Fructose-1,6-bisphosphatase opposes renal carcinoma progression

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197 · see citing works

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

Gerlinger, M., Rowan, A. J., Horswell, S., Larkin, J., Endesfelder, D., Gronroos, E., Martinez, P., Matthews, N., Stewart, A., Tarpey, P., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1113205 · Cited by 7,774 · see citing works

Comprehensive molecular characterization of clear cell renal cell carcinoma

The Cancer Genome Atlas Research Network (2013) · Nature · doi:10.1038/nature12222 · Cited by 3,485 · see citing works

Hypoxia-inducible factors and the response to hypoxic stress

Majmundar, A. J., Wong, W. J., & Simon, M. C. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.09.022 · Cited by 2,380 · see citing works

Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Metallo, C. M., Gameiro, P. A., Bell, E. L., Mattaini, K. R., Yang, J., Hiller, K., Jewell, C. M., Johnson, Z. R., Irvine, D. J., Guarente, L., et al. (2012) · Nature · doi:10.1038/nature10602 · Cited by 1,791 · see citing works

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3183 · Cited by 1,693 · see citing works

Functional genomics reveal that the serine synthesis pathway is essential in breast cancer

Possemato, R., Marks, K. M., Shaul, Y. D., Pacold, M. E., Kim, D., Birsoy, K., Sethumadhavan, S., Woo, H.-K., Jang, H. G., Jha, A. K., et al. (2011) · Nature · doi:10.1038/nature10350 · Cited by 1,683 · see citing works

Renal cell carcinoma

Rini, B. I., Campbell, S. C., & Escudier, B. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60229-4 · Cited by 1,634 · see citing works

Renal-Cell Carcinoma

Cohen, H. T., & McGovern, F. J. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043172 · Cited by 1,575 · see citing works

Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma

Varela, I., Tarpey, P. S., Raine, K. M., Huang, D., Ong, C. K., Stephens, P., Davies, H. R., Jones, D., Lin, M., Teague, J. W., et al. (2011) · Nature · doi:10.1038/nature09639 · Cited by 1,278 · see citing works

Integrated molecular analysis of clear-cell renal cell carcinoma

Sato, Y., Yoshizato, T., Shiraishi, Y., Maekawa, S., Okuno, Y., Kamura, T., Shimamura, T., Sato‐Otsubo, A., Nagae, G., Suzuki, H., et al. (2013) · Nature Genetics · doi:10.1038/ng.2699 · Cited by 1,223 · see citing works

Identification of a signal for rapid export of proteins from the nucleus

Wen, W., Meinkotht, J. L., Tsien, R. Y., & Taylor, S. S. (1995) · Cell · doi:10.1016/0092-8674(95)90435-2 · Cited by 1,190 · see citing works

Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes

Dalgliesh, G. L., Furge, K., Greenman, C., Chen, L., Bignell, G., Butler, A., Davies, H., Edkins, S., Hardy, C., Latimer, C., et al. (2010) · Nature · doi:10.1038/nature08672 · Cited by 1,173 · see citing works

Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us?

DeBerardinis, R. J., & Thompson, C. B. (2012) · Cell · doi:10.1016/j.cell.2012.02.032 · Cited by 858 · see citing works

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19253 · Cited by 629 · see citing works

Renal Gluconeogenesis

Gerich, J. E., Meyer, C., Woerle, H. J., & Stümvoll, M. (2001) · Diabetes Care · doi:10.2337/diacare.24.2.382 · Cited by 602 · see citing works

Improved Identification of von Hippel-Lindau Gene Alterations in Clear Cell Renal Tumors

Nickerson, M. L., Jaeger, E., Shi, Y., Durocher, J. A., Mahurkar, S., Zaridze, D. G., Matveev, V. B., Janout, V., Kollárová, H., Bencko, V., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-4921 · Cited by 589 · see citing works

Genetic and Functional Studies Implicate <i>HIF1</i> α as a 14q Kidney Cancer Suppressor Gene

Shen, C., Beroukhim, R., Schumacher, S. E., Zhou, J., Chang, M., Signoretti, S., & Kaelin, W. G. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0098 · Cited by 413 · see citing works

Adverse Outcomes in Clear Cell Renal Cell Carcinoma with Mutations of 3p21 Epigenetic Regulators BAP1 and SETD2 : A Report by MSKCC and the KIRC TCGA Research Network

Hakimi, A. A., Ostrovnaya, I., Reva, B. A., Schultz, N. D., Chen, Y., Gönen, M., Liu, H., Takeda, S., Voss, M. H., Tickoo, S. K., et al. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-3886 · Cited by 358 · see citing works

Renal Cyst Development in Mice with Conditional Inactivation of the von Hippel-Lindau Tumor Suppressor

