Trisomy 21–induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259 · see citing works

WGCNA: an R package for weighted correlation network analysis

Langfelder, P., & Horvath, S. (2008) · BMC Bioinformatics · doi:10.1186/1471-2105-9-559 · Cited by 27,252 · see citing works

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219 · see citing works

Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype

Kim, D., Paggi, J. M., Park, C., Bennett, C., & Salzberg, S. L. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0201-4 · Cited by 15,022 · see citing works

Neuroinflammation in Alzheimer's disease

Heneka, M. T., Carson, M. J., Khoury, J. E., Landreth, G. E., Brosseron, F., Feinstein, D. L., Jacobs, A. H., Wyss-Coray, T., Vitorica, J., Ransohoff, R. M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)70016-5 · Cited by 6,226 · see citing works

A General Framework for Weighted Gene Co-Expression Network Analysis

Zhang, B., & Horvath, S. (2005) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1128 · Cited by 5,684 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

Oakley, H., Cole, S. L., Logan, S., Maus, E., Shao, P., Craft, J., Guillozet-Bongaarts, A., Ohno, M., Disterhoft, J., Van Eldik, L., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1202-06.2006 · Cited by 3,530 · cited 1× · see citing works

Complement and microglia mediate early synapse loss in Alzheimer mouse models

Hong, S., Beja-Glasser, V. F., Nfonoyim, B. M., Frouin, A., Li, S., Ramakrishnan, S., Merry, K. M., Shi, Q., Rosenthal, A., Barres, B. A., et al. (2016) · Science · doi:10.1126/science.aad8373 · Cited by 3,343 · see citing works

The neuropathological diagnosis of Alzheimer's disease

DeTure, M. A., & Dickson, D. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0333-5 · Cited by 3,329 · see citing works

Microglia Function in the Central Nervous System During Health and Neurodegeneration

Colonna, M., & Butovsky, O. (2017) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052358 · Cited by 2,894 · see citing works

Immune attack: the role of inflammation in Alzheimer disease

Heppner, F. L., Ransohoff, R. M., & Becher, B. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3880 · Cited by 2,134 · see citing works

Microglia and macrophages in brain homeostasis and disease

Li, Q., & Barres, B. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.125 · Cited by 1,999 · see citing works

NLRP3 inflammasome activation drives tau pathology

Ising, C., Venegas, C., Zhang, S., Scheiblich, H., Schmidt, S. V., Vieira-Saecker, A., Schwartz, S., Albasset, S., McManus, R. M., Tejera, D., et al. (2019) · Nature · doi:10.1038/s41586-019-1769-z · Cited by 1,487 · see citing works

Cellular quality control by the ubiquitin-proteasome system and autophagy

Pohl, C., & Đikić, I. (2019) · Science · doi:10.1126/science.aax3769 · Cited by 1,229 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Down syndrome

Antonarakis, S. E., Skotko, B. G., Rafii, M. S., Strydom, A., Pape, S. E., Bianchi, D. W., Sherman, S. L., & Reeves, R. H. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-019-0143-7 · Cited by 964 · see citing works

TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

Zhao, Y., Wu, X., Li, X., Jiang, L.-L., Gui, X., Liu, Y., Sun, Y., Zhu, B., Piña-Crespo, J. C., Zhang, M., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.01.031 · Cited by 763 · see citing works

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

Wiseman, F. K., Al-Janabi, T., Hardy, J., Karmiloff-Smith, A., Nizetic, D., Tybulewicz, V. L. J., Fisher, E. M. C., & Strydom, A. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3983 · Cited by 562 · see citing works

Complement C3aR Inactivation Attenuates Tau Pathology and Reverses an Immune Network Deregulated in Tauopathy Models and Alzheimer’s Disease

Litvinchuk, A., Wan, Y.-W., Swartzlander, D. B., Chen, F., Cole, A., Propson, N. E., Wang, Q., Zhang, B., Liu, Z., & Zheng, H. (2018) · Neuron · doi:10.1016/j.neuron.2018.10.031 · Cited by 523 · see citing works

LC3-Associated Endocytosis Facilitates β-Amyloid Clearance and Mitigates Neurodegeneration in Murine Alzheimer’s Disease

Heckmann, B. L., Teubner, B. J. W., Tummers, B., Boada-Romero, E., Harris, L., Yang, M., Guy, C. S., Zakharenko, S. S., & Green, D. R. (2019) · Cell · doi:10.1016/j.cell.2019.05.056 · Cited by 503 · see citing works

New insights into the role of TREM2 in Alzheimer’s disease

Gratuze, M., Leyns, C. E. G., & Holtzman, D. M. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0298-9 · Cited by 489 · see citing works

Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease.

