TREM2 dependent and independent functions of microglia in Alzheimer’s disease

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A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

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The Classical Complement Cascade Mediates CNS Synapse Elimination

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Alzheimer’s Disease

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The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

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NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

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Type I interferons in infectious disease

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Single-cell transcriptomic analysis of Alzheimer’s disease

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Variant of <i>TREM2</i> Associated with the Risk of Alzheimer's Disease

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The NALP3 inflammasome is involved in the innate immune response to amyloid-β

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Complex cell-state changes revealed by single cell RNA sequencing of 76,149 microglia throughout the mouse lifespan and in the injured brain

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Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model

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Tissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment

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Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

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Colony-Stimulating Factor 1 Receptor Signaling Is Necessary for Microglia Viability, Unmasking a Microglia Progenitor Cell in the Adult Brain

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Microglia in Alzheimer’s disease

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TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

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Depletion of microglia and inhibition of exosome synthesis halt tau propagation

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A polarizing question: do M1 and M2 microglia exist?

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Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

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CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

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NLRP3 inflammasome activation drives tau pathology

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An english translation of alzheimer’s 1907 paper, “über eine eigenartige erkankung der hirnrinde”

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Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain

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Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

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Environment Drives Selection and Function of Enhancers Controlling Tissue-Specific Macrophage Identities

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TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

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ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

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Microglia development follows a stepwise program to regulate brain homeostasis

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Microglial brain region-dependent diversity and selective regional sensitivities to aging

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Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

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Developmental Heterogeneity of Microglia and Brain Myeloid Cells Revealed by Deep Single-Cell RNA Sequencing

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Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

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Large-scale proteomic analysis of Alzheimer’s disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and astrocyte activation

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Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

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Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex

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Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

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TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

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Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model

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CD36 coordinates NLRP3 inflammasome activation by facilitating intracellular nucleation of soluble ligands into particulate ligands in sterile inflammation

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The Major Risk Factors for Alzheimer’s Disease: Age, Sex, and Genes Modulate the Microglia Response to Aβ Plaques

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TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

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Brain cell type–specific enhancer–promoter interactome maps and disease <b>-</b> risk association

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TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy

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Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

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The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation

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TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function

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Microglia Promote the Death of Developing Purkinje Cells

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TREM2 regulates microglial cholesterol metabolism upon chronic phagocytic challenge

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Transcriptomic analysis of purified human cortical microglia reveals age-associated changes

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Temporal Tracking of Microglia Activation in Neurodegeneration at Single-Cell Resolution

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White matter changes in Alzheimer’s disease: A focus on myelin and oligodendrocytes

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Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques

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Eliminating microglia in Alzheimer’s mice prevents neuronal loss without modulating amyloid-β pathology

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The Microglial Innate Immune Receptor TREM2 Is Required for Synapse Elimination and Normal Brain Connectivity

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Mutations in Two Genes Encoding Different Subunits of a Receptor Signaling Complex Result in an Identical Disease Phenotype

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TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

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Diverse Brain Myeloid Expression Profiles Reveal Distinct Microglial Activation States and Aspects of Alzheimer’s Disease Not Evident in Mouse Models

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Microglia: Dynamic Mediators of Synapse Development and Plasticity

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TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

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A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

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The Physiology, Pathology, and Potential Therapeutic Applications of the TREM2 Signaling Pathway

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Comparative Lipidomic Analysis of Mouse and Human Brain with Alzheimer Disease

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Quantification of myelin loss in frontal lobe white matter in vascular dementia, Alzheimer’s disease, and dementia with Lewy bodies

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APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease

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TREM2 sustains macrophage-hepatocyte metabolic coordination in nonalcoholic fatty liver disease and sepsis

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Neurodegenerative disease mutations in TREM2 reveal a functional surface and distinct loss-of-function mechanisms

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Microglial Dynamics During Human Brain Development

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Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination

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Alzheimer’s-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia

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Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

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Mechanisms of lysophosphatidylcholine‐induced demyelination: A primary lipid disrupting myelinopathy

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Transcriptional control of microglia phenotypes in health and disease

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Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2)

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Activated microglia mitigate Aβ-associated tau seeding and spreading

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Integration of Alzheimer’s disease genetics and myeloid genomics identifies disease risk regulatory elements and genes

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Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model

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Human fetal microglia acquire homeostatic immune-sensing properties early in development

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TREM-2 promotes macrophage survival and lung disease after respiratory viral infection

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IFN-γ Promotes Complement Expression and Attenuates Amyloid Plaque Deposition in Amyloid β Precursor Protein Transgenic Mice

