Yang, Xia

An integrative genomics approach to infer causal associations between gene expression and disease

Schadt, E. E., Lamb, J., Yang, X., Zhu, J., Edwards, S., GuhaThakurta, D., Sieberts, S. K., Monks, S., Reitman, M., Zhang, C., et al. (2005) · Nature Genetics

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 1,043

Tissue-specific expression and regulation of sexually dimorphic genes in mice

Yang, X., Schadt, E. E., Wang, S., Wang, H., Arnold, A. P., Ingram-Drake, L., Drake, T. A., & Lusis, A. J. (2006) · Genome Research

Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesGenetic Mapping and Diversity in Plants and Animals

Cited by 922

Variations in DNA elucidate molecular networks that cause disease

Chen, Y., Zhu, J., Lum, P. Y., Yang, X., Pinto, S., MacNeil, D. J., Zhang, C., Lamb, J., Edwards, S., Sieberts, S. K., et al. (2008) · Nature

Bioinformatics and Genomic NetworksNutrition, Genetics, and Disease

Cited by 887

Co-regulatory networks of human serum proteins link genetics to disease

Emilsson, V., Ilkov, M., Lamb, J. R., Finkel, N., Gudmundsson, E. F., Pitts, R., Hoover, H., Gudmundsdottir, V., Horman, S. R., Aspelund, T., et al. (2018) · Science

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 680

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks

Yang, X., Deignan, J. L., Qi, H., Zhu, J., Qian, S., Zhong, J., Torosyan, G., Majid, S., Falkard, B., Kleinhanz, R. R., et al. (2009) · Nature Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 288

Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

He, X., Fuller, C. K., Song, Y., Meng, Q., Zhang, B., Yang, X., & Li, H. (2013) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 241

Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

Narayanan, M., Huynh, J. L., Wang, K., Yang, X., Yoo, S., McElwee, J., Zhang, B., Zhang, C., Lamb, J. R., Xie, T., et al. (2014) · Molecular Systems Biology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 208

Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Mäkinen, V.-P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segrè, A. V., Ghosh, S., Vivar, J., et al. (2014) · PLoS Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 196

Single cell molecular alterations reveal target cells and pathways of concussive brain injury

Arneson, D., Zhang, G., Ying, Z., Zhuang, Y., Byun, H. R., Ahn, I. S., Gomez-Pinilla, F., & Yang, X. (2018) · Nature Communications

Traumatic Brain Injury ResearchTraumatic Brain Injury and Neurovascular Disturbances

Cited by 193

A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease

Huan, T., Zhang, B., Wang, Z., Joehanes, R., Zhu, J., Johnson, A. D., Ying, S., Munson, P. J., Raghavachari, N., Wang, R., et al. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

Cited by 167

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., Paananen, J., Hansson, O., Pankow, J., Goodarzi, M. O., Carcamo-Orive, I., et al. (2015) · Journal of Clinical Investigation

Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 141

Diurnal variation of the human adipose transcriptome and the link to metabolic disease

Loboda, A., Kraft, W. K., Fine, B., Joseph, J., Nebozhyn, M., Zhang, C., He, Y., Yang, X., Wright, C., Morris, M., et al. (2009) · BMC Medical Genomics

Circadian rhythm and melatoninAdipose Tissue and Metabolism

Cited by 124

Prediction of Causal Candidate Genes in Coronary Artery Disease Loci

Brænne, I., Civelek, M., Vilne, B., Di Narzo, A., Johnson, A. D., Zhao, Y., Reiz, B., Codoni, V., Webb, T. R., Foroughi Asl, H., et al. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 109

Network modeling of single-cell omics data: challenges, opportunities, and progresses

Blencowe, M., Arneson, D., Ding, J., Chen, Y.-W., Saleem, Z., & Yang, X. (2019) · Emerging Topics in Life Sciences

Gene Regulatory Network AnalysisBioinformatics and Genomic Networks

Cited by 73

The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1

Camacho, J., Truong, L., Kurt, Z., Chen, Y.-W., Morselli, M., Gutierrez, G., Pellegrini, M., Yang, X., & Allard, P. (2018) · Cell Reports

Epigenetics and DNA MethylationEffects and risks of endocrine disrupting chemicals

Cited by 72

The Genetic Architecture of Diet‐Induced Hepatic Fibrosis in Mice

Hui, S. T., Kurt, Z., Tuominen, I., Norheim, F., C.Davis, R., Pan, C., Dirks, D. L., Magyar, C. E., French, S. W., Chella Krishnan, K., et al. (2018) · Hepatology

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

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SCING: Inference of robust, interpretable gene regulatory networks from single cell and spatial transcriptomics

Littman, R., Cheng, M., Wang, N., Peng, C., & Yang, X. (2023) · iScience

Gene Regulatory Network AnalysisSingle-cell and spatial transcriptomics

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IDOL regulates systemic energy balance through control of neuronal VLDLR expression

Lee, S. D., Priest, C., Bjursell, M., Gao, J., Arneson, D. V., Ahn, I. S., Diamante, G., van Veen, J. E., Massa, M. G., Calkin, A. C., et al. (2019) · Nature Metabolism

Regulation of Appetite and ObesityCholesterol and Lipid Metabolism

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Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions

Zuo, Y., Iemolo, A., Montilla-Perez, P., Li, H.-R., Yang, X., & Telese, F. (2022) · Neuropsychopharmacology

Cannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on Behavior

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Therapeutic Idol reduction ameliorates amyloidosis and improves cognitive function in APP/PS1 mice

Gao, J., Littman, R., Diamante, G., Xiao, X., Ahn, I. S., Yang, X., Cole, T. A., & Tontonoz, P. (2020) · Molecular and Cellular Biology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 15