Amyloid β-Peptide Clearance Through Transport Across the Blood–Brain Barrier

Deane, R., Wu, Z., & Zlokovic, B. V. (2004) · Stroke

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 392

Direct neuronal glucose uptake heralds activity-dependent increases in cerebral metabolism

Lundgaard, I., Li, B., Xie, L., Kang, H., Sanggaard, S., Haswell, J. D. R., Sun, W., Goldman, S., Blekot, S., Nielsen, M., et al. (2015) · Nature Communications

Neuroscience and Neuropharmacology ResearchAdvanced MRI Techniques and Applications

Cited by 381

Early-onset and Robust Cerebral Microvascular Accumulation of Amyloid β-Protein in Transgenic Mice Expressing Low Levels of a Vasculotropic Dutch/Iowa Mutant Form of Amyloid β-Protein Precursor

Davis, J., Xu, F., Deane, R., Romanov, G., Previti, M. L., Zeigler, K., Zlokovic, B. V., & Van Nostrand, W. E. (2004) · Journal of Biological Chemistry

Alzheimer's disease research and treatmentsIntracerebral and Subarachnoid Hemorrhage Research

Cited by 373

Evaluating glymphatic pathway function utilizing clinically relevant intrathecal infusion of CSF tracer

Yang, L., Kress, B. T., Weber, H. J., Thiyagarajan, M., Wang, B., Deane, R., Benveniste, H., Iliff, J. J., & Nedergaard, M. (2013) · Journal of Translational Medicine

Cerebrospinal fluid and hydrocephalusBarrier Structure and Function Studies

Cited by 317

Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease

Wu, Z., Guo, H., Chow, N., Sallstrom, J., Bell, R. D., Deane, R., Brooks, A. I., Kanagala, S., Rubio, A., Sagare, A., et al. (2005) · Nature Medicine

Barrier Structure and Function StudiesAlzheimer's disease research and treatments

Cited by 280

SRF and myocardin regulate LRP-mediated amyloid-β clearance in brain vascular cells

Bell, R. D., Deane, R., Chow, N., Long, X., Sagare, A., Singh, I., Streb, J. W., Guo, H., Rubio, A., Van Nostrand, W., et al. (2009) · Nature Cell Biology

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 261

Low‐density lipoprotein receptor‐related protein‐1: a serial clearance homeostatic mechanism controlling Alzheimer’s amyloid β‐peptide elimination from the brain

Zlokovic, B. V., Deane, R., Sagare, A. P., Bell, R. D., & Winkler, E. A. (2010) · Journal of Neurochemistry

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

Cited by 261

Serum response factor and myocardin mediate arterial hypercontractility and cerebral blood flow dysregulation in Alzheimer's phenotype

Chow, N., Bell, R. D., Deane, R., Streb, J. W., Chen, J., Brooks, A., Van Nostrand, W., Miano, J. M., & Zlokovic, B. V. (2007) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsNeurological Disease Mechanisms and Treatments

Cited by 209