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TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant

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Mechanisms of Cell Signaling and Inflammation in Alzheimers Disease

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Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer’s disease

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TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination

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Oxidized phosphatidylcholines found in multiple sclerosis lesions mediate neurodegeneration and are neutralized by microglia

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ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

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Absence of microglia promotes diverse pathologies and early lethality in Alzheimer’s disease mice

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The Role of TGFβ Signaling in Microglia Maturation and Activation

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High‐affinity interactions and signal transduction between Aβ oligomers and TREM2

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Molecular basis for the loss-of-function effects of the Alzheimer’s disease-associated R47H variant of the immune receptor TREM2

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Type-1 interferon signaling mediates neuro-inflammatory events in models of Alzheimer’s disease

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Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer’s disease

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Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease

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A tetravalent TREM2 agonistic antibody reduced amyloid pathology in a mouse model of Alzheimer’s disease

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A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia

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Overexpressing low‐density lipoprotein receptor reduces tau‐associated neurodegeneration in relation to apoE‐linked mechanisms

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Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation

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DAP12 stabilizes the C-terminal fragment of the triggering receptor expressed on myeloid cells-2 (TREM2) and protects against LPS-induced pro-inflammatory response

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Adult-onset CNS myelin sulfatide deficiency is sufficient to cause Alzheimer’s disease-like neuroinflammation and cognitive impairment

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Opposite microglial activation stages upon loss of PGRN or TREM2 result in reduced cerebral glucose metabolism

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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia

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Hippocampal expression of murine TNFα results in attenuation of amyloid deposition in vivo

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A rare coding variant in TREM2 increases risk for Alzheimer's disease in Han Chinese

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The triggering receptor expressed on myeloid cells 2 ( <i>TREM2</i> ) is associated with enhanced inflammation, neuropathological lesions and increased risk for Alzheimer's dementia

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Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression

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Tissue-specific macrophages: how they develop and choreograph tissue biology

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Emerging diagnostics and therapeutics for Alzheimer disease

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Neuroinflammation across neurological diseases

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Preclinical and first-in-human evaluation of AL002, a novel TREM2 agonistic antibody for Alzheimer’s disease

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TREM2 regulates microglial lipid droplet formation and represses post-ischemic brain injury

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Stimulation of TREM2 with agonistic antibodies—an emerging therapeutic option for Alzheimer's disease

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Decoding microglial immunometabolism: a new frontier in Alzheimer's disease research

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Microglial function, INPP5D/SHIP1 signaling, and NLRP3 inflammasome activation: implications for Alzheimer’s disease

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From Homeostasis to Neuroinflammation: Insights into Cellular and Molecular Interactions and Network Dynamics

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Neuroimmune crosstalk in chronic neuroinflammation: microglial interactions and immune modulation

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A single-cell and spatial RNA-seq database for Alzheimer’s disease (ssREAD)

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Current views on meningeal lymphatics and immunity in aging and Alzheimer’s disease

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Alzheimer’s disease and neuroinflammation: will new drugs in clinical trials pave the way to a multi-target therapy?

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Microglia, Trem2, and Neurodegeneration

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TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice

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Complement-mediated synapse loss in Alzheimer’s disease: mechanisms and involvement of risk factors

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C5aR1 antagonism suppresses inflammatory glial responses and alters cellular signaling in an Alzheimer’s disease mouse model

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BHLHE40/41 regulate Microglia and Peripheral Macrophage Responses Associated With Alzheimer's Disease and Other Disorders of Lipid‐rich Tissues

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Beyond Amyloid and Tau: The Critical Role of Microglia in Alzheimer’s Disease Therapeutics

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Itaconate restrains acute proinflammatory activation of microglia MG after traumatic brain injury in mice

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Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model

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Single-cell spatial transcriptomics reveals distinct patterns of dysregulation in non-neuronal and neuronal cells induced by the Trem2R47H Alzheimer’s risk gene mutation

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Brain border-associated macrophages: common denominators in infection, aging, and Alzheimer’s disease?

