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The Effect of Body Posture on Brain Glymphatic Transport
Open accessAbstract
The glymphatic pathway expedites clearance of waste, including soluble amyloid β (Aβ) from the brain. Transport through this pathway is controlled by the brain's arousal level because, during sleep or anesthesia, the brain's interstitial space volume expands (compared with wakefulness), resulting in faster waste removal. Humans, as well as animals, exhibit different body postures during sleep, which may also affect waste removal. Therefore, not only the level of consciousness, but also body posture, might affect CSF-interstitial fluid (ISF) exchange efficiency. We used dynamic-contrast-enhanced MRI and kinetic modeling to quantify CSF-ISF exchange rates in anesthetized rodents' brains in supine, prone, or lateral positions. To validate the MRI data and to assess specifically the influence of body posture on clearance of Aβ, we used fluorescence microscopy and radioactive tracers, respectively. The analysis showed that glymphatic transport was most efficient in the lateral position compared with the supine or prone positions. In the prone position, in which the rat's head was in the most upright position (mimicking posture during the awake state), transport was characterized by "retention" of the tracer, slower clearance, and more CSF efflux along larger caliber cervical vessels. The optical imaging and radiotracer studies confirmed that glymphatic transport and Aβ clearance were superior in the lateral and supine positions. We propose that the most popular sleep posture (late…
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Anesthesia is commonly used as a proxy for sleep because it is difficult to control when rodents enter natural sleep.
“Since it is difficult to control when rodents enter natural sleep, anesthesia is commonly used as a proxy for sleep1,24,99,100.”
From Norepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep (2025) · cites this paper as [99]
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Self-citationSleep Drives Metabolite Clearance from the Adult Brain
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MethodSelf-citationCerebral Arterial Pulsation Drives Paravascular CSF–Interstitial Fluid Exchange in the Murine Brain
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“Physiological parameters in rats during MRI studies It was demonstrated previously that pulsatility drives glymphatic influx (Iliff et al., 2013b) and that respiratory rate influences intracranial pressure as well as CSF flow (Grubb et al., 1974; Grant et al., 1989; Newell et al., 1996; Schneider…”
BackgroundMethodInfluentialSelf-citationBrain-wide pathway for waste clearance captured by contrast-enhanced MRI
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Self-citationInspiration is the major regulator of human CSF flow.
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BackgroundSleep and Synaptic Homeostasis: Structural Evidence in Drosophila
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β-Amyloid accumulation in the human brain after one night of sleep deprivation
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Self-citationPerivascular spaces in the brain: anatomy, physiology and pathology
Wardlaw, J. M., Benveniste, H., Nedergaard, M., Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., MacIntosh, B. J., et al. (2020) · Nature Reviews Neurology · doi:10.1038/s41582-020-0312-z · Cited by 870
Self-citationGlymphatic MRI in idiopathic normal pressure hydrocephalus
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Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
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Self-citationThe Glymphatic System and Waste Clearance with Brain Aging: A Review
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Self-citationNorepinephrine-mediated slow vasomotion drives glymphatic clearance during sleep
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Self-citationImpairment of the glymphatic system after diabetes
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Self-citationImpaired Glymphatic Transport in Spontaneously Hypertensive Rats
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Sleep Disorders Associated With Alzheimer's Disease: A Perspective
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Quantitative Gd‐DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA‐SPGR at 9.4T
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The relationship between amyloid-beta and brain capillary endothelial cells in Alzheimer’s disease
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Metadata
- Authors
- Lee, H., Xie, L., Yu, M., Kang, H., Feng, T., Deane, R., Logan, J., Nedergaard, M., & Benveniste, H.
- Affiliations
- University of Rochester Medicine (US)
- Stony Brook University (US)
- NYU Langone Health (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2015-08-05
- Volume
- 35
- Issue
- 31
- Pages
- 11034-11044
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC4524974
- OpenAlex
- W1932367580
- Cited by
- 456
- References
- 8
- Citations by year
- 2026: 58 · 2025: 57 · 2024: 44 · 2023: 53 · 2022: 43 · 2021: 52 · 2020: 35 · 2019: 34 · 2018: 35 · 2017: 25 · 2016: 13 · 2015: 5
- FWCI
- 16.72
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (R01AG048769)
- National Institute of Neurological Disorders and Stroke (R01NS078304, R01NS078167, R01NS075177)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Cerebrospinal fluid and hydrocephalus
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- glymphatic system, posture, amyloid-beta clearance, sleep, lateral position, prone position, supine position, cervical vessels, dynamic contrast-enhanced MRI, kinetic modeling
- MeSH terms
- Animals, Biological Transport, Brain, Cerebrospinal Fluid, Female, Magnetic Resonance Imaging, Posture, Amyloid beta-Peptides, Rats, Sprague-Dawley, Mice, Rats
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