Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.

Biochemistry and molecular cell biology of diabetic complications

Brownlee, M. (2001) · Nature · doi:10.1038/414813a · Cited by 9,107 · see citing works

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works

Insulin signalling and the regulation of glucose and lipid metabolism

Saltiel, A. R., & Kahn, C. R. (2001) · Nature · doi:10.1038/414799a · Cited by 5,326 · see citing works

Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage

Nishikawa, T., Edelstein, D., Du, X. L., Yamagishi, S.-I., Matsumura, T., Kaneda, Y., Yorek, M. A., Beebe, D., Oates, P. J., Hammes, H.-P., et al. (2000) · Nature · doi:10.1038/35008121 · Cited by 4,277 · see citing works

Signal transduction by the JNK group of MAP kinases

Davis, R. J. (2000) · Cell · doi:10.1016/s0092-8674(00)00116-1 · Cited by 4,237 · see citing works

Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Özcan, U., Cao, Q., Yilmaz, E., Lee, A.-H., Iwakoshi, N. N., Özdelen, E., Tuncman, G., Görgün, C., Glimcher, L. H., & Hotamisligil, G. S. (2004) · Science · doi:10.1126/science.1103160 · Cited by 3,844 · see citing works

A central role for JNK in obesity and insulin resistance

Hirosumi, J., Tuncman, G., Chang, L., Görgün, C. Z., Uysal, K. T., Maeda, K., Karin, M., & Hotamisligil, G. S. (2002) · Nature · doi:10.1038/nature01137 · Cited by 3,359 · see citing works

SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase

Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.251194298 · Cited by 2,558 · see citing works

Reactive oxygen species have a causal role in multiple forms of insulin resistance

Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works

Oxidative Stress and Stress-Activated Signaling Pathways: A Unifying Hypothesis of Type 2 Diabetes

Evans, J. L., Goldfine, I. D., Maddux, B. A., & Grodsky, G. M. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0039 · Cited by 2,232 · see citing works

Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM

Boden, G. (1997) · Diabetes · doi:10.2337/diab.46.1.3 · Cited by 1,728 · see citing works

The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307

Aguirre, V., Uchida, T., Yenush, L., Davis, R., & White, M. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.12.9047 · Cited by 1,487 · see citing works

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

Cao, H.-M., Gerhold, K., Mayers, J. R., Wiest, M., Watkins, S., & Hotamışlıgil, G. S. (2008) · Cell · doi:10.1016/j.cell.2008.07.048 · Cited by 1,142 · see citing works

Transcriptional and Translational Control in the Mammalian Unfolded Protein Response

Harding, H. P., Calfon, M. A., Urano, F., Novoa, I., & Ron, D. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.011402.160624 · Cited by 918 · see citing works

TRB3: A <i>tribbles</i> Homolog That Inhibits Akt/PKB Activation by Insulin in Liver

Du, K., Herzig, S., Kulkarni, R. N., & Montminy, M. (2003) · Science · doi:10.1126/science.1079817 · Cited by 842 · see citing works

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

Kim, J. K., Fillmore, J. J., Chen, Y., Yu, C., Moore, I. K., Pypaert, M., Lutz, E. P., Kako, Y., Velez-Carrasco, W., Goldberg, I. J., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121164498 · Cited by 753 · see citing works

A role for ceramide, but not diacylglycerol, in the antagonism of insulin signal transduction by saturated fatty acids

Chavez, J. A., Knotts, T. A., Wang, L.-P., Li, G., Dobrowsky, R. T., Florant, G. L., & Summers, S. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212307200 · Cited by 617 · see citing works

Ceramide Generation Is Sufficient to Account for the Inhibition of the Insulin-stimulated PKB Pathway in C2C12 Skeletal Muscle Cells Pretreated with Palmitate

Schmitz-Peiffer, C., Craig, D. L., & Biden, T. J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.34.24202 · Cited by 592 · see citing works

Chronic Palmitate But Not Oleate Exposure Induces Endoplasmic Reticulum Stress, Which May Contribute to INS-1 Pancreatic β-Cell Apoptosis

Karaskov, E., Scott, C. C., Zhang, L., Teodoro, T., Ravazzola, M., & Volchuk, A. (2006) · Endocrinology · doi:10.1210/en.2005-1494 · Cited by 573 · see citing works

Increased oxidative stress precedes the onset of high-fat diet–induced insulin resistance and obesity

Nagata, N., Takamura, T., Ando, H., Nakamura, S., Kurita, S., Misu, H., Ota, T., Yokoyama, M., Honda, M., Miyamoto, K., et al. (2008) · Metabolism · doi:10.1016/j.metabol.2008.03.010 · Cited by 537 · see citing works

Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver

Boden, G., She, P., Mozzoli, M., Cheung, P., Gumireddy, K., Reddy, P., Xiang, X., Luo, Z., & Ruderman, N. (2005) · Diabetes · doi:10.2337/diabetes.54.12.3458 · Cited by 528 · see citing works

Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet

Matsuzawa, N., Takamura, T., Kurita, S., Misu, H., Ota, T., Ando, H., Yokoyama, M., Honda, M., Zen, Y., Nakanuma, Y., et al. (2007) · Hepatology · doi:10.1002/hep.21874 · Cited by 516 · see citing works

Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes

Chavez, J. A., & Summers, S. A. (2003) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2003.08.020 · Cited by 498 · see citing works

Involvement of Endoplasmic Reticulum Stress in Insulin Resistance and Diabetes

Nakatani, Y., Kaneto, H., Kawamori, D., Yoshiuchi, K., Hatazaki, M., Matsuoka, T., Ozawa, K., Ogawa, S., Hori, M., Yamasaki, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411860200 · Cited by 462 · see citing works

JNK and Tumor Necrosis Factor-α Mediate Free Fatty Acid-induced Insulin Resistance in 3T3-L1 Adipocytes

Nguyen, M. T. A., Satoh, H., Favelyukis, S., Babendure, J. L., Imamura, T., Sbodio, J. I., Zalevsky, J., Dahiyat, B. I., Chi, N.-W., & Olefsky, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504611200 · Cited by 411 · see citing works

SREBPs suppress IRS-2-mediated insulin signalling in the liver

Ide, T., Shimano, H., Yahagi, N., Matsuzaka, T., Nakakuki, M., Yamamoto, T., Nakagawa, Y., Takahashi, A., Suzuki, H., Sone, H., et al. (2004) · Nature Cell Biology · doi:10.1038/ncb1111 · Cited by 321 · see citing works

Saturated fatty acids inhibit induction of insulin gene transcription by JNK-mediated phosphorylation of insulin-receptor substrates

Solinas, G., Naugler, W., Galimi, F., Lee, M.-S., & Karin, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0607626103 · Cited by 284 · see citing works

Metabolic aspects of peroxisomal β-oxidation

Osmundsen, H., Bremer, J., & Pedersen, J. I. (1991) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(91)90089-z · Cited by 281 · see citing works

1,2-Diacylglycerol and ceramide levels in insulin-resistant tissues of the rat in vivo.

Turinsky, J., O'Sullivan, D. M., & Bayly, B. P. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)44844-7 · Cited by 269 · see citing works

Intracellular ceramide synthesis and protein kinase Cζ activation play an essential role in palmitate-induced insulin resistance in rat L6 skeletal muscle cells

POWELL, D. J., TURBAN, S., GRAY, A., HAJDUCH, E., & HUNDAL, H. S. (2004) · Biochemical Journal · doi:10.1042/bj20040139 · Cited by 267 · see citing works

Sodium Palmitate Induces Partial Mitochondrial Uncoupling and Reactive Oxygen Species in Rat Pancreatic Isletsin Vitro1

Carlsson, C., Borg, L., & Welsh, N. (1999) · Endocrinology · doi:10.1210/endo.140.8.6908 · Cited by 238 · see citing works

Modulation of the JNK Pathway in Liver Affects Insulin Resistance Status

Nakatani, Y., Kaneto, H., Kawamori, D., Hatazaki, M., Miyatsuka, T., Matsuoka, T., Kajimoto, Y., Matsuhisa, M., Yamasaki, Y., & Hori, M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406963200 · Cited by 230 · see citing works

Insulin Resistance Accelerates a Dietary Rat Model of Nonalcoholic Steatohepatitis

Ota, T., Takamura, T., Kurita, S., Matsuzawa, N., Kita, Y., Uno, M., Akahori, H., Misu, H., Sakurai, M., Zen, Y., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.10.014 · Cited by 227 · see citing works

Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes

Miller, T. A., LeBrasseur, N. K., Cote, G. M., Trucillo, M. P., Pimentel, D. R., Ido, Y., Ruderman, N. B., & Sawyer, D. B. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.08.088 · Cited by 146 · see citing works

NADPH Oxidase in the Liver: Defensive, Offensive, or Fibrogenic?

Minicis, S. D., Bataller, R. A., & Brenner, D. A. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.048 · Cited by 121 · see citing works

Glutamate Regulates Kainate-binding Protein Expression in Cultured Chick Bergmann Glia through an Activator Protein-1 Binding Site

Aguirre, A. A., López, T., López‐Bayghen, E., & Ortega, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002847200 · Cited by 61 · see citing works

Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease

Sakurai, M., Takamura, T., Ota, T., Ando, H., Akahori, H., Kaji, K., Sasaki, M., Nakanuma, Y., Miura, K., & Kaneko, S. (2007) · Journal of Gastroenterology · doi:10.1007/s00535-006-1948- · Cited by 52 · see citing works

Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes

Kaneto, H., Kawamori, D., Nakatani, Y., Gorogawa, S.-I., & Matsuoka, T. (2004) · Drug News & Perspectives · doi:10.1358/dnp.2004.17.7.863704 · Cited by 36 · see citing works

It's what you do with the fat that matters!

Bruce, C. R., & Febbraio, M. A. (2007) · Nature Medicine · doi:10.1038/nm1007-1137 · Cited by 9 · see citing works

Role of oxidative stress in the pathogenesis of nonalcoholic steatohepatitis

Rolo, A. P., Teodoro, J. S., & Palmeira, C. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.10.003 · Cited by 955 · see citing works

The role of mitochondria in the pathogenesis of type 2 diabetes

Patti, M.-E., & Corvera, S. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0027 · Cited by 551 · see citing works

Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver

Satapati, S., Sunny, N. E., Kucejova, B., Fu, X., He, T. T., Méndez-Lucas, A., Shelton, J. M., Perales, J. C., Browning, J. D., & Burgess, S. C. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m023382 · Cited by 407 · see citing works

Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Ly, L. D., Xu, S., Choi, S.-K., Ha, C.-M., Thoudam, T., Cha, S.-K., Wiederkehr, A., Wollheim, C. B., Lee, I.-K., & Park, K.-S. (2017) · Experimental &amp; Molecular Medicine · doi:10.1038/emm.2016.157 · Cited by 378 · see citing works

Mitochondrial dysfunction in aging: Much progress but many unresolved questions

Payne, B. A. I., & Chinnery, P. F. (2015) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2015.05.022 · Cited by 335 · see citing works

Linking mitochondrial bioenergetics to insulin resistance via redox biology

Fisher-Wellman, K. H., & Neufer, P. D. (2012) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2011.12.008 · Cited by 316 · see citing works

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

Yuzefovych, L., Wilson, G., & Rachek, L. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00238.2010 · Cited by 280 · see citing works

SIRT3 regulates progression and development of diseases of aging

McDonnell, E., Peterson, B. S., Bomze, H. M., & Hirschey, M. D. (2015) · Trends in Endocrinology &amp; Metabolism · doi:10.1016/j.tem.2015.06.001 · Cited by 217 · see citing works

Cell Culture Models of Fatty Acid Overload: Problems and Solutions

Alsabeeh, N., Chausse, B., Kakimoto, P. A., Kowaltowski, A. J., & Shirihai, O. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2017.11.006 · Cited by 167 · see citing works

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α

Melo, H. M., Seixas da Silva, G. D. S., Sant’Ana, M. R., Teixeira, C. V. L., Clarke, J. R., Miya Coreixas, V. S., de Melo, B. C., Fortuna, J. T. S., Forny-Germano, L., Ledo, J. H., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.072 · Cited by 140 · see citing works

Augmentation of Glucotoxicity, Oxidative Stress, Apoptosis and Mitochondrial Dysfunction in HepG2 Cells by Palmitic Acid

Alnahdi, A., John, A., & Raza, H. (2019) · Nutrients · doi:10.3390/nu11091979 · Cited by 134 · see citing works

Fatty Acids - Induced Lipotoxicity and Inflammation

Savary, S., Trompier, D., Andreoletti, P., Le Borgne, F., Demarquoy, J., & Lizard, G. (2012) · Current Drug Metabolism · doi:10.2174/138920012803762729 · Cited by 111 · see citing works

Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: The roles of long chain fatty acids

Hafizi Abu Bakar, M., Kian Kai, C., Wan Hassan, W. N., Sarmidi, M. R., Yaakob, H., & Zaman Huri, H. (2015) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2601 · Cited by 91 · see citing works

Mitochondrial Inhibitor as a New Class of Insulin Sensitizer

Zhang, Y., & Ye, J. (2012) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2012.06.010 · Cited by 47 · see citing works

Mitochondrial metabolism of reactive oxygen species

Andreyev, A. Y., Kushnareva, Y. E., & Starkov, A. A. (2005) · Biochemistry (Moscow) · doi:10.1007/s10541-005-0102-7 · Cited by 1,336 · see citing works

Reactive Oxygen Species and Oxidative Stress in Obesity—Recent Findings and Empirical Approaches

McMurray, F., Patten, D. A., & Harper, M. (2016) · Obesity · doi:10.1002/oby.21654 · Cited by 245 · see citing works

The role of mitochondria in reactive oxygen species metabolism and signaling

Starkov, A. A. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1427.015 · Cited by 846 · see citing works

Mitochondrial ROS and ageing

Sanz, A. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.04.059 · Cited by 10 · see citing works

Gold-induced reactive oxygen species (ROS) do not mediate suppression of monocytic mitochondrial or secretory function

Omata, Y., Lewis, J. B., Lockwood, P. E., Tseng, W., Messer, R. L. W., Bouillaguet, S., & Wataha, J. C. (2005) · Toxicology in Vitro · doi:10.1016/j.tiv.2005.11.001 · Cited by 14 · see citing works