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Rejuvenating aged microglia by p16ink4a-siRNA-loaded nanoparticles increases amyloid-β clearance in animal models of Alzheimer’s disease

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The TREM2 agonistic antibody AL002 in early Alzheimer’s disease: a phase 2 randomized trial

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The dual nature of neuroinflammation in networked brain

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Decoding mechanisms and protein markers in lung-brain axis

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Neutral or Detrimental Effects of TREM2 Agonist Antibodies in Preclinical Models of Alzheimer’s Disease and Multiple Sclerosis

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Neuroimaging biomarkers and CSF sTREM2 levels in Alzheimer’s disease: a longitudinal study

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PET imaging of microglia in Alzheimer's disease using copper-64 labeled TREM2 antibodies

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Myelin debris phagocytosis in demyelinating disease

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ncRNAs and their impact on dopaminergic neurons: Autophagy pathways in Parkinson's disease

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Systemic Administration of Neurotransmitter‐Derived Lipidoids‐PROTACs‐DNA Nanocomplex Promotes Tau Clearance and Cognitive Recovery for Alzheimer's Disease Therapy

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The Interplay Between Accumulation of Amyloid-Beta and Tau Proteins, PANoptosis, and Inflammation in Alzheimer’s Disease

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Microglia in ALS: Insights into Mechanisms and Therapeutic Potential

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Clinical relevance of animal models in aging-related dementia research

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TREM2-dependent activation of microglial cell protects photoreceptor cell during retinal degeneration via PPARγ and CD36

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Advancements and challenges in mouse models of Alzheimer’s disease

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EVOO Polyphenols Exert Anti-Inflammatory Effects on the Microglia Cell through TREM2 Signaling Pathway

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Macrophage activation contributes to diabetic retinopathy

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TREM2 regulates microglial phagocytosis of synapses in innate immune tolerance

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Microglia-Mediated Phagocytosis in Alzheimer’s Disease: Mechanisms, Heterogeneity, and Therapeutic Insights

Hassan, H., Rawlinson, C., Lan, Y., Jenkins, S. I., & Chen, R. (2025) · Biomolecules · doi:10.3390/biom15111629 · Cited by 24 · see citing works

TREM2 in Neurodegenerative Disorders: Mutation Spectrum, Pathophysiology, and Therapeutic Targeting

Yang, H.-W., Kim, D., Yang, Y., Bagyinszky, E., & An, S. S. A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157057 · Cited by 25 · see citing works

Microglial polarization in Alzheimer's disease: Mechanisms, implications, and therapeutic opportunities

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Comparative Insight into Microglia/Macrophages-Associated Pathways in Glioblastoma and Alzheimer’s Disease

Shi, J., & Huang, S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010016 · Cited by 22 · see citing works

Exploring novel roles of lipid droplets and lipid metabolism in regulating inflammation and blood–brain barrier function in neurological diseases

Fu, L., Luo, T., Hao, Z., Pan, Y., Xin, W., Zhang, L., Lai, Z., Zhang, H., Liu, H., & Wei, W. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1603292 · Cited by 20 · see citing works

Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing

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The Immuno-Glial Connectome in Alzheimer’s Disease: Integrating Central and Peripheral Inflammatory Networks

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Identification of potential therapeutic targets for Alzheimer's disease from the proteomes of plasma and cerebrospinal fluid in a multicenter Mendelian randomization study

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Inflammation and Brain Structure in Alzheimer’s Disease and Other Neurodegenerative Disorders: a Mendelian Randomization Study

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Expression of INPP5D Isoforms in Human Brain: Impact of Alzheimer’s Disease Neuropathology and Genetics

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Microglial Neuroinflammation in Alzheimer’s Disease: Mechanisms and Therapies

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Microglial apolipoprotein E particles contribute to neuronal senescence and synaptotoxicity

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Neuroinflammation: An Oligodendrocentric View

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Emerging Role of Oligodendrocytes Malfunction in the Progression of Alzheimer's Disease

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Docosahexaenoic Acid (DHA) Reduces LPS-Induced Inflammatory Response Via ATF3 Transcription Factor and Stimulates Src/Syk Signaling-Dependent Phagocytosis in Microglia

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Distinct brain alterations and neurodegenerative processes in cognitive impairment associated with post-acute sequelae of COVID-19

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Extracellular vesicles mediate inflammasome signaling in the brain and heart of Alzheimer’s disease mice

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The role of microglial TREM2 in development: A path toward neurodegeneration?

