Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits
Open accessAbstract
Genome-wide association studies of 146 plasma protein levels in 818 individuals revealed 56 genome-wide significant associations (28 novel) with 47 analytes. Loci associated with plasma levels of 39 proteins tested have been previously associated with various complex traits such as heart disease, inflammatory bowel disease, Type 2 diabetes and multiple sclerosis. These data suggest that these plasma protein levels may constitute informative endophenotypes for these complex traits. We found three potential pleiotropic genes: ABO for plasma SELE and ACE levels, FUT2 for CA19-9 and CEA plasma levels and APOE for ApoE and CRP levels. We also found multiple independent signals in loci associated with plasma levels of ApoH, CA19-9, FetuinA, IL6r and LPa. Our study highlights the power of biological traits for genetic studies to identify genetic variants influencing clinically relevant traits, potential pleiotropic effects and complex disease associations in the same locus.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
No statistical methods were used to predetermine sample sizes within each tissue type, but the sample sizes are much larger or comparable to those in previous publications.
“No statistical methods were used to predetermine sample sizes within each tissue type, but our sample sizes are much larger or comparable to those in previous publications13,14,16.”
From Genomic atlas of the proteome from brain, CSF and plasma prioritizes proteins implicated in neurological disorders (2021) · cites this paper as [13]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
PLINK: a tool set for whole-genome association and population-based linkage analyses.
Purcell, S., Neale, B., Todd-Brown, K., Thomas, L., Ferreira, M. A. R., Bender, D., Maller, J., Sklar, P., de Bakker, P. I. W., Daly, M. J., et al. (2007) · The American Journal of Human Genetics · doi:10.1086/519795 · Cited by 34,089 · see citing works
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072 · see citing works
Self-citationANNOVAR: functional annotation of genetic variants from high-throughput sequencing data
Wang, K., Li, M., & Hakonarson, H. H. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq603 · Cited by 14,380 · see citing works
Principal components analysis corrects for stratification in genome-wide association studies
Price, A. L., Patterson, N. J., Plenge, R. M., Weinblatt, M. E., Shadick, N. A., & Reich, D. (2006) · Nature Genetics · doi:10.1038/ng1847 · Cited by 10,248 · see citing works
The Clinical Dementia Rating (CDR): Current version and scoring rules
Morris, J. C. (1993) · Neurology · doi:10.1212/wnl.43.11.2412-a · Cited by 9,882 · see citing works
Self-citationAcute-Phase Proteins and Other Systemic Responses to Inflammation
Gabay, C., & Kushner, I. (1999) · New England Journal of Medicine · doi:10.1056/nejm199902113400607 · Cited by 6,734 · see citing works
METAL: fast and efficient meta-analysis of genomewide association scans
Willer, C. J., Li, Y., & Abecasis, G. R. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq340 · Cited by 5,205 · see citing works
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
The International IBD Genetics Consortium (IIBDGC), Jostins, L., Ripke, S., Weersma, R. K., Duerr, R. H., McGovern, D. P., Hui, K. Y., Lee, J. C., Philip Schumm, L., Sharma, Y., et al. (2012) · Nature · doi:10.1038/nature11582 · Cited by 4,722 · see citing works
Self-citationBiological, clinical and population relevance of 95 loci for blood lipids
Teslovich, T. M., Musunuru, K., Smith, A. V., Edmondson, A. C., Stylianou, I. M., Koseki, M., Pirruccello, J. P., Ripatti, S., Chasman, D. I., Willer, C. J., et al. (2010) · Nature · doi:10.1038/nature09270 · Cited by 3,487 · see citing works
Self-citationBrowning, S. R., & Browning, B. L. (2007) · The American Journal of Human Genetics · doi:10.1086/521987 · Cited by 3,138 · see citing works
Annotation of functional variation in personal genomes using RegulomeDB
Boyle, A. P., Hong, E. L., Hariharan, M., Cheng, Y., Schaub, M. A., Kasowski, M., Karczewski, K. J., Park, J., Hitz, B. C., Weng, S., et al. (2012) · Genome Research · doi:10.1101/gr.137323.112 · Cited by 2,722 · see citing works
LocusZoom: regional visualization of genome-wide association scan results
Pruim, R. J., Welch, R. P., Sanna, S., Teslovich, T. M., Chines, P. S., Gliedt, T. P., Boehnke, M., Abecasis, G. R., & Willer, C. J. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq419 · Cited by 2,707 · see citing works
Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis
The International Multiple Sclerosis Genetics Consortium & The Wellcome Trust Case Control Consortium 2 (2011) · Nature · doi:10.1038/nature10251 · Cited by 2,697 · see citing works
An atlas of genetic influences on human blood metabolites
The Multiple Tissue Human Expression Resource (MuTHER) Consortium, Shin, S.-Y., Fauman, E. B., Petersen, A.-K., Krumsiek, J., Santos, R., Huang, J., Arnold, M., Erte, I., Forgetta, V., et al. (2014) · Nature Genetics · doi:10.1038/ng.2982 · Cited by 1,515 · see citing works
Self-citationCommon variants at 30 loci contribute to polygenic dyslipidemia
Kathiresan, S., Willer, C. J., Peloso, G. M., Demissie, S., Musunuru, K., Schadt, E. E., Kaplan, L., Bennett, D., Li, Y., Tanaka, T., et al. (2009) · Nature Genetics · doi:10.1038/ng.291 · Cited by 1,364 · see citing works
Hwang, S., Ballantyne, C. M., Sharrett, A. R., Smith, L. C., DAVIS, C. E., Gotto, A. M., & Boerwinkle, E. (1997) · Circulation · doi:10.1161/01.cir.96.12.4219 · Cited by 1,340 · see citing works
Skol, A. D., Scott, L. J., Abecasis, G. R., & Boehnke, M. (2006) · Nature Genetics · doi:10.1038/ng1706 · Cited by 1,286 · see citing works
DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium, Mahajan, A., Asian Genetic Epidemiology Network Type 2 Diabetes (AGEN-T2D) Consortium, South Asian Type 2 Diabetes (SAT2D) Consortium, Mexican American Type 2 Diabetes (MAT2D) Consortium, Type 2 Diabetes Genetic Exploration by Next-generation sequencing in multi-Ethnic Samples (T2D-GENES) Consortium, Go, M. J., Zhang, W., Below, J. E., Gaulton, K. J., et al. (2014) · Nature Genetics · doi:10.1038/ng.2897 · Cited by 1,034 · see citing works
Multiple common variants for celiac disease influencing immune gene expression
Dubois, P. C. A., Trynka, G., Franke, L., Hunt, K. A., Romanos, J., Curtotti, A., Zhernakova, A., Heap, G., Ádány, R., Aromaa, A. J., et al. (2010) · Nature Genetics · doi:10.1038/ng.543 · Cited by 1,026 · see citing works
Wynn, T. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141142 · Cited by 962 · see citing works
Biological and clinical significance of haptoglobin polymorphism in humans
Langlois, M. R., & Delanghe, J. R. (1996) · Clinical Chemistry · doi:10.1093/clinchem/42.10.1589 · Cited by 942 · see citing works
Legler, D. F., Loetscher, M., Roos, R. S., Clark‐Lewis, I., Baggiolini, M., & Moser, B. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.4.655 · Cited by 838 · see citing works
A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1
Gunn, M. D., Ngo, V. N., Ansel, K. M., Ekland, E. H., Cyster, J. G., & Williams, L. T. (1998) · Nature · doi:10.1038/35876 · Cited by 825 · see citing works
Macrophage inflammatory protein-1
Maurer, M., & von Stebut, E. (2004) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2003.10.019 · Cited by 769 · see citing works
Genetics meets metabolomics: a genome-wide association study of metabolite profiles in human serum
Gieger, C., Geistlinger, L., Altmaier, E., Hrabé de Angelis, M., Kronenberg, F., Meitinger, T., Mewes, H.-W., Wichmann, H.-E., Weinberger, K. M., Adamski, J., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000282 · Cited by 737 · see citing works
Molecular Cloning and Functional Expression of a New Human CC-Chemokine Receptor Gene
Samson, M., Labbé, O., Mollereau, C., Vassart, G., & Parmentier, M. (1996) · Biochemistry · doi:10.1021/bi952950g · Cited by 686 · see citing works
Newly identified genetic risk variants for celiac disease related to the immune response
