Zhang, Bin

Sex Differences in Alzheimer’s Disease: Insights From the Multiomics Landscape

Guo, L., Zhong, M. B., Zhang, L., Zhang, B., & Cai, D. (2022) · Biological Psychiatry

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 164

AD-linked R47H- TREM2 mutation induces disease-enhancing microglial states via AKT hyperactivation

Sayed, F. A., Kodama, L., Fan, L., Carling, G. K., Udeochu, J. C., Le, D., Li, Q., Zhou, L., Wong, M. Y., Horowitz, R., et al. (2021) · Science Translational Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 155

Multiscale network modeling of oligodendrocytes reveals molecular components of myelin dysregulation in Alzheimer’s disease

McKenzie, A. T., Moyon, S., Wang, M., Katsyv, I., Song, W.-M., Zhou, X., Dammer, E. B., Duong, D. M., Aaker, J., Zhao, Y., et al. (2017) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 154

Cell-autonomous effects of APOE4 in restricting microglial response in brain homeostasis and Alzheimer’s disease

Liu, C.-C., Wang, N., Chen, Y., Inoue, Y., Shue, F., Ren, Y., Wang, M., Qiao, W., Ikezu, T. C., Li, Z., et al. (2023) · Nature Immunology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 146

Artificial intelligence framework identifies candidate targets for drug repurposing in Alzheimer’s disease

Fang, J., Zhang, P., Wang, Q., Chiang, C.-W., Zhou, Y., Hou, Y., Xu, J., Chen, R., Zhang, B., Lewis, S. J., et al. (2022) · Alzheimer's Research & Therapy

Alzheimer's disease research and treatmentsComputational Drug Discovery Methods

Cited by 140

Deficiency of TYROBP, an adapter protein for TREM2 and CR3 receptors, is neuroprotective in a mouse model of early Alzheimer’s pathology

Haure-Mirande, J.-V., Audrain, M., Fanutza, T., Kim, S. H., Klein, W. L., Glabe, C., Readhead, B., Dudley, J. T., Blitzer, R. D., Wang, M., et al. (2017) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 127

The landscape of multiscale transcriptomic networks and key regulators in Parkinson’s disease

Wang, Q., Zhang, Y., Wang, M., Song, W.-M., Shen, Q., McKenzie, A., Choi, I., Zhou, X., Pan, P.-Y., Yue, Z., et al. (2019) · Nature Communications

Parkinson's Disease Mechanisms and TreatmentsBioinformatics and Genomic Networks

Cited by 121

The landscape of human tissue and cell type specific expression and co-regulation of senescence genes

Xu, P., Wang, M., Song, W.-M., Wang, Q., Yuan, G.-C., Sudmant, P. H., Zare, H., Tu, Z., Orr, M. E., & Zhang, B. (2022) · Molecular Neurodegeneration

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 114

Autophagy protein NRBF2 has reduced expression in Alzheimer’s brains and modulates memory and amyloid-beta homeostasis in mice

Lachance, V., Wang, Q., Sweet, E., Choi, I., Cai, C.-Z., Zhuang, X.-X., Zhang, Y., Jiang, J. L., Blitzer, R. D., Bozdagi-Gunal, O., et al. (2019) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsAutophagy in Disease and Therapy

Cited by 96

Moringa Oleifera Alleviates Homocysteine-Induced Alzheimer’s Disease-Like Pathology and Cognitive Impairments

Mahaman, Y. A. R., Huang, F., Wu, M., Wang, Y., Wei, Z., Bao, J., Salissou, M. T. M., Ke, D., Wang, Q., Liu, R., et al. (2018) · Journal of Alzheimer s Disease

Alzheimer's disease research and treatmentsMoringa oleifera research and applications

Cited by 93

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in cerebral Aβ amyloidosis mouse normalizes clinical phenotype and complement subnetwork molecular pathology without reducing Aβ burden

Haure-Mirande, J.-V., Wang, M., Audrain, M., Fanutza, T., Kim, S. H., Heja, S., Readhead, B., Dudley, J. T., Blitzer, R. D., Schadt, E. E., et al. (2019) · Molecular Psychiatry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 84

Opposing effects of apoE2 and apoE4 on microglial activation and lipid metabolism in response to demyelination

Wang, N., Wang, M., Jeevaratnam, S., Rosenberg, C., Ikezu, T. C., Shue, F., Doss, S. V., Alnobani, A., Martens, Y. A., Wren, M., et al. (2022) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsMultiple Sclerosis Research Studies

