Cited by 525Traumatic Brain Injury and Neurovascular DisturbancesCerebrospinal fluid and hydrocephalusTraumatic Brain Injury Research

Biomarkers of traumatic injury are transported from brain to blood via the glymphatic system.

Open access
Plog, Benjamin A., Dashnaw, Matthew L., Hitomi, Emi, Peng, Weiguo, Liao, Yonghong, Lou, Nanhong, Deane, Rashid, Nedergaard, Maiken·2015·The Journal of Neuroscience

Abstract

The nonspecific and variable presentation of traumatic brain injury (TBI) has motivated an intense search for blood-based biomarkers that can objectively predict the severity of injury. However, it is not known how cytosolic proteins released from traumatized brain tissue reach the peripheral blood. Here we show in a murine TBI model that CSF movement through the recently characterized glymphatic pathway transports biomarkers to blood via the cervical lymphatics. Clinically relevant manipulation of glymphatic activity, including sleep deprivation and cisternotomy, suppressed or eliminated TBI-induced increases in serum S100β, GFAP, and neuron specific enolase. We conclude that routine TBI patient management may limit the clinical utility of blood-based biomarkers because their brain-to-blood transport depends on glymphatic activity.

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Crossref · 10.1523/jneurosci.3742-14.2015

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  • Disruption of glymphatic function results in lower levels of TBI-associated biomarkers in the cervical lymph nodes and bloodstream.

    “disruption of glymphatic function results in lower levels of TBI-associated biomarkers in the cervical lymph nodes and bloodstream”

    From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Plog et al., 2015

  • The brain glymphatic and meningeal lymphatic systems work together to clear waste and macromolecules from the brain parenchyma in homeostasis and following injury.

    “The brain glymphatic and meningeal lymphatic systems work together to clear waste and macromolecules from the brain parenchyma in homeostasis and following injury”

    From Living on the Edge of the CNS: Meninges Cell Diversity in Health and Disease (2021) · cites this paper as Plog et al., 2015

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Authors
Plog, B. A., Dashnaw, M. L., Hitomi, E., Peng, W., Liao, Y., Lou, N., Deane, R., & Nedergaard, M.
Affiliations
University of Rochester Medicine (US)
Corresponding author
Nedergaard, Maiken
Venue
The Journal of Neuroscience
Published
2015-01-14
Volume
35
Issue
2
Pages
518-526
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2032220418
Cited by
525
References
70
Citations by year
2026: 46 · 2025: 41 · 2024: 47 · 2023: 43 · 2022: 57 · 2021: 47 · 2020: 46 · 2019: 40 · 2018: 54 · 2017: 38 · 2016: 33 · 2015: 32
FWCI
36.90
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Defense
  • National Institutes of Health
  • National Institute on Aging (R01AG048769)
  • National Institute of Neurological Disorders and Stroke (R01NS078304, R01NS078167, R01NS075177)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P01HD076892)
Topics
  • Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Cerebrospinal fluid and hydrocephalus
  • Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
Keywords
traumatic brain injury, blood-based biomarkers, glymphatic system, cerebrospinal fluid, S100β, glial fibrillary acidic protein, neuron-specific enolase, sleep deprivation, serum biomarkers
MeSH terms
Animals, Blood-Brain Barrier, Brain Injuries, Female, Glial Fibrillary Acidic Protein, Metabolic Clearance Rate, Mice, Inbred C57BL, Neuroglia, Sleep Deprivation, Biomarkers, Extracellular Fluid, Mice, S100 Calcium Binding Protein beta Subunit

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