Rankin, E. B., Tomaszewski, J. E., & Haase, V. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3241 · Cited by 356 · see citing works

Metabolism at a glance

Salway, J. G. (1993) · Cited by 261 · see citing works

Genome-wide identification of hypoxia-inducible factor binding sites and target genes by a probabilistic model integrating transcription-profiling data and in silico binding site prediction

Ortiz-Barahona, A., Villar, D., Pescador, N., Amigo, J., & del Peso, L. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp1205 · Cited by 202 · see citing works

Glutamine transport by the blood-brain barrier: a possible mechanism for nitrogen removal

Lee, W.-J., Hawkins, R. A., Viña, J. R., & Peterson, D. R. (1998) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1998.274.4.c1101 · Cited by 191 · see citing works

Mass isotopomer study of the nonoxidative pathways of the pentose cycle with [1,2-13C2]glucose

Lee, W. P., Boros, L. G., Puigjaner, J., Bassilian, S., Lim, S. K., & Cascante, M. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.5.e843 · Cited by 183 · see citing works

Regulation of Fructose‐Bisphosphatase Activity

Tejwani, G. A. (1983) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122990.ch3 · Cited by 170 · see citing works

Crystal Structures of Fructose 1,6-Bisphosphatase: Mechanism of Catalysis and Allosteric Inhibition Revealed in Product Complexes,

Choe, J., Fromm, H. J., & Honzatko, R. B. (2000) · Biochemistry · doi:10.1021/bi000574g · Cited by 71 · see citing works

Genomic copy number alterations in clear cell renal carcinoma: associations with case characteristics and mechanisms of VHL gene inactivation

Moore, L. E., Jaeger, E., Nickerson, M. L., Brennan, P., Vries, S. D., Roy, R., Toro, J. R., Li, H., Karami, S., Lenz, P., et al. (2012) · Oncogenesis · doi:10.1038/oncsis.2012.14 · Cited by 69 · see citing works

Integrative Genomic Analyses of Sporadic Clear Cell Renal Cell Carcinoma Define Disease Subtypes and Potential New Therapeutic Targets

Dondeti, V. R., Wubbenhorst, B. S., Lal, P., Gordan, J. D., D'Andrea, K. P., Attiyeh, E. F., Simon, M. C., & Nathanson, K. L. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-1698 · Cited by 67 · see citing works

Effects of a glucokinase activator on hepatic intermediary metabolism: study with 13C-isotopomer-based metabolomics

Nissim, I., Horyn, O., Nissim, I. B., Daikhin, Y., Wehrli, S. L., Yudkoff, M., & Matschinsky, F. M. (2012) · Biochemical Journal · doi:10.1042/bj20120163 · Cited by 46 · see citing works

Fructose 1,6‐bisphosphatase deficiency: enzyme and mutation analysis performed on calcitriol‐stimulated monocytes with a note on long‐term prognosis

Åsberg, C., Hjalmarson, O., Alm, J., Martinsson, T., Waldenström, J., & Hellerud, C. (2010) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-009-9034-5 · Cited by 39 · see citing works

Misdiagnosis of clear cell renal cell carcinoma

Valera, V., & Merino, M. J. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2011.64 · Cited by 37 · see citing works

Understanding the Intersections between Metabolism and Cancer Biology

Heiden, M. G. V., & DeBerardinis, R. J. (2017) · Cell · doi:10.1016/j.cell.2016.12.039 · Cited by 2,316 · see citing works

Cancer metabolism: looking forward

Martínez‐Reyes, I., & Chandel, N. S. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00378-6 · Cited by 1,852 · see citing works

The role of ROS in tumour development and progression

Cheung, E. C., & Vousden, K. H. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-021-00435-0 · Cited by 1,623 · see citing works

Defective fatty acid oxidation in renal tubular epithelial cells has a key role in kidney fibrosis development

Kang, H. M., Ahn, S. H., Choi, P., Ko, Y.-A., Han, S. H., Chinga, F., Park, A. S. D., Tao, J., Sharma, K., Pullman, J., et al. (2015) · Nature Medicine · doi:10.1038/nm.3762 · Cited by 1,555 · see citing works

Metabolic pathways promoting cancer cell survival and growth

Boroughs, L. K., & DeBerardinis, R. J. (2015) · Nature Cell Biology · doi:10.1038/ncb3124 · Cited by 1,459 · see citing works

The hallmarks of cancer metabolism: still emerging

Pavlova, N. N., Zhu, J., & Thompson, C. B. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.01.007 · Cited by 1,418 · see citing works

Glutathione metabolism in cancer progression and treatment resistance

Bansal, A., & Simon, M. C. (2018) · The Journal of Cell Biology · doi:10.1083/jcb.201804161 · Cited by 1,234 · see citing works

Reprogramming glucose metabolism in cancer: can it be exploited for cancer therapy?