Hunt, K. A., Zhernakova, A., Turner, G., Heap, G., Franke, L., Bruinenberg, M., Romanos, J., Dinesen, L. C., Ryan, A. W., Panesar, D., et al. (2008) · Nature Genetics · doi:10.1038/ng.102 · Cited by 675 · see citing works
Hancock, D. B., Eijgelsheim, M., Wilk, J. B., Gharib, S. A., Loehr, L. R., Marciante, K. D., Franceschini, N., van Durme, Y. M. T. A., Chen, T.-H., Barr, R. G., et al. (2009) · Nature Genetics · doi:10.1038/ng.500 · Cited by 633 · see citing works
Systems genetics approaches to understand complex traits
Civelek, M., & Lusis, A. J. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3575 · Cited by 621 · see citing works
A genome-wide scan for common alleles affecting risk for autism
Anney, R., Klei, L., Pinto, D., Regan, R., Conroy, J., Magalhaes, T. R., Correia, C., Abrahams, B. S., Sykes, N., Pagnamenta, A. T., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq307 · Cited by 593 · see citing works
Genome-wide association study identifies five loci associated with lung function
Repapi, E., The NSHD Respiratory Study Team, Sayers, I., Wain, L. V., Burton, P. R., Johnson, T., Obeidat, M., Zhao, J. H., Ramasamy, A., Zhai, G., et al. (2009) · Nature Genetics · doi:10.1038/ng.501 · Cited by 581 · see citing works
Krumbholz, M., Theil, D. J., Cepok, S., Hemmer, B., Kivisäkk, P., Ransohoff, R. M., Hofbauer, M., Farina, C., Derfuss, T. J., Hartle, C., et al. (2005) · Brain · doi:10.1093/brain/awh680 · Cited by 561 · see citing works
Buckley, D., Fu, R. F., Freeman, M., Rogers, K. R., & Helfand, M. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-7-200910060-00009 · Cited by 557 · see citing works
Genome-wide association study identifies multiple loci influencing human serum metabolite levels
Kettunen, J., Tukiainen, T., Sarin, A.-P., Ortega-Alonso, A., Tikkanen, E., Lyytikäinen, L.-P., Kangas, A. J., Soininen, P., Würtz, P., Silander, K., et al. (2012) · Nature Genetics · doi:10.1038/ng.1073 · Cited by 553 · see citing works
The Australia and New Zealand Multiple Sclerosis Genetics Consortium (ANZgene) (2009) · Nature Genetics · doi:10.1038/ng.396 · Cited by 550 · see citing works
Dehghan, A., Dupuis, J., Barbalić, M., Bis, J. C., Eiríksdóttir, G., Lu, C., Pellikka, N., Wallaschofski, H., Kettunen, J., Henneman, P., et al. (2011) · Circulation · doi:10.1161/circulationaha.110.948570 · Cited by 512 · see citing works
Self-citationLeptin- and Leptin Receptor-Deficient Rodent Models: Relevance for Human Type 2 Diabetes
Wang, B., Chandrasekera, P. C., & Pippin, J. J. (2014) · Current Diabetes Reviews · doi:10.2174/1573399810666140508121012 · Cited by 511 · see citing works
A genome-wide association study identifies protein quantitative trait loci (pQTLs)
Melzer, D., Perry, J. R. B., Hernandez, D., Corsi, A.-M., Stevens, K., Rafferty, I., Lauretani, F., Murray, A., Gibbs, J. R., Paolisso, G., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000072 · Cited by 480 · see citing works
Saykin, A. J., Shen, L., Foroud, T. M., Potkin, S. G., Swaminathan, S., Kim, S., Risacher, S. L., Nho, K., Huentelman, M. J., Craig, D. W., et al. (2010) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2010.03.013 · Cited by 442 · see citing works
Self-citationDelayed Wound Healing in CXCR2 Knockout Mice
Devalaraja, R. M., Nanney, L. B., Qian, Q., Du, J., Yu, Y., Devalaraja, M. N., & Richmond, A. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00034.x · Cited by 429 · see citing works
Comuzzie, A. G., Cole, S. A., Laston, S., Voruganti, V. S., Haack, K., Gibbs, R. A., & Butte, N. F. (2012) · PLoS ONE · doi:10.1371/journal.pone.0051954 · Cited by 383 · see citing works
GWAS of Cerebrospinal Fluid Tau Levels Identifies Risk Variants for Alzheimer’s Disease
Cruchaga, C., Kauwe, J. S. K., Harari, O., Jin, S. C., Cai, Y., Karch, C. M., Benitez, B. A., Jeng, A. T., Skorupa, T., Carrell, D., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.02.026 · Cited by 383 · see citing works
Self-citationGenome‐wide meta‐analysis identifies novel multiple sclerosis susceptibility loci
Patsopoulos, N. A., the Bayer Pharma MS Genetics Working Group, T. S. C. O. S. E. I. A. A. C., & de Bakker, P. I. W. (2011) · Annals of Neurology · doi:10.1002/ana.22609 · Cited by 353 · see citing works
A list of candidate cancer biomarkers for targeted proteomics.
Polanski, M., & Anderson, N. L. (2007) · PubMed Central · Cited by 350 · see citing works
Chasman, D. I., Paré, G., Mora, S., Hopewell, J. C., Peloso, G., Clarke, R., Cupples, L. A., Hamsten, A., Kathiresan, S., Mälarstig, A., et al. (2009) · PLoS Genetics · doi:10.1371/journal.pgen.1000730 · Cited by 337 · see citing works
Macrophage inflammatory protein 1 modulates macrophage function
Fahey, T. J., Tracey, K. J., Tekamp-Olson, P., Cousens, L. S., Jones, W. G., Shires, G. T., Cerami, A., & Sherry, B. A. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.9.2764 · Cited by 320 · see citing works
Chemokines and receptors in HIV encephalitis
Sanders, V. J., Pittman, C. A., White, M. G., Wang, G., Wiley, C. A., & Achim, C. L. (1998) · AIDS · doi:10.1097/00002030-199809000-00009 · Cited by 319 · see citing works
Chalasani, N., Guo, X., Loomba, R. S., Goodarzi, M. O., Haritunians, T., Kwon, S., Cui, J., Taylor, K. D., Wilson, L., Cummings, O. W., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.07.057 · Cited by 315 · see citing works
Effect of predicted protein-truncating genetic variants on the human transcriptome
Rivas, M. A., Pirinen, M., Conrad, D. F., Lek, M., Tsang, E. K., Karczewski, K. J., Maller, J. B., Kukurba, K. R., DeLuca, D. S., Fromer, M., et al. (2015) · Science · doi:10.1126/science.1261877 · Cited by 313 · see citing works
Self-citationKim, Y. J., Go, M. J., Hu, C., Hong, C. B., Kim, Y. K., Lee, J. Y., Hwang, J., Oh, J. H., Kim, D. J., Kim, N. H., et al. (2011) · Nature Genetics · doi:10.1038/ng.939 · Cited by 293 · see citing works
Self-citationChanges in B- and T-Lymphocyte and Chemokine Levels With Rituximab Treatment in Multiple Sclerosis
Piccio, L. M., Naismith, R. T., Trinkaus, K. M., Klein, R. S., Parks, B. J., Lyons, J., & Cross, A. H. (2010) · Archives of Neurology · doi:10.1001/archneurol.2010.99 · Cited by 274 · see citing works
Self-citationIncreased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome
Ohga, E., Nagase, T., Tomita, T., Teramoto, S., Matsuse, T., Katayama, H., & Ouchi, Y. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.10 · Cited by 265 · see citing works
Asleh, R., Marsh, S., Shilkrut, M., Binah, O., Guetta, J., Lejbkowicz, F., Enav, B., Shehadeh, N., KANTER, Y., Lache, O., et al. (2003) · Circulation Research · doi:10.1161/01.res.0000076889.23082.f1 · Cited by 260 · see citing works
Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients
Saraheimo, M., Teppo, A.-M., Forsblom, C., Fagerudd, J., & Groop, P.-H. (2003) · Diabetologia · doi:10.1007/s00125-003-1194-5 · Cited by 255 · see citing works
Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease
Hu, W. T., Holtzman, D. M., Fagan, A. M., Shaw, L. M. J., Perrin, R. J., Arnold, S. E., Grossman, M., Xiong, C., Craig‐Schapiro, R., Clark, C. M., et al. (2012) · Neurology · doi:10.1212/wnl.0b013e318266fa70 · Cited by 234 · see citing works
Self-citationWasmeier, C., & Hutton, J. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.18161 · Cited by 225 · see citing works
Increased cerebrospinal fluid concentrations of the chemokine CXCL13 in active MS
Sellebjerg, F. T., Börnsen, L. S., Khademi, M., Krakauer, M., Olsson, T. P., Frederiksen, J. L., & Sørensen, P. S. (2009) · Neurology · doi:10.1212/wnl.0b013e3181c5b457 · Cited by 217 · see citing works
Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease
Cruchaga, C., Kauwe, J. S. K., Nowotny, P., Bales, K., Pickering, E. H., Mayo, K., Bertelsen, S., Hinrichs, A., Fagan, A. M., Holtzman, D. M., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds296 · Cited by 207 · see citing works
Self-citationLiu, C., Batliwalla, F., Li, W., Lee, A., Roubenoff, R., Beckman, E. M., Khalili, H., Damle, A., Kern, M., Furie, R. A., et al. (2008) · Molecular Medicine · doi:10.2119/2008-00056.liu · Cited by 207 · see citing works
Paterson, A. D., Lopes-Virella, M. F., Waggott, D. M., Boright, A. P., Hosseini, S. M., Carter, R. E., Enqing, S., Mirea, L., Bharaj, B., Sun, L., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.192971 · Cited by 206 · see citing works
