The apoptosome: Signalling platform of cell death
Abstract
Recent work on the initial switches that trigger cell death has revealed surprising inventions of nature that ensure the ordered suicide of a cell that has been selected for demise. Particularly intriguing is how a signal--the release of cytochrome c from the mitochondria--is translated into the activation of the death cascade, which leads to a point of no return. Now there is new understanding of how this crucial process is delicately handled by a cytosolic signalling platform known as the apoptosome. The formation of the apoptosome and the activation of its effector, caspase-9, reveals a sophisticated mechanism that might be more common than was initially thought.
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The intrinsic pathway involved in UVR-induced apoptosis results from DNA damage and cytochrome c release from mitochondria.
“The intrinsic pathway involved in UVR-induced apoptosis results from DNA damage and cytochrome c release from mitochondria (Figure 2) [39,40].”
From Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy (2013) · cites this paper as [40]
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- Authors
- Riedl, S. J., & Salvesen, G. S.
- Affiliations
- Sanford Burnham Prebys Medical Discovery Institute (US)
- ORCID
- Salvesen, Guy S.
- Venue
- Nature Reviews Molecular Cell Biology
- Published
- 2007-03-21
- Volume
- 8
- Issue
- 5
- Pages
- 405-413
- ISSN
- 1471-0072 (ISSN-L)
- 1471-0080
- OpenAlex
- W1991455654
- Cited by
- 1,097
- References
- 0
- Citations by year
- 2026: 28 · 2025: 34 · 2024: 37 · 2023: 33 · 2022: 44 · 2021: 43 · 2020: 48 · 2019: 36 · 2018: 60 · 2017: 40 · 2016: 45 · 2015: 69 · 2014: 74 · 2013: 83 · 2012: 76
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Molecular Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- V Foundation for Cancer Research
- Leukemia and Lymphoma Society
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Social Sciences › Anthropology › Death, Funerary Practices, and Mourning
- Keywords
- apoptosome, apoptosis, caspase-9, cytochrome c release, programmed cell death
- MeSH terms
- Animals, Cytosol, Deoxyadenine Nucleotides, Humans, Membrane Proteins, Models, Biological, Models, Molecular, Signal Transduction, Apoptosis, Inflammation Mediators, Dimerization, Caspases, Effector, Caspases, Initiator, Apoptosomes
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