SNX27 and SORLA Interact to Reduce Amyloidogenic Subcellular Distribution and Processing of Amyloid Precursor Protein

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease

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Amyloid Precursor Protein Trafficking, Processing, and Function

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APP processing in Alzheimer’s disease.

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Oligomeric amyloid β associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques

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Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations.

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Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein

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Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

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A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

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SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors

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Model‐guided microarray implicates the retromer complex in Alzheimer's disease

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Endosomal sorting and signalling: an emerging role for sorting nexins

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Endosome function and dysfunction in Alzheimer's disease and other neurodegenerative diseases

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Sorting nexins provide diversity for retromer-dependent trafficking events

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Loss of apolipoprotein E receptor LR11 in Alzheimer disease

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High frequency of potentially pathogenic SORL1 mutations in autosomal dominant early-onset Alzheimer disease

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Generation of Alzheimer β-amyloid protein in the trans-Golgi network in the apparent absence of vesicle formation

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The Lipoprotein Receptor LR11 Regulates Amyloid β Production and Amyloid Precursor Protein Traffic in Endosomal Compartments

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VPS35 haploinsufficiency increases Alzheimer’s disease neuropathology

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SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane

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Retromer Binds the FANSHY Sorting Motif in SorLA to Regulate Amyloid Precursor Protein Sorting and Processing

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Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Aβ accumulation

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Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome

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Pharmacological chaperones stabilize retromer to limit APP processing

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Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system

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Interaction of the Cytosolic Domains of sorLA/LR11 with the Amyloid Precursor Protein (APP) and β-Secretase β-Site APP-Cleaving Enzyme

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Lysosomal Sorting of Amyloid-β by the SORLA Receptor Is Impaired by a Familial Alzheimer’s Disease Mutation

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A unique sorting nexin regulates trafficking of potassium channels via a PDZ domain interaction

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Trafficking regulation of proteins in Alzheimer’s disease

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Nicastrin Is Critical for Stability and Trafficking but Not Association of Other Presenilin/γ-Secretase Components

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Dysregulation of protein trafficking in neurodegeneration

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Sortilin-related Receptor with A-type Repeats (SORLA) Affects the Amyloid Precursor Protein-dependent Stimulation of ERK Signaling and Adult Neurogenesis

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Induced Dimerization of the Amyloid Precursor Protein Leads to Decreased Amyloid-β Protein Production

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Sorting Nexin 27 regulates basal and activity-dependent trafficking of AMPARs

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Sorting Nexin 27 Regulates Aβ Production through Modulating γ-Secretase Activity

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Quantitative modelling of amyloidogenic processing and its influence by SORLA in Alzheimer's disease

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GGA1-mediated endocytic traffic of LR11/SorLA alters APP intracellular distribution and amyloid-β production

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A novel Rac1 GAP splice variant relays poly-Ub accumulation signals to mediate Rac1 inactivation

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Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

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GPCR Signaling and Trafficking: The Long and Short of It

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The Alzheimer’s gene SORL1 is a regulator of endosomal traffic and recycling in human neurons

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The Retromer Complex: From Genesis to Revelations

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Endosomal sorting and trafficking, the retromer complex and neurodegeneration

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A pharmacological chaperone improves memory by reducing Aβ and tau neuropathology in a mouse model with plaques and tangles

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The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases

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Endo-lysosomal pathway and ubiquitin-proteasome system dysfunction in Alzheimer's disease pathogenesis

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Trafficking in Alzheimer’s Disease: Modulation of APP Transport and Processing by the Transmembrane Proteins LRP1, SorLA, SorCS1c, Sortilin, and Calsyntenin

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The physical approximation of APP and BACE‐1: A key event in alzheimer's disease pathogenesis

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Multi-omic comparison of Alzheimer’s variants in human ESC–derived microglia reveals convergence at APOE

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Dysregulation of Rab5-Mediated Endocytic Pathways in Alzheimer’s Disease

