Zhang, Bin

Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility

Bagot, R. C., Cates, H. M., Purushothaman, I., Lorsch, Z. S., Walker, D. M., Wang, J., Huang, X., Schlüter, O. M., Maze, I., Peña, C. J., et al. (2016) · Neuron

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

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Postmortem Cortex Samples Identify Distinct Molecular Subtypes of ALS: Retrotransposon Activation, Oxidative Stress, and Activated Glia

Tam, O. H., Rozhkov, N. V., Shaw, R., Kim, D., Hubbard, I., Fennessey, S., Propp, N., Phatnani, H., Kwan, J., Sareen, D., et al. (2019) · Cell Reports

Amyotrophic Lateral Sclerosis ResearchAlzheimer's disease research and treatments

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Senolytic therapy to modulate the progression of Alzheimer’s Disease (SToMP-AD) – Outcomes from the first clinical trial of senolytic therapy for Alzheimer's disease

Orr, M., Gonzales, M., Garbarino, V., Kautz, T., Palavicini, J., Lopez-Cruzan, M., Dehkordi, S. K., Mathews, J., Zare, H., Xu, P., et al. (2023) · Nature Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

Wang, M., Roussos, P., McKenzie, A., Zhou, X., Kajiwara, Y., Brennand, K. J., De Luca, G. C., Crary, J. F., Casaccia, P., Buxbaum, J. D., et al. (2016) · Genome Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis

Henderson, M. X., Cornblath, E. J., Darwich, A., Zhang, B., Brown, H., Gathagan, R. J., Sandler, R. M., Bassett, D. S., Trojanowski, J. Q., & Lee, V. M. Y. (2019) · Nature Neuroscience

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

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The mouse cortico–basal ganglia–thalamic network

Foster, N. N., Barry, J., Korobkova, L., Garcia, L., Gao, L., Becerra, M., Sherafat, Y., Peng, B., Li, X., Choi, J.-H., et al. (2021) · Nature

Deep Brain Stimulation and Movement DisordersNeuroscience and Neuropharmacology Research

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Molecular subtyping of Alzheimer’s disease using RNA sequencing data reveals novel mechanisms and targets

Neff, R. A., Wang, M., Vatansever, S., Guo, L., Ming, C., Wang, Q., Wang, E., Horgusluoglu-Moloch, E., Song, W.-M., Li, A., et al. (2021) · Science Advances

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Mouse Model of Multiple System Atrophy α-Synuclein Expression in Oligodendrocytes Causes Glial and Neuronal Degeneration

Yazawa, I., Giasson, B. I., Sasaki, R., Zhang, B., Joyce, S., Uryu, K., Trojanowski, J. Q., & Lee, V. M.-Y. (2005) · Neuron

Parkinson's Disease Mechanisms and TreatmentsNeuroinflammation and Neurodegeneration Mechanisms

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Meta-Analysis of the Alzheimer’s Disease Human Brain Transcriptome and Functional Dissection in Mouse Models

Wan, Y.-W., Al-Ouran, R., Mangleburg, C. G., Perumal, T. M., Lee, T. V., Allison, K., Swarup, V., Funk, C. C., Gaiteri, C., Allen, M., et al. (2020) · Cell Reports

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2

Zhou, X., Wahane, S., Friedl, M.-S., Kluge, M., Friedel, C. C., Avrampou, K., Zachariou, V., Guo, L., Zhang, B., He, X., et al. (2020) · Nature Neuroscience

Spinal Cord Injury ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Sherlock: Detecting Gene-Disease Associations by Matching Patterns of Expression QTL and GWAS

He, X., Fuller, C. K., Song, Y., Meng, Q., Zhang, B., Yang, X., & Li, H. (2013) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

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Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk

Rajarajan, P., Borrman, T., Liao, W., Schrode, N., Flaherty, E., Casiño, C., Powell, S., Yashaswini, C., LaMarca, E. A., Kassim, B., et al. (2018) · Science

Genomics and Chromatin DynamicsSchizophrenia research and treatment

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Metabolic Network Analysis Reveals Altered Bile Acid Synthesis and Metabolism in Alzheimer’s Disease