Mueller-Steiner, S., Zhou, Y.-G., Arai, H., Roberson, E., Sun, B.-G., Chen, J., Wang, X., Yu, G.-Q., Esposito, L., Mucke, L., et al. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.027 · Cited by 466 · see citing works

Alzheimer's disease in Down's syndrome: Clinicopathologic studies

Wisniewski, K. E., Dalton, A. J., McLachlan, D. R. C., Wen, G. Y., & Wisniewski, H. M. (1985) · Neurology · doi:10.1212/wnl.35.7.957 · Cited by 417 · see citing works

A rapid Percoll gradient procedure for preparation of synaptosomes

Dunkley, P. R., Jarvie, P. E., & Robinson, P. J. (2008) · Nature Protocols · doi:10.1038/nprot.2008.171 · Cited by 410 · see citing works

Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model

Zhong, L., Xu, Y., Zhuo, R., Wang, T., Wang, K., Huang, R., Wang, D., Gao, Y., Zhu, Y., Sheng, X., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09118-9 · Cited by 371 · see citing works

Dysregulation of Ubiquitin-Proteasome System in Neurodegenerative Diseases

Zheng, Q., Huang, T. Y., Zhang, L., Zhou, Y., Luo, H., Xu, H., & Wang, X. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00303 · Cited by 312 · see citing works

Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

Zhou, X., Wahane, S., Friedl, M.-S., Kluge, M., Friedel, C. C., Avrampou, K., Zachariou, V., Guo, L., Zhang, B., He, X., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-0597-7 · Cited by 275 · see citing works

Down syndrome and the complexity of genome dosage imbalance

Antonarakis, S. (2016) · Nature reviews genetics · doi:10.1038/nrg.2016.154 · Cited by 264 · see citing works

Microglial cell loss after ischemic stroke favors brain neutrophil accumulation

Otxoa-de-Amezaga, A., Miró-Mur, F., Pedragosa, J., Gallizioli, M., Justicia, C., Gaja-Capdevila, N., Ruíz-Jaen, F., Salas-Perdomo, A., Bosch, A., Calvo, M., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-018-1954-4 · Cited by 258 · see citing works

Down’s syndrome, neuroinflammation, and Alzheimer neuropathogenesis

Wilcock, D. M., & Griffin, W. S. T. (2013) · Journal of Neuroinflammation · doi:10.1186/1742-2094-10-84 · Cited by 230 · see citing works

Dual‐specificity tyrosine(Y)‐phosphorylation regulated kinase 1A‐mediated phosphorylation of amyloid precursor protein: evidence for a functional link between Down syndrome and Alzheimer’s disease

Ryoo, S., Cho, H., Lee, H. W., Jeong, H. K., Radnaabazar, C., Kim, Y., Kim, M., Son, M., Seo, H., Chung, S., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05075.x · Cited by 227 · see citing works

Deficiency in LRP6-mediated Wnt signaling contributes to synaptic abnormalities and amyloid pathology in Alzheimer’s disease

Liu, C.-C., Tsai, C.-W., Deak, F., Rogers, J., Penuliar, M., Sung, Y. M., Maher, J. N., Fu, Y., Li, X., Xu, H., et al. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.048 · Cited by 222 · see citing works

Duplication of the entire 22.9 Mb human chromosome 21 syntenic region on mouse chromosome 16 causes cardiovascular and gastrointestinal abnormalities

Li, Z., Yu, T., Morishima, M., Pao, A., LaDuca, J., Conroy, J., Nowak, N., Matsui, S.-I., Shiraishi, I., & Yu, Y. E. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm086 · Cited by 218 · see citing works

Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

Zhong, L., Wang, Z., Wang, D., Wang, Z., Martens, Y. A., Wu, L., Xu, Y., Wang, K., Li, J., Huang, R., et al. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0247-7 · Cited by 217 · see citing works

Early Amyloid Deposition in the Medial Temporal Lobe of Young Down Syndrome Patients: A Regional Quantitative Analysis

Leverenz, J. B., & Raskind, M. A. (1998) · Experimental Neurology · doi:10.1006/exnr.1997.6777 · Cited by 214 · see citing works

Negative regulation of IL-17-mediated signaling and inflammation by the ubiquitin-specific protease USP25

Zhong, B., Liu, X., Wang, X., Chang, S. H., Liu, X., Wang, A., Reynolds, J. M., & Dong, C. (2012) · Nature Immunology · doi:10.1038/ni.2427 · Cited by 206 · see citing works

Positive and negative regulation of APP amyloidogenesis by sumoylation

Li, Y., Wang, H., Wang, S., Quon, D. H., Liu, Y.-W., & Cordell, B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0235361100 · Cited by 165 · see citing works

Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice

Shoji, H., Takao, K., Hattori, S., & Miyakawa, T. (2014) · Journal of Visualized Experiments · doi:10.3791/50871 · Cited by 149 · see citing works

Ubiquitin-Specific Protease 25 Regulates TLR4-Dependent Innate Immune Responses Through Deubiquitination of the Adaptor Protein TRAF3

Zhong, B., Liu, X., Wang, X., Liu, X., Li, H., Darnay, B. G., Lin, X., Sun, S., & Dong, C. (2013) · Science Signaling · doi:10.1126/scisignal.2003708 · Cited by 140 · see citing works

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of <i>APP</i>

Wiseman, F. K., Pulford, L. J., Barkus, C., Liao, F., Portelius, E., Webb, R., Chávez-Gutiérrez, L., Cleverley, K., Noy, S., Sheppard, O., et al. (2018) · Brain · doi:10.1093/brain/awy159 · Cited by 133 · see citing works

Effects of individual segmental trisomies of human chromosome 21 syntenic regions on hippocampal long-term potentiation and cognitive behaviors in mice

Yu, T., Liu, C., Belichenko, P., Clapcote, S. J., Li, S., Pao, A., Kleschevnikov, A., Bechard, A. R., Asrar, S., Chen, R., et al. (2010) · Brain Research · doi:10.1016/j.brainres.2010.09.107 · Cited by 127 · see citing works