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Engineering exosomes for Alzheimer's disease: Multi‐target therapeutic strategies from pathogenesis to clinical translation

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The emerging role of the microglia triggering receptor expressed on myeloid cells (TREM) 2 in multiple sclerosis

Farzan, M., Rounkian, M. S., Rizi, A. A., Heidari, Z., Farzan, M., Fathi, M., Aghaei, A., Azadegan‐Dehkordi, F., & Bagheri, N. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115071 · Cited by 14 · see citing works

Microglial Dysfunction and Amyloid-Beta Pathology in Alzheimer’s Disease and HIV-Associated Neurocognitive Disorders

Njoku, G. C., & Kanmogne, G. D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26189069 · Cited by 15 · see citing works

The Pathogenesis in Alzheimer's Disease: TREM2 as a Potential Target

Liu, G., Zhang, L., Fan, Y., & Ji, W. (2023) · Journal of Integrative Neuroscience · doi:10.31083/j.jin2206150 · Cited by 13 · see citing works

Variants in the MS4A cluster interact with soluble TREM2 expression on biomarkers of neuropathology

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General Pathophysiology of Microglia

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Exosomes derived from TREM-2 knocked-out macrophages alleviated renal fibrosis via HSPa1b/AKT pathway

Xiao, Z., Wang, Y., Chen, Y., Jin, L., Shi, Y., Liu, C., Fu, C., & Cao, Y. (2024) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00219.2024 · Cited by 12 · see citing works

Role of TREM2 in immune and neurological diseases: Structure, function, and implications

Yin, P., Su, Z., Shu, X., Dong, Z., & Tian, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113286 · Cited by 12 · see citing works

TREM2 Alleviates Neuroinflammation by Maintaining Cellular Metabolic Homeostasis and Mitophagy Activity During Early Inflammation

Hu, L., Liu, J., Peng, J., Li, X., Huang, Z., Zhang, C., & Fan, S. (2025) · Diseases · doi:10.3390/diseases13020060 · Cited by 11 · see citing works

Variable and interactive effects of Sex, APOE ε4 and TREM2 on the deposition of tau in entorhinal and neocortical regions

Giorgio, J., Jonson, C., Wang, Y., Yokoyama, J. S., Wang, J., Jagust, W. J., & Initiative, O. B. O. T. A. D. N. (2025) · Nature Communications · doi:10.1038/s41467-025-60370-8 · Cited by 12 · see citing works

News & views: anti-amyloid antibodies and novel emerging approaches to Alzheimer’s disease in 2023

Gandy, S. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00656-x · Cited by 11 · see citing works

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease

McKinney, J. E., Bennett, M. L., & Bennett, F. C. (2026) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-042624-114332 · Cited by 12 · see citing works

Systems biology of Alzheimer’s Disease: a scoping review of key pathways and mechanisms

Bice, P. J., Nho, K. T., Ertekin‐Taner, N., & Saykin, A. J. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00934-4 · Cited by 13 · see citing works

Disentangling causality in brain aging: The complex interplay between glial senescence, neuroinflammation, and neurodegeneration

Suk, K. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.115737 · Cited by 10 · see citing works

Both TREM2-dependent macrophages and Kupffer cells play a protective role in APAP-induced acute liver injury

Chao, S., Shan, S., Liu, Z., Liu, Z., Wang, S., Qiang, Y., Ni, W., Li, H., Dong, C., Jia, Q., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112926 · Cited by 11 · see citing works

Novel insights into the role of TREM2 in cerebrovascular diseases

Awuah, W. A., Ben-Jaafar, A., Kong, J. S. H., Sanker, V., Shah, M. H., Poornaselvan, J., Frimpong, M., Imran, S., Alocious, T., Abdul-Rahman, T., et al. (2024) · Brain Research · doi:10.1016/j.brainres.2024.149245 · Cited by 10 · see citing works

TREM 2 in Parkinson’s Disease: A Promising Candidate Gene for Disease Susceptibility and Progression

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Targeting the chemokine-microglia nexus: A novel strategy for modulating neuroinflammation in Alzheimer's disease

Xu, B., Tang, C., Han, R., Zhu, C., Yang, Y., Li, H. J., Wu, N., & He, D. (2025) · Journal of Alzheimer s Disease Reports · doi:10.1177/25424823251326044 · Cited by 10 · see citing works

TREM2 on microglia cell surface binds to and forms functional binary complexes with heparan sulfate modified with 6-O-sulfation and iduronic acid

McMillan, I. O., Liang, L., Su, G.-W., Song, X.-H., Drago, K., Yang, H., Alvarez, C., Sood, A., Gibson, J. M., Woods, R., et al. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107691 · Cited by 10 · see citing works

Pathologic and Therapeutic Schwann Cells

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A novel Mediterranean diet-inspired supplement reduces hippocampal amyloid deposits and microglial activation through the modulation of the microbiota gut-brain axis in 5xFAD mice

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Metabolic reprogramming and signalling networks in microglial activation: Implications for neurodegeneration

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Brain-immune interactions: implication for cognitive impairments in Alzheimer's disease and autoimmune disorders

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The role of TREM2 in myelin sheath dynamics: A comprehensive perspective from physiology to pathology