Self-citationShi, J., & Kandror, K. V. (2005) · Developmental Cell · doi:10.1016/j.devcel.2005.04.004 · Cited by 202 · see citing works
Ramanan, V. K., Risacher, S. L., Nho, K. T., Kim, S., Swaminathan, S., Shen, L., Foroud, T., Hakonarson, H. H., Huentelman, M. J., Aisen, P. S. S., et al. (2013) · Molecular Psychiatry · doi:10.1038/mp.2013.19 · Cited by 202 · see citing works
Self-citationPapagianni, A. A., Alexopoulos, E., Giamalis, P., Gionanlis, L., Belechri, A., Koukoudis, P., & Memmos, D. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.3.435 · Cited by 194 · see citing works
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling
Vægter, C. B., Jansen, P., Fjorback, A. W., Glerup, S., Skeldal, S., Kjølby, M., Richner, M., Erdmann, B., Nyengaard, J. R., Tessarollo, L., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2689 · Cited by 192 · see citing works
Ullah, A. Z. M. D., Lemoine, N. R., & Chelala, C. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks364 · Cited by 185 · see citing works
Qi, L., Cornelis, M. C., Kraft, P. L., Jensen, M. K., van Dam, R. M., Sun, Q., Girman, C. J., Laurie, C. C., Mirel, D. B., Hunter, D. J., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq057 · Cited by 185 · see citing works
The tumorigenic and angiogenic effects of MGSA/GRO proteins in melanoma
Haghnegahdar, H., Du, J., Wang, D., Strieter, R. M., Burdick, M. D., Nanney, L. B., Cardwell, N. L., Luan, J. Y., Shattuck-Brandt, R. L., & Richmond, A. J. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.1.53 · Cited by 181 · see citing works
Genome-wide association study identifies three novel loci for type 2 diabetes
Hara, K., Fujita, H., Johnson, T. A., Yamauchi, T., Yasuda, K., Horikoshi, M., Chen, P., Hu, C., Ronald, C. W., Imamura, M., et al. (2013) · Human Molecular Genetics · doi:10.1093/hmg/ddt399 · Cited by 169 · see citing works
Variants in TF and HFE Explain ∼40% of Genetic Variation in Serum-Transferrin Levels
Benyamin, B., McRae, A. F., Zhu, G., Gordon, S. D., Henders, A. K., Palotie, A. V., Peltonen, L., Martin, N. G., Montgomery, G. W., Whitfield, J. B., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.11.011 · Cited by 169 · see citing works
Hancock, D. B., Artigas, M. S., Gharib, S. A., Henry, A. P., Manichaikul, A. W., Ramasamy, A., Loth, D. W., Imboden, M., Koch, B., McArdle, W. L., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003098 · Cited by 166 · see citing works
Self-citationInouye, M., Ripatti, S., Kettunen, J., Lyytikäinen, L., Oksala, N., Laurila, P., Kangas, A. J., Soininen, P., Savolainen, M. J., Viikari, J. S. A., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1002907 · Cited by 165 · see citing works
Regulation and function of the CXC chemokine ENA-78 in monocytes and its role in disease
Walz, A., Schmutz, P., Mueller, C., & Schnyder‐Candrian, S. (1997) · Journal of Leukocyte Biology · doi:10.1002/jlb.62.5.604 · Cited by 158 · see citing works
Jahanshad, N., Rajagopalan, P., Hua, X., Hibar, D. P., Nir, T. M., Toga, A. W., Jack, C. R., Saykin, A. J., Green, R. C., Weiner, M. W., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1216206110 · Cited by 152 · see citing works
Self-citationSpronk, P. E., Bootsma, H., Huitema, M. G., Limburg, P. C., & Kallenberg, C. G. M. (1994) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1994.tb06107.x · Cited by 151 · see citing works
Carrasquillo, M. M., Nicholson, A. M., Finch, N. A., Gibbs, J. R., Baker, M. C., Rutherford, N. J., Hunter, T. A., DeJesus‐Hernandez, M., Bisceglio, G. D., Mackenzie, I. R., et al. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.11.002 · Cited by 138 · see citing works
Self-citationLittler, A. J., Buckley, C. D., Wordsworth, P., Collins, I., Martinson, J. J., & Simmons, D. L. (1997) · Lara D. Veeken · doi:10.1093/rheumatology/36.2.164 · Cited by 133 · see citing works
Haptoglobin Phenotype and Vascular Complications in Patients with Diabetes
Levy, A. P., Roguin, A., Hochberg, I., Herer, P., Marsh, S., Nakhoul, F. M., & Skorecki, K. L. (2000) · New England Journal of Medicine · doi:10.1056/nejm200009283431313 · Cited by 131 · see citing works
Z’graggen, K., Walz, A., Mazzucchelli, L., Strieter, R. M., & Mueller, C. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70175-6 · Cited by 130 · see citing works
Reiner, A. P., Beleza, S. S., Franceschini, N., Auer, P. L., Robinson, J. G., Kooperberg, C. L., Peters, U., & Tang, H. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.07.023 · Cited by 127 · see citing works
Holliday, E. G., Smith, A. V., Cornes, B. K., Buitendijk, G. H. S., Jensen, R. A., Sim, X., Aspelund, T., Aung, T., Baird, P. N., Boerwinkle, E., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053830 · Cited by 126 · see citing works
Self-citationKauwe, J. S. K., Bailey, M. H., Ridge, P. G., Perry, R., Wadsworth, M. E., Hoyt, K. L., Staley, L. A., Karch, C. M., Harari, O., Cruchaga, C., et al. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004758 · Cited by 125 · see citing works
Self-citationChung, C.-M., Wang, R.-Y., Chen, J.-W., Fann, C. S. J., Leu, H.-B., Ho, H., Ting, C.-T., Lin, T.-H., Sheu, S. H., Tsai, W.-C., et al. (2010) · The Pharmacogenomics Journal · doi:10.1038/tpj.2009.70 · Cited by 124 · see citing works
Desch, K. C., Ozel, A. B., Siemieniak, D. R., Kalish, Y., Shavit, J. A., Thornburg, C. D., Sharathkumar, A. A., McHugh, C., Laurie, C. C., Crenshaw, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219885110 · Cited by 109 · see citing works
Schmidt, A. M., Crandall, J. P., Hori, O., Cao, R. Y., & Lakatta, E. G. (1996) · British Journal of Haematology · doi:10.1046/j.1365-2141.1996.379915.x · Cited by 105 · see citing works
Genetic Determinants Influencing Human Serum Metabolome among African Americans
Yu, B., Zheng, Y., Alexander, D. C., Morrison, A. C., Coresh, J., & Boerwinkle, E. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004212 · Cited by 102 · see citing works
Tang, W., Schwienbacher, C., Lopez, L. M., Ben‐Shlomo, Y., Oudot‐Mellakh, T., Johnson, A. D., Samani, N. J., Basu, S., Gögele, M., Davies, G., et al. (2012) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2012.05.009 · Cited by 102 · see citing works
Fox, E. R., Benjamin, E. J., Sarpong, D. F., Nagarajarao, H. S., Taylor, J. K., Steffes, M. W., Salahudeen, A. K., Flessner, M. F., Akylbekova, E. L., Fox, C. S., et al. (2010) · BMC Nephrology · doi:10.1186/1471-2369-11-1 · Cited by 100 · see citing works
Self-citationFisher, E., Stefan, N., Saar, K., Drogan, D., Schulze, M. B., Fritsche, A., Joost, H., Häring, H., Hübner, N., Boeing, H., et al. (2009) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.109.870410 · Cited by 97 · see citing works
Jakubowski, A., Rosa, M. D., Bixler, S. A., Lobb, R. R., & Burkly, L. C. (1995) · Cell Communication & Adhesion · doi:10.3109/15419069509081282 · Cited by 96 · see citing works
Qi, Q., Workalemahu, T., Zhang, C., Hu, F. B., & Qi, L. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr350 · Cited by 94 · see citing works
Ober, C., Nord, A. S., Thompson, E. E., Pan, L., Tan, Z., Cusanovich, D. A., Sun, Y., Nicolae, R. I., Edelstein, C., Schneider, D., et al. (2009) · Journal of Lipid Research · doi:10.1194/jlr.m800515-jlr200 · Cited by 93 · see citing works
Okada, Y., Takahashi, A., Ohmiya, H., Kumasaka, N., Kamatani, Y., Hosono, N., Tsunoda, T., Matsuda, K., Tanaka, T., Kubo, M., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq551 · Cited by 93 · see citing works
Yang, Q., Kathiresan, S., Lin, J., Tofler, G. H., & O’Donnell, C. J. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s12 · Cited by 91 · see citing works
20 YEARS OF LEPTIN: Leptin in common obesity and associated disorders of metabolism
DePaoli, A. M. (2014) · Journal of Endocrinology · doi:10.1530/joe-14-0258 · Cited by 86 · see citing works
Petrovski, S., Fellay, J., Shianna, K. V., Carpenetti, N., Kumwenda, J., Kamanga, G., Kamwendo, D., Letvin, N. L., McMichael, A. J., Haynes, B. F., et al. (2010) · AIDS · doi:10.1097/qad.0b013e328343817b · Cited by 85 · see citing works