Baloni, P., Funk, C. C., Yan, J., Yurkovich, J. T., Kueider-Paisley, A., Nho, K., Heinken, A., Jia, W., Mahmoudiandehkordi, S., Louie, G., et al. (2020) · Cell Reports Medicine

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Integrated analysis of ultra-deep proteomes in cortex, cerebrospinal fluid and serum reveals a mitochondrial signature in Alzheimer’s disease

Wang, H., Dey, K. K., Chen, P.-C., Li, Y., Niu, M., Cho, J.-H., Wang, X., Bai, B., Jiao, Y., Chepyala, S. R., et al. (2020) · Molecular Neurodegeneration

Alzheimer's disease research and treatmentsAdvanced Proteomics Techniques and Applications

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Common dysregulation network in the human prefrontal cortex underlies two neurodegenerative diseases

Narayanan, M., Huynh, J. L., Wang, K., Yang, X., Yoo, S., McElwee, J., Zhang, B., Zhang, C., Lamb, J. R., Xie, T., et al. (2014) · Molecular Systems Biology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence

Choi, I., Wang, M., Yoo, S., Xu, P., Seegobin, S. P., Li, X., Han, X., Wang, Q., Peng, J., Zhang, B., et al. (2023) · Nature Cell Biology

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

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Integrative Genomics Reveals Novel Molecular Pathways and Gene Networks for Coronary Artery Disease

Mäkinen, V.-P., Civelek, M., Meng, Q., Zhang, B., Zhu, J., Levian, C., Huan, T., Segrè, A. V., Ghosh, S., Vivar, J., et al. (2014) · PLoS Genetics

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

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Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity

Luk, K. C., Covell, D. J., Kehm, V. M., Zhang, B., Song, I. Y., Byrne, M. D., Pitkin, R. M., Decker, S. C., Trojanowski, J. Q., & Lee, V. M.-Y. (2016) · Cell Reports

Parkinson's Disease Mechanisms and TreatmentsAlzheimer's disease research and treatments

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Transformative Network Modeling of Multi-omics Data Reveals Detailed Circuits, Key Regulators, and Potential Therapeutics for Alzheimer’s Disease

Wang, M., Li, A., Sekiya, M., Beckmann, N. D., Quan, X., Schrode, N., Fernando, M. B., Yu, A., Zhu, L., Cao, J., et al. (2021) · Neuron

Alzheimer's disease research and treatmentsBioinformatics and Genomic Networks

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Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

Horgusluoglu, E., Neff, R., Song, W., Wang, M., Wang, Q., Arnold, M., Krumsiek, J., Galindo‐Prieto, B., Ming, C., Nho, K., et al. (2022) · Alzheimer's & Dementia

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Multiscale causal networks identify VGF as a key regulator of Alzheimer’s disease

Beckmann, N. D., Lin, W.-J., Wang, M., Cohain, A. T., Charney, A. W., Wang, P., Ma, W., Wang, Y.-C., Jiang, C., Audrain, M., et al. (2020) · Nature Communications

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

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Profiling senescent cells in human brains reveals neurons with CDKN2D/p19 and tau neuropathology

Dehkordi, S. K., Walker, J., Sah, E., Bennett, E., Atrian, F., Frost, B., Woost, B., Bennett, R. E., Orr, T. C., Zhou, Y., et al. (2021) · Nature Aging

Telomeres, Telomerase, and SenescenceAlzheimer's disease research and treatments

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Peripheral apoE4 enhances Alzheimer’s pathology and impairs cognition by compromising cerebrovascular function

Liu, C.-C., Zhao, J., Fu, Y., Inoue, Y., Ren, Y., Chen, Y., Doss, S. V., Shue, F., Jeevaratnam, S., Bastea, L., et al. (2022) · Nature Neuroscience

Alzheimer's disease research and treatmentsBarrier Structure and Function Studies

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A Systems Biology Framework Identifies Molecular Underpinnings of Coronary Heart Disease

Huan, T., Zhang, B., Wang, Z., Joehanes, R., Zhu, J., Johnson, A. D., Ying, S., Munson, P. J., Raghavachari, N., Wang, R., et al. (2013) · Arteriosclerosis, Thrombosis, and Vascular Biology

Bioinformatics and Genomic NetworksGenetic Associations and Epidemiology

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