WDFY1 mediates TLR3/4 signaling by recruiting TRIF

Hu, Y., Zhang, Y., Jiang, L., Wang, S., Lei, C., Sun, M., Shu, H., & Liu, Y. (2015) · EMBO Reports · doi:10.15252/embr.201439637 · Cited by 97 · see citing works

Molecular and functional signatures in a novel Alzheimer’s disease mouse model assessed by quantitative proteomics

Kim, D. K., Park, J., Han, D., Yang, J., Kim, A., Woo, J., Kim, Y., & Mook-Jung, I. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0234-4 · Cited by 95 · see citing works

Identification and Characterization of Dual Inhibitors of the USP25/28 Deubiquitinating Enzyme Subfamily

Wrigley, J. D. J., Gavory, G., Simpson, I. D., Preston, M., Plant, H., Bradley, J., Goeppert, A. U., Rozycka, E., Davies, G. M., Walsh, J. J., et al. (2017) · ACS Chemical Biology · doi:10.1021/acschembio.7b00334 · Cited by 87 · see citing works

Functional alterations of myeloid cells during the course of Alzheimer’s disease

Thome, A. D., Faridar, A., Beers, D. R., Thonhoff, J. R., Zhao, W., Wen, S., Pascual, B., Masdeu, J. C., & Appel, S. H. (2018) · Molecular Neurodegeneration · doi:10.1186/s13024-018-0293-1 · Cited by 83 · see citing works

Activity-Dependent p25 Generation Regulates Synaptic Plasticity and Aβ-Induced Cognitive Impairment

Seo, J., Giusti‐Rodríguez, P., Zhou, Y., Rudenko, A., Cho, S., Ota, K. T., Park, C. S., Patzke, H., Madabhushi, R., Pan, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.01.065 · Cited by 80 · see citing works

USP25, a Novel Gene Encoding a Deubiquitinating Enzyme, Is Located in the Gene-Poor Region 21q11.2

Valero, R., Marfany, G., Olga, G.-A., González, G. G., Puelles, L., & Gonzàlez‐Duarte, R. (1999) · Genomics · doi:10.1006/geno.1999.6025 · Cited by 63 · see citing works

Contextual and Cued Fear Conditioning Test Using a Video Analyzing System in Mice

Shoji, H., Takao, K., Hattori, S., & Miyakawa, T. (2014) · Journal of Visualized Experiments · doi:10.3791/50871-v · Cited by 56 · see citing works

The ubiquitin-specific protease USP25 interacts with three sarcomeric proteins

Bosch-Comas, A., Lindsten, K., Gonzàlez‐Duarte, R., Masucci, M. G., & Marfany, G. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5533-1 · Cited by 55 · see citing works

Polymorphisms in BACE2 may affect the age of onset Alzheimer's dementia in Down syndrome

Mok, K. Y., Jones, E. L., Hanney, M., Harold, D., Sims, R., Williams, J., Ballard, C., & Hardy, J. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.12.022 · Cited by 48 · see citing works

The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability

Zeng, F., Ma, X., Zhu, L., Xu, Q., Zeng, Y., Gao, Y., Li, G., Guo, T., Zhang, H., Tang, X., et al. (2019) · PLoS Biology · doi:10.1371/journal.pbio.3000525 · Cited by 43 · see citing works

The chromosome 21 transcription factor ETS2 transactivates the β-APP promoter: implications for Down syndrome

Wolvetang, E. J., Bradfield, O., Tymms, M. J., Zavarsek, S., Hatzistavrou, T., Kola, I., & Hertzog, P. J. (2003) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/s0167-4781(03)00121-0 · Cited by 42 · see citing works

Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease

Pandey, R. S., Graham, L., Uyar, A., Preuss, C., Howell, G. R., & Carter, G. W. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0351-3 · Cited by 37 · see citing works

miR155 regulation of behavior, neuropathology, and cortical transcriptomics in Alzheimer's disease

Readhead, B., Haure-Mirande, J.-V., Mastroeni, D., Audrain, M., Fanutza, T., Kim, S. H., Blitzer, R. D., Gandy, S., Dudley, J. T., & Ehrlich, M. E. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02185-z · Cited by 37 · see citing works

A Novel In Vitro Live-imaging Assay of Astrocyte-mediated Phagocytosis Using pH Indicator-conjugated Synaptosomes

Byun, Y. G., & Chung, W. (2018) · Journal of Visualized Experiments · doi:10.3791/56647 · Cited by 18 · see citing works

Microglia Metabolic Breakdown Drives Alzheimer’s Pathology

Bennett, F. C., & Liddelow, S. A. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.08.017 · Cited by 16 · see citing works

Alzheimer’s disease: insights into pathology, molecular mechanisms, and therapy

Zheng, Q., & Wang, X. (2024) · Protein & Cell · doi:10.1093/procel/pwae026 · Cited by 454 · see citing works

Deubiquitinating enzymes (DUBs): decipher underlying basis of neurodegenerative diseases

Liu, B., Ruan, J., Chen, M., Li, Z., Manjengwa, G. M., Schlüter, D., Song, W., & Wang, X. (2021) · Molecular Psychiatry · doi:10.1038/s41380-021-01233-8 · Cited by 103 · see citing works

ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Lin, Y., Lin, A., Cai, L., Huang, W., Yan, S., Wei, Y., Ruan, X., Fang, W., Dai, X., Cheng, J., et al. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00625-4 · Cited by 91 · see citing works

β2-Microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice

Zhao, Y., Zheng, Q., Hong, Y., Gao, Y., Hu, J., Lang, M., Zhang, H., Zhou, Y., Luo, H., Zhang, X., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01352-1 · Cited by 84 · see citing works

Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis

Zhang, S., Gao, Y., Zhao, Y., Huang, T. Y., Zheng, Q., & Wang, X. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00812-5 · Cited by 78 · see citing works

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function

Gao, Y., Hong, Y., Huang, L., Zheng, S., Zhang, H., Wang, S., Yao, Y., Zhao, Y., Zhu, L., Xu, Q., et al. (2023) · Cell · doi:10.1016/j.cell.2023.01.021 · Cited by 75 · see citing works

USP25 inhibition ameliorates Alzheimer’s pathology through the regulation of APP processing and Aβ generation

Zheng, Q., Song, B., Li, G., Cai, F., Wu, M., Zhao, Y., Jiang, L., Guo, T., Shen, M., Hou, H., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci152170 · Cited by 73 · see citing works

Mitochondrial dysfunction as a therapeutic strategy for neurodegenerative diseases: Current insights and future directions

Gu, Y., Zhao, X., Zhang, N., Yang, Y., Yi, Y., Shao, Q.-H., Liu, M.-X., & Zhang, X.-L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102577 · Cited by 58 · see citing works

Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability

Zhang, H., Zheng, Q., Guo, T., Zhang, S., Zheng, S., Wang, R., Deng, Q., Yang, G., Zhang, S., Tang, L., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01521-x · Cited by 44 · see citing works

Deubiquitinases in Neurodegeneration

Bello, A. I., Goswami, R., Brown, S. L., Costanzo, K. M., Shores, T., Allan, S. K., Odah, R., & Mohan, R. D. (2022) · Cells · doi:10.3390/cells11030556 · Cited by 40 · see citing works

Emerging Roles of Ubiquitin-Specific Protease 25 in Diseases

Zhu, W., Zheng, D., Wang, D., Yang, L., Zhao, C., & Huang, X. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.698751 · Cited by 38 · see citing works

A retrotransposon storm marks clinical phenoconversion to late-onset Alzheimer’s disease

Macciardi, F., Giulia Bacalini, M., Miramontes, R., Boattini, A., Taccioli, C., Modenini, G., Malhas, R., Anderlucci, L., Gusev, Y., Gross, T. J., et al. (2022) · GeroScience · doi:10.1007/s11357-022-00580-w · Cited by 37 · see citing works

Mechanisms orchestrating the enzymatic activity and cellular functions of deubiquitinases

Estavoyer, B., Messmer, C., Echbicheb, M., Rudd, C. E., Milot, É., & Affar, E. B. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102198 · Cited by 37 · see citing works

Downregulating PTBP1 Fails to Convert Astrocytes into Hippocampal Neurons and to Alleviate Symptoms in Alzheimer's Mouse Models

Guo, T., Pan, X., Jiang, G., Zhang, D., Qi, J., Shao, L., Wang, Z., Xu, H., & Zhao, Y. (2022) · Journal of Neuroscience · doi:10.1523/jneurosci.1060-22.2022 · Cited by 37 · see citing works

Salvianolic acid B ameliorates retinal deficits in an early-stage Alzheimer’s disease mouse model through downregulating BACE1 and Aβ generation

Wang, M.-D., Zhang, S., Liu, X., Wang, P., Zhu, Y.-F., Zhu, J., Lv, C.-S., Li, S., Liu, S.-F., & Wen, L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01125-3 · Cited by 33 · see citing works

DUBs in Alzheimer’s disease: mechanisms and therapeutic implications

Qin, B., Chen, X., Wang, F., & Wang, Y. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02237-3 · Cited by 33 · see citing works

Metabolic Reprogramming of Microglia Enhances Proinflammatory Cytokine Release through EphA2/p38 MAPK Pathway in Alzheimer’s Disease

Ma, X., Zhang, Y., Gou, D., Ma, J., Du, J., Wang, C., Li, S., & Cui, H. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220227 · Cited by 30 · see citing works

USP25 ameliorates diabetic nephropathy by inhibiting TRAF6-mediated inflammatory responses

Liu, B., Miao, X., Shen, J., Lou, L., Chen, K., Mei, F., Chen, M., Su, X., Du, X., Zhu, Z., et al. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110877 · Cited by 28 · see citing works

Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02774-1 · Cited by 25 · see citing works

YOD1 regulates microglial homeostasis by deubiquitinating MYH9 to promote the pathogenesis of Alzheimer's disease

Sun, J., Chen, F., She, L., Zeng, Y., Tang, H., Ye, B., Zheng, W., Xiong, L., Li, L., Li, L., et al. (2025) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.11.020 · Cited by 24 · see citing works

Ubiquitin-specific protease 28: the decipherment of its dual roles in cancer development

Ren, X., Jiang, M., Ding, P., Zhang, X., Zhou, X. J., Shen, J., Liu, D., Yan, X., & Ma, Z. (2023) · Experimental Hematology and Oncology · doi:10.1186/s40164-023-00389-z · Cited by 23 · see citing works