Hay, N. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.77 · Cited by 1,124 · see citing works

An Integrated Metabolic Atlas of Clear Cell Renal Cell Carcinoma

Hakimi, A. A., Reznik, E., Lee, C., Creighton, C. J., Brannon, A. R., Luna, A., Aksoy, B. A., Liu, E. M., Shen, R., Lee, W., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2015.12.004 · Cited by 791 · see citing works

Targeting renal cell carcinoma with a HIF-2 antagonist

Chen, W., Hill, H., Christie, A., Kim, M. S., Holloman, E., Pavia-Jimenez, A., Homayoun, F., Ma, Y., Patel, N., Yell, P., et al. (2016) · Nature · doi:10.1038/nature19796 · Cited by 709 · see citing works

Regulated necrosis: disease relevance and therapeutic opportunities

Conrad, M., Angeli, J. P. F., Vandenabeele, P., & Stockwell, B. R. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.6 · Cited by 630 · see citing works

Mechanisms and Implications of Metabolic Heterogeneity in Cancer

Kim, J., & DeBerardinis, R. J. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.013 · Cited by 606 · see citing works

Metabolic reprogramming in clear cell renal cell carcinoma

Wettersten, H. I., Aboud, O. A., Lara, P. N., & Weiss, R. H. (2017) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.59 · Cited by 573 · see citing works

Regulation of chromatin and gene expression by metabolic enzymes and metabolites

Li, X., Egervári, G., Wang, Y., Berger, S. L., & Lu, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0029-7 · Cited by 486 · see citing works

Pyruvate kinase M2 activation may protect against the progression of diabetic glomerular pathology and mitochondrial dysfunction

Qi, W., Keenan, H. A., Li, Q., Ishikado, A., Kannt, A., Sadowski, T., Yorek, M. A., Wu, I., Lockhart, S. M., Coppey, L. J., et al. (2017) · Nature Medicine · doi:10.1038/nm.4328 · Cited by 482 · see citing works

HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism

Du, W., Zhang, L., Brett-Morris, A., Aguila, B., Kerner, J., Hoppel, C. L., Puchowicz, M., Serra, D., Herrero, L., Rini, B. I., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01965-8 · Cited by 468 · see citing works

The ever-expanding role of HIF in tumour and stromal biology

LaGory, E. L., & Giaccia, A. J. (2016) · Nature Cell Biology · doi:10.1038/ncb3330 · Cited by 432 · see citing works

Oxygen availability and metabolic adaptations

Nakazawa, M. S., Keith, B., & Simon, M. C. (2016) · Nature reviews. Cancer · doi:10.1038/nrc.2016.84 · Cited by 431 · see citing works

Hypoxia, Hypoxia-inducible Transcription Factors, and Renal Cancer

Schödel, J., Grampp, S., Maher, E. R., Moch, H., Ratcliffe, P. J., Russo, P., & Mole, D. R. (2015) · European Urology · doi:10.1016/j.eururo.2015.08.007 · Cited by 411 · see citing works

HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma

Qiu, B., Ackerman, D., Sanchez, D. J., Li, B., Ochocki, J. D., Grazioli, A., Bobrovnikova-Marjon, E., Diehl, J. A., Keith, B., & Simon, M. C. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1507 · Cited by 394 · see citing works

Dysfunction of Natural Killer Cells by FBP1-Induced Inhibition of Glycolysis during Lung Cancer Progression

Cong, J., Wang, X., Zheng, X., Wang, D., Fu, B., Sun, R., Tian, Z., & Wei, H. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.021 · Cited by 376 · see citing works

Four Key Steps Control Glycolytic Flux in Mammalian Cells

Tanner, L. B., Goglia, A. G., Wei, M. H., Sehgal, T., Parsons, L. R., Park, J. O., White, E., Toettcher, J. E., & Rabinowitz, J. D. (2018) · Cell Systems · doi:10.1016/j.cels.2018.06.003 · Cited by 368 · see citing works

The glutathione redox system is essential to prevent ferroptosis caused by impaired lipid metabolism in clear cell renal cell carcinoma

Miess, H., Dankworth, B., Gouw, A. M., Rosenfeldt, M., Schmitz, W., Jiang, M., Saunders, B., Howell, M., Downward, J., Felsher, D. W., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0315-z · Cited by 361 · see citing works

What is cancer metabolism?

