Rorsman, Patrik

Activation of Ca2+-Dependent K+ Channels Contributes to Rhythmic Firing of Action Potentials in Mouse Pancreatic β Cells

Göpel, S. O., Kanno, T., Barg, S., Eliasson, L., Galvanovskis, J., Renström, E., & Rorsman, P. (1999) · The Journal of General Physiology

Pancreatic function and diabetesIon channel regulation and function

Cited by 137

Membrane Potential-Dependent Inactivation of Voltage-Gated Ion Channels in α-Cells Inhibits Glucagon Secretion From Human Islets

Ramracheya, R., Ward, C., Shigeto, M., Walker, J. N., Amisten, S., Zhang, Q., Johnson, P. R., Rorsman, P., & Braun, M. (2010) · Diabetes

Pancreatic function and diabetesIon channel regulation and function

Cited by 136

Activation by adrenaline of a low-conductance G protein-dependent K+ channel in mouse pancreatic B cells

Rorsman, P., Bokvist, K., Ämmälä, C., Arkhammar, P., Berggren, P.-O., Larsson, O., & Wåhlander, K. (1991) · Nature

Pancreatic function and diabetesIon channel regulation and function

Cited by 135

Characterisation of sulphonylurea and ATP-regulated K+ channels in rat pancreatic A-cells

Bokvist, K., Olsen, H. L., Høy, M., Gotfredsen, C. F., Holmes, W. F., Buschard, K., Rorsman, P., & Gromada, J. (1999) · Pflügers Archiv

Ion channel regulation and functionPancreatic function and diabetes

Cited by 132

Regulated Exocytosis of GABA-containing Synaptic-like Microvesicles in Pancreatic β-cells

Braun, M., Wendt, A., Birnir, B., Broman, J., Eliasson, L., Galvanovskis, J., Gromada, J., Mulder, H., & Rorsman, P. (2004) · The Journal of General Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 130

GLP-1 suppresses glucagon secretion in human pancreatic alpha-cells by inhibition of P/Q-type Ca 2+ channels

Ramracheya, R., Chapman, C., Chibalina, M., Dou, H., Miranda, C., González, A., Moritoh, Y., Shigeto, M., Zhang, Q., Braun, M., et al. (2018) · Physiological Reports

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 128

Glucagon-Like Peptide I Increases Cytoplasmic Calcium in Insulin-Secreting βTC3-Cells by Enhancement of Intracellular Calcium Mobilization

Gromada, J., Dissing, S., Bokvist, K., Renström, E., Frøkjær-Jensen, J., Wulff, B. S., & Rorsman, P. (1995) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 125

Hyperglycaemia induces metabolic dysfunction and glycogen accumulation in pancreatic β-cells

Brereton, M. F., Rohm, M., Shimomura, K., Holland, C., Tornovsky-Babeay, S., Dadon, D., Iberl, M., Chibalina, M. V., Lee, S., Glaser, B., et al. (2016) · Nature Communications

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 124

Somatostatin inhibits exocytosis in rat pancreatic α‐cells by G i2 ‐dependent activation of calcineurin and depriming of secretory granules

Gromada, J., Høy, M., Buschard, K., Salehi, A., & Rorsman, P. (2001) · The Journal of Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 120

R-type Ca2+-channel-evoked CICR regulates glucose-induced somatostatin secretion

Zhang, Q., Bengtsson, M., Partridge, C., Salehi, A., Braun, M., Cox, R., Eliasson, L., Johnson, P. R., Renström, E., Schneider, T., et al. (2007) · Nature Cell Biology

Pancreatic function and diabetesIon channel regulation and function

Cited by 110

Multisite regulation of insulin secretion by cAMP-increasing agonists: evidence that glucagon-like peptide 1 and glucagon act via distinct receptors

Gromada, J., Ding, W.-G., Barg, S., Renström, E., & Rorsman, P. (1997) · Pfl�gers Archiv European Journal of Physiology

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 110

Glucagon secretion from pancreatic α-cells

Briant, L., Salehi, A., Vergari, E., Zhang, Q., & Rorsman, P. (2016) · Upsala Journal of Medical Sciences

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 109

Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic β cells recapitulates neonatal diabetes