Que, X., Zhang, T., Liu, X. Y., Yin, Y., Xia, X., Gong, P., Song, W., Qin, Q., Xu, Q., & Tang, Y. (2025) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2025.102732 · Cited by 8 · see citing works

Elucidating the Role of Trem2 in Lipid Metabolism and Neuroinflammation

Zhao, C., Qi, W., Lv, X., Gao, X.-L., Liu, C.-N., & Zheng, S.-M. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70338 · Cited by 7 · see citing works

KChIP3 fosters neuroinflammation and synaptic dysfunction in the 5XFAD mouse model of Alzheimer’s disease

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Interpretable deep learning framework for understanding molecular changes in human brains with Alzheimer’s disease: implications for microglia activation and sex differences

Trivedi, M. R., Joshi, A. M., Shah, J., Readhead, B. P., Wilson, M. A., Su, Y., Reiman, E. M., Wu, T., & Wang, Q. (2025) · npj Aging · doi:10.1038/s41514-025-00258-5 · Cited by 8 · see citing works

Regional desynchronization of microglial activity is associated with cognitive decline in Alzheimer’s disease

Zatcepin, A., Gnörich, J. S., Rauchmann, B., Bartos, L. M., Wagner, S., Franzmeier, N., Malpetti, M., Xiang, X., Shi, Y., Parhizkar, S., et al. (2024) · Molecular Neurodegeneration · doi:10.1186/s13024-024-00752-6 · Cited by 7 · see citing works

Neuronal guidance signaling in neurodegenerative diseases: Key regulators that function at neuron-glia and neuroimmune interfaces

Yuasa‐Kawada, J., Kinoshita-Kawada, M., Hiramoto, M., Yamagishi, S., Mishima, T., Yasunaga, S., Tsuboi, Y., Hattori, N., & Wu, J. Y. (2025) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-24-01330 · Cited by 8 · see citing works

Advances of therapeutic strategies for Alzheimer’s disease

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The dual role of microglia in neurodegenerative diseases: A review

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Epigenome erosion in Alzheimer’s disease brain cells and induced neuronsPreprint

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Synergistic potential of TREM2 agonists and exercise training in Alzheimer’s disease

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Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism

Schauer, S. P., Cho, C. H., Novikova, G., Roth, G. A., Lee, J., Sharma, A. D., Foley, A. R., Ng, C., Shen, P., Choi, M., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.13921 · Cited by 5 · see citing works

BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissuesPreprint

Podleśny-Drabiniok, A., Novikova, G., Liu, Y.-Y., Dunst, J., Temizer, R., Giannarelli, C., Marro, S. G., Kreslavsky, T., Marcora, E., & Goate, A. (2023) · bioRxiv · doi:10.1101/2023.02.13.528372 · Cited by 5 · see citing works

Soluble TREM2 drives triple-negative breast cancer progression via activation of the AKT pathway

Yin, P., Jiang, Y., Ji, X., Lin, X., Su, Z., & Tian, Y. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113750 · Cited by 5 · see citing works

Resilience mechanisms underlying Alzheimer’s disease

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Antibody Therapies for Alzheimer’s Disease: A New Strategy for Targeted Therapy and Blood–Brain Barrier Delivery

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Modulating Amyloid Pathology–Neural Hyperexcitability Crosstalk for Alzheimer’s Disease Therapy

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Ethanol induces neuroimmune dysregulation and soluble TREM2 generation in a human iPSC neuron, astrocyte, microglia triculture model

Boreland, A. J., Abbo, Y., Li, X., Stillitano, A. C., Zhang, S., Duan, J., Pang, Z. P., & Hart, R. P. (2025) · Alcohol · doi:10.1016/j.alcohol.2025.10.006 · Cited by 5 · see citing works

Dysregulated Resolution of Inflammation After Respiratory Viral Infections: Molecular Pathways Linking Neuroinflammation to Post-Viral Neuropathic Pain—A Narrative Review

Popa, A. E., Popa, E., Dramba, T., Coman, A. E., Poroch, M., Ungureanu, M. I., Bacușcă, A. I., Slănină, A. M., Bacoanu, G., & Poroch, V. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262311383 · Cited by 5 · see citing works

TREM2, microglia, and Alzheimer’s disease.

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TREM2 — a key player in microglial biology and Alzheimer disease

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TREM2-Dependent Effects on Microglia in Alzheimer’s Disease

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TREM2, microglia, and neurodegenerative diseases

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TREM2 in Alzheimer’s Disease: Microglial Survival and Energy Metabolism

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