Finley, L. W. S. (2023) · Cell · doi:10.1016/j.cell.2023.01.038 · Cited by 331 · see citing works

Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade

Li, L., Chen, K., Wang, T., Wu, Y., Xing, G., Chen, M., Hao, Z., Zhang, C., Zhang, J., Ma, B., et al. (2020) · Nature Metabolism · doi:10.1038/s42255-020-0267-9 · Cited by 317 · see citing works

Gluconeogenesis in Cancer: Function and Regulation of PEPCK, FBPase, and G6Pase

Wang, Z., & Dong, C. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.11.003 · Cited by 294 · see citing works

Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer

Becker, L. M., O’Connell, J. T., Vo, A. P., Cain, M. P., Tampe, D., Bizarro, L., Sugimoto, H., McGow, A. K., Asara, J. M., Lovisa, S., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107701 · Cited by 293 · see citing works

Isotope tracing of human clear cell renal cell carcinomas demonstrates suppressed glucose oxidation in vivo

Courtney, K. D., Bezwada, D., Mashimo, T., Pichumani, K., Vemireddy, V., Funk, A. M., Wimberly, J., McNeil, S. S., Kapur, P., Lotan, Y., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.07.020 · Cited by 280 · see citing works

Targeting the Warburg effect: A revisited perspective from molecular mechanisms to traditional and innovative therapeutic strategies in cancer

Liao, M., Yao, D., Wu, L., Luo, C., Wang, Z., Zhang, J., & Liu, B. (2023) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2023.12.003 · Cited by 280 · see citing works

Metabolic Enzymes Moonlighting in the Nucleus: Metabolic Regulation of Gene Transcription

Boukouris, A. E., Zervopoulos, S. D., & Michelakis, E. D. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.05.013 · Cited by 274 · see citing works

EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape

Lim, S., Li, C., Xia, W., Lee, H., Chang, S.-S., Shen, J., Hsu, J. L., Raftery, D., Djukovic, D., Gu, H., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2478 · Cited by 263 · see citing works

Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow

Johnson, R. W., Finger, E. C., Olcina, M. M., Vilalta, M., Aguilera, T. A., Miao, Y. R., Merkel, A. R., Johnson, J., Sterling, J. A. R., Wu, J. Y., et al. (2016) · Nature Cell Biology · doi:10.1038/ncb3408 · Cited by 261 · see citing works

MYC oncogene overexpression drives renal cell carcinoma in a mouse model through glutamine metabolism

Shroff, E. H., Eberlin, L. S., Dang, V. M., Gouw, A. M., Gabay, M., Adam, S. J., Bellovin, D. I., Tran, P. T., Philbrick, W. M., Garcia-Ocana, A., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1507228112 · Cited by 255 · see citing works

Epithelial–mesenchymal transition in human cancer: Comprehensive reprogramming of metabolism, epigenetics, and differentiation

Li, L., & Li, W. (2015) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2015.01.004 · Cited by 254 · see citing works

The Evolving Landscape of Noncanonical Functions of Metabolic Enzymes in Cancer and Other Pathologies

Xu, D., Shao, F., Bian, X., Meng, Y., Liang, T., & Lu, Z. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.015 · Cited by 253 · see citing works

Glutamine fuels proliferation but not migration of endothelial cells

Kim, B., Li, J., Jang, C., & Arany, Z. P. (2017) · The EMBO Journal · doi:10.15252/embj.201796436 · Cited by 251 · see citing works

Metabolic reprogramming in triple-negative breast cancer

Wang, Z., Jiang, Q., & Dong, C. (2020) · Cancer Biology and Medicine · doi:10.20892/j.issn.2095-3941.2019.0210 · Cited by 248 · see citing works

Cancer Stem Cells: Targeting the Roots of Cancer, Seeds of Metastasis, and Sources of Therapy Resistance

Adorno-Cruz, V., Kibria, G., Liu, X., Doherty, M. R., Junk, D. J., Guan, D., Hubert, C., Venere, M., Mulkearns-Hubert, E. E., Sinyuk, M., et al. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3225 · Cited by 238 · see citing works

Gluconeogenesis in cancer cells – Repurposing of a starvation-induced metabolic pathway?