Rodent Modeling of Alzheimer's Disease in Down Syndrome: In vivo and ex vivo Approaches

Farrell, C., Mumford, P., & Wiseman, F. K. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.909669 · Cited by 22 · see citing works

Genetic Mapping of APP and Amyloid-β Biology Modulation by Trisomy 21

Mumford, P., Tosh, J., Anderle, S., Gkanatsiou Wikberg, E., Lau, G., Noy, S., Cleverley, K., Saito, T., Saido, T. C., Yu, E., et al. (2022) · The Journal of Neuroscience · doi:10.1523/jneurosci.0521-22.2022 · Cited by 22 · see citing works

Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome

Chen, X., Xing, Z., Chen, Q.-D., Salvi, R., Zhang, X., Tycko, B., Mobley, W. C., & Yu, Y. E. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.700280 · Cited by 22 · see citing works

Targeted Mitochondrial Epigenetics: A New Direction in Alzheimer’s Disease Treatment

Song, Y., Zhu, X., Zhang, X.-M., & Xiong, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179703 · Cited by 21 · see citing works

Structural basis for the bi-specificity of USP25 and USP28 inhibitors

Patzke, J. V., Sauer, F., Nair, R. K., Endres, E., Proschak, E., Hernández‐Olmos, V., Sotriffer, C., & Kisker, C. (2024) · EMBO Reports · doi:10.1038/s44319-024-00167-w · Cited by 20 · see citing works

Heterozygous variants in USP25 cause genetic generalized epilepsy

Fan, C.-X., Liu, X., Mei, D., Li, B.-M., Li, W., Xie, H., Wang, J., Shen, N.-X., Ye, Z.-L., You, Q.-L., et al. (2024) · Brain · doi:10.1093/brain/awae191 · Cited by 20 · see citing works

The Genetic Landscape of Sleep Disorders in Parkinson’s Disease

Kalinderi, K., Papaliagkas, V. T., & Fidani, L. (2024) · Diagnostics · doi:10.3390/diagnostics14010106 · Cited by 18 · see citing works

Structure and function of the highly homologous deubiquitinases ubiquitin specific peptidase 25 and 28: Insights into their pathophysiological and therapeutic roles

Zhou, L., Qin, B., Yassine, D. M., Luo, M., Liu, X., Wang, F., & Wang, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115624 · Cited by 17 · see citing works

Ailanthone Inhibits Proliferation, Migration and Invasion of Osteosarcoma Cells by Downregulating the Serine Biosynthetic Pathway

Zhang, Y., Gong, R., Liu, Y., Sun, X., Liang, J., Zhou, Y., Wang, Y., Yu, W., Wang, Y., Tang, L., et al. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.842406 · Cited by 16 · see citing works

Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease-Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin B

Wu, Y., Mumford, P., Noy, S., Cleverley, K., Mrzyglod, A., Luo, D., van Dalen, F., Verdoes, M., Fisher, E. M. C., & Wiseman, F. K. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01632-8 · Cited by 16 · see citing works

Ubiquitin-specific peptidase 25 exacerbated osteoarthritis progression through facilitating TXNIP ubiquitination and NLRP3 inflammasome activation

Sui, J., Dai, F., Shi, J., & Zhou, C. (2023) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-023-04083-y · Cited by 15 · see citing works

USP25 directly interacts with and deubiquitinates PPARα to increase PPARα stability in hepatocytes and attenuate high-fat diet-induced MASLD in mice

Jin, L., Zhu, W., Hu, X., Lin, Y., Lou, S., Zhang, Q., Wang, M., Ye, B., Min, J., Wang, Y., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01444-4 · Cited by 14 · see citing works

Neuroprotective Effect of miR-483-5p Against Cardiac Arrest-Induced Mitochondrial Dysfunction Mediated Through the TNFSF8/AMPK/JNK Signaling Pathway

Zhang, Q., Zhan, H., Liu, C., Zhang, C., Wei, H., Li, B., Zhou, D., Lu, Y., Huang, S., Cheng, J., et al. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01296-3 · Cited by 14 · see citing works

A New Modulator of Neuroinflammation in Diabetic Retinopathy: USP25

Hu, Q., Zhang, X., Peng, H., Guan, J., Huang, Z., Jiang, B., & Sun, D. (2024) · Inflammation · doi:10.1007/s10753-024-01991-x · Cited by 13 · see citing works

OTUD1 positively regulates microglia neuroinflammation and promotes the pathogenesis of Alzheimer’s disease by deubiquitinating C/EBPβ

She, L., Li, L., Tang, H., Yu, Q., Gao, F.-Y., Zeng, Y.-Q., Chen, L., Li, X., Li, L.-W., Chen, F., et al. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01566-y · Cited by 9 · see citing works

Aerobic exercise alleviates cognitive impairment in T2DM mice through gut microbiota

Ruan, S., Liu, J., Yuan, X., Ye, X., & Zhang, Q. (2025) · Scientific Reports · doi:10.1038/s41598-025-07220-1 · Cited by 9 · see citing works

The ubiquitin-proteasome system in Alzheimer’s disease: mechanism of action and current status of treatment

Jia, S., Li, Q., Rui, X., Qin, W., Zhang, W., Dou, J., & Zhang, X. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1730206 · Cited by 8 · see citing works

Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions

Li, Y., Xing, Z., Yu, T., Pao, A., Daadi, M. M., & Yu, Y. E. (2021) · Genes · doi:10.3390/genes12081215 · Cited by 9 · see citing works

Chronic salmon calcitonin exerts an antidepressant effect via modulating the p38 MAPK signaling pathway

Wenhui, Z., Li, W., Jiang, J., Wang, D., Mao, X., Zhang, J., Zhang, X., Chang, J., Yao, P., Yang, X., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1071327 · Cited by 8 · see citing works

Interferon signaling modulates Down syndrome-associated Alzheimer’s disease pathology in a mouse model

Araya, P., Niemeyer, B., Schade, K., Dunn, L. N., Waugh, K., Busquet, N., Brindley, C., Brown, C., Winkler, C., Lyford, H. R., et al. (2025) · iScience · doi:10.1016/j.isci.2025.113130 · Cited by 7 · see citing works

A novel dual CCK/ GLP-1 receptor agonist ameliorates cognitive impairment in 5 × FAD mice by modulating mitophagy via the PINK1/Parkin pathway

Luo, R., Kang, Y., Ma, H., Zhang, Z., Hölscher, C., Li, H., & Zhang, Z. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114612 · Cited by 7 · see citing works

Regulation of USP25 by SP1 Associates with Amyloidogenesis

Li, R., Song, B., Xu, L., Zheng, J., Pan, W., Cai, F., Wang, J., Wu, Y., & Song, W. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221184 · Cited by 7 · see citing works

Increased level of RAB39B leads to neuronal dysfunction and behavioural changes in mice

Wang, Z., Niu, M., Zheng, N., Meng, J., Jiang, Y., Yang, D., Yao, P., Yao, T., Luo, H., Xu, H., et al. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17704 · Cited by 7 · see citing works

Prenatal Diagnosis and Genetic Analysis of 21q21.1–q21.2 Aberrations in Seven Chinese Pedigrees

Hu, H., Zhang, R., Ma, Y., Luo, Y., Pan, Y., Xu, J., Jiang, L., & Wang, D. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.731815 · Cited by 6 · see citing works

Premature Aging in Aneuploid Yeast is Caused in Part by Aneuploidy-Induced Defects in Ribosome Quality ControlPreprint

Escalante, L. E., Hose, J., Howe, H., Paulsen, N., Place, M., & Gasch, A. P. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.22.600216 · Cited by 6 · see citing works

Proteomic and transcriptomic analysis of the effects of dietary jellyfish on the midgut of Pampus argenteus

Wang, Y., Wang, Q., Lian, S., Yue, Y., Gao, Q., & Peng, S. (2022) · Aquaculture · doi:10.1016/j.aquaculture.2022.738689 · Cited by 5 · see citing works

Effects of USP25 knockout on the gut microbial diversity and composition in mice

Li, J., Chen, Z., Yan, X., Chen, Q., Chen, C., Liu, H., & Shen, J. (2025) · BMC Microbiology · doi:10.1186/s12866-025-04035-y · Cited by 5 · see citing works

TMEM59 deficiency activates chaperone‐mediated autophagy and ameliorates disease‐like pathologies in tauopathy model mice

Zheng, N., Wang, Z., Cao, J., Li, K., Xu, H., Wang, J., Zhang, L., Meng, J., Tang, Z., Luo, H., et al. (2025) · Alzheimer s & Dementia · doi:10.1002/alz.70369 · Cited by 5 · see citing works

USP25 ameliorates vascular remodeling by deubiquitinating FOXO3 and promoting autophagic degradation of FOXO3

Chen, Y., Ye, B., Xu, D., Lin, W., Fang, Z., Qu, X., Han, X., Luo, W., Chen, C., Huang, W., et al. (2024) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2024.12.033 · Cited by 4 · see citing works

Astrocytic calcium-dependent enzyme PAD2 governs microglia activity to exacerbate amyloid pathology via citrullinated vimentin

Zhang, J., Huang, Y., Chen, Y., Zhang, Y., Chen, J., Huang, Y., Zhong, H., He, H., Dai, X., Yan, X., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.007 · Cited by 5 · see citing works

Transcriptome research of human amniocytes identifies hub genes associated with developmental dysplasia in down syndrome

Guo, Z., Xiao, H., Yang, W., Li, T., Hao, B., & Liao, S. (2023) · Aging · doi:10.18632/aging.205291 · Cited by 4 · see citing works

Regulation of Neuroinflammation by Microglial DUBA‐IRAK1‐IKKβ Signaling Loop

Zhu, Z., Li, Z., Lambertsen, K. L., Cao, Z., Chen, M., Xu, Y., Clausen, B. H., Jin, K., Lu, Y., Mei, F., et al. (2025) · Advanced Science · doi:10.1002/advs.202503972 · Cited by 4 · see citing works

USP25-mediated talin-1 stabilization in platelets: a novel mechanism of hyperreactivity and thrombosis risk during aging

Jia, X., Jiang, S., Cheng, H., Wang, Z., Chen, Z., Dong, W., Zhong, H., Zhang, Q., Song, X., Zhang, S., et al. (2025) · Blood · doi:10.1182/blood.2023023352 · Cited by 4 · see citing works

