RLIP76 protein knockdown attenuates obesity due to a high-fat diet
Open accessAbstract
Feeding a Western high-fat diet (HFD) to C57BL/6 mice induces obesity, associated with a chronic inflammatory state, lipid transport, and metabolic derangements, and organ system effects that particularly prominent in the kidneys. Here, we report that RLIP76 homozygous knock-out ( RLIP76 −/− ) mice are highly resistant to obesity as well as these other features of metabolic syndrome caused by HFD. The normal increase in pro-inflammatory and fibrotic markers associated with HFD induced obesity in wild-type C57B mice was broadly and nearly completely abrogated in RLIP76 −/− mice. This is a particularly striking finding because chemical markers of oxidative stress including lipid hydroperoxides and alkenals were significantly higher in RLIP76 −/− mice. Whereas HFD caused marked suppression of AMPK in wild-type C57B mice, RLIP76 −/− mice had baseline activation of AMP-activated protein kinase, which was not further affected by HFD. The baseline renal function was reduced in RLIP76 −/− mice as compared with wild-type, but was unaffected by HFD, in marked contrast to severe renal impairment and glomerulopathy in the wild-type mice given HFD. Our findings confirm a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines, and provide a novel mechanism for targeted therapy of obesity and metabolic syndrome. Background: RLIP76 homozygous knock-out mice ( RLIP76 −/− ) display a partially anti-metabolic syndrome phenotype characterized by insulin sensitivity, hypoglycemia, and hypolipidemia. Results: RLIP76 −/− mice are highly resistant to obesity as well as these other features of metabolic syndrome (MetS) caused by a high-fat diet. Conclusion: Our findings confirm a fundamental role of RLIP76 in regulating the function of obesity-promoting pro-inflammatory cytokines. Significance: Present studies provide a novel mechanism for targeted therapy of obesity and MetS.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
AMPK can be suppressed by alcohol or other agents such as high fat diet and APAP.
“In contrast, AMPK can be suppressed by alcohol [137] or other agents such as high fat diet [138] and APAP [139].”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Alberti, K. G. M. M., Eckel, R. H., Grundy, S. M., Zimmet, P. Z., Cleeman, J. I., Donato, K. A., Fruchart, J.-C., James, W. P. T., Loria, C. M., & Smith, S. C. (2009) · Circulation · doi:10.1161/circulationaha.109.192644 · Cited by 14,860 · see citing works
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
Identification and expression cloning of a leptin receptor, OB-R.
Tartaglia, L. A., Dembski, M., Weng, X., Deng, N., Culpepper, J., Devos, R., Richards, G. J., Campfield, L. A., Clark, F. T., Deeds, J., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90151-5 · Cited by 3,496 · see citing works
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works
Kern, P. A., Ranganathan, S., Li, C., Wood, L., & Ranganathan, G. (2001) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2001.280.5.e745 · Cited by 1,883 · see citing works
Frederich, R. C., Hamann, A., Anderson, S., Löllmann, B., Lowell, B. B., & Flier, J. S. (1995) · Nature Medicine · doi:10.1038/nm1295-1311 · Cited by 1,660 · see citing works
Ogden, C. L., Yanovski, S. Z., Carroll, M. D., & Flegal, K. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.052 · Cited by 1,561 · see citing works
High-fat diet-induced obesity in animal models
Hariri, N., & Thibault, L. (2010) · Nutrition Research Reviews · doi:10.1017/s0954422410000168 · Cited by 1,090 · see citing works
Mechanisms of leptin action and leptin resistance.