Girard, C. A., Wunderlich, F. T., Shimomura, K., Collins, S., Kaizik, S., Proks, P., Abdulkader, F., Clark, A., Ball, V., Zubcevic, L., et al. (2008) · Journal of Clinical Investigation

Pancreatic function and diabetesIon channel regulation and function

Cited by 105

Electrophysiology of pancreatic β-cells in intact mouse islets of Langerhans

Rorsman, P., Eliasson, L., Kanno, T., Zhang, Q., & Gopel, S. (2011) · Progress in Biophysics and Molecular Biology

Pancreatic function and diabetesIon channel regulation and function

Cited by 103

Phosphatidylinositol 4-kinase serves as a metabolic sensor and regulates priming of secretory granules in pancreatic β cells

Olsen, H. L., Høy, M., Zhang, W., Bertorello, A. M., Bokvist, K., Capito, K., Efanov, A. M., Meister, B., Thams, P., Yang, S.-N., et al. (2003) · Proceedings of the National Academy of Sciences

Pancreatic function and diabetesCellular transport and secretion

Cited by 101

Corelease and Differential Exit via the Fusion Pore of GABA, Serotonin, and ATP from LDCV in Rat Pancreatic β Cells

Braun, M., Wendt, A., Karanauskaite, J., Galvanovskis, J., Clark, A., MacDonald, P. E., & Rorsman, P. (2007) · The Journal of General Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 100

Synaptotagmin‐7 is a principal Ca2+ sensor for Ca2+‐induced glucagon exocytosis in pancreas

Gustavsson, N., Wei, S., Hoang, D. N., Lao, Y., Zhang, Q., Radda, G. K., Rorsman, P., Südhof, T. C., & Han, W. (2009) · The Journal of Physiology

Cellular transport and secretionPancreatic function and diabetes

Cited by 100

CaM kinase II‐dependent mobilization of secretory granules underlies acetylcholine‐induced stimulation of exocytosis in mouse pancreatic B‐cells

Gromada, J., Høy, M., Renström, E., Bokvist, K., Eliasson, L., Göpel, S., & Rorsman, P. (1999) · The Journal of Physiology

Pancreatic function and diabetesCellular transport and secretion

Cited by 98

Voltage-activated currents in guinea pig pancreatic alpha 2 cells. Evidence for Ca2+-dependent action potentials.

Rorsman, P., & Hellman, B. (1988) · The Journal of general physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 97

Block of ATP‐regulated and Ca2(+)‐activated K+ channels in mouse pancreatic beta‐cells by external tetraethylammonium and quinine.

Bokvist, K., Rorsman, P., & Smith, P. A. (1990) · The Journal of Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 96

Na+ current properties in islet α‐ and β‐cells reflect cell‐specific Scn3a and Scn9a expression

Zhang, Q., Chibalina, M. V., Bengtsson, M., Groschner, L. N., Ramracheya, R., Rorsman, N. J. G., Leiss, V., Nassar, M. A., Welling, A., Gribble, F. M., et al. (2014) · The Journal of Physiology

Ion channel regulation and functionPancreatic function and diabetes

Cited by 90

Glucose‐dependent regulation of rhythmic action potential firing in pancreatic β‐cells by kATP‐channel modulation

Kanno, T., Rorsman, P., & Göpel, S. O. (2002) · The Journal of Physiology

Pancreatic function and diabetesIon channel regulation and function

Cited by 89

Palmitate increases L‐type Ca2+ currents and the size of the readily releasable granule pool in mouse pancreatic β‐cells

Olofsson, C. S., Salehi, A., Holm, C., & Rorsman, P. (2004) · The Journal of Physiology

Pancreatic function and diabetesIon channel regulation and function

Cited by 88

Long-Term Exposure to Glucose and Lipids Inhibits Glucose-Induced Insulin Secretion Downstream of Granule Fusion With Plasma Membrane

Olofsson, C. S., Collins, S., Bengtsson, M., Eliasson, L., Salehi, A., Shimomura, K., Tarasov, A., Holm, C., Ashcroft, F., & Rorsman, P. (2007) · Diabetes

Pancreatic function and diabetesDiabetes Treatment and Management

Cited by 87