Hwang, S.-J., Yang, Q., Meigs, J., Pearce, E., & Fox, C. (2007) · BMC Medical Genetics · doi:10.1186/1471-2350-8-s1-s10 · Cited by 84 · see citing works
Identification of cis-regulatory variation influencing protein abundance levels in human plasma
Lourdusamy, A., Newhouse, S., Lunnon, K., Proitsi, P., Powell, J. F., Hodges, A., Nelson, S. K., Stewart, A., Williams, S. A., Kłoszewska, I., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds186 · Cited by 84 · see citing works
Curtis, D., Vine, A. E., McQuillin, A., Bass, N. J., Pereira, A. C., Kandaswamy, R., Lawrence, J., Anjorin, A., Choudhury, K., Datta, S. R., et al. (2010) · Psychiatric Genetics · doi:10.1097/ypg.0b013e3283413382 · Cited by 83 · see citing works
Slavin, T. P., Feng, T., Schnell, A., Zhu, X., & Elston, R. C. (2011) · Human Genetics · doi:10.1007/s00439-011-1009-6 · Cited by 82 · see citing works
Harari, O., Cruchaga, C., Kauwe, J. S. K., Ainscough, B. J., Bales, K., Pickering, E. H., Bertelsen, S., Fagan, A. M., Holtzman, D. M., Morris, J. C., et al. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.11.032 · Cited by 82 · see citing works
Self-citationAlzheimer’s disease risk variants show association with cerebrospinal fluid amyloid beta
Kauwe, J. S. K., Wang, J., Mayo, K., Morris, J. C., Fagan, A. M., Holtzman, D. M., & Goate, A. M. (2009) · neurogenetics · doi:10.1007/s10048-008-0150-4 · Cited by 82 · see citing works
Self-citationHe, M., Wu, C. H., Xu, J., Guo, H., Yang, H., Zhang, X., Sun, J., Yu, D., Zhou, L., Peng, T., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-303434 · Cited by 82 · see citing works
Self-citationHe, J., Kelly, T. N., Zhao, Q., Li, H., Huang, J., Wang, L., Jaquish, C. E., Sung, Y. J., Shimmin, L. C., Lu, F., et al. (2013) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000307 · Cited by 79 · see citing works
Monach, P. A. (2013) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000009 · Cited by 76 · see citing works
Makita, S., Nakamura, M., Satoh, K., Tanaka, F., Onoda, T., Kawamura, K., Ohsawa, M., Tanno, K., Itai, K., Sakata, K., et al. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.07.040 · Cited by 76 · see citing works
Hart, A. B., Engelhardt, B. E., Wardle, M. C., Sokoloff, G., Stephens, M., de Wit, H., & Palmer, A. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042646 · Cited by 75 · see citing works
Kauwe, J. S. K., Cruchaga, C., Karch, C. M. M., Sadler, B. E., Lee, M., Mayo, K., Latu, W., Su'a, M., Fagan, A. M., Holtzman, D. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015918 · Cited by 72 · see citing works
Self-citationSansonno, D. E., Tucci, F. A., Troiani, L., Lauletta, G., Montrone, M., Conteduca, V., Sansonno, L., & Dammacco, F. (2008) · Blood · doi:10.1182/blood-2008-02-137455 · Cited by 71 · see citing works
Genetic variants associated with disordered eating
Wade, T. D., Gordon, S. D., Medland, S. E., Bulik, C. M., Heath, A. C., Montgomery, G. W., & Martin, N. G. (2013) · International Journal of Eating Disorders · doi:10.1002/eat.22133 · Cited by 71 · see citing works
Soluble Adhesion Molecules and the Search for Biomarkers for Atherosclerosis
Ballantyne, C. M., & Entman, M. L. (2002) · Circulation · doi:10.1161/01.cir.0000028397.68936.12 · Cited by 71 · see citing works
Elevated Serum Transferrin Saturation and Mortality
Mainous, A. G. (2004) · The Annals of Family Medicine · doi:10.1370/afm.25 · Cited by 69 · see citing works
Kang, P., Tian, C., & Jia, C. (2012) · Gene · doi:10.1016/j.gene.2012.03.056 · Cited by 66 · see citing works
Elevated MMP‐7 levels in patients with systemic sclerosis: correlation with pulmonary involvement
Moinzadeh, P., Krieg, T. M., Hellmich, M., Brinckmann, J., Neumann, E., Müller‐Ladner, U., Kreuter, A., Dumitrescu, D., Rosenkranz, S., & Hunzelmann, N. (2011) · Experimental Dermatology · doi:10.1111/j.1600-0625.2011.01321.x · Cited by 62 · see citing works
Thun, G. A., Imboden, M., Ferrarotti, I., Kumar, A., Obeidat, M., Zorzetto, M., Haun, M., Curjuric, I., Alves, A. C., Jackson, V. E., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003585 · Cited by 62 · see citing works
Kwon, H., Laurent, S., Tang, Y., Zong, H., Vemulapalli, P., & Pessin, J. E. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.068 · Cited by 61 · see citing works
Holme, I., AASTVEIT, A. H., Hammar, N., Jungner, I., & Walldius, G. (2009) · Annals of Medicine · doi:10.1080/07853890903089453 · Cited by 60 · see citing works
Prospective study of MMP7 serum levels in the diagnosis of cholangiocarcinoma
Leelawat, K. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i37.4697 · Cited by 59 · see citing works
Influence of Genetic Variation on Plasma Protein Levels in Older Adults Using a Multi-Analyte Panel
Kim, S., Swaminathan, S., Inlow, M. H., Risacher, S. L., Nho, K. T., Shen, L., Foroud, T., Petersen, R. C., Aisen, P. S. S., Soares, H. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0070269 · Cited by 53 · see citing works
Self-citationMeng, W., Butterworth, J. A., Bradley, D., Hughes, A. E., Soler, V. J., Calvas, P., & Malecaze, F. (2012) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.12-10409 · Cited by 53 · see citing works
Low, S., Chung, S., Takahashi, A., Zembutsu, H., Mushiroda, T., Kubo, M., & Nakamura, Y. (2013) · Cancer Science · doi:10.1111/cas.12186 · Cited by 49 · see citing works
Collaborators, A., van Dongen, J., Jansen, R., Smit, D. J. A., Hottenga, J., Mbarek, H., Willemsen, G. A. H. M., Kluft, C., Penninx, B. W. J. H., Ferreira, M. A. R., et al. (2014) · Behavior Genetics · doi:10.1007/s10519-014-9656-8 · Cited by 47 · see citing works
Dorajoo, R., Li, R., Ikram, M. K., Liu, J., Froguel, P., Lee, J., Sim, X., Ong, R. T., Tay, W. T., Chen, P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067650 · Cited by 47 · see citing works
Self-citationInterleukin 13 and inflammatory markers in human sepsis
Collighan, N., Giannoudis, P. V., Kourgeraki, O., Perry, S., Guillou, P. J., & Bellamy, M. C. (2004) · British journal of surgery · doi:10.1002/bjs.4521 · Cited by 44 · see citing works
Kauwe, J. S. K., Cruchaga, C., Bertelsen, S. E., Mayo, K., Latu, W., Nowotny, P., Hinrichs, A. L., Fagan, A. M., Holtzman, D. M., Initiative, A. D. N., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-091711 · Cited by 43 · see citing works
Self-citationJabaudon, M., Hamroun, N., Roszyk, L., Guérin, R., Bazin, J.-É., Sapin, V., Pereira, B., & Constantin, J. (2015) · Intensive Care Medicine · doi:10.1007/s00134-015-3726-0 · Cited by 42 · see citing works
Froguel, P., Ndiaye, N. C., Bonnefond, A., Bouatia‐Naji, N., Dechaume, A., Siest, G., Herbeth, B., Falchi, M., Bottolo, L., Guéant‐Rodriguez, R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032327 · Cited by 42 · see citing works
Njajou, O. T., Alizadeh, B. Z., Aulchenko, Y. S., Zillikens, M. C., Pols, H. A. P., Oostra, B. A., Swinkels, D. W., & van Duijn, C. M. (2006) · Human Heredity · doi:10.1159/000094777 · Cited by 42 · see citing works
Haptoglobin Polymorphism and Infection
Kasvosve, I., Speeckaert, M. M., Speeckaert, R., Masukume, G., & Delanghe, J. (2010) · Advances in clinical chemistry · doi:10.1016/s0065-2423(10)50002-7 · Cited by 40 · see citing works
Seppälä, I., Kleber, M. E., Lyytikäinen, L., Hernesniemi, J. A., Mäkelä, K.-M., Oksala, N., Laaksonen, R., Pilz, S., Tomaschitz, A., Silbernagel, G., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht447 · Cited by 40 · see citing works
Duell, E. J., Bonet, C., Muñoz, X., Luján‐Barroso, L., Weiderpass, E., Boutron‐Ruault, M., Racine, A., Severi, G., Canzian, F., Rizzato, C., et al. (2014) · International Journal of Cancer · doi:10.1002/ijc.29034 · Cited by 39 · see citing works
Kocarnik, J., Pendergrass, S. A., Carty, C. L., Pankow, J. S., Schumacher, F. R., Cheng, I. C., Durda, P., Ambite, J. L., Deelman, E., Cook, N. R., et al. (2014) · Circulation Cardiovascular Genetics · doi:10.1161/circgenetics.113.000173 · Cited by 38 · see citing works
Garge, N., Pan, H., Rowland, M. D., Cargile, B. J., Zhang, X., Cooley, P. C., Page, G. P., & Bunger, M. K. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900378-mcp200 · Cited by 36 · see citing works
Prognostic and predictive potential molecular biomarkers in colon cancer.
Năstase, A., Pâslaru, L., Niculescu, A. M., Ionescu, M., Dumitraşcu, T., Herlea, V., Dima, S., Gheorghe, C., Lazar, V., & Popescu, I. (2011) · PubMed · Cited by 36 · see citing works
Genetic Loci Associated With C-Reactive Protein Levels and Risk of Coronary Heart Disease
Elliott, P. (2009) · JAMA · doi:10.1001/jama.2009.954 · Cited by 35 · see citing works
Morillo-Bernal, J., Fernández-Santos, J. M., Utrilla, J. C., de Miguel, M., García‐Marín, R., & Martín‐Lacave, I. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2009.01095.x · Cited by 35 · see citing works
[Decrease of haptoglobin serum level in patients with chronic viral hepatitis C].
Bacq, Y., Schillio, Y., Bréchot, J.-F., Muret, A. D., Dubois, F., & Metman, E. H. (1993) · PubMed · Cited by 33 · see citing works
Surakka, I. L., Whitfield, J. B., Perola, M., Visscher, P. M., Montgomery, G. W., Falchi, M., Willemsen, G. A. H. M., de Geus, E. J. C., Magnusson, P. K. E., Christensen, K., et al. (2012) · Twin Research and Human Genetics · doi:10.1017/thg.2012.63 · Cited by 30 · see citing works
Genome-Wide Association Study of Antiphospholipid Antibodies
Kamboh, M. I., Wang, X., Kao, A. H., Barmada, M. M., Clarke, A. E., Ramsey‐Goldman, R., Manzi, S., & Demirci, F. Y. (2013) · Autoimmune Diseases · doi:10.1155/2013/761046 · Cited by 29 · see citing works
Genome‐wide association study of atypical psychosis
Kanazawa, T., Ikeda, M., Glatt, S. J., Tsutsumi, A., Kikuyama, H., Kawamura, Y., Nishida, N., Miyagawa, T., Hashimoto, R., Takeda, M., et al. (2013) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.32164 · Cited by 29 · see citing works
Should C-Reactive Protein Be a Target of Therapy?
Oh, J., Teoh, H., & Leiter, L. A. (2011) · Diabetes Care · doi:10.2337/dc11-s211 · Cited by 29 · see citing works
Leptin and cardiometabolic risk factors in obese children and adolescents
Gonzaga, N. C., Medeiros, C. C. M., de Carvalho, D. F., & Alves, J. G. (2014) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.12610 · Cited by 28 · see citing works
Socha, L. A., Gowardman, J. R., Silva, D. A. S., Correcha, M., & Petrosky, N. (2006) · Intensive Care Medicine · doi:10.1007/s00134-005-0020-6 · Cited by 23 · see citing works
Kimura, M., Hattori, T., Matsuda, Y., Yoshioka, T., Sumi, N., Umeda, Y., Nakashima, S., & Okano, Y. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134639 · Cited by 22 · see citing works
Yu, L., Tang, W., Huang, T., Gao, Y., Tan, A., Yang, X., Zhang, H., Hu, Y., Qin, X. Y., Li, S., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097923 · Cited by 21 · see citing works
Voruganti, V. S., Laston, S., Haack, K., Mehta, N. R., Smith, C. W., Cole, S. A., Butte, N. F., & Comuzzie, A. G. (2012) · Cytokine · doi:10.1016/j.cyto.2012.08.029 · Cited by 21 · see citing works
Self-citationÅkerblom, A., Eriksson, N., Wallentin, L. C., Siegbahn, A. G., Barratt, B. J., Becker, R. C., Budaj, A., Himmelmänn, A., Husted, S., Storey, R. F., et al. (2014) · American Heart Journal · doi:10.1016/j.ahj.2014.03.010 · Cited by 20 · see citing works
Calcitonin gene methylation in chronic myeloproliferative disorders.
Ihalainen, J., Juvonen, E., Savolainen, E. R., Ruutu, T., & Palotie, A. V. (1994) · PubMed · Cited by 19 · see citing works
Genetic Association Analysis of Complex Diseases Incorporating Intermediate Phenotype Information
Li, Y., Huang, J., & Amos, C. I. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046612 · Cited by 18 · see citing works
Athanasiadis, G. I., Sabater‐Lleal, M., Buil, A., Souto, J. C., Borrell, M., Lathrop, M. G., Watkins, H. C., Almasy, L. A., Hamsten, A., & Soria, J. M. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12120 · Cited by 18 · see citing works
Ryndel, M., Behre, C. J., Brohall, G., Prahl, U., Schmidt, C. B., Bergström, G. M. L., Fagerberg, B., & Olson, F. J. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.12.025 · Cited by 16 · see citing works
Immunohistochemical expression of MMP-7 protein and its serum level in colorectal cancer
Pryczynicz, A., Gryko, M., Niewiarowska, K., Dymicka-Piekarska, V., Ustymowicz, M., Hawryluk, M., Cepowicz, D., Borsuk, A., Kemonä, A., FAMULSKI, W., et al. (2013) · Folia Histochemica et Cytobiologica · doi:10.5603/fhc.2013.0029 · Cited by 16 · see citing works
Sürücü, B., & Koç, E. (2008) · Clinical and Experimental Dermatology · doi:10.1111/j.1365-2230.2007.02629.x · Cited by 14 · see citing works
Yoshida, T., Kato, K., Yokoi, K., Oguri, M., Watanabe, S., Metoki, N., Yoshida, H., Satoh, K., Aoyagi, Y., Nozawa, Y., et al. (2009) · Experimental and Therapeutic Medicine · doi:10.3892/etm_00000023 · Cited by 11 · see citing works
Zhou, L.-F., Li, J., Li, Z.-H., & Kang, J. (2010) · PubMed · Cited by 8 · see citing works
Hypohaptoglobinaemia as a biochemical and epidemiological marker of falciparum malaria.
Mohapatra, M. K., Mohanty, S., Bk, M., & Gn, S. (1999) · PubMed · Cited by 7 · see citing works
Eĭsaev, B. A. (1995) · PubMed · Cited by 6 · see citing works
Role of IL-13 in the pathogenesis of bronchial asthma.
Shehata, I. H., Mostafa, M. M., Ziada, K. W., & Saeed, A. M. (2007) · PubMed · Cited by 4 · see citing works
Immunoreactive Calcitonin: A Tumor Marker for Myelogenous Leukemias
Foa, P., Ortolani, S., Pogliani, E., Iurlo, A., Gualdonj, A., Maiolo, A. T., & Polli, E. E. (1990) · The International Journal of Biological Markers · doi:10.1177/172460089000500105 · Cited by 3 · see citing works
[Association of leptin with obesity and hypertension in an ethnic Kyrgyz group].
Kerimkulova, A. S., Lunegova, O. S., Mirrakhimov, E. M., Alibaeva, N., Neronova, K., Bairamukova, A., & Mirrakhimov, E. M. (2014) · PubMed · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The MR-Base platform supports systematic causal inference across the human phenome
Hemani, G., Zheng, J., Elsworth, B., Wade, K. H., Haberland, V., Baird, D., Laurin, C., Burgess, S., Bowden, J., Langdon, R., et al. (2018) · eLife · doi:10.7554/elife.34408 · Cited by 7,959 · see citing works
Genomic atlas of the human plasma proteome
Sun, B. B., Maranville, J. C., Peters, J. E., Stacey, D., Staley, J. R., Blackshaw, J., Burgess, S., Jiang, T., Paige, E., Surendran, P., et al. (2018) · Nature · doi:10.1038/s41586-018-0175-2 · Cited by 2,268 · see citing works
Self-citationGenetics meets proteomics: perspectives for large population-based studies
Suhre, K., McCarthy, M. I., & Schwenk, J. M. (2021) · Nature Reviews Genetics · doi:10.1038/s41576-020-0268-2 · Cited by 478 · see citing works
Yang, C., Farias, F. H. G., Ibanez, L., Suhy, A., Sadler, B., Fernandez, M. V., Wang, F., Bradley, J. L., Eiffert, B., Bahena, J. A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00886-6 · Cited by 290 · see citing works
Self-citationThe <i>MS4A</i> gene cluster is a key modulator of soluble TREM2 and Alzheimer’s disease risk
Deming, Y., Filipello, F., Cignarella, F., Cantoni, C., Hsu, S., Mikesell, R., Li, Z., Del-Aguila, J. L., Dube, U., Farias, F. G., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aau2291 · Cited by 271 · see citing works
Self-citation(ADNI), A. D. N. I., Deming, Y., The Alzheimer Disease Genetic Consortium (ADGC), Li, Z., Kapoor, M., Harari, O., Del-Aguila, J. L., Black, K., Carrell, D., Cai, Y., et al. (2017) · Acta Neuropathologica · doi:10.1007/s00401-017-1685-y · Cited by 231 · see citing works
Self-citationHemani, G., Zheng, J., Wade, K. H., Laurin, C., Elsworth, B., Burgess, S., Bowden, J., Langdon, R., Tan, V. Y., Yarmolinsky, J., et al. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/078972 · Cited by 133 · see citing works
Li, Z., Farias, F. H. G., Dube, U., Del-Aguila, J. L., Mihindukulasuriya, K. A., Fernandez, M. V., Ibanez, L., Budde, J. P., Wang, F., Lake, A. M., et al. (2020) · Acta Neuropathologica · doi:10.1007/s00401-019-02066-0 · Cited by 85 · see citing works
Self-citationBurgess, S. (2018) · Apollo (University of Cambridge) · doi:10.17863/cam.26250 · Cited by 118 · see citing works
Liang, X., Yee, S. W., Chien, H., Chen, E. C., Luo, Q., Zou, L., Piao, M., Mifune, A., Chen, L., Calvert, M., et al. (2018) · PLoS Biology · doi:10.1371/journal.pbio.2002907 · Cited by 63 · see citing works
Hillary, R. F., Baños, D. T., Kousathanas, A., McCartney, D. L., Harris, S. E., Stevenson, A. J., Patxot, M., Ojavee, S. E., Zhang, Q., Liewald, D. C. M., et al. (2020) · Genome Medicine · doi:10.1186/s13073-020-00754-1 · Cited by 61 · see citing works
Assessment of the Genetic Architecture of Alzheimer’s Disease Risk in Rate of Memory Decline
Del-Aguila, J. L., Fernández, M. V., Schindler, S., Ibanez, L., Deming, Y., Ma, S., Saef, B., Black, K., Budde, J., Norton, J., et al. (2018) · Journal of Alzheimer’s Disease · doi:10.3233/jad-170834 · Cited by 60 · see citing works
Self-citationHaddick, P. C. G., Alzheimer’s Disease Genetic Consortium (ADGC), A. D. N. I. (., Larson, J. L., Rathore, N., Bhangale, T. R., Phung, Q. T., Srinivasan, K., Hansen, D. V., Lill, J. R., Pericak-Vance, M. A., et al. (2017) · Journal of Alzheimer's Disease · doi:10.3233/jad-160524 · Cited by 55 · see citing works
Self-citationSun, Q., Graff, M., Rowland, B., Wen, J., Huang, L., Miller‐Fleming, T. W., Haessler, J., Preuss, M. H., Chai, J. F., Lee, M. P., et al. (2021) · Journal of Human Genetics · doi:10.1038/s10038-021-00968-0 · Cited by 53 · see citing works
Timsina, J., Ali, M., Do, A. N., Wang, L., Western, D., Sung, Y. J., & Cruchaga, C. (2023) · Neurobiology of Disease · doi:10.1016/j.nbd.2023.106373 · Cited by 47 · see citing works
Self-citationSortilin as a Biomarker for Cardiovascular Disease Revisited
Møller, P. L., Rohde, P. D., Winther, S., Breining, P., Nissen, L., Nykjær, A., Bøttcher, M., Nyegaard, M., & Kjølby, M. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.652584 · Cited by 39 · see citing works
Caron, B., Patin, É., Rotival, M., Charbit, B., Albert, M. L., Quintana‐Murci, L., Duffy, D., Rausell, A., Abel, L., Alcover, A., et al. (2022) · Genome Medicine · doi:10.1186/s13073-022-01032-y · Cited by 39 · see citing works
Self-citationLee, J., Fernández‐Cadenas, I., & Lindgren, A. G. (2021) · Stroke · doi:10.1161/strokeaha.121.032622 · Cited by 39 · see citing works
Self-citationParrillo, V., Pereira, A. D. L. S., Riedel, T., & Rodriguez‐Emmenegger, C. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.03.007 · Cited by 38 · see citing works
Dimou, N. L., & Tsilidis, K. K. (2018) · Methods in molecular biology · doi:10.1007/978-1-4939-7868-7_13 · Cited by 32 · see citing works
Yang, C., Farias, F. G., Ibáñez, L., Sadler, B. E., Fernández, M. V., Wang, F., Bradley, J. L., Eiffert, B., Bahena, J. A., Budde, J., et al. (2020) · medRxiv · doi:10.1101/2020.06.25.20140277 · Cited by 29 · see citing works
Self-citationCausal association of plasma circulating metabolites with nephritis: a Mendelian randomization study
Shao, F., Yao, Y., Weng, D., Wang, R., Liu, R., Zhang, Y., Li, E., Wang, M., Tang, Y., Ding, Y., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1364841 · Cited by 17 · see citing works
Kim, S., Kim, K., Nho, K. T., Myung, W., & Won, H. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-200671 · Cited by 7 · see citing works
Self-citationPolymerase Chain Reaction Chips for Biomarker Discovery and Validation in Drug Development
Vo, D.-K., & Trinh, K. T. L. (2025) · Micromachines · doi:10.3390/mi16030243 · Cited by 5 · see citing works
CXCL13 polymorphism is associated with essential hypertension in Tatars from Russia
Timasheva, Y., Насибуллин, Т. Р., Tuktarova, I. A., Эрдман, В. В., & Mustafina, O. E. (2018) · Molecular Biology Reports · doi:10.1007/s11033-018-4257-x · Cited by 5 · see citing works
Farias, F., Benítez, B. A., & Cruchaga, C. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105247 · Cited by 4 · see citing works
Self-citationZhang, H., Xie, Y., Wei, G., Liu, J., Shang, W., Pan, M., Zou, Y., Yan, L., Zhou, T., Chi, J., et al. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.12.045 · Cited by 3 · see citing works
Huang, B., Tian, Y., & Li, . (2025) · Hepatobiliary & pancreatic diseases international · doi:10.1016/j.hbpd.2025.11.005 · Cited by 1 · see citing works
- Authors