Myers, M. G., Cowley, M. A., & Münzberg, H. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100707 · Cited by 1,074 · see citing works
The Role of Adiponectin in Cancer: A Review of Current Evidence
Dalamaga, Μ., Diakopoulos, K. N., & Mantzoros, C. S. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1015 · Cited by 639 · see citing works
Circulating Interleukin‐6 in Relation to Adiposity, Insulin Action, and Insulin Secretion
Vozarova, B., Weyer, C., Hanson, K. A., Tataranni, P. A., Bogardus, C., & Pratley, R. E. (2001) · Obesity Research · doi:10.1038/oby.2001.54 · Cited by 638 · see citing works
Bastard, J., Maachi, M., Nhieu, J. T. V., Jardel, C., Bruckert, É., Grimaldi, A., Robert, J., Capeau, J., & Hainque, B. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8450 · Cited by 625 · see citing works
Landsberg, L., Aronne, L. J., Beilin, L. J., Burke, V., Igel, L. I., Lloyd‐Jones, D., & Sowers, J. (2013) · The Journal of Clinical Hypertension · doi:10.1111/jch.12049 · Cited by 528 · see citing works
Receptor for AGE (RAGE): Signaling mechanisms in the pathogenesis of diabetes and its complications
Ramasamy, R., Yan, S. F., & Schmidt, A. M. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06320.x · Cited by 521 · see citing works
Recombinant ob protein reduces feeding and body weight in the ob/ob mouse.
Weigle, D. S., Bukowski, T. R., Foster, D. C., Holderman, S. D., Kramer, J. M., Lasser, G. W., Lofton–Day, C., Prunkard, D. E., Raymond, C. K., & Kuijper, J. L. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118254 · Cited by 420 · see citing works
Epidemiology, Trends, and Morbidities of Obesity and the Metabolic Syndrome
Bray, G. A., & Bellanger, T. (2006) · Endocrine · doi:10.1385/endo:29:1:109 · Cited by 419 · see citing works
Inhibiting MicroRNA-192 Ameliorates Renal Fibrosis in Diabetic Nephropathy
Putta, S., Lanting, L. L., Sun, G., Lawson, G. W., Kato, M. V., & Natarajan, R. D. (2012) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011050485 · Cited by 369 · see citing works
Selective Insulin and Leptin Resistance in Metabolic Disorders
Könner, A. C., & Brüning, J. C. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.07.004 · Cited by 304 · see citing works
Endoplasmic reticulum stress and atherosclerosis
Hotamışlıgil, G. S. (2010) · Nature Medicine · doi:10.1038/nm0410-396 · Cited by 300 · see citing works
Yamagishi, S., Maeda, S., Matsui, T., Ueda, S., Fukami, K., & Okuda, S. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.03.014 · Cited by 297 · see citing works
Inflammation and endoplasmic reticulum stress in obesity and diabetes
Hotamışlıgil, G. S. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.238 · Cited by 285 · see citing works
The growing challenge of obesity and cancer: an inflammatory issue
Harvey, A. E., Lashinger, L. M., & Hursting, S. D. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06096.x · Cited by 272 · see citing works
AMPK Mediates the Initiation of Kidney Disease Induced by a High-Fat Diet
Declèves, A., Mathew, A. V., Cunard, R. A., & Sharma, K. (2011) · Journal of the American Society of Nephrology · doi:10.1681/asn.2011010026 · Cited by 252 · see citing works
Hypertrophy and hyperplasia of abdominal adipose tissues in women
Drolet, R., Richard, C., Sniderman, A. D., Mailloux, J. R., Fortier, M. P., Huot, C., Rhéaume, C., & Tchernof, A. (2007) · International Journal of Obesity · doi:10.1038/sj.ijo.0803708 · Cited by 243 · see citing works
Challenges and Opportunities of Defining Clinical Leptin Resistance
Myers, M. G., Heymsfield, S. B., Haft, C. R., Kahn, B. B., Laughlin, M. R., Leibel, R. L., Tschöp, M. H., & Yanovski, J. A. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.002 · Cited by 241 · see citing works
Epigenetic Histone Methylation Modulates Fibrotic Gene Expression
Sun, G., Reddy, M. A., Yuan, H., Lanting, L. L., Kato, M. V., & Natarajan, R. D. (2010) · Journal of the American Society of Nephrology · doi:10.1681/asn.2010060633 · Cited by 238 · see citing works
Clinical Relevance of Adipokines
Blüher, M. (2012) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2012.36.5.317 · Cited by 202 · see citing works
Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin
Awasthi, S., Cheng, J., Singhal, S. S., Saini, M. K., Pandya, U., Pikula, S., Bandorowicz-Pikula, J., Singh, S. V., Zimniak, P., & Awasthi, Y. C. (2000) · Biochemistry · doi:10.1021/bi992964c · Cited by 159 · see citing works
Lee, J. (2013) · Archives of Pharmacal Research · doi:10.1007/s12272-013-0023-8 · Cited by 157 · see citing works
Apelin and visfatin: unique "beneficial" adipokines upregulated in obesity?
