Takayama, Hiroaki

A liver-derived secretory protein, selenoprotein P, causes insulin resistance

Misu, H., Takamura, T., Takayama, H., Hayashi, H., Matsuzawa-Nagata, N., Kurita, S., Ishikura, K., Ando, H., Takeshita, Y., Ota, T., et al. (2010) · Cell Metabolism

Adipokines, Inflammation, and Metabolic DiseasesSelenium in Biological Systems

Cited by 583

Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.

Nakamura, S., Takamura, T., Matsuzawa-Nagata, N., Takayama, H., Misu, H., Noda, H., Nabemoto, S., Kurita, S., Ota, T., Ando, H., et al. (2009) · Journal of Biological Chemistry

Liver Disease Diagnosis and TreatmentMetabolism, Diabetes, and Cancer

Cited by 426

LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance

Lan, F., Misu, H., Chikamoto, K., Takayama, H., Kikuchi, A., Mohri, K., Takata, N., Hayashi, H., Matsuzawa-Nagata, N., Takeshita, Y., et al. (2014) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 158

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

Misu, H., Takayama, H., Saito, Y., Mita, Y., Kikuchi, A., Ishii, K.-A., Chikamoto, K., Kanamori, T., Tajima, N., Lan, F., et al. (2017) · Nature Medicine

Exercise and Physiological ResponsesSelenium in Biological Systems

Cited by 156

The influence of adiposity and acute exercise on circulating hepatokines in normal-weight and overweight/obese men

Sargeant, J. A., Aithal, G. P., Takamura, T., Misu, H., Takayama, H., Douglas, J. A., Turner, M. C., Stensel, D. J., Nimmo, M. A., Webb, D. R., et al. (2018) · Applied Physiology, Nutrition, and Metabolism

Adipokines, Inflammation, and Metabolic DiseasesFibroblast Growth Factor Research

Cited by 56

Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice

Chikamoto, K., Misu, H., Takayama, H., Kikuchi, A., Ishii, K.-A., Lan, F., Takata, N., Tajima-Shirasaki, N., Takeshita, Y., Tsugane, H., et al. (2016) · Biochemical and Biophysical Research Communications

Adipokines, Inflammation, and Metabolic DiseasesLiver Disease Diagnosis and Treatment

Cited by 37

Acute hyperenergetic, high-fat feeding increases circulating FGF21, LECT2, and fetuin-A in healthy men

Willis, S. A., Sargeant, J. A., Yates, T., Takamura, T., Takayama, H., Gupta, V., Brittain, E., Crawford, J., Parry, S. A., Thackray, A. E., et al. (2020) · The Journal of Nutrition

Fibroblast Growth Factor ResearchAdipokines, Inflammation, and Metabolic Diseases

Cited by 34

Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases

Abuduwaili, H., Kamoshita, K., Ishii, K.-A., Takahashi, K., Abuduyimiti, T., Qifang, L., Isobe, Y., Goto, H., Nakano, Y., Takeshita, Y., et al. (2023) · American Journal of Physiology-Endocrinology and Metabolism

Muscle Physiology and DisordersNutrition and Health in Aging

Cited by 7