- Deming, Y., Xia, J., Cai, Y., Lord, J., Del-Aguila, J. L., Fernandez, M. V., Carrell, D., Black, K., Budde, J., Ma, S., Saef, B., Howells, B., Bertelsen, S., Bailey, M., Ridge, P. G., (ADNI), A. D. N. I., Hefti, F., Fillit, H., Zimmerman, E. A., Celmins, D., Brown, A. D., Carrillo, M., Fleisher, A., Reeder, S., Trncic, N., Burke, A., Tariot, P., Reiman, E. M., Chen, K., Sabbagh, M. N., Beiden, C. M., Jacobson, S. A., Sirrel, S. A., Doody, R. S., Villanueva-Meyer, J., Chowdhury, M., Rountree, S., Dang, M., Kowall, N., Killiany, R., Budson, A. E., Norbash, A., Johnson, P. L., Green, R. C., Marshall, G., Johnson, K. A., Sperling, R. A., Snyder, P., Salloway, S., Malloy, P., Correia, S., Bernick, C., Munic, D., Stern, Y., Honig, L. S., Bell, K. L., Relkin, N., Chaing, G., Ravdin, L., Paul, S., Flashman, L. A., Seltzer, M., Hynes, M. L., Santulli, R. B., Bates, V., Capote, H., Rainka, M., Friedl, K., Murali Doraiswamy, P., Petrella, J. R., Borges-Neto, S., James, O., Wong, T., Coleman, E., Schwartz, A., Cellar, J. S., Levey, A. L., Lah, J. J., Behan, K., Scott Turner, R., Johnson, K., Reynolds, B., Pearlson, G. D., Blank, K., Anderson, K., Obisesan, T. O., Wolday, S., Allard, J., Lerner, A., Ogrocki, P., Tatsuoka, C., Fatica, P., Farlow, M. R., Saykin, A. J., Foroud, T. M., Shen, L., Faber, K., Kim, S., Nho, K., Marie Hake, A., Matthews, B. R., Brosch, J. R., Herring, S., Hunt, C., Albert, M., Onyike, C., D’Agostino, D., Kielb, S., Graff-Radford, N. R., Parfitt, F., Kendall, T., Johnson, H., Petersen, R., Jack, C. R., Bernstein, M., Borowski, B., Gunter, J., Senjem, M., Vemuri, P., Jones, D., Kantarci, K., Ward, C., Mason, S. S., Albers, C. S., Knopman, D., Johnson, K., Chertkow, H., Hosein, C., Mintzer, J., Spicer, K., Bachman, D., Grossman, H., Mitsis, E., Pomara, N., Hernando, R., Sarrael, A., Potter, W., Buckholtz, N., Hsiao, J., Kittur, S., Galvin, J. E., Cerbone, B., Michel, C. A., Pogorelec, D. M., Rusinek, H., de Leon, M. J., Glodzik, L., De Santi, S., Johnson, N., Chuang-Kuo, Kerwin, D., Bonakdarpour, B., Weintraub, S., Grafman, J., Lipowski, K., Mesulam, M.-M., Scharre, D. W., Kataki, M., Adeli, A., Kaye, J., Quinn, J., Silbert, L., Lind, B., Carter, R., Dolen, S., Borrie, M., Lee, T.-Y., Bartha, R., Martinez, W., Villena, T., Sadowsky, C., Khachaturian, Z., Ott, B. R., Querfurth, H., Tremont, G., Frank, R., Fleischman, D., Arfanakis, K., Shah, R. C., deToledo-Morrell, L., Sorensen, G., Finger, E., Pasternack, S., Rachinsky, I., Drost, D., Rogers, J., Kertesz, A., Furst, A. J., Chad, S., Yesavage, J., Taylor, J. L., Lane, B., Rosen, A., Tinklenberg, J., Black, S., Stefanovic, B., Caldwell, C., Robin Hsiung, G.-Y., Mudge, B., Assaly, M., Fox, N., Schultz, S. K., Boles Ponto, L. L., Shim, H., Ekstam Smith, K., Burns, J. M., Swerdlow, R. H., Brooks, W. M., Marson, D., Griffith, R., Clark, D., Geldmacher, D., Brockington, J., Roberson, E., Natelson Love, M., DeCarli, C., Carmichael, O., Olichney, J., Maillard, P., Fletcher, E., Nguyen, D., Preda, A., Potkin, S., Mulnard, R. A., Thai, G., McAdams-Ortiz, C., Landau, S., Jagust, W., Apostolova, L., Tingus, K., Woo, E., Silverman, D. H. S., Lu, P. H., Bartzokis, G., Thompson, P., Donohue, M., Thomas, R. G., Walter, S., Gessert, D., Brewer, J., Vanderswag, H., Sather, T., Jiminez, G., Balasubramanian, A. B., Mason, J., Sim, I., Aisen, P., Davis, M., Morrison, R., Harvey, D., Thal, L., Beckett, L., Neylan, T., Finley, S., Weiner, M. W., Hayes, J., Rosen, H. J., Miller, B. L., Perry, D., Massoglia, D., Brawman-Mentzer, O., Schuff, N., Smith, C. D., Hardy, P., Sinha, P., Oates, E., Conrad, G., Koeppe, R. A., Lord, J. L., Heidebrink, J. L., Arnold, S. E., Karlawish, J. H., Wolk, D., Clark, C. M., Trojanowki, J. Q., Shaw, L. M., Lee, V., Korecka, M., Figurski, M., Toga, A. W., Crawford, K., Neu, S., Schneider, L. S., Pawluczyk, S., Beccera, M., Teodoro, L., Spann, B. M., Womack, K., Mathews, D., Quiceno, M., Foster, N., Montine, T., Fruehling, J. J., Harding, S., Johnson, S., Asthana, S., Carlsson, C. M., Petrie, E. C., Peskind, E., Li, G., Porsteinsson, A. P., Goldstein, B. S., Martin, K., Makino, K. M., Ismail, M. S., Brand, C., Smith, A., Ashok Raj, B., Fargher, K., Kuller, L., Mathis, C., Ann Oakley, M., Lopez, O. L., Simpson, D. M., Sink, K. M., Gordineer, L., Williamson, J. D., Garg, P., Watkins, F., Cairns, N. J., Raichle, M., Morris, J. C., Householder, E., Taylor-Reinwald, L., Holtzman, D., Ances, B., Carroll, M., Creech, M. L., Franklin, E., Mintun, M. A., Schneider, S., Oliver, A., Duara, R., Varon, D., Greig, M. T., Roberts, P., Varma, P., MacAvoy, M. G., Carson, R. E., van Dyck, C. H., Davies, P., Holtzman, D., Morris, J. C., Bales, K., Pickering, E. H., Lee, J.-M., Heitsch, L., Kauwe, J., Goate, A., Piccio, L., & Cruchaga, C.
- Affiliations
- Washington University in St. Louis (US)
- Central South University (CN)
- Brigham Young University (US)
- Alzheimer's Drug Discovery Foundation (US)
- Albany Medical College (US)
- Alzheimer's Association (US)
- Banner Alzheimer’s Institute (US)
- Banner Sun Health Research Institute (US)
- Baylor College of Medicine (US)
- Boston University (US)
- Brigham and Women's Hospital (US)
- Brown University (US)
- Butler Hospital (US)
- Cleveland Clinic (US)
- Columbia University Irving Medical Center (US)
- Cornell University (US)
- Dartmouth–Hitchcock Medical Center (US)
- Dent Neurologic Institute (US)
- United States Department of Defense (US)
- Duke Medical Center (US)
- Eli Lilly (United States) (US)
- Emory University (US)
- Georgetown University Medical Center (US)
- Hartford Hospital (US)
- Howard University (US)
- Indiana University (US)
- Johns Hopkins University (US)
- Mayo Clinic in Florida (US)
- Mayo Clinic (US)
- McGill University (CA)
- Medical University of South Carolina (US)
- Icahn School of Medicine at Mount Sinai (US)
- Nathan Kline Institute for Psychiatric Research (US)
- National Institute on Aging (US)
- New York University (US)
- Northwestern University (US)
- The Ohio State University (US)
- Oregon Health & Science University (US)
- Premiere Research Institute (US)
- Rhode Island Hospital (US)
- Rush University Medical Center (US)
- Siemens (Germany) (DE)
- St Joseph's Health Care (CA)
- Stanford University (US)
- Sunnybrook Health Science Centre (CA)
- University College London (GB)
- University of Iowa (US)
- University of Kansas Medical Center (US)
- University of Alabama at Birmingham (US)
- University of California, Davis (US)
- University of California, Irvine (US)
- University of California, Berkeley (US)
- University of California, Los Angeles (US)
- University of California San Diego (US)
- University of California, San Francisco (US)
- University of Kentucky (US)
- University of Michigan (US)
- University of Pennsylvania (US)
- University of Southern California (US)
- The University of Texas Southwestern Medical Center (US)
- University of Utah (US)
- University of Washington (US)
- University of Rochester Medicine (US)
- University of South Florida (US)
- University of Pittsburgh (US)
- Wake Forest University (US)
- Yale University (US)
- Yeshiva University (US)
- Pfizer (United States) (US)
- Corresponding author
- Cruchaga, Carlos
- ORCID
- Deming, Yuetiva
- Xia, Jian
- Lord, Jenny
- Carrell, David
- Budde, John
- Bertelsen, Sarah
- Bailey, Matthew
- Ridge, Perry G.
