Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases
Abstract
Selenoprotein P (SeP) is a hepatokine that is upregulated in type 2 diabetes and aging and causes signal resistances via reductive stress. Immobilization (IMM) significantly reduced skeletal muscle mass in mice, which was prevented in SeP knockout (KO) mice. IMM-induced Foxos/KLF15-atrogene upregulation was suppressed in the skeletal muscle of KO mice. These findings suggest that SeP-mediated reductive stress is involved in and may be a therapeutic target for physical inactivity-mediated muscle atrophy.
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SeP is a hepatokine upregulated in aging that causes signaling resistance via reductive stress, which is involved in physical inactivity-mediated muscle atrophy.
“Of new note, SeP is identified as a hepatokine upregulated in aging, and it causes signaling resistance via reductive stress, which is involved in physical inactivity-mediated muscle atrophy [126].”
From Exerkines and Sarcopenia: Unveiling the Mechanism Behind Exercise-Induced Mitochondrial Homeostasis (2025) · cites this paper as [126]
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- Authors
- Abuduwaili, H., Kamoshita, K., Ishii, K.-A., Takahashi, K., Abuduyimiti, T., Qifang, L., Isobe, Y., Goto, H., Nakano, Y., Takeshita, Y., Takayama, H., Harada, K., & Takamura, T.
- Affiliations
- Kanazawa University (JP)
- Department of Endocrinology and Metabolism, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan
- Corresponding author
- Takamura, Toshinari
- ORCID
- Venue
- American Journal of Physiology-Endocrinology and Metabolism
- Publisher
- American Physiological Society
- Published
- 2023-06-01
- Volume
- 324
- Issue
- 6
- Pages
- E542-E552
- ISSN
- 0193-1849 (ISSN-L)
- 1522-1555
- OpenAlex
- W4353045914
- Cited by
- 7
- References
- 58
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 2
- FWCI
- 0.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Endocrinology and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Culture, Sports, Science and Technology (17H04199, 18K19560)
- Takeda Science Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Nursing › Nutrition and Dietetics › Selenium in Biological Systems
- Keywords
- selenoprotein P, skeletal muscle atrophy, immobilization, E3 ubiquitin ligase, reductive stress, FOXO, KLF15, hepatokines, physical inactivity, type 2 diabetes, aging
- MeSH terms
- Tripartite Motif Proteins, Animals, Diabetes Mellitus, Type 2, Muscular Atrophy, Muscle, Skeletal, Ubiquitin-Protein Ligases, Selenoprotein P, Mice, Sarcopenia
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