Bełtowski, J. (2006) · PubMed · Cited by 130 · see citing works
Gil, Á., Aguilera, C. M., Gil‐Campos, M., & Cañete, R. (2007) · British Journal Of Nutrition · doi:10.1017/s0007114507838050 · Cited by 127 · see citing works
Regulation of Food Intake Through Hypothalamic Signaling Networks Involving mTOR
Woods, S. C., Seeley, R. J., & Cota, D. (2008) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.28.061807.155505 · Cited by 125 · see citing works
Adiponectin Induces Pro-inflammatory Programs in Human Macrophages and CD4+ T Cells
Cheng, X., Folco, E. J. E., Shimizu, K., & Libby, P. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.409516 · Cited by 122 · see citing works
Epidemiology of Obesity, the Metabolic Syndrome, and Chronic Kidney Disease
Tanner, R. M., Brown, T. M., & Muntner, P. (2012) · Current Hypertension Reports · doi:10.1007/s11906-012-0254-y · Cited by 121 · see citing works
Yang, J., & Holman, G. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410213200 · Cited by 118 · see citing works
Malavazos, A., Corsi, M., Ermetici, F., Coman, C., Sardanelli, F., Rossi, A., Morricone, L., & Ambrosi, B. (2007) · NMCD. Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2006.01.001 · Cited by 105 · see citing works
Ito, A., Suganami, T., Miyamoto, Y., Yoshimasa, Y., Takeya, M., Kamei, Y., & Ogawa, Y. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m701549200 · Cited by 97 · see citing works
Epidemiology of Obesity in the United States
Pender, J. R., & Pories, W. J. (2005) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2004.12.010 · Cited by 96 · see citing works
RLIP76 is a major determinant of radiation sensitivity
Awasthi, S., Singhal, S. S., Yadav, S., Singhal, J., Drake, K., Nadkar, A., Zajac, E., Wickramarachchi, D., Rowe, N., Yacoub, A., et al. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0968 · Cited by 88 · see citing works
Alterations in peripheral blood lymphocyte cytokine expression in obesity
O’Rourke, R. W., Kay, T., Lyle, E. A., Traxler, S., Deveney, C. W., Jobe, B. A., Roberts, C. T., Marks, D. L., & Rosenbaum, J. T. (2006) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2006.03186.x · Cited by 76 · see citing works
Okwan-Duodu, D. K., Umpierrez, G. E., Brawley, O. W., & Diaz, R. (2013) · Europe PMC (PubMed Central) · Cited by 68 · see citing works
The role of PPARγ in high-fat diet-induced obesity and insulin resistance
Kadowaki, T., Hara, K., Kubota, N., Tobe, K., Terauchi, Y., Yamauchi, T., Eto, K., Kadowaki, H., Noda, M., Hagura, R., et al. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00206-9 · Cited by 67 · see citing works
Sahin-Efe, A., Katsikeris, F., & Mantzoros, C. S. (2012) · Metabolism · doi:10.1016/j.metabol.2012.09.001 · Cited by 65 · see citing works
Górnicka, A., Fettig, J., Eguchi, A., Berk, M. P., Thapaliya, S., Dixon, L. J., & Feldstein, A. E. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00022.2012 · Cited by 63 · see citing works
Singhal, S. S., Wickramarachchi, D., Yadav, S., Singhal, J., Leake, K., Vatsyayan, R., Chaudhary, P., Lelsani, P., Suzuki, S., Yang, S., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0699 · Cited by 62 · see citing works
The role of SOCS-3 protein in leptin resistance and obesity.