- Hefti, Franz
- Fillit, Howard
- Fleisher, Adam
- Burke, Anna
- Tariot, Pierre
- Reiman, Eric M.
- Chen, Kewei
- Sabbagh, Marwan N.
- Jacobson, Sandra A.
- Kowall, Neil
- Killiany, Ronald
- Budson, Andrew E.
- Norbash, Alexander
- Green, Robert C.
- Marshall, Gad
- Johnson, Keith A.
- Sperling, Reisa A.
- Snyder, Peter
- Salloway, Stephen
- Correia, Stephen
- Bernick, Charles
- Stern, Yaakov
- Honig, Lawrence S.
- Bell, Karen L.
- Relkin, Norman
- Ravdin, Lisa
- Paul, Steven
- Flashman, Laura A.
- Hynes, Mary L.
- Santulli, Robert B.
- Friedl, Karl
- Petrella, Jeffrey R.
- Wong, Terence
- Lah, James J.
- Pearlson, Godfrey D.
- Obisesan, Thomas O.
- Lerner, Alan
- Tatsuoka, Curtis
- Farlow, Martin R.
- Saykin, Andrew J.
- Foroud, Tatiana M.
- Shen, Li
- Kim, Sungeun
- Nho, Kwangsik
- Brosch, Jared R.
- Albert, Marilyn
- Onyike, Chiadi
- D’Agostino, Daniel
- Kielb, Stephanie
- Johnson, Heather
- Petersen, Ronald
- Jack, Clifford R.
- Vemuri, Prashanthi
- Jones, David
- Kantarci, Kejal
- Knopman, David
- Johnson, Kris
- Chertkow, Howard
- Bachman, David
- Pomara, Nunzio
- Potter, William
- Hsiao, John
- Galvin, James E.
- Cerbone, Brittany
- Rusinek, Henry
- Glodzik, Lidia
- Kerwin, Diana
- Bonakdarpour, Borna
- Grafman, Jordan
- Scharre, Douglas W.
- Kataki, Maria
- Kaye, Jeffrey
- Silbert, Lisa
- Ott, Brian R.
- Tremont, Geoffrey
- Fleischman, Debra
- Arfanakis, Konstantinos
- Shah, Raj C.
- Finger, Elizabeth
- Furst, Ansgar J.
- Yesavage, Jerome
- Taylor, Joy L.
- Lane, Barton
- Rosen, Allyson
- Black, Sandra
- Stefanovic, Bojana
- Fox, Nick
- Schultz, Susan K.
- Shim, Hyungsub
- Burns, Jeffrey M.
- Swerdlow, Russell H.
- Brooks, William M.
- Marson, Daniel
- Clark, David
- Geldmacher, David
- Roberson, Erik
- DeCarli, Charles
- Carmichael, Owen
- Olichney, John
- Maillard, Pauline
- Nguyen, Dana
- Potkin, Steven
- Thai, Gaby
- Jagust, William
- Apostolova, Liana
- Silverman, Daniel H.S.
- Lu, Po H.
- Thompson, Paul
- Donohue, Michael
- Thomas, Ronald G.
- Walter, Sarah
- Balasubramanian, Archana B.
- Aisen, Paul
- Beckett, Laurel
- Neylan, Thomas
- Weiner, Michael W.
- Hayes, Jacqueline
- Miller, Bruce L.
- Perry, David
- Smith, Charles D.
- Hardy, Peter
- Sinha, Partha
- Koeppe, Robert A.
- Lord, Joanne L.
- Heidebrink, Judith L.
- Arnold, Steven E.
- Karlawish, Jason H.
- Wolk, David
- Shaw, Leslie M.
- Lee, Virginia
- Korecka, Magdalena
- Toga, Arthur W.
- Crawford, Karen
- Schneider, Lon S.
- Womack, Kyle
- Quiceno, Mary
- Johnson, Sterling
- Asthana, Sanjay
- Carlsson, Cynthia M.
- Petrie, Eric C.
- Peskind, Elaine
- Porsteinsson, Anton P.
- Sink, Kaycee M.
- Williamson, Jeff D.
- Garg, Pradeep
- Cairns, Nigel J.
- Ances, Beau
- Carroll, Maria
- Franklin, Erin
- Oliver, Angela
- Duara, Ranjan
- Carson, Richard E.
- Lee, Jin-Moo
- Heitsch, Laura
- Kauwe, John
- Goate, Alison
- Piccio, Laura
- Cruchaga, Carlos
- Venue
- Scientific Reports
- Published
- 2016-01-04
- Volume
- 6
- Issue
- 1
- Pages
- 18092-18092
- ISSN
- 2045-2322 (ISSN-L)
- PMC
- PMC4698720
- OpenAlex
- W2225056762
- Cited by
- 28
- References
- 159
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 6 · 2020: 3 · 2019: 2 · 2018: 7 · 2017: 3 · 2016: 1
- FWCI
- 3.50
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Scientific Reports (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- U.S. Department of Defense (U01 AG024904, W81XWH, W81XWH-12-2-, W81XWH-12, W81XWH1220012, AG024904)
- Foundation for the National Institutes of Health (W81XWH-12-2-0012, U01AG024904, Grant U01 AG024904, AG024904)
- National Multiple Sclerosis Society (JF 2144A2/1)
- Alzheimer's Association (R01-AG044546, P01 AG003991, AG05681, U01 AG024904, NIRG-11-200110, W81XWH-12-2-0012)
- American Federation for Aging Research
- Bristol-Myers Squibb (U01 AG024904, AG024904, W81XWH-12-2-0012)
- Eli Lilly and Company (U01 AG024904, AG024904, W81XWH-12-2-0012)
- Pfizer (AG024904, W81XWH-12-2-0012, U01 AG024904)
- Yale University
- Biogen (W81XWH-12-2-0012, U01 AG024904, AG024904)
- University of Southern California (W81XWH-12-2-0012, P01 AG026276, U01 AG024904, P50 AG05681)
- BrightFocus Foundation (A2013359S)
- University of Pennsylvania
- F. Hoffmann-La Roche (W81XWH-12-2-0012, AG024904, U01 AG024904)
- Medpace (U01 AG024904)
- Meso Scale Diagnostics (U01 AG024904, AG024904, W81XWH-12-2-0012)
- Synarc (U01 AG024904)
- Wake Forest University
- Yeshiva University
- Alzheimer's Disease Neuroimaging Initiative (W81XWH-12-2–0012, U01AG024904, AG024904, W81XWH-12-2-, Department of Defense award number W81XWH-12-2-0012)
- BioClinica (U01 AG024904, W81XWH-12-2-0012, AG024904)
- University of Washington (P01 AG03991, P01 AG026276)
- University of Pittsburgh
- Novartis Pharmaceuticals Corporation (W81XWH-12-2-0012, U01 AG024904, AG024904)
- Northern California Institute for Research and Education (U01 AG024904, W81XWH-12-2-0012)
- Wellcome Trust (200110)
- Hope Center for Neurological Disorders
- Eisai (W81XWH-12-2-0012, U01 AG024904, AG024904)
- Servier (AG024904, W81XWH-12-2-0012, U01 AG024904)
- IXICO (AG024904, W81XWH-12-2-0012, U01 AG024904)
- National Institutes of Health (5u01ag024904-10, W81XWH, NIH P50, W81XWH-12-2-0012, U01-AG024904, AG05681, Grant U01 AG024904, AG024904, AG003991, AG 03991, AG026276)
- Genentech (W81XWH-12-2-0012, AG024904, U01 AG024904)
- University of California, Los Angeles
- University of California, Davis
- University of California, San Diego
- University of California, San Francisco
- University of California, Irvine
- Medical Research Council (U01 AG024904, G0300429)
- National Institute on Aging (U01-AG-024904, AG03991, W81XWH-12-2–0012, AG 024904, AG 05681, R01AG035083, U01AG032984, AG003991, P 50 AG05681, R01AG044546, AG026276, P50AG005681, P01 AG0 3991, P01AG003991, AG035083, P01AG026276)
- National Institute of Neurological Disorders and Stroke (R01NS085419)
- National Institute of Biomedical Imaging and Bioengineering (W81XWH-12-2-0012, U01 AG024904, AG024904)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Keywords
- plasma protein levels, biomarkers, complex traits, endophenotypes, pleiotropy, genome-wide association study, Turku, FUT2, apolipoprotein E, SELE, CA19-9, CEA, beta2-glycoprotein I, IL-6 receptor, LPA, C-reactive protein, heart disease, inflammatory bowel disease, type 2 diabetes, multiple sclerosis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review