Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice
Open accessAbstract
Dieting often leads to body weight cycling involving repeated weight loss and regain. However, little information is available regarding rapid-response serum markers of overnutrition that predict body weight alterations during weight cycling. Here, we report the rapid response of serum leukocyte cell-derived chemotaxin 2 (LECT2), a hepatokine that induces insulin resistance in skeletal muscle, during diet-induced weight cycling in mice. A switch from a high-fat diet (HFD) to a regular diet (RD) in obese mice gradually decreased body weight but rapidly decreased serum LECT2 levels within 10 days. In contrast, a switch from a RD to a HFD rapidly elevated serum LECT2 levels. Serum LECT2 levels showed a positive correlation with liver triglyceride contents but not with adipose tissue weight. This study demonstrates the rapid response of LECT2 preceding body weight alterations during weight cycling in mice and suggests that measurement of serum LECT2 may be clinically useful in the management of obesity.
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Self-citation
- Authors
- Chikamoto, K., Misu, H., Takayama, H., Kikuchi, A., Ishii, K.-A., Lan, F., Takata, N., Tajima-Shirasaki, N., Takeshita, Y., Tsugane, H., Kaneko, S., Matsugo, S., & Takamura, T.
- Affiliations
- Kanazawa University (JP)
- Corresponding author
- Misu, Hirofumi
- Takamura, Toshinari
- ORCID
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 2016-09
- Volume
- 478
- Issue
- 3
- Pages
- 1310-1316
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2508544196
- Cited by
- 37
- References
- 31
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 6 · 2022: 7 · 2021: 5 · 2020: 5 · 2019: 2 · 2018: 1 · 2017: 3
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- JSPS KAKENHI (25461334)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- LECT2, hepatokines, high-fat diet, obesity, hepatic steatosis, serum biomarkers, insulin resistance, skeletal muscle, hepatic triglycerides, overnutrition
- MeSH terms
- Adipose Tissue, Animals, Body Weight, Disease Models, Animal, Fatty Liver, Insulin, Liver, Male, Mice, Inbred C57BL, Organ Size, Biomarkers, Intercellular Signaling Peptides and Proteins, Overnutrition, Adiposity, Diet, High-Fat
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