Ramadhinara, A., Widia, F., Soegondo, S., & Setiawati, A. (2008) · PubMed · Cited by 61 · see citing works
Kim, D., Puri, N., Sodhi, K., Falck, J. R., Abraham, N. G., Shapiro, J., & Schwartzman, M. L. (2013) · Journal of Lipid Research · doi:10.1194/jlr.m033894 · Cited by 55 · see citing works
Inflammation and Oxidative Stress in Obesity, Metabolic Syndrome, and Diabetes
Galassetti, P. R. (2012) · Experimental Diabetes Research · doi:10.1155/2012/943706 · Cited by 53 · see citing works
RLIP76 in Defense of Radiation Poisoning
Singhal, J., Singhal, S. S., Yadav, S., Suzuki, S., Warnke, M. M., Yacoub, A., Dent, P., Bae, S., Sharma, R., Awasthi, S., et al. (2008) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2008.06.1497 · Cited by 52 · see citing works
Singhal, J., Nagaprashantha, L. D., Vatsyayan, R., Awasthi, S., & Singhal, S. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024688 · Cited by 48 · see citing works
Skurk, T., van Harmelen, V., Lee, Y., Wirth, A., & Hauner, H. (2002) · Hormone and Metabolic Research · doi:10.1055/s-2002-38253 · Cited by 44 · see citing works
Pathophysiology of Obesity-Related Renal Dysfunction Contributes to Diabetic Nephropathy
Bayliss, G., Weinrauch, L., & D'Elia, J. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0288-1 · Cited by 43 · see citing works
IL6 and IL1B Polymorphisms are Associated With Fat Mass in Older Men: The MrOS Study Sweden
Grahnemo, L., Mellström, D., Ljunggren, Ö., Grundberg, E., Karlsson, M. K., Holmberg, A. H., ORWOLL, E. S., Eriksson, A. L., Svedberg, J., Bengtsson, M., et al. (2008) · Obesity · doi:10.1038/oby.2007.95 · Cited by 43 · see citing works
Bikai, R. E., Welman, M., Margaron, Y., Côté, J., MacQueen, L. A., Buschmann, M. D., Fahmi, H., Shi, Q., Maghni, K., Fernandes, J., et al. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3173 · Cited by 39 · see citing works
A Central Role of RLIP76 in Regulation of Glycemic Control
Awasthi, S., Singhal, S. S., Yadav, S., Singhal, J., Vatsyayan, R., Zając, E., Luchowski, R., Borvak, J., Gryczynski, K., & Awasthi, S. (2009) · Diabetes · doi:10.2337/db09-0911 · Cited by 34 · see citing works
Ghrelin: New Molecular Pathways Modulating Appetite and Adiposity
Nogueiras, R., Williams, L. M., & Diéguez, C. (2010) · Obesity Facts · doi:10.1159/000321265 · Cited by 30 · see citing works
The Anti-Coronary Club: 1957 to 1972
Singman, H. S., Berman, S. N., Cowell, C., Maslansky, E., & Archer, M. (1980) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/33.6.1183 · Cited by 23 · see citing works
Tracey, K. J., & Warren, H. S. (2004) · Nature · doi:10.1038/429035a · Cited by 21 · see citing works
An Epidemiological Approach to Obesity
Nordsiek, F. W. (1964) · American Journal of Public Health and the Nations Health · doi:10.2105/ajph.54.10.1689 · Cited by 20 · see citing works
Flagged first, then by citations
1 of the 60 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Song, B.-J., Akbar, M., Abdelmegeed, M. A., Byun, K., Lee, B., Yoon, S. K., & Hardwick, J. P. (2014) · Redox Biology · doi:10.1016/j.redox.2014.10.004 · Cited by 123 · see citing works
“In contrast, AMPK can be suppressed by alcohol [137] or other agents such as high fat diet [138] and APAP [139].”
BackgroundScopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice
Cheon, S. Y., Koo, B., Kim, S. Y., Kam, E. H., Nam, J., & Kim, E. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87790-y · Cited by 97 · see citing works
Blüher, S., Käpplinger, J., Herget, S., Reichardt, S., Böttcher, Y., Grimm, A., Kratzsch, J., & Petroff, D. (2017) · Metabolism: Clinical and Experimental · doi:10.1016/j.metabol.2016.11.015 · Cited by 51 · see citing works
Transcriptional and Translational Modulation of myo-Inositol Oxygenase (Miox) by Fatty Acids
Tominaga, T., Dutta, R. K., Joladarashi, D., Doi, T., Reddy, J. K., & Kanwar, Y. S. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.698191 · Cited by 38 · see citing works
2′‐Hydroxyflavanone inhibits in vitro and in vivo growth of breast cancer cells by targeting RLIP76
Singhal, J., Chikara, S., Horne, D. A., Salgia, R., Awasthi, S., & Singhal, S. S. (2018) · Molecular Carcinogenesis · doi:10.1002/mc.22894 · Cited by 26 · see citing works
Nagaprashantha, L. D., Singhal, J., Li, H., Warden, C., Liu, X., Horne, D. A., Awasthi, S., Salgia, R., & Singhal, S. S. (2018) · Oncotarget · doi:10.18632/oncotarget.24720 · Cited by 24 · see citing works
Targeting RLIP with CRISPR/Cas9 controls tumor growth
Singhal, J., Chikara, S., Horne, D. A., Awasthi, S., Salgia, R., & Singhal, S. S. (2020) · Carcinogenesis · doi:10.1093/carcin/bgaa048 · Cited by 22 · see citing works
Sreedhar, R., Arumugam, S., Thandavarayan, R. A., Karuppagounder, V., Koga, Y., Nakamura, T., Harima, M., & Watanabe, K. (2017) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2017.05.009 · Cited by 21 · see citing works
Topical 2′-Hydroxyflavanone for Cutaneous Melanoma
Bose, C., Singh, S. P., Igid, H. P., Green, W. C., Singhal, S. S., Lee, J., Palade, P., Rajan, A., Ball, S., Tonk, V. S., et al. (2019) · Cancers · doi:10.3390/cancers11101556 · Cited by 16 · see citing works
Plaza‐Florido, A., Pérez‐Prieto, I., Molina‐García, P., Radom‐Aizik, S., Ortega, F. B., & Altmäe, S. (2022) · Frontiers in Pediatrics · doi:10.3389/fped.2022.917152 · Cited by 16 · see citing works
Singhal, S. S., Horne, D. A., Singhal, J., Vonderfecht, S. L., Salgia, R., & Awasthi, S. (2019) · Molecular Carcinogenesis · doi:10.1002/mc.23026 · Cited by 13 · see citing works
Singhal, S. S., Garg, R., Horne, D. A., Singhal, S. S., Awasthi, S., & Salgia, R. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188803 · Cited by 10 · see citing works
RLIP: An existential requirement for breast carcinogenesis
Singhal, S. S., Salgia, R., Singhal, S., Horne, D., & Awasthi, S. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.02.001 · Cited by 10 · see citing works
Rlip Depletion Suppresses Growth of Breast Cancer
Bose, C., Yadav, S., Singhal, S. S., Singhal, J., Hindle, A., Lee, J., Cheedella, N. K. S., Rehman, S., Layeequr Rahman, R., Jones, C., et al. (2020) · Cancers · doi:10.3390/cancers12061446 · Cited by 10 · see citing works
Sharma, I., Deng, F., & Kanwar, Y. S. (2020) · Biomedicines · doi:10.3390/biomedicines8070217 · Cited by 9 · see citing works
Singh, S. P., Lee, J., Bose, C., Li, H., Yuan, Y., Hindle, A., Singhal, S. S., Kopel, J. J., Palade, P., Jones, C., et al. (2021) · Cancers · doi:10.3390/cancers13133329 · Cited by 6 · see citing works
Jeong, J. I., Kim, J.-I., Kim, K. M., Choi, I., Pratley, R. E., & Lee, Y. (2014) · Animal Cells and Systems · doi:10.1080/19768354.2014.940383 · Cited by 5 · see citing works
