Liu, Guang-Hui

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

Suzuki, K., Tsunekawa, Y., Hernandez-Benitez, R., Wu, J., Zhu, J., Kim, E. J., Hatanaka, F., Yamamoto, M., Araoka, T., Li, Z., et al. (2016) · Nature

CRISPR and Genetic EngineeringRNA regulation and disease

Cited by 1,150

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

Liu, G.-H., Qu, J., & Shen, X. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Genomics, phytochemicals, and oxidative stressNF-κB Signaling Pathways

Cited by 697

Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome

Liu, G.-H., Barkho, B. Z., Ruiz, S., Diep, D., Qu, J., Yang, S.-L., Panopoulos, A. D., Suzuki, K., Kurian, L., Walsh, C., et al. (2011) · Nature

Nuclear Structure and FunctionPluripotent Stem Cells Research

Cited by 575

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

Zhang, W., Li, J., Suzuki, K., Qu, J., Wang, P., Zhou, J., Liu, X., Ren, R., Xu, X., Ocampo, A., et al. (2015) · Science

Telomeres, Telomerase, and SenescenceNuclear Structure and Function

Cited by 551

Repression of the Antioxidant NRF2 Pathway in Premature Aging

Kubben, N., Zhang, W., Wang, L., Voss, T. C., Yang, J., Qu, J., Liu, G.-H., & Misteli, T. (2016) · Cell

Nuclear Structure and FunctionGenetics, Aging, and Longevity in Model Organisms

Cited by 489

A Single-Cell Transcriptomic Atlas of Human Skin Aging

Zou, Z., Long, X., Zhao, Q., Zheng, Y., Song, M., Ma, S., Jing, Y., Wang, S., He, Y., Esteban, C. R., et al. (2021) · Developmental Cell

Single-cell and spatial transcriptomicsSkin Protection and Aging

Cited by 402

Resurrection of endogenous retroviruses during aging reinforces senescence

Liu, X., Liu, Z., Wu, Z., Ren, J., Fan, Y., Sun, L., Cao, G., Niu, Y., Zhang, B., Ji, Q., et al. (2023) · Cell

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 390

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

Ma, S., Sun, S., Geng, L., Song, M., Wang, W., Ye, Y., Ji, Q., Zou, Z., Wang, S., He, X., et al. (2020) · Cell

Genetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

Cited by 349

Progressive degeneration of human neural stem cells caused by pathogenic LRRK2

Liu, G.-H., Qu, J., Suzuki, K., Nivet, E., Li, M., Montserrat, N., Yi, F., Xu, X., Ruiz, S., Zhang, W., et al. (2012) · Nature

Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and Signaling

Cited by 339

A human circulating immune cell landscape in aging and COVID-19

Zheng, Y., Liu, X., Le, W., Xie, L., Li, H., Wen, W., Wang, S., Ma, S., Huang, Z., Ye, J., et al. (2020) · Protein & Cell

Single-cell and spatial transcriptomicsT-cell and B-cell Immunology

Cited by 270

Metformin decelerates aging clock in male monkeys

Yang, Y., Lu, X., Liu, N., Ma, S., Zhang, H., Zhang, Z., Yang, K., Jiang, M., Zheng, Z., Qiao, Y., et al. (2024) · Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 227

Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.

Ma, S., Wang, S., Ye, Y., Ren, J., Chen, R., Li, W., Li, J., Zhao, L., Zhao, Q., Sun, G., et al. (2022) · Cell Stem Cell

Genetics, Aging, and Longevity in Model OrganismsHematopoietic Stem Cell Transplantation

Cited by 189

Metformin alleviates human cellular aging by upregulating the endoplasmic reticulum glutathione peroxidase 7

Fang, J., Yang, J., Wu, X., Zhang, G., Li, T., Wang, X., Zhang, H., Wang, C., Liu, G., & Wang, L. (2018) · Aging Cell

Genetics, Aging, and Longevity in Model OrganismsMetabolism, Diabetes, and Cancer

Cited by 179

Targeted Gene Correction Minimally Impacts Whole-Genome Mutational Load in Human-Disease-Specific Induced Pluripotent Stem Cell Clones

Suzuki, K., Yu, C., Qu, J., Li, M., Yao, X., Yuan, T., Goebl, A., Tang, S., Ren, R., Aizawa, E., et al. (2014) · Cell Stem Cell

CRISPR and Genetic EngineeringVirus-based gene therapy research

Cited by 169

Antiageing strategy for neurodegenerative diseases: from mechanisms to clinical advances

Jiang, Q., Liu, J., Huang, S., Wang, X.-Y., Chen, X., Liu, G.-H., Ye, K., Song, W., Masters, C. L., Wang, J., et al. (2025) · Signal Transduction and Targeted Therapy

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 165

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

Ma, S., Ji, Z., Zhang, B., Geng, L., Cai, Y., Nie, C., Li, J., Zuo, Y., Sun, Y., Xu, G., et al. (2024) · Cell

Single-cell and spatial transcriptomicsGenetics, Aging, and Longevity in Model Organisms

Cited by 162

Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases

Wu, Z., Qu, J., & Liu, G.-H. (2024) · Nature Reviews Molecular Cell Biology

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 118

Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

Liu, Z., Ji, Q., Ren, J., Yan, P., Wu, