Wang, Xin

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

He, W.-T., Wan, H., Hu, L., Chen, P., Wang, X., Huang, Z., Yang, Z.-H., Zhong, C.-Q., & Han, J. (2015) · Cell Research

Inflammasome and immune disordersImmune Response and Inflammation

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Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

Chen, X., He, W.-T., Hu, L., Li, J., Fang, Y., Wang, X., Xu, X., Wang, Z., Huang, K., & Han, J. (2016) · Cell Research

Inflammasome and immune disordersCell death mechanisms and regulation

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TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway

Zheng, H., Jia, L., Liu, C.-C., Rong, Z., Zhong, L., Yang, L., Chen, X.-F., Fryer, J. D., Wang, X., Zhang, Y.-W., et al. (2017) · The Journal of Neuroscience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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DSCAM/PAK1 pathway suppression reverses neurogenesis deficits in iPSC-derived cerebral organoids from patients with Down syndrome

Tang, X.-Y., Xu, L., Wang, J., Hong, Y., Wang, Y., Zhu, Q., Wang, D., Zhang, X.-Y., Liu, C.-Y., Fang, K.-H., et al. (2021) · Journal of Clinical Investigation

Down syndrome and intellectual disability researchNeurogenesis and neuroplasticity mechanisms

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Appoptosin-Mediated Caspase Cleavage of Tau Contributes to Progressive Supranuclear Palsy Pathogenesis

Zhao, Y., Tseng, I.-C., Heyser, C. J., Rockenstein, E., Mante, M., Adame, A., Zheng, Q., Huang, T., Wang, X., Arslan, P. E., et al. (2015) · Neuron

Alzheimer's disease research and treatmentsParkinson's Disease Mechanisms and Treatments

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Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Zheng, Q., Li, G., Wang, S., Zhou, Y., Liu, K., Gao, Y., Zhou, Y., Zheng, L., Zhu, L., Deng, Q., et al. (2021) · Science Advances

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis

Zhang, S., Gao, Y., Zhao, Y., Huang, T. Y., Zheng, Q., & Wang, X. (2025) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity

Wang, X., Huang, T., Zhao, Y., Zheng, Q., Thompson, R. C., Bu, G., Zhang, Y.-W., Hong, W., & Xu, H. (2014) · Cell Reports

Alzheimer's disease research and treatmentsCellular transport and secretion

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β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function

Gao, Y., Hong, Y., Huang, L., Zheng, S., Zhang, H., Wang, S., Yao, Y., Zhao, Y., Zhu, L., Xu, Q., et al. (2023) · Cell

Neuroscience and Neuropharmacology ResearchDown syndrome and intellectual disability research

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SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

Huang, T. Y., Zhao, Y., Li, X., Wang, X., Tseng, I.-C., Thompson, R., Tu, S., Willnow, T. E., Zhang, Y.-W., & Xu, H. (2016) · The Journal of Neuroscience

Alzheimer's disease research and treatmentsCellular transport and secretion

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Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing

Zhao, Y., Wang, Y., Yang, J., Wang, X., Zhao, Y., Zhang, X., & Zhang, Y.-W. (2012) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsCellular transport and secretion

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Gut-brain axis in the pathogenesis of sepsis-associated encephalopathy

Wang, X., Wen, X., Yuan, S., & Zhang, J. (2024) · Neurobiology of Disease

Sepsis Diagnosis and TreatmentIntensive Care Unit Cognitive Disorders

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Interdependence of neural network dysfunction and microglial alterations in Alzheimer’s disease-related models

Das, M., Mao, W., Shao, E., Tamhankar, S., Yu, G.-Q., Yu, X., Ho, K., Wang, X., Wang, J., & Mucke, L. (2021) · iScience

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Chronic stress induces depression-like behaviors and Parkinsonism via upregulating α-synuclein

Xia, D., Xiong, M., Yang, Y., Wang, X., Chen, Q., Li, S., Meng, L., & Zhang, Z. (2025) · npj Parkinson's Disease

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

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