Nho, Kwangsik

INPP5D expression is associated with risk for Alzheimer's disease and induced by plaque-associated microglia

Tsai, A. P., Lin, P. B.-C., Dong, C., Moutinho, M., Casali, B. T., Liu, Y., Lamb, B. T., Landreth, G. E., Oblak, A. L., & Nho, K. (2021) · Neurobiology of Disease

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 104

Harnessing peripheral DNA methylation differences in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) to reveal novel biomarkers of disease

Vasanthakumar, A., Davis, J. W., Idler, K., Waring, J. F., Asque, E., Riley-Gillis, B., Grosskurth, S., Srivastava, G., Kim, S., Nho, K., et al. (2020) · Clinical Epigenetics

Dementia and Cognitive Impairment ResearchEpigenetics and DNA Methylation

Cited by 98

Bile acid synthesis, modulation, and dementia: A metabolomic, transcriptomic, and pharmacoepidemiologic study

Varma, V. R., Wang, Y., An, Y., Varma, S., Bilgel, M., Doshi, J., Legido-Quigley, C., Delgado, J. C., Oommen, A. M., Roberts, J. A., et al. (2021) · PLOS Medicine

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 97

Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis

Zhou, X., Chen, Y., Mok, K. Y., Zhao, Q., Chen, K., Chen, Y., Hardy, J., Li, Y., Fu, A. K. Y., Guo, Q., et al. (2018) · Proceedings of the National Academy of Sciences

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 96

PLCG2 is associated with the inflammatory response and is induced by amyloid plaques in Alzheimer’s disease

Tsai, A. P., Dong, C., Lin, P. B.-C., Messenger, E. J., Casali, B. T., Moutinho, M., Liu, Y., Oblak, A. L., Lamb, B. T., Landreth, G. E., et al. (2022) · Genome Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 92

Deep learning-based identification of genetic variants: application to Alzheimer’s disease classification

Jo, T., Nho, K., Bice, P., Saykin, A. J., & Initiative, F. T. A. D. N. (2022) · Briefings in Bioinformatics

Genetic Associations and EpidemiologyAlzheimer's disease research and treatments

Cited by 80

Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease

Young, C. B., Winer, J. R., Younes, K., Cody, K. A., Betthauser, T. J., Johnson, S. C., Schultz, A., Sperling, R. A., Greicius, M. D., Cobos, I., et al. (2022) · JAMA Neurology

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 79

Genome-wide association study of brain amyloid deposition as measured by Pittsburgh Compound-B (PiB)-PET imaging

(ADNI), F. T. A. D. N. I., Yan, Q., Nho, K., Del-Aguila, J. L., Wang, X., Risacher, S. L., Fan, K.-H., Snitz, B. E., Aizenstein, H. J., Mathis, C. A., et al. (2021) · Molecular Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 73

APOE Promoter Polymorphism-219T/G is an Effect Modifier of the Influence of APOE ε4 on Alzheimer’s Disease Risk in a Multiracial Sample

Choi, K., Lee, J., Gunasekaran, T., Kang, S., Lee, W., Jeong, J., Lim, H., Zhang, X., Zhu, C., Won, S.-Y., et al. (2019) · Journal of Clinical Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 72

GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia

Shade, L. M. P., Katsumata, Y., Abner, E. L., Aung, K. Z., Claas, S. A., Qiao, Q., Heberle, B. A., Brandon, J. A., Page, M. L., Hohman, T. J., et al. (2024) · Nature Genetics

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 72

Genetic variants of phospholipase C-γ2 alter the phenotype and function of microglia and confer differential risk for Alzheimer’s disease

Tsai, A. P., Dong, C., Lin, P. B.-C., Oblak, A. L., Viana Di Prisco, G., Wang, N., Hajicek, N., Carr, A. J., Lendy, E. K., Hahn, O., et al. (2023) · Immunity

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 71

White matter abnormalities and cognition in aging and Alzheimer disease

Peter, C., Sathe, A., Shashikumar, N., Pechman, K. R., Workmeister, A. W., Jackson, T. B., Huo, Y., Mukherjee, S., Mez, J., Dumitrescu, L. C., et al. (2025) · JAMA Neurology

Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and Applications

Cited by 59

KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimer’s disease

Neitzel, J., Franzmeier, N., Rubinski, A., Dichgans, M., Brendel, M., (ADNI), A. D. N. I., Weiner, M., Aisen, P., Petersen, R., Jack, C. R., et al. (2021) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 57

Multimodal Hippocampal Subfield Grading For Alzheimer’s Disease Classification

Hett, K., Ta, V.-T., Catheline, G., Tourdias, T., Manjón, J. V., Coupé, P., Initiative, A. D. N., Weiner, M. W., Aisen, P., Petersen, R., et al. (2019) · Scientific Reports

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 49

TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation

Moutinho, M., Coronel, I., Tsai, A. P., Di Prisco, G. V., Pennington, T., Atwood, B. K., Puntambekar, S. S., Smith, D. C., Martinez, P., Han, S., et al. (2023) · Genome Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 42

Comprehensive Gene- and Pathway-Based Analysis of Depressive Symptoms in Older Adults

Nho, K., Ramanan, V. K., Horgusluoglu, E., Kim, S., Inlow, M. H., Risacher, S. L., McDonald, B. C., Farlow, M. R., Foroud, T. M., Gao, S., et al. (2015) · Journal of Alzheimer’s Disease

Genetic Associations and EpidemiologyTreatment of Major Depression

Cited by 41

Targeted genetic analysis of cerebral blood flow imaging phenotypes implicates the INPP5D gene

Yao, X., Risacher, S. L., Nho, K., Saykin, A. J., Wang, Z., & Shen, L. (2019) · Neurobiology of Aging

Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatments

Cited by 40

Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits

Deming, Y., Xia, J., Cai, Y., Lord, J., Del-Aguila, J. L., Fernandez, M. V., Carrell, D., Black, K., Budde, J., Ma, S., et al. (2016) · Scientific Reports

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 28

A missense variant in SHARPIN mediates Alzheimer’s disease-specific brain damages

Park, J. Y., Lee, D., Lee, J. J., Gim, J., Gunasekaran, T. I., Choi, K. Y., Kang, S., Do, A. R., Jo, J., Park, J., et al. (2021) · Translational Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 21

Integrative-omics for discovery of network-level disease biomarkers: a case study in Alzheimer’s disease

Xie, L., He, B., Varathan, P., Nho, K., Risacher, S. L., Saykin, A. J., Salama, P., & Yan, J. (2021) · Briefings in Bioinformatics

Bioinformatics and Genomic NetworksAlzheimer's disease research and treatments

Cited by 16

ADAS-viewer: web-based application for integrative analysis of multi-omics data in Alzheimer’s disease

Han, S., Shin, J., Jung, H., Ryu, J., Minassie, H., Nho, K., Koh, I., & Lee, Y. (2021) · npj Systems Biology and Applications

Alzheimer's disease research and treatmentsBioinformatics and Genomic Networks

Cited by 16

A simulative deep learning model of SNP interactions on chromosome 19 for predicting Alzheimer's disease risk and rates of disease progression

Bae, J., Logan, P. E., Acri, D. J., Bharthur, A., Nho, K., Saykin, A. J., Risacher, S. L., Nudelman, K., Polsinelli, A. J., Pentchev, V., et al. (2023) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 14

Identification of functionally connected multi-omic biomarkers for Alzheimer’s disease using modularity-constrained Lasso

Xie, L., Varathan, P., Nho, K., Saykin, A. J., Salama, P., & Yan, J. (2020) · PLOS ONE

Bioinformatics and Genomic NetworksAlzheimer's disease research and treatments

Cited by 9

PLCG2 as a Risk Factor for Alzheimer's Disease.

Tsai, A. P., Dong, C., Preuss, C., Moutinho, M., Lin, P. B.-C., Hajicek, N., Sondek, J., Bissel, S. J., Oblak, A. L., Carter, G. W., et al. (2020)

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 7