Bluemel, G., Smolle, E., Olschewski, H., & Leithner, K. (2019) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2019.05.006 · Cited by 237 · see citing works

Metabolic Reprogramming in Breast Cancer and Its Therapeutic Implications

Gandhi, N. S., & Das, G. M. (2019) · Cells · doi:10.3390/cells8020089 · Cited by 227 · see citing works

A Clearer View of the Molecular Complexity of Clear Cell Renal Cell Carcinoma

Frew, I. J., & Moch, H. (2014) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012414-040306 · Cited by 224 · see citing works

An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes

Chen, S., Wu, X., Wadas, B. C., Oh, J., & Varshavsky, A. J. (2017) · Science · doi:10.1126/science.aal3655 · Cited by 224 · see citing works

Conserved and Divergent Features of Human and Mouse Kidney Organogenesis

Lindström, N. O., McMahon, J. A., Guo, J., Tran, T., Guo, Q., Rutledge, E. A., Parvez, R. K., Saribekyan, G., Schuler, R. E., Liao, C., et al. (2018) · Journal of the American Society of Nephrology · doi:10.1681/asn.2017080887 · Cited by 220 · see citing works

Metabolic reprogramming by PCK1 promotes TCA cataplerosis, oxidative stress and apoptosis in liver cancer cells and suppresses hepatocellular carcinoma

Liu, M., Jin, L., Sun, S.-J., Liu, P., Feng, X., Cheng, Z., Liu, W., Guan, K., Shi, Y., Yuan, H., et al. (2018) · Oncogene · doi:10.1038/s41388-017-0070-6 · Cited by 213 · see citing works

Undercover: gene control by metabolites and metabolic enzymesPreprint

van der Knaap, J. A., & Verrijzer, C. P. (2016) · Genes & Development · doi:10.1101/gad.289140.116 · Cited by 213 · see citing works

Oncometabolites in renal cancer

Yong, C., Stewart, G. D., & Frezza, C. (2019) · Nature Reviews Nephrology · doi:10.1038/s41581-019-0210-z · Cited by 212 · see citing works

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome

Li, F., Huangyang, P., Burrows, M., Guo, K., Riscal, R., Godfrey, J. T., Lee, K. E., Lin, N., Lee, P., Blair, I. A., et al. (2020) · Nature Cell Biology · doi:10.1038/s41556-020-0511-2 · Cited by 211 · see citing works

Regulation of gene expression by glycolytic and gluconeogenic enzymes

Bian, X., Jiang, H., Meng, Y., Li, Y.-P., Fang, J., & Lu, Z. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.02.003 · Cited by 211 · see citing works

Metabolic reprogramming in renal cancer: Events of a metabolic disease

Chakraborty, S., Balan, M., Sabarwal, A., Choueiri, T. K., & Pal, S. (2021) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2021.188559 · Cited by 208 · see citing works

Fructose-1,6-bisphosphate couples glycolytic flux to activation of Ras

Peeters, K., Van Leemputte, F., Fischer, B., Bonini, B. M., Quezada, H., Tsytlonok, M., Haesen, D., Vanthienen, W., Bernardes, N., Gonzalez-Blas, C. B., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01019-z · Cited by 203 · see citing works

Oxygen availability and metabolic reprogramming in cancer

Xie, H. J., & Simon, M. C. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.r117.799973 · Cited by 203 · see citing works

Snail reprograms glucose metabolism by repressing phosphofructokinase PFKP allowing cancer cell survival under metabolic stress

Kim, N. H., Cha, Y. H., Lee, J., Lee, S.-H., Yang, J. H., Yun, J. S., Cho, E. S., Zhang, X., Nam, M., Kim, N., et al. (2017) · Nature Communications · doi:10.1038/ncomms14374 · Cited by 202 · see citing works

Moonlighting functions of metabolic enzymes and metabolites in cancer

Pan, C., Li, B., & Simon, M. C. (2021) · Molecular Cell · doi:10.1016/j.molcel.2021.08.031 · Cited by 194 · see citing works

Inosine Monophosphate Dehydrogenase Dependence in a Subset of Small Cell Lung Cancers

Huang, F., Ni, M., Chalishazar, M. D., Huffman, K. E., Kim, J., Cai, L., Shi, X., Cai, F., Zacharias, L. G., Ireland, A. S., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.005 · Cited by 186 · see citing works

CD36 promotes NLRP3 inflammasome activation via the mtROS pathway in renal tubular epithelial cells of diabetic kidneys

Hou, Y., Wang, Q., Han, B., Chen, Y., Qiao, X., & Wang, L. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-03813-6 · Cited by 185 · see citing works

The folate cycle enzyme MTHFD2 induces cancer immune evasion through PD-L1 up-regulation

Shang, M., Yang, H., Yang, R., Chen, T., Fu, Y., Li, Y., Fang, X.-L., Zhang, K., Jianju, Z., Li, H., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-22173-5 · Cited by 184 · see citing works

Applications of metabolomics to study cancer metabolism

Kaushik, A. K., & DeBerardinis, R. J. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.04.009 · Cited by 179 · see citing works

The Pentose Phosphate Pathway as a Potential Target for Cancer Therapy

Cho, E. S., Cha, Y. H., Kim, H. S., Kim, N. H., & Yook, J. I. (2017) · Biomolecules & Therapeutics · doi:10.4062/biomolther.2017.179 · Cited by 179 · see citing works

Renal tubular epithelial cells response to injury in acute kidney injury

Li, Z., Li, X., Zhou, Y. N., Wang, B., Lv, L., & Liu, B. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105294 · Cited by 176 · see citing works

A landscape of metabolic variation across tumor types

Reznik, E., Luna, A., Aksoy, B. A., Liu, E. M., La, K., Ostrovnaya, I., Creighton, C. J., Hakimi, A. A., & Sander, C. (2018) · Cell Systems · doi:10.1016/j.cels.2017.12.014 · Cited by 172 · see citing works

DUB3 Promotes BET Inhibitor Resistance and Cancer Progression by Deubiquitinating BRD4

Jin, X., Yan, Y., Wang, D., Ding, D., Ma, T., Ye, Z., Jiménez, R. E., Wang, L., Wu, H., & Huang, H. (2018) · Molecular Cell · doi:10.1016/j.molcel.2018.06.036 · Cited by 167 · see citing works

Genetic and metabolic hallmarks of clear cell renal cell carcinoma

Sanchez, D. J., & Simon, M. C. (2018) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2018.06.003 · Cited by 160 · see citing works

Cancer-Associated Fibroblasts Drive Glycolysis in a Targetable Signaling Loop Implicated in Head and Neck Squamous Cell Carcinoma Progression

Kumar, D., New, J., Vishwakarma, V., Joshi, R., Enders, J. D., Lin, F., Dasari, S., Gutierrez, W. R., Leef, G. C., Ponnurangam, S., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-17-1076 · Cited by 157 · see citing works

GCN2 inhibition sensitizes arginine-deprived hepatocellular carcinoma cells to senolytic treatment

Missiaen, R., Anderson, N. M., Kim, L. C., Nance, B., Burrows, M., Skuli, N., Carens, M., Riscal, R., Steensels, A., Li, F., et al. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.06.010 · Cited by 154 · see citing works

Targeting Glutathione Metabolism: Partner in Crime in Anticancer Therapy

Desideri, E., Ciccarone, F., & Ciriolo, M. R. (2019) · Nutrients · doi:10.3390/nu11081926 · Cited by 153 · see citing works

Renal Gluconeogenesis: An Underestimated Role of the Kidney in Systemic Glucose Metabolism

Legouis, D., Faivre, A., Cippà, P. E., & de Seigneux, S. (2022) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/gfaa302 · Cited by 151 · see citing works

Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma

Hirata, H., Sugimachi, K., Komatsu, H., Ueda, M., Masuda, T., Uchi, R., Sakimura, S., Nambara, S., Saito, T., Shinden, Y., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2601 · Cited by 151 · see citing works

Malic Enzyme Couples Mitochondria with Aerobic Glycolysis in Osteoblasts

Lee, W., Ji, X., Nissim, I., & Long, F. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108108 · Cited by 143 · see citing works

Antagonism of PPAR-γ signaling expands human hematopoietic stem and progenitor cells by enhancing glycolysis

Guo, B., Huang, X., Lee, M. R., Lee, S. A., & Broxmeyer, H. E. (2018) · Nature Medicine · doi:10.1038/nm.4477 · Cited by 141 · see citing works

The tumour microenvironment and metabolism in renal cell carcinoma targeted or immune therapy

Lai, Y., Tang, F., Huang, Y., He, C., Chen, C., Zhao, J., Wu, W., & He, Z. (2020) · Journal of Cellular Physiology · doi:10.1002/jcp.29969 · Cited by 139 · see citing works

Nur77 suppresses hepatocellular carcinoma via switching glucose metabolism toward gluconeogenesis through attenuating phosphoenolpyruvate carboxykinase sumoylation

Bian, X., Chen, H., Yang, P., Li, Y.-P., Zhang, F.-N., Zhang, J.-Y., Wang, W.-J., Zhao, W., Zhang, S., Chen, Q.-T., et al. (2017) · Nature Communications · doi:10.1038/ncomms14420 · Cited by 137 · see citing works

Transcriptional Response to Hypoxia: The Role of HIF-1-Associated Co-Regulators

Yfantis, A., Mylonis, I., Chachami, G., Nikolaidis, M., Amoutzias, G. D., Paraskeva, E., & Simos, G. (2023) · Cells · doi:10.3390/cells12050798 · Cited by 136 · see citing works

Biological insights through nontargeted metabolomics

Sévin, D. C., Kuehne, A., Zamboni, N., & Sauer, U. (2014) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2014.10.001 · Cited by 134 · see citing works