Synthetic Disaggregators Enhance Central‐Peripheral Amyloid‐β Clearance in Alzheimer's Disease

Tang, C., Han, K., Wen, X., Zhang, J., Sun, W., Yue, X., Shi, L., Liu, Z., Zhao, J., Yan, C., et al. (2026) · Advanced Materials · doi:10.1002/adma.202520002 · Cited by 3 · see citing works

USP25 regulates atherosclerosis by restricting RIPK1-mediated inflammatory responses

Su, X., Zhou, B., Xu, Y., Du, X., Chen, J., Yin, M., Miao, X., Zhao, Y., Wang, D., Zhu, Z., et al. (2026) · EBioMedicine · doi:10.1016/j.ebiom.2026.106213 · Cited by 3 · see citing works

Microglial mitochondria transfer to astrocytes via GPNMB-enriched extracellular vesicles alleviates cognitive deficits in tauopathy mice

Liang, C., Zhou, Y., Zhuang, K., Wang, S., Zhong, L., Can, D., Lei, A., Li, H., Zhang, J., & Leng, L. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02317-w · Cited by 3 · see citing works

USP25 attenuates anti-GBM nephritis in mice by negative feedback regulation of Th17 cell differentiation

Xu, R., Huang, F., Liu, Q., Lv, Y., Hu, L., & Zhang, Q. (2024) · Renal Failure · doi:10.1080/0886022x.2024.2338932 · Cited by 3 · see citing works

USP25 inhibition ameliorates Parkinson’s disease by restoring mitophagy

Xu, Y., Jin, K., Chen, J., Li, Z., Zhu, Z., Su, X. W., Shen, J., Zhou, B., Cao, Z., Lou, L., et al. (2026) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2516471123 · Cited by 2 · see citing works

The Ubiquitin-proteasome system in neuroinflammation and neurodegeneration: Molecular insights and therapeutic avenues

Guo, Y., Wang, N., Tao, Z., Huang, X., Yu, W., Zeng, J., Liu, X., Chen, S., Hua, F., & Wang, X. (2026) · International Immunopharmacology · doi:10.1016/j.intimp.2026.116599 · Cited by 2 · see citing works

Mammalian Sterile 20-Like Kinase 2 Knockdown Alleviates Neuropathic Pain in Rats by Mitochondrial Protection

Zeng, Q., Huang, B.-X., Liu, C., Liang, N., Yu, J., & Liao, S. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05202-y · Cited by 1 · see citing works

Chromosome duplication causes premature aging via defects in ribosome quality control

Escalante, L. E., Hose, J., Ahrens, J. M., Howe, H., Paulsen, N., Liss, S. J., Place, M., & Gasch, A. P. (2025) · PLoS Biology · doi:10.1371/journal.pbio.3003509 · Cited by 1 · see citing works

Use of anti–amyloid‐β monoclonal antibodies in persons with Down syndrome Alzheimer's disease

Farrell, C., Saini, F., Beidas, M. M., Ryan, N. S., Strydom, A., & Wiseman, F. K. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71404 · Cited by 1 · see citing works

Microglial OTUD6A promotes neuroinflammation and Alzheimer’s disease pathogenesis by deubiquitinating C/EBPβ

She, L., Li, M., Chen, F., Wu, X., Zhang, J., Jiang, W., Sun, Z., Li, L., Ren, J., Chen, D., et al. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108280 · Cited by 1 · see citing works

The deubiquitinase USP25 contributes to stemness and malignant progression of breast cancer by stabilizing C1ql4

Li, X., Xing, Z., Fang, H., Zhao, M., Li, Q., Feng, N., & Xu, F. (2026) · Scientific Reports · doi:10.1038/s41598-026-49272-x · Cited by 1 · see citing works

Genetic mapping of APP and amyloid-β biology modulation by trisomy 21Preprint

Mumford, P., Tosh, J., Anderle, S., Gkanatsiou, E., Lau, G., Noy, S., Cleverley, K., Saito, T., Saido, T. C., Yu, E. Y., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.10.483782 · Cited by 1 · see citing works

Cathepsin B abundance, activity and microglial localisation in Alzheimer’s disease – Down syndrome and early onset Alzheimer’s disease; the role of elevated cystatin BPreprint

Wu, Y., Mumford, P., Noy, S., Cleverley, K., Mrzyglod, A., Luo, D., van Dalen, F. J., Verdoes, M., Fisher, E., & Wiseman, F. K. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.20.545700 · Cited by 1 · see citing works

The Struggle of Neural Progenitors in Down Syndrome Brain: The Need for Neuromodulation Beyond Symptomatic Mitigations

Ling, K., & Cheah, P.-S. (2022) · Malaysian Journal of Medicine and Health Sciences · doi:10.47836/mjmhs.18.6.1

Down Syndrome: Progress in Defining Pathogenesis and Treatments for Neurodevelopmental Deficits and Alzheimer’s Disease

Bartesaghi, R., Chen, X., Johnstone, A. D., Das, U., & Mobley, W. C. (2025) · Springer eBooks · doi:10.1007/978-3-031-89307-0_19

Oxidative stress in Down syndrome: unraveling the intertwined pathways for novel target identification

Lim, C.-W., Hamid, H. A., Ling, K., & Cheah, P.-S. (2025) · Current Opinion in Physiology · doi:10.1016/j.cophys.2025.100864

