Torti, Frank M.

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell

Ferroptosis and cancer prognosisIron Metabolism and Disorders

Cited by 7,695

Iron and cancer: more ore to be mined

Torti, S. V., & Torti, F. M. (2013) · Nature Reviews Cancer

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 1,621

Regulation of ferritin genes and protein

Torti, F. M., & Torti, S. V. (2002) · Blood

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 1,173

Ferritin heavy chain upregulation by NF-κB inhibits TNFα-induced apoptosis by suppressing reactive oxygen species

Pham, C. G., Bubici, C., Zazzeroni, F., Papa, S., Jones, J., Alvarez, K., Jayawardena, S., De Smaele, E., Cong, R., Beaumont, C., et al. (2004) · Cell

NF-κB Signaling PathwaysCell death mechanisms and regulation

Cited by 663

Ferritin and the response to oxidative stress

ORINO, K., LEHMAN, L., TSUJI, Y., AYAKI, H., TORTI, S. V., & TORTI, F. M. (2001) · Biochemical Journal

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 535

Iron and cancer: recent insights

Manz, D. H., Blanchette, N. L., Paul, B. T., Torti, F. M., & Torti, S. V. (2016) · Annals of the New York Academy of Sciences

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 507

Ferroportin and Iron Regulation in Breast Cancer Progression and Prognosis

Pinnix, Z. K., Miller, L. D., Wang, W., D’Agostino, R., Kute, T., Willingham, M. C., Hatcher, H., Tesfay, L., Sui, G., Di, X., et al. (2010) · Science Translational Medicine

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 448

Iron and Cancer

Torti, S. V., Manz, D. H., Paul, B. T., Blanchette-Farra, N., & Torti, F. M. (2018) · Annual Review of Nutrition

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 426

The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene.

Torti, S. V., Kwak, E. L., Miller, S. C., Miller, L. L., Ringold, G. M., Myambo, K. B., Young, A. P., & Torti, F. M. (1988) · Journal of Biological Chemistry

Iron Metabolism and DisordersNeurological diseases and metabolism

Cited by 295

Coordinate Transcriptional and Translational Regulation of Ferritin in Response to Oxidative Stress

Tsuji, Y., Ayaki, H., Whitman, S. P., Morrow, C. S., Torti, S. V., & Torti, F. M. (2000) · Molecular and Cellular Biology

Iron Metabolism and DisordersGenomics, phytochemicals, and oxidative stress

Cited by 285

Nrf2 Mediates the Induction of Ferritin H in Response to Xenobiotics and Cancer Chemopreventive Dithiolethiones

Pietsch, E. C., Chan, J. Y., Torti, F. M., & Torti, S. V. (2003) · Journal of Biological Chemistry

Genomics, phytochemicals, and oxidative stressBioactive Compounds and Antitumor Agents

Cited by 284

Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator

Jiao, Y., Wilkinson, J., Di, X., Wang, W., Hatcher, H., Kock, N. D., D'Agostino, R., Knovich, M. A., Torti, F. M., & Torti, S. V. (2009) · Blood

Iron Metabolism and DisordersCurcumin's Biomedical Applications

Cited by 266

Synthetic and natural iron chelators: Therapeutic potential and clinical use

Hatcher, H. C., Singh, R. N., Torti, F. M., & Torti, S. V. (2009) · Future Medicinal Chemistry

Iron Metabolism and DisordersHeavy Metal Exposure and Toxicity

Cited by 242

TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis

Chen, T. T., Li, L., Chung, D.-H., Allen, C. D. C., Torti, S. V., Torti, F. M., Cyster, J. G., Chen, C.-Y., Brodsky, F. M., Niemi, E. C., et al. (2005) · The Journal of Experimental Medicine

Iron Metabolism and DisordersT-cell and B-cell Immunology

Cited by 219

Iron-independent induction of ferritin H chain by tumor necrosis factor

Miller, L. L., Miller, S. C., Torti, S. V., Tsuji, Y., & Torti, F. M. (1991) · Proceedings of the National Academy of Sciences

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 213

An iron regulatory gene signature predicts outcome in breast cancer

Miller, L. D., Coffman, L. G., Chou, J. W., Black, M. A., Bergh, J., D'Agostino, R., Torti, S. V., & Torti, F. M. (2011) · Cancer Research

Ferroptosis and cancer prognosisBreast Cancer Treatment Studies

Cited by 202

Role for NF-κB in the regulation of ferritin H by tumor necrosis factor-α

Kwak, E. L., Larochelle, D. A., Beaumont, C., Torti, S. V., & Torti, F. M. (1995) · Journal of Biological Chemistry

Iron Metabolism and DisordersNF-κB Signaling Pathways

Cited by 189

Hepcidin regulation in prostate and its disruption in prostate cancer

Tesfay, L., Clausen, K. A., Kim, J. W., Hegde, P., Wang, X., Miller, L. D., Deng, Z., Blanchette, N., Arvedson, T., Miranti, C. K., et al. (2015) · Cancer Research

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 186

Iron: the cancer connection

Torti, S. V., & Torti, F. M. (2020) · Molecular Aspects of Medicine

Iron Metabolism and DisordersFerroptosis and cancer prognosis

Cited by 153

Tumor necrosis factor-alpha and interleukin 1-alpha regulate transferrin receptor in human diploid fibroblasts. Relationship to the induction of ferritin heavy chain.

Tsuji, Y., Miller, L. L., Miller, S. C., Torti, S. V., & Torti, F. M. (1991) · Journal of Biological Chemistry

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 103

Transcriptional Regulation of the Mouse Ferritin H Gene

Tsuji, Y., Moran, E., Torti, S. V., & Torti, F. M. (1999) · Journal of Biological Chemistry

Genomics and Chromatin DynamicsIron Metabolism and Disorders

Cited by 37

Activation of the Ferritin H Enhancer, FER-1, by the Cooperative Action of Members of the AP1 and Sp1 Transcription Factor Families

Tsuji, Y., Torti, S. V., & Torti, F. M. (1998) · Journal of Biological Chemistry

Iron Metabolism and DisordersGenomics and Chromatin Dynamics

Cited by 36