Fructose 2,6-Bisphosphate in Cancer Cell Metabolism

Bartrons, R., Simon‐Molas, H., Rodríguez‐García, A., Castaño, E., Navarro‐Sabaté, À., Manzano, À., & Martinez‐Outschoorn, U. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00331 · Cited by 134 · see citing works

MAGE-TRIM28 complex promotes the Warburg effect and hepatocellular carcinoma progression by targeting FBP1 for degradation

Jin, X., Pan, Y., Wang, L., Zhang, L., Ravichandran, R., Potts, P. R., Jiang, J., Wu, H., & Huang, H. (2017) · Oncogenesis · doi:10.1038/oncsis.2017.21 · Cited by 131 · see citing works

Dual Targeting of Histone Methyltransferase G9a and DNA‐Methyltransferase 1 for the Treatment of Experimental Hepatocellular Carcinoma

Bárcena‐Varela, M., Caruso, S., Llerena, S., Álvarez‐Sola, G., Uriarte, I., Latasa, M. U., Urtasun, R., Rebouissou, S., Alvarez, L., Jimenez, M., et al. (2019) · Hepatology · doi:10.1002/hep.30168 · Cited by 130 · see citing works

STAT3 as a mediator of oncogenic cellular metabolism: Pathogenic and therapeutic implications

Tošić, I., & Frank, D. A. (2021) · Neoplasia · doi:10.1016/j.neo.2021.10.003 · Cited by 130 · see citing works

Glycolysis, the sweet appetite of the tumor microenvironment

Kooshan, Z., Cárdenas-Piedra, L., Clements, J. A., & Batra, J. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.217156 · Cited by 129 · see citing works

Arginase 2 Suppresses Renal Carcinoma Progression via Biosynthetic Cofactor Pyridoxal Phosphate Depletion and Increased Polyamine Toxicity

Ochocki, J. D., Khare, S., Hess, M., Ackerman, D., Qiu, B., Daisak, J. I., Worth, A. J., Lin, N., Lee, P., Xie, H. J., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.04.009 · Cited by 127 · see citing works

ULK1/2 Constitute a Bifurcate Node Controlling Glucose Metabolic Fluxes in Addition to Autophagy

Li, T. Y., Sun, Y., Liang, Y., Liu, Q., Shi, Y., Zhang, C., Zhang, C., Song, L., Zhang, P., Zhang, X., et al. (2016) · Molecular Cell · doi:10.1016/j.molcel.2016.04.009 · Cited by 122 · see citing works

Cholesterol Auxotrophy as a Targetable Vulnerability in Clear Cell Renal Cell Carcinoma

Riscal, R., Bull, C. J., Mesaros, C., Finan, J. M., Carens, M., Ho, E. S., Xu, J. P., Godfrey, J., Brennan, P., Johansson, M., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-21-0211 · Cited by 120 · see citing works

Hypoxia signaling in cancer: Implications for therapeutic interventions

Zhuang, Y., Liu, K., He, Q., Gu, X., Jiang, C., & Wu, J. (2023) · MedComm · doi:10.1002/mco2.203 · Cited by 119 · see citing works

The thermogenic activity of adjacent adipocytes fuels the progression of ccRCC and compromises anti-tumor therapeutic efficacy

Wei, G., Sun, H., Dong, K., Hu, L., Wang, Q., Zhuang, Q., Zhu, Y., Zhang, X., Shao, Y., Tang, H., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.08.012 · Cited by 119 · see citing works

MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma

Green, N. H., Galvan, D. L., Badal, S. S., Chang, B. H., LeBleu, V. S., Long, J., Jonasch, E., & Danesh, F. R. (2019) · Oncogene · doi:10.1038/s41388-019-0869-4 · Cited by 117 · see citing works

A compendium of proteins that interact with HIF-1α

Semenza, G. L. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.03.041 · Cited by 114 · see citing works

Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

Wang, Y., Wu, C., Du, Y., Li, Z., Li, M., Hou, P., Shen, Z., Chu, S., Zheng, J., & Bai, J. (2022) · Molecular Cancer · doi:10.1186/s12943-021-01484-7 · Cited by 112 · see citing works

Organ-Specific Cancer Metabolism and Its Potential for Therapy

Elia, I., Schmieder, R., Christen, S., & Fendt, S. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_10 · Cited by 111 · see citing works

Aldolase B suppresses hepatocellular carcinogenesis by inhibiting G6PD and pentose phosphate pathways

Li, M., He, X., Guo, W., Yu, H., Zhang, S., Wang, N., Liu, G., Sa, R., Shen, X., Jiang, Y., et al. (2020) · Nature Cancer · doi:10.1038/s43018-020-0086-7 · Cited by 111 · see citing works

Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma

Li, L., Yang, L., Fan, Z., Xue, W., Shen, Z., Yuan, Y., Sun, X., Wang, D., Lian, J., Wang, L., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0152-8 · Cited by 110 · see citing works

Metabolic dysregulation in monogenic disorders and cancer — finding method in madness

Erez, A., & DeBerardinis, R. J. (2015) · Nature Reviews Cancer · doi:10.1038/nrc3949 · Cited by 105 · see citing works

Ribonucleotide Reductase Requires Subunit Switching in Hypoxia to Maintain DNA Replication

Foskolou, I. P., Jorgensen, C., Leszczyńska, K. B., Olcina, M. M., Tarhonskaya, H., Haisma, B., D’Angiolella, V., Myers, W. K., Domene, C., Flashman, E., et al. (2017) · Molecular Cell · doi:10.1016/j.molcel.2017.03.005 · Cited by 105 · see citing works

PI3K-mTORC2 but not PI3K-mTORC1 regulates transcription of HIF2A/EPAS1 and vascularization in neuroblastoma

Mohlin, S., Hamidian, A., von Stedingk, K., Bridges, E., Wigerup, C., Bexell, D., & Påhlman, S. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-0708 · Cited by 104 · see citing works

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies

Xiao, Y., & Meierhofer, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153672 · Cited by 101 · see citing works

Targeting glutamine metabolism slows soft tissue sarcoma growth

Lee, P., Malik, D. M., Perkons, N. R., Huangyang, P., Khare, S., Rhoades, S. D., Gong, Y.-Y., Burrows, M., Finan, J. M., Nissim, I., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-14374-1 · Cited by 101 · see citing works

Inhibiting histone deacetylases suppresses glucose metabolism and hepatocellular carcinoma growth by restoring FBP1 expression

Yang, H. J., Jin, X., Yan, Y., Shao, Y., Pan, Y., Roberts, L. R., Zhang, J., Huang, H., & Jiang, J. (2017) · Scientific Reports · doi:10.1038/srep43864 · Cited by 100 · see citing works

Deficiency of the X-inactivation escaping gene KDM5C in clear cell renal cell carcinoma promotes tumorigenicity by reprogramming glycogen metabolism and inhibiting ferroptosis

Zheng, Q., Li, P., Zhou, X., Qiang, Y., Fan, J., Lin, Y., Chen, Y., Guo, J., Wang, F., Xue, H., et al. (2021) · Theranostics · doi:10.7150/thno.60233 · Cited by 99 · see citing works

Flux balance analysis predicts essential genes in clear cell renal cell carcinoma metabolism

Gatto, F., Miess, H., Schulze, A., & Nielsen, J. (2015) · Scientific Reports · doi:10.1038/srep10738 · Cited by 99 · see citing works

Fructose-1,6-bisphosphatase Inhibits ERK Activation and Bypasses Gemcitabine Resistance in Pancreatic Cancer by Blocking IQGAP1–MAPK Interaction

Jin, X., Pan, Y., Wang, L., Ma, T., Zhang, L., Tang, A., Billadeau, D. D., Wu, H., & Huang, H. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3143 · Cited by 98 · see citing works

Epithelial–mesenchymal transition induces similar metabolic alterations in two independent breast cancer cell lines

Kondaveeti, Y., Reed, I. K. G., & White, B. A. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.04.025 · Cited by 97 · see citing works

Metabolic alterations in renal cell carcinoma

Massari, F., Ciccarese, C., Santoni, M., Brunelli, M., Piva, F., Modena, A., Bimbatti, D., Fantinel, E., Santini, D., Liang Cheng, C., et al. (2015) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2015.07.002 · Cited by 97 · see citing works

FBP1 is suppressed in kidney tumours

Alderton, G. K. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3810 · Cited by 18 · see citing works

Loss of Fructose-1,6-Bisphosphatase 1 Is Critical for Renal Carcinoma

(2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2014-161

FBP1 depletion feeds ccRCC

Phillips, R. (2014) · Nature Reviews Urology · doi:10.1038/nrurol.2014.200 · Cited by 12 · see citing works

AB180. The relationship between fructose-1, 6-bisphosphatase and hypoxia related genes expression in clear cell renal cell carcinoma

Ning, X., Li, T., Peng, S., Wang, J., Chen, J., & Gong, K. (2015) · PubMed Central · doi:10.3978/j.issn.2223-4683.2015.s180

MLN4924 suppresses tumor metabolism and growth of clear cell renal cell carcinoma by stabilizing nuclear FBP1

Yang, Y., Ma, Y., Fan, S., Zhu, J., Ye, B., Zhang, R., Li, J., Li, H., Zheng, Z., Li, Y., et al. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02426-8 · Cited by 7 · see citing works