Chen, Yun

An atlas of active enhancers across human cell types and tissues

The FANTOM Consortium, Andersson, R., Gebhard, C., Miguel-Escalada, I., Hoof, I., Bornholdt, J., Boyd, M., Chen, Y., Zhao, X., Schmidl, C., et al. (2014) · Nature

Genomics and Chromatin DynamicsCancer-related molecular mechanisms research

Cited by 2,550

PINK1-Phosphorylated Mitofusin 2 Is a Parkin Receptor for Culling Damaged Mitochondria

Chen, Y., & Dorn, G. W. (2013) · Science

Autophagy in Disease and TherapyParkinson's Disease Mechanisms and Treatments

Cited by 1,323

TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Molgora, M., Esaulova, E., Vermi, W., Hou, J., Chen, Y., Luo, J., Brioschi, S., Bugatti, M., Omodei, A. S., Ricci, B., et al. (2020) · Cell

Cancer Immunotherapy and BiomarkersImmune cells in cancer

Cited by 656

Mitochondrial Fission and Fusion Factors Reciprocally Orchestrate Mitophagic Culling in Mouse Hearts and Cultured Fibroblasts

Song, M., Mihara, K., Chen, Y., Scorrano, L., & Dorn, G. W. (2015) · Cell Metabolism

Mitochondrial Function and PathologyAutophagy in Disease and Therapy

Cited by 482

TREM2 drives microglia response to amyloid-β via SYK-dependent and -independent pathways

Wang, S., Sudan, R., Peng, V., Zhou, Y., Du, S., Yuede, C. M., Lei, T., Hou, J., Cai, Z., Cella, M., et al. (2022) · Cell

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 471

Microglia in Alzheimer's disease at single-cell level. Are there common patterns in humans and mice?

Chen, Y., & Colonna, M. (2021) · Journal of Experimental Medicine

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 339

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. (2021) · Neuron

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 298

Bax regulates primary necrosis through mitochondrial dynamics

Whelan, R. S., Konstantinidis, K., Wei, A.-C., Chen, Y., Reyna, D. E., Jha, S., Yang, Y., Calvert, J. W., Lindsten, T., Thompson, C. B., et al. (2012) · Proceedings of the National Academy of Sciences

Cell death mechanisms and regulationMitochondrial Function and Pathology

Cited by 290

Identification of a Nuclear Exosome Decay Pathway for Processed Transcripts

Meola, N., Domanski, M., Karadoulama, E., Chen, Y., Gentil, C., Pultz, D., Vitting-Seerup, K., Lykke-Andersen, S., Andersen, J. S., Sandelin, A., et al. (2016) · Molecular Cell

RNA Research and SplicingRNA regulation and disease

Cited by 290

Activated microglia mitigate Aβ-associated tau seeding and spreading

Gratuze, M., Chen, Y., Parhizkar, S., Jain, N., Strickland, M. R., Serrano, J. R., Colonna, M., Ulrich, J. D., & Holtzman, D. M. (2021) · Journal of Experimental Medicine

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 215

TREM2 dependent and independent functions of microglia in Alzheimer’s disease

Hou, J., Chen, Y., Grajales-Reyes, G., & Colonna, M. (2022) · Molecular Neurodegeneration

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 191

APOE3ch alters microglial response and suppresses Aβ-induced tau seeding and spread

Chen, Y., Song, S., Parhizkar, S., Lord, J., Zhu, Y., Strickland, M. R., Wang, C., Park, J., Tabor, G. T., Jiang, H., et al. (2024) · Cell

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 120

TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma

Sun, R., Han, R., McCornack, C., Khan, S., Tabor, G. T., Chen, Y., Hou, J., Jiang, H., Schoch, K. M., Mao, D. D., et al. (2023) · Science Advances

Glioma Diagnosis and TreatmentImmune cells in cancer

Cited by 119

Transcriptomic atlas and interaction networks of brain cells in mouse CNS demyelination and remyelination

Hou, J., Zhou, Y., Cai, Z., Terekhova, M., Swain, A., Andhey, P. S., Guimaraes, R. M., Ulezko Antonova, A., Qiu, T., Sviben, S., et al. (2023) · Cell Reports

Multiple Sclerosis Research StudiesSingle-cell and spatial transcriptomics

Cited by 85

Principles for RNA metabolism and alternative transcription initiation within closely spaced promoters

Chen, Y., Pai, A. A., Herudek, J., Lubas, M., Meola, N., Järvelin, A. I., Andersson, R., Pelechano, V., Steinmetz, L. M., Jensen, T. H., et al. (2016) · Nature Genetics

Genomics and Chromatin DynamicsRNA Research and Splicing

Cited by 78

Skin basal cell carcinomas assemble a pro-tumorigenic spatially organized and self-propagating Trem2+ myeloid niche

Haensel, D., Daniel, B., Gaddam, S., Pan, C., Fabo, T., Bjelajac, J., Jussila, A. R., Gonzalez, F., Li, N. Y., Chen, Y., et al. (2023) · Nature Communications

Immune cells in cancerCancer Immunotherapy and Biomarkers

Cited by 29

Apolipoprotein E secreted by astrocytes forms antiparallel dimers in discoidal lipoproteins

Strickland, M. R., Rau, M. J., Summers, B., Basore, K., Wulf, J., Jiang, H., Chen, Y., Ulrich, J. D., Randolph, G. J., Zhang, R., et al. (2024) · Neuron

Alzheimer's disease research and treatmentsCholesterol and Lipid Metabolism

Cited by 28

Acute TREM2 inhibition depletes MAFB-high microglia and hinders remyelination

Hou, J., Magliozzi, R., Chen, Y., Wu, J., Wulf, J., Strout, G., Fang, X., & Colonna, M. (2025) · Proceedings of the National Academy of Sciences

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 20

New insights into innate immunity in Alzheimer’s disease: From APOE protective variants to therapies

Chen, Y., & Holtzman, D. M. (2024) · Trends in Immunology

Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration Mechanisms

Cited by 19

Towards an AI biomedical scientist: Accelerating discoveries in neurodegenerative disease

Roberts, K. F., Landsness, E. C., Reese, J., Elbert, D., Strobel, G., Wu, E., Chen, Y., Lai, A., Abrams, Z. B., Zhu, M., et al. (2026) · The Journal of Prevention of Alzheimer's Disease

Artificial Intelligence in Healthcare and EducationArtificial Intelligence Applications

Cited by 1