Transcriptome analyses reveal the fertility defect in the Dp(16)1Yey/+ mouse model of Down syndrome

Ma, X., Xu, X., Wang, M., Ma, J., Zhang, H., Yang, F., Cong, M., Shao, Z., Aziz, T., Qiu, Y., et al. (2025) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-025-03767-0

Additional file 7 of Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593178

Additional file 2 of Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593163

Additional file 3 of Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593166

Additional file 2 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Lin, Y., Lin, A., Cai, L., Huang, W., Yan, S., Wei, Y., Ruan, X., Fang, W., Dai, X., Cheng, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26603815

Additional file 1 of Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593160

Additional file 1 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Lin, Y., Lin, A., Cai, L., Huang, W., Yan, S., Wei, Y., Ruan, X., Fang, W., Dai, X., Cheng, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26603812

Additional file 3 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Lin, Y., Lin, A., Cai, L., Huang, W., Yan, S., Wei, Y., Ruan, X., Fang, W., Dai, X., Cheng, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26603818

Additional file 4 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Lin, Y., Lin, A., Cai, L., Huang, W., Yan, S., Wei, Y., Ruan, X., Fang, W., Dai, X., Cheng, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26603821

Additional file 4 of Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593169

Additional file 6 of Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593175

Additional file 5 of ACSS2-dependent histone acetylation improves cognition in mouse model of Alzheimer’s disease

Lin, Y., Lin, A., Cai, L., Huang, W., Yan, S., Wei, Y., Ruan, X., Fang, W., Dai, X., Cheng, J., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26603824

Additional file 5 of Minocycline protects against microgliopathy in a Csf1r haplo-insufficient mouse model of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP)

Li, X., Hu, B., Xiaoyan, G., Wang, Z., Zhou, Y., Sun, H., Zhang, X., Li, Y., Huang, X., Zhao, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26593172

Identification of secondary microglial formation centers in the human fetal brain

Song, C., Chen, X., Ji, R., Liu, Y., Han, Y., Ye, F., Zhang, L., Li, L., Gao, L., He, Q., et al. (2026) · The Journal of Experimental Medicine · doi:10.1084/jem.20251801

MAPT-derived circTau6 induces tau pathogenesis and neurodegeneration by encoding Tau variants

Jiang, G., Wang, D., Shao, L., Mao, X., Xiong, X., Zhang, D., Chen, W. N., Yuan, H., Wang, S., Zhang, J., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03764-4

Ubiquitin-specific protease 25: a new regulator for cardiovascular and cerebrovascular diseases

Shao, Y., Jiang, S., Zhai, L., & Sun, F. (2026) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2026.1802539

Deubiquitinase inhibitors: from evolving concepts to preclinical evaluation

Maubach, G., Hamann, L., Stein, M., Haak, E., & Naumann, M. (2026) · Drug Discovery Today · doi:10.1016/j.drudis.2026.104751

TMEM59 regulates microglial Aβ phagocytosis in a TREM2‐dependent manner and acts as a potential therapeutic target for Aβ amyloidosis

Meng, J., Wang, Y., Wang, J., Chen, Y., Zhao, Z., Tang, Z., Cao, J., Zhang, X., Luo, H., 李徽徽, et al. (2026) · Alzheimer s & Dementia · doi:10.1002/alz.71873

Enzyme−Targeted Therapeutics for Neurological Disorders

Massignan, L., Lokesh, K., Ziadat, S., Uehling, D., Weaver, D. F., & Reed, M. A. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.6c01274

Deubiquitinating Enzymes in Alzheimer’s Disease: From Protein Homeostasis to Diverse Pathological Processes

Shi, X., Chen, G., Wang, X., Ma, R., & Li, G. (2026) · Biomolecules · doi:10.3390/biom16101494

A Novel Peptide Targeting the USP25 – SIRT1 Interaction Activates SIRT1 to Suppress Cell Senescence

Zhou, Y., Wang, X., Zhang, J., Qiang, H., Zhao, X., Luo, J., Ji, Y., Yao, J., Zhai, L., Zhang, T., et al. (2026) · Aging Cell · doi:10.1111/acel.70786

Phenotypic and genetic alterations of trisomic microglia during brain development

Rivera, I. (2024) · eScholarship (California Digital Library)

Functional characterization of Alzheimer’s disease-related Plcγ2-P522R knock-in and Trem2 knock-out microglia

Kervinen, I. (2023) · UEF eRepo (University of Eastern Finland)

Trisomy of human chromosome 21 and the development of Alzheimer’s disease : a mouse model

Wiseman, F. K., Sheppard, O., Barkus, C., Pettingill, P., Ruparelia, A., Slender, A., Taylor, A., Bannerman, D., Tybulewicz, V. L. J., & Fisher, E. (n.d.) · UCL Discovery (University College London)

Regulation of USP25 by SP1 Associates with Amyloidogenesis

Li, R., Song, B., Xu, L., Zheng, J., Pan, W., Cai, F., Wang, J., Wu, Y., & Song, W. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-221184 · Cited by 7 · see citing works

P53 orchestrates the microglial response upon amyloid-beta-induced neurodegeneration in vivo

González-Guerrero, S., Lapresa, R., Agulla, J., & Almeida, Á. (2021) · DIGITAL.CSIC (Spanish National Research Council (CSIC))