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Sorting receptor SORLA: cellular mechanisms and implications for disease

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The emerging role of retromer in neuroprotection

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Human myeloperoxidase (hMPO) is expressed in neurons in the substantia nigra in Parkinson's disease and in the hMPO-α-synuclein-A53T mouse model, correlating with increased nitration and aggregation of α-synuclein and exacerbation of motor impairment

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VPS10P Domain Receptors: Sorting Out Brain Health and Disease

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Assembly and fission of tubular carriers mediating protein sorting in endosomes

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SORLA attenuates EphA4 signaling and amyloid β–induced neurodegeneration

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Toward Understanding the Molecular Role of SNX27/Retromer in Human Health and Disease

Chandra, M., Kendall, A. K., & Jackson, L. P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.642378 · Cited by 49 · see citing works

Brothers in Arms: ProBDNF/BDNF and sAPPα/Aβ-Signaling and Their Common Interplay with ADAM10, TrkB, p75NTR, Sortilin, and sorLA in the Progression of Alzheimer’s Disease

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Sorting Out the Role of the Sortilin-Related Receptor 1 in Alzheimer’s Disease

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Sorting Out Sorting Nexins Functions in the Nervous System in Health and Disease

Vieira, N., Rito, T., Correia‐Neves, M., & Sousa, N. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02388-9 · Cited by 37 · see citing works

Impaired SorLA maturation and trafficking as a new mechanism for SORL1 missense variants in Alzheimer disease

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Finding memo: versatile interactions of the VPS10p-Domain receptors in Alzheimer’s disease

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Dimerization of the Alzheimer’s disease pathogenic receptor SORLA regulates its association with retromer

Jensen, A. M. G., Kitago, Y., Fazeli, E., Vægter, C. B., Small, S. A., Petsko, G. A., & Andersen, O. M. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2212180120 · Cited by 33 · see citing works

Soluble SORLA Enhances Neurite Outgrowth and Regeneration through Activation of the EGF Receptor/ERK Signaling Axis

Stupack, J., Xiong, X.-P., Jiang, L.-L., Zhang, T., Zhou, L., Campos, A. R., Ranscht, B., Mobley, W. C., Pasquale, E. B., Xu, H., et al. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.0723-20.2020 · Cited by 32 · see citing works

The retromer complex system in a transgenic mouse model of AD: influence of age

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SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate

Zhang, H., Hong, Y., Yang, W., Wang, R., Yao, T., Wang, J., Liu, K., Yuan, H., Xu, C., Zhou, Y., et al. (2021) · National Science Review · doi:10.1093/nsr/nwab024 · Cited by 26 · see citing works

Regulation of beta‐amyloid for the treatment of Alzheimer's disease: Research progress of therapeutic strategies and bioactive compounds

Qiu, W., Liu, H., Liu, Y., Lü, X., Wang, L., Hu, Y., Feng, F., Li, Q., & Sun, H. (2023) · Medicinal Research Reviews · doi:10.1002/med.21947 · Cited by 20 · see citing works

Enhancing α-secretase Processing for Alzheimer’s Disease—A View on SFRP1

Tang, B. L. (2020) · Brain Sciences · doi:10.3390/brainsci10020122 · Cited by 20 · see citing works

Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer’s disease

Wang, X., Xie, Y., Fan, X., Wu, X., Wang, D., & Li, Z. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01489-6 · Cited by 22 · see citing works

Melanocortin receptor activation alleviates amyloid pathology and glial reactivity in an Alzheimer’s disease transgenic mouse model

Lau, J. K. Y., Tian, M., Shen, Y., Lau, S., Fu, W., Fu, A. K. Y., & Ip, N. Y. (2021) · Scientific Reports · doi:10.1038/s41598-021-83932-4 · Cited by 19 · see citing works

High glucose‐mediated VPS26a down‐regulation dysregulates neuronal amyloid precursor protein processing and tau phosphorylation

Chae, C. W., Choi, G. E., Jung, Y. H., Lim, J. R., Cho, J. H., Yoon, J. H., & Han, H. J. (2022) · British Journal of Pharmacology · doi:10.1111/bph.15836 · Cited by 17 · see citing works

Amyloidogenesis and Neurotrophic Dysfunction in Alzheimer’s Disease: Do They have a Common Regulating Pathway?

