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Alzheimer’s disease like neuropathology in Down syndrome cortical organoids

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Induced Pluripotent Stem Cell-Derived Organoids: Their Implication in COVID-19 Modeling

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In Vitro Recapitulation of Neuropsychiatric Disorders with Pluripotent Stem Cells-Derived Brain Organoids

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Extracellular Vesicle Treatment Alleviates Neurodevelopmental and Neurodegenerative Pathology in Cortical Spheroid Model of Down Syndrome

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Risk of Alzheimer's disease in Down syndrome: Insights gained by multi‐omics

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Enhanced GIRK2 channel signaling in Down syndrome: A feasible role in the development of abnormal nascent neural circuits

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Modeling maternal cholesterol exposure reveals a reduction of neural progenitor proliferation using human cerebral organoids

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Genes Associated with Disturbed Cerebral Neurogenesis in the Embryonic Brain of Mouse Models of Down Syndrome

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Trisomy 21 Alters Cell Proliferation and Migration of iPSC-Derived Cardiomyocytes on Type VI Collagen

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A neuroimmune cerebral assembloid model to study the pathophysiology of familial Alzheimer’s disease

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Strategic use of organoids and organs-on-chip as biomimetic tools

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Migration deficits of the neural crest caused by CXADR triplication in a human Down syndrome stem cell model

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Cell type characterization of spatiotemporal gene co-expression modules in Down syndrome brain

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Identifying Multiomic Signatures of X‐Linked Retinoschisis‐Derived Retinal Organoids and Mice Harboring Patient‐Specific Mutation Using Spatiotemporal Single‐Cell Transcriptomics

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Biomedical applications of organoids in genetic diseases

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Generation of human nucleus basalis organoids with functional nbM-cortical cholinergic projections in transplanted assembloids

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The role of Down syndrome cell adhesion molecule in Down syndrome

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From wings to whiskers to stem cells: why every model matters in fragile X syndrome research

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Reversal of neurodevelopmental impairment and cognitive enhancement by pharmacological intervention with the polyphenol polydatin in a Down syndrome model

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Human Brain Organoids Model Abnormal Prenatal Neural Development Induced by Thermal Stimulation

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Advances and applications of brain organoids in central nervous system disorders: Bridging the gap from laboratory to clinic

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Single-cell atlas of the developing Down syndrome brain cortex

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In and out: Benchmarking in vitro, in vivo, ex vivo, and xenografting approaches for an integrative brain disease modeling pipeline

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Deciphering neuronal deficit and protein profile changes in human brain organoids from patients with creatine transporter deficiency

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Pathogenic PPP2R5D variants disrupt neuronal development and neurite outgrowth in patient-derived neurons that are reversed by allele-specific knockdown

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iPSCs-Derived Neurons and Brain Organoids from Patients

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Stem cell-based therapeutic strategies for down syndrome and Alzheimer’s disease

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Loss of SHROOM3 affects neuroepithelial cell shape through regulating cytoskeleton proteins in cynomolgus monkey organoids

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Aberrant Cortical Layer Development of Brain Organoids Derived from Noonan Syndrome-iPSCs

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Chromosomal and cellular therapeutic approaches for Down syndrome: A research update

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Trisomy 21-driven metabolite alterations are linked to cellular injuries in Down syndrome

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Reduced REST Expression in Neural Progenitor Cells, Adult Cortex, and Impaired REST Nuclear Translocation in the Prefrontal Cortex of Ts1Cje Mouse Model of Down Syndrome

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Application of brain organoids in neurodevelopmental disorders

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Mid-gestational cell-type-specific transcriptomic signatures in the prefrontal and superior temporal cortex in Down syndrome

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Pluripotent stem cells-based neural organoids for modelling human brain development and diseases

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A Novel Acetylcholine Nanosensor for Single Vesicle Storage and Sub‐Quantal Exocytosis in Living Neurons and Organoids

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The sodium channel SCN2A regulates cortical excitatory and inhibitory neurogenesis

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Exploring perspectives of Dscam for cognitive deficits: a review of multifunction for regulating neural wiring in homeostasis

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Brain organoids and genome editing: A new era in understanding human brain development and disorders

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Cellularity Defects Are Not Ubiquitous in the Brains of Fetuses With Down Syndrome

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Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter DeficiencyPreprint

Broca-Brisson, L., Harati, R., Disdier, C., Mózner, O., Gaston-Breton, R., Maïza, A., Costa, N., Guyot, A.-C., Sarkadi, B., Apáti, Á., et al. (2023) · eLife · doi:10.7554/elife.88459.1 · Cited by 3 · see citing works

Neural Organoids Protect Engineered Heart Tissues From Glucolipotoxicity by Transferring Versican in a Co‐Culture System

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Pharmacological Inhibition of p-21 Activated Kinase (PAK) Restores Impaired Neurite Outgrowth and Remodeling in a Cellular Model of Down Syndrome

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Integration of Magnetic-Field-Directed Self-Assembly-Based Cell Culture and Biosensing Platform for Improving hPSCs-Derived Neurons and Quantitative Detection of Neurotransmitter

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Perspectives in the investigation of Cockayne syndrome group B neurological disease: the utility of patient-derived brain organoid models

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Modeling Down syndrome neurodevelopment with isogenic cerebral organoidsPreprint

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The lncRNA Snhg11 is required for synaptic function, neurogenesis and memory and is downregulated in the dentate gyrus of Down syndrome mouse modelsPreprint

Sierra, C., Sabariego-Navarro, M., Fernández‐Blanco, Á., & Dierssen, M. (2022) · Research Square · doi:10.21203/rs.3.rs-2014117/v1 · Cited by 2 · see citing works

Spatiotemporal expression of Rest in the brain of Ts1Cje mouse model of Down syndromePreprint

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Modeling Down Syndrome Cortical Neurogenesis in Human Cerebral Organoids

Davis, C. J. (2019) · Figshare · doi:10.25417/uic.12481619

Amyloid precursor protein mediates deficits in corticogenesis in Down syndrome cortical organoidsPreprint

Rakowiecki, K., Patel, D., Cofresi, L. A., & Lazarov, O. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.26.666926

Alzheimer’s disease like neuropathology in Down syndrome cortical organoids

Zhao, H., & Haddad, G. G. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.1050432 · Cited by 12 · see citing works

In Vitro Modeling of Down Syndrome Neurogenesis Using Human-Induced Pluripotent Stem Cells

Sharma, V., Chhawari, H., Joshi, P., Nehra, S., & Singhal, N. (2025) · Journal of Visualized Experiments · doi:10.3791/67382 · Cited by 1 · see citing works

Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome

Silva, A. L. T. E., Yokota-Moreno, B. Y., Sertie, A. L., & Zampieri, B. L. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10497-8 · Cited by 16 · see citing works