Meda, S., Singh, S. P., Palade, P., Tonk, S. S., & Awasthi, S. (2019) · The Southwest Respiratory and Critical Care Chronicles · doi:10.12746/swrccc.v7i27.511 · Cited by 5 · see citing works
Activating p53 function by targeting RLIP
Singhal, S. S., Horne, D. A., Singhal, J., Awasthi, S., & Salgia, R. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188512 · Cited by 5 · see citing works
Prevention of mammary carcinogenesis in MMTV‐neu mice by targeting RLIP
Singhal, J., Kulkarni, P., Horne, D. A., Awasthi, S., Salgia, R., & Singhal, S. S. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23285 · Cited by 5 · see citing works
Regression of ovarian cancer xenografts by depleting or inhibiting RLIP
Ramisetty, S. K., Garg, P. K., Mohanty, A. R., Mirzapoiazova, T., Yue, E., Wang, W., Horne, D. A., Awasthi, S., Kulkarni, P., Salgia, R., et al. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115847 · Cited by 4 · see citing works
Rlip Depletion Alters Oncogene Transcription at Multiple Distinct Regulatory Levels
Hindle, A., Bose, C., Lee, J., Palade, P., Peterson, C., Reddy, P. H., Awasthi, S., & Singh, S. P. (2022) · Cancers · doi:10.3390/cancers14030527 · Cited by 1 · see citing works
Scopolamine-induced Delirium Promotes Neuroinflammation and Neuropsychiatric Disorder in MicePreprint
Cheon, S. Y., Koo, B., Kim, S. Y., Kam, E. H., Nam, J., & Kim, E. J. (2020) · Research Square · doi:10.21203/rs.3.rs-126768/v1 · Cited by 1 · see citing works
Role of oxidative stress in the severity of SARS-COV-2 infection
Singh, S. P., Awasthi, S., Hindle, A., & Bose, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-15256-6.00016-7
Bhattacharjee, P., Ghosh, D., Singh, G., Porel, P., Aran, K. R., Debnath, B., & Jamal, M. H. (2026) · Inflammopharmacology · doi:10.1007/s10787-026-02147-z
Biomarkers of Cardiovascular Stress: A Historical Review
Khosla, H., Kopel, J. J., Abohelwa, M., Awasthi, M., Mohlere, V., Singh, S. P., Shurmur, S. W., Ansari, M. A., Awasthi, Y., & Awasthi, S. (2026) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd13080358
- Authors
- Singhal, S. S., Figarola, J., Singhal, J., Reddy, M. A., Liu, X., Berz, D., Natarajan, R., & Awasthi, S.
- Affiliations
- City Of Hope National Medical Center (US)
- Corresponding author
- Singhal, Sharad S.
- Awasthi, Sanjay
- ORCID
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 288
- Issue
- 32
- Pages
- 23394-23406
- ISSN
- 0021-9258 (ISSN-L)
- PMC
- PMC3743508
- OpenAlex
- W2078739444
- Cited by
- 26
- References
- 60
- Citations by year
- 2026: 2 · 2023: 2 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 4 · 2018: 2 · 2017: 1 · 2016: 1 · 2015: 1 · 2014: 2
- FWCI
- 0.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biological Chemistry (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Perricone Family Foundation
- Beckman Research Institute, City of Hope
- National Institutes of Health
- National Cancer Institute (R01 CA77495, R01CA077495, P30CA033572)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK065073)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- RLIP76, obesity, high-fat diet, metabolic syndrome, inflammatory cytokines, renal fibrosis, oxidative stress, lipid hydroperoxides, alkenals, AMPK, renal function, glomerular disease, obesity resistance
- MeSH terms
- Animals, Dietary Fats, Enzyme Activation, Inflammation, Obesity, Biomarkers, Cytokines, Mice, Knockout, Oxidative Stress, GTPase-Activating Proteins, Metabolic Syndrome, Mice, AMP-Activated Protein Kinases, Gene Knockdown Techniques
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