Jiao, F., Jiang, D., Li, Y., Mei, J., Wang, Q., & Li, X. (2022) · Cells · doi:10.3390/cells11203201 · Cited by 16 · see citing works

Endosomal Sorting Protein SNX27 and Its Emerging Roles in Human Cancers

Deb, S., & Sun, J. (2022) · Cancers · doi:10.3390/cancers15010070 · Cited by 12 · see citing works

Alzheimer's Disease Risk Gene SORL1 Promotes Receptiveness of Human Microglia to Pro‐Inflammatory Stimuli

Ovesen, P. L., Juul‐Madsen, K., Telugu, N. S., Schmidt, V., Frahm, S., Radbruch, H., Louth, E. L., Korshoej, A. R., Heppner, F. L., Diecke, S., et al. (2024) · Glia · doi:10.1002/glia.24659 · Cited by 10 · see citing works

SNX8 Enhances Non-amyloidogenic APP Trafficking and Attenuates Aβ Accumulation and Memory Deficits in an AD Mouse

Xie, Y., Niu, M., Ji, C., Huang, T. Y., Zhang, C., Tian, Y., Shi, Z., Wang, C., Zhao, Y., Luo, H., et al. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00410 · Cited by 12 · see citing works

Snx27 Deletion Promotes Recovery From Spinal Cord Injury by Neuroprotection and Reduces Macrophage/Microglia Proliferation

Zeng, Y., Wang, N., Guo, T., Zheng, Q., Wang, S., Wu, S., Li, X., Wu, J. C., Chen, Z., Xu, H., et al. (2018) · Frontiers in Neurology · doi:10.3389/fneur.2018.01059 · Cited by 11 · see citing works

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genesPreprint

Kroll, F., Donnelly, J., Özcan, G. G., Mackay, E., & Rihel, J. (2024) · eLife · doi:10.7554/elife.96839 · Cited by 10 · see citing works

Beware of Misdelivery: Multifaceted Role of Retromer Transport in Neurodegenerative Diseases

Yoshida, S., & Hasegawa, T. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.897688 · Cited by 8 · see citing works

De novo resonance assignment of the transmembrane domain of LR11/SorLA in E. coli membranes

Ding, X., Fu, R., & Tian, F. (2019) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2019.106639 · Cited by 6 · see citing works

The role of membrane trafficking and retromer complex in Parkinson's and Alzheimer's disease

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Downregulation of SNX27 expression does not exacerbate amyloidogenesis in the APP/PS1 Alzheimer's disease mouse model

Milne, M., Qian, L., Turnbull, M. T., Kinna, G., Collins, B. M., Teasdale, R. D., & Coulson, E. J. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.01.011 · Cited by 4 · see citing works

Internally tagged Vps10p-domain receptors reveal uptake of the neurotrophin BDNF

Klein, M., Failla, A. V., & Hermey, G. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105216 · Cited by 3 · see citing works

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes

Kroll, F., Donnelly, J., Özcan, G. G., Mackay, E., & Rihel, J. (2025) · eLife · doi:10.7554/elife.96839.3 · Cited by 3 · see citing works

The PKCι-β-arrestin2 axis disrupts SORLA retrograde trafficking, driving its degradation and amyloid pathology in Alzheimer’s disease

Rehman, H., Yan, S., Saggu, S., Aida, M., Zhang, F., Shu, Y., Jones, A., Trang, A., Dew, E., Zhi, W., et al. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00865-6 · Cited by 3 · see citing works

Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes

Juul‐Madsen, K., Rudolph, I., Gomes, J. P., Meyer, K., Ovesen, P. L., Gorniak‐Walas, M., Kokoli, M., Telugu, N. S., Sivertsen, M. V. T., Febbraro, F., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70591 · Cited by 2 · see citing works

Soluble SorLA in CSF, a novel biomarker to explore disrupted trafficking of SorLA protein in Alzheimer disease

Castelot, R., Zaréa, A., Wallon, D., Rovelet‐Lecrux, A., Schramm, C., Quillard‐Muraine, M., Beaume, A., Blanc, F., Bousiges, O., Dumurgier, J., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01748-0 · Cited by 2 · see citing works

NCAM2 promotes targeting of APP from the cell surface to BACE1-containing recycling endosomes.

Pfundstein, G., Keable, R., Hu, S.-F., Al-Hadi, M., Baker, M., Schachner, M., Leshchyns’ka, I., & Sytnyk, V. (2025) · Progress in neurobiology · doi:10.1016/j.pneurobio.2025.102807 · Cited by 1 · see citing works

BDNF alters β-cleavage of APP and subcellular distribution of BACE1

Hallam, R. D., Foran, G., Fletcher, N. K., MacPherson, R. E. K., & Necakov, A. (2026) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00642.2025 · Cited by 2 · see citing works

Alzheimer’s disease risk protein SorLA regulates ER homeostasis and lipid metabolism in human microglia, with conserved effects in neurons

Haq, I., Ngo, J. C., Roy, N., Lee, E., Choudhury, M. A., Soni, R. K., Teich, A. F., Mayeux, R. P., Jager, P. L. D., He, Y., et al. (2026) · Acta Neuropathologica · doi:10.1007/s00401-026-03002-9 · Cited by 2 · see citing works

Phosphatidylinositol‐4‐phosphate 5‐kinase type 1α attenuates Aβ production by promoting non‐amyloidogenic processing of amyloid precursor protein

Wu, P., Bhore, N., Lee, Y.-L., Chou, J., Chen, Y., Wu, P., Hsu, W., Lee, H., Huang, Y., Lu, P., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000113r · Cited by 2 · see citing works

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genesPreprint

Kroll, F., Donnelly, J., Özcan, G. G., Mackay, E., & Rihel, J. (2024) · eLife · doi:10.7554/elife.96839.1 · Cited by 2 · see citing works

Anti-amyloid Monoclonal Antibodies for Alzheimer’s Disease: A New Hope? (Review)

Мазеркина, И. А. (2025) · Safety and Risk of Pharmacotherapy · doi:10.30895/2312-7821-2025-13-1-7-19 · Cited by 1 · see citing works

Lysosomal dysfunction in neurodegenerative disease

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SNX27: A trans-species cognitive modulator with implications for anxiety and stress susceptibility

Armada, G., Roque, S., Serre-Miranda, C., Ferreira, L., Vale, A., Rodrigues, A. J., Hong, W., Correia‐Neves, M., & Vieira, N. (2024) · Neurobiology of Stress · doi:10.1016/j.ynstr.2024.100619 · Cited by 1 · see citing works

Retromer deficiency in amyotrophic lateral sclerosis

Perez-Torres, E. J. (2020) · doi:10.7916/d8-71jz-q460 · Cited by 1 · see citing works

Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genesPreprint

Kroll, F., Donnelly, J., Özcan, G. G., Mackay, E., & Rihel, J. (2025) · eLife · doi:10.7554/elife.96839.2 · Cited by 1 · see citing works

SORLA upregulation suppresses global pathological effects in aged tauopathy mouse brainPreprint

Huang, H., Shi, C. H., Yang, W., Piña-Crespo, J., Bhatnagar, J., Curatolo, J., Murad, R., Shah, P. M., Campos, A. R., Houser, A. K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.25.661599 · Cited by 1 · see citing works

Reconstructing developmental and disease progression with sample-level embeddingsPreprint

Jiang, L., Tan, Z. C., Grabski, I. N., Hao, Y., Nakatsuka, N. J., Sarkar, S., Shenoy, A., & Satija, R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.10.693462 · Cited by 2 · see citing works

Familial Alzheimer disease mutation identifies novel role of SORLA in release of neurotrophic exosomesPreprint

Juul‐Madsen, K., Rudolph, I., Gomes, J. P., Meyer, K., Ovesen, P. L., Górniak-Walas, M. J., Kokoli, M., Telugu, N. S., Sivertsen, M. V. T., Sutherland, D. S., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.22.649924

Additional file 1 of Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer’s disease

Wang, X., Xie, Y., Fan, X., Wu, X., Wang, D., & Zhu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26728936

Additional file 2 of Intermittent hypoxia training enhances Aβ endocytosis by plaque associated microglia via VPS35-dependent TREM2 recycling in murine Alzheimer’s disease

Wang, X., Xie, Y., Fan, X., Wu, X., Wang, D., & Zhu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26728939

A luminescent reporter assay to quantify SORL1 ectodomain shedding and retromer-dependent endosome recycling activity

Fazeli, E., Jan, A., Huber, A.-K., Jensen, A. M. G., Fazeli, E., Klein, J. W., Merchant, K., & Andersen, O. M. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.111136

Etude des mécanismes physiοpathοlοgiques de la maladie d'Alzheimer : appοrt de l'étude des variants du gène SΟRL1

Castelot, R. (2024) · theses.fr (ABES) · doi:10.70675/c2a7ce1ez8caaz4593zbb3azae8add8055b5

Alzheimer's disease risk single nucleotide polymorphism rs11218343 is linked to functional expression of SORL1 in microglia

Gorniak‐Walas, M., Telugu, N. S., Rudolph, I., Diecke, S., & Willnow, T. E. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71390

SORLA up-regulation suppresses pathological effects in aged tauopathy mouse brain

Huang, H., Shi, C. H., Yang, W., Piña-Crespo, J., Bhatnagar, J., Curatolo, J., Murad, R., Shah, P., Campos, A., Houser, A. M., et al. (2026) · Science Advances · doi:10.1126/sciadv.aed6825 · Cited by 1 · see citing works

Pathway‐specific polygenic risk scores modify the association between amyloid and tau PET accumulation in patients with Alzheimer's disease

Valentim, C., Denecke, J., Frerich, S., Betthauser, T. J., Li, Y., Ahmadi, R., Franzmeier, N., (ADNI), A. D. N. I., Malik, R., & Ewers, M. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71939

Sorting receptor SORLA – a trafficking path to avoid Alzheimer disease

Willnow, T. E., & Andersen, O. M. (2013) · Journal of Cell Science · doi:10.1242/jcs.125393 · Cited by 121 · see citing works

P2‐096: Quantitative modeling of amyloidogenic processing and its influence by SORLA/SORL1 in Alzheimer's disease

Schmidt, V., Baum, K., Lao, A. R., Rateitschak, K., Teichmann, A., Wiesner, B., Wolf, J., Olaf Wolkenhauer, A., & Willnow, T. E. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.800

P2‐313: Quantitative modeling of amyloidogenic processing and its influence by SORLA/SORL1 in AlzheimerÂś disease

Schmidt, V., Baum, K., Lao, A. R., Rateitschak, K., Petersen, C. M., Wolf, J., Olaf Wolkenhauer, A., & Willnow, T. E. (2011) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2011.05.1191

Overexpression of SNX7 reduces Aβ production by enhancing lysosomal degradation of APP

Xu, S., Zhang, L., & Brodin, L. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.10.127 · Cited by 15 · see citing works

P4‐225: SORLA/LR11 regulates processing of amyloid precursor protein via interaction with adaptors GGA and PACS‐1

Schmidt, V., Sporbert, A., Rohe, M., Reimer, T. A., Rehm, A., Andersen, O. M., & Willnow, T. E. (2008) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2008.05.2293