Singhal, Sharad S.

Emerging Therapeutic Strategies to Overcome Drug Resistance in Cancer Cells

Garg, P., Malhotra, J., Kulkarni, P., Horne, D., Salgia, R., & Singhal, S. S. (2024) · Cancers

Drug Transport and Resistance MechanismsCancer Cells and Metastasis

Cited by 339

Accelerated metabolism and exclusion of 4-hydroxynonenal through induction of RLIP76 and hGST5.8 is an early adaptive response of cells to heat and oxidative stress

Cheng, J.-Z., Sharma, R., Yang, Y., Singhal, S. S., Sharma, A., Saini, M. K., Singh, S. V., Zimniak, P., Awasthi, S., & Awasthi, Y. C. (2001) · Journal of Biological Chemistry

Redox biology and oxidative stressGlutathione Transferases and Polymorphisms

Cited by 185

Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin

Awasthi, S., Cheng, J., Singhal, S. S., Saini, M. K., Pandya, U., Pikula, S., Bandorowicz-Pikula, J., Singh, S. V., Zimniak, P., & Awasthi, Y. C. (2000) · Biochemistry

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 159

Transport of glutathione conjugates and chemotherapeutic drugs by RLIP76 (RALBP1): A novel link between G-protein and tyrosine kinase signaling and drug resistance

Awasthi, S., Singhal, S. S., Sharma, R., Zimniak, P., & Awasthi, Y. C. (2003) · International Journal of Cancer

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 120

Cells Preconditioned with Mild, Transient UVA Irradiation Acquire Resistance to Oxidative Stress and UVA-induced Apoptosis

Yang, Y., Sharma, A., Sharma, R., Patrick, B., Singhal, S. S., Zimniak, P., Awasthi, S., & Awasthi, Y. C. (2003) · Journal of Biological Chemistry

Cell death mechanisms and regulationRedox biology and oxidative stress

Cited by 90

RLIP76 is a major determinant of radiation sensitivity

Awasthi, S., Singhal, S. S., Yadav, S., Singhal, J., Drake, K., Nadkar, A., Zajac, E., Wickramarachchi, D., Rowe, N., Yacoub, A., et al. (2005) · Cancer Research

Effects of Radiation ExposureDrug Transport and Resistance Mechanisms

Cited by 88

RLIP76, a Novel Transporter Catalyzing ATP-Dependent Efflux of Xenobiotics

Awasthi, S., Sharma, R., Singhal, S. S., Zimniak, P., & Awasthi, Y. C. (2002) · Drug Metabolism and Disposition

Drug Transport and Resistance MechanismsPharmacogenetics and Drug Metabolism

Cited by 86

Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer

Mohanty, A., Nam, A., Srivastava, S., Jones, J., Lomenick, B., Singhal, S. S., Guo, L., Cho, H., Li, A., Behal, A., et al. (2023) · Science Advances

Lung Cancer Treatments and MutationsProtein Kinase Regulation and GTPase Signaling

Cited by 79

Lipid Peroxidation Products in Human Health and Disease 2014

Ramana, K. V., Srivastava, S., & Singhal, S. S. (2014) · Oxidative Medicine and Cellular Longevity

Antioxidant Activity and Oxidative StressRedox biology and oxidative stress

Cited by 64

Glutathione-conjugate transport by RLIP76 is required for clathrin-dependent endocytosis and chemical carcinogenesis

Singhal, S. S., Wickramarachchi, D., Yadav, S., Singhal, J., Leake, K., Vatsyayan, R., Chaudhary, P., Lelsani, P., Suzuki, S., Yang, S., et al. (2011) · Molecular Cancer Therapeutics

Drug Transport and Resistance MechanismsCellular transport and secretion

Cited by 62

Hsf-1 and POB1 induce drug sensitivity and apoptosis by inhibiting Ralbp1

Singhal, S. S., Yadav, S., Drake, K., Singhal, J., & Awasthi, S. (2008) · Journal of Biological Chemistry

Heat shock proteins researchProtein Kinase Regulation and GTPase Signaling

Cited by 55

Lipid Peroxidation Products in Human Health and Disease 2019

Ramana, K. V., Srivastava, S., & Singhal, S. S. (2019) · Oxidative Medicine and Cellular Longevity

Antioxidant Activity and Oxidative StressRedox biology and oxidative stress

Cited by 54

SR4 Uncouples Mitochondrial Oxidative Phosphorylation, Modulates AMP-dependent Kinase (AMPK)-Mammalian Target of Rapamycin (mTOR) Signaling, and Inhibits Proliferation of HepG2 Hepatocarcinoma Cells

Figarola, J. L., Singhal, J., Tompkins, J. D., Rogers, G. W., Warden, C., Horne, D., Riggs, A. D., Awasthi, S., & Singhal, S. S. (2015) · Journal of Biological Chemistry

Mitochondrial Function and PathologyMetabolism, Diabetes, and Cancer

Cited by 41

Rlip depletion prevents spontaneous neoplasia in TP53 null mice

Awasthi, S., Tompkins, J., Singhal, J., Riggs, A. D., Yadav, S., Wu, X., Singh, S., Warden, C., Liu, Z., Wang, J., et al. (2018) · Proceedings of the National Academy of Sciences

Cancer-related Molecular PathwaysCell death mechanisms and regulation

Cited by 33

RLIP76 protein knockdown attenuates obesity due to a high-fat diet

Singhal, S. S., Figarola, J., Singhal, J., Reddy, M. A., Liu, X., Berz, D., Natarajan, R., & Awasthi, S. (2013) · Journal of Biological Chemistry

Adipokines, Inflammation, and Metabolic DiseasesDiet, Metabolism, and Disease

Cited by 26

Targeting p53-null neuroblastomas through RLIP76

Singhal, J., Yadav, S., Nagaprashantha, L. D., Vatsyayan, R., Singhal, S. S., & Awasthi, S. (2011) · Cancer Prevention Research

Drug Transport and Resistance MechanismsNeuroblastoma Research and Treatments

Cited by 25

1,3-bis(3,5-dichlorophenyl) Urea Compound ‘COH-SR4’ Inhibits Proliferation and Activates Apoptosis in Melanoma

Singhal, S. S., Figarola, J., Singhal, J., Leake, K., Nagaprashantha, L., Lincoln, C., Gabriel Gugiu, B., Horne, D., Jove, R., Awasthi, S., et al. (2012) · Biochemical Pharmacology

Melanoma and MAPK PathwaysHeterocyclic Compound Synthesis and Bioactivity

Cited by 20

Novel Compound 1, 3-bis (3, 5-dichlorophenyl) urea Inhibits Lung Cancer Progression

Singhal, S. S., Figarola, J., Singhal, J., Nagaprashantha, L., Berz, D., Rahbar, S., & Awasthi, S. (2013) · Biochemical Pharmacology

Cancer-related Molecular PathwaysLung Cancer Treatments and Mutations

Cited by 14

Rlip Depletion Suppresses Growth of Breast Cancer

Bose, C., Yadav, S., Singhal, S. S., Singhal, J., Hindle, A., Lee, J., Cheedella, N. K. S., Rehman, S., Layeequr Rahman, R., Jones, C., et al. (2020) · Cancers

Mechanisms of cancer metastasisCancer-related Molecular Pathways

Cited by 10

RLIP: An existential requirement for breast carcinogenesis

Singhal, S. S., Salgia, R., Singhal, S., Horne, D., & Awasthi, S. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Drug Transport and Resistance MechanismsCell death mechanisms and regulation

Cited by 10