Cited by 82

O-GlcNAcylation is required for mutant KRAS-induced lung tumorigenesis

Taparra, K., Wang, H., Malek, R., Lafargue, A., Barbhuiya, M. A., Wang, X., Simons, B. W., Ballew, M., Nugent, K., Groves, J., et al. (2018) · Journal of Clinical Investigation

Glycosylation and Glycoproteins ResearchCancer, Hypoxia, and Metabolism

Cited by 80

Deep Multilayer Brain Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression

Bai, B., Wang, X., Li, Y., Chen, P.-C., Yu, K., Dey, K. K., Yarbro, J. M., Han, X., Lutz, B. M., Rao, S., et al. (2020) · Neuron

Alzheimer's disease research and treatmentsAdvanced Proteomics Techniques and Applications

Cited by 78

Microglial INPP5D limits plaque formation and glial reactivity in the PSAPP mouse model of Alzheimer's disease

Castranio, E. L., Hasel, P., Haure‐Mirande, J., Ramirez Jimenez, A. V., Hamilton, B. W., Kim, R. D., Glabe, C. G., Wang, M., Zhang, B., Gandy, S., et al. (2023) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 74

Culture shock: microglial heterogeneity, activation, and disrupted single-cell microglial networks in vitro

Cadiz, M. P., Jensen, T. D., Sens, J. P., Zhu, K., Song, W.-M., Zhang, B., Ebbert, M., Chang, R., & Fryer, J. D. (2022) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsSingle-cell and spatial transcriptomics

Cited by 73

Integrative approach to sporadic Alzheimer’s disease: deficiency of TYROBP in a tauopathy mouse model reduces C1q and normalizes clinical phenotype while increasing spread and state of phosphorylation of tau

Audrain, M., Haure-Mirande, J.-V., Wang, M., Kim, S. H., Fanutza, T., Chakrabarty, P., Fraser, P., St George-Hyslop, P. H., Golde, T. E., Blitzer, R. D., et al. (2019) · Molecular Psychiatry

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 68

Diversified transcriptional responses of myeloid and glial cells in spinal cord injury shaped by HDAC3 activity

Wahane, S., Zhou, X., Zhou, X., Guo, L., Friedl, M.-S., Kluge, M., Ramakrishnan, A., Shen, L., Friedel, C. C., Zhang, B., et al. (2021) · Science Advances

Spinal Cord Injury ResearchNeuroinflammation and Neurodegeneration Mechanisms

Cited by 67

Reactive or transgenic increase in microglial TYROBP reveals a TREM2‐independent TYROBP–APOE link in wild‐type and Alzheimer's‐related mice

Audrain, M., Haure‐Mirande, J., Mleczko, J., Wang, M., Griffin, J. K., St George‐Hyslop, P. H., Fraser, P., Zhang, B., Gandy, S., & Ehrlich, M. E. (2021) · Alzheimer's & Dementia

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 65

Network models of primary melanoma microenvironments identify key melanoma regulators underlying prognosis

Song, W.-M., Agrawal, P., Von Itter, R., Fontanals-Cirera, B., Wang, M., Zhou, X., Mahal, L. K., Hernando, E., & Zhang, B. (2021) · Nature Communications

Bioinformatics and Genomic NetworksCutaneous Melanoma Detection and Management

Cited by 62

Sex specific molecular networks and key drivers of Alzheimer’s disease

Guo, L., Cao, J., Hou, J., Li, Y., Huang, M., Zhu, L., Zhang, L., Lee, Y., Duarte, M. L., Zhou, X., et al. (2023) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 49

A brain proteomic signature of incipient Alzheimer’s disease in young APOE ε4 carriers identifies novel drug targets

Roberts, J. A., Varma, V. R., An, Y., Varma, S., Candia, J., Fantoni, G., Tiwari, V., Anerillas, C., Williamson, A., Saito, A., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 49

EPRS is a critical regulator of cell proliferation and estrogen signaling in ER+ breast cancer

Katsyv, I., Wang, M., Song, W. M., Zhou, X., Zhao, Y., Park, S., Zhu, J., Zhang, B., & Irie, H. Y. (2016) · Oncotarget

Estrogen and related hormone effectsRNA and protein synthesis mechanisms

Cited by 47

EMUDRA: Ensemble of Multiple Drug Repositioning Approaches to improve prediction accuracy

Zhou, X., Wang, M., Katsyv, I., Irie, H., & Zhang, B. (2018) · Bioinformatics

Computational Drug Discovery MethodsBioinformatics and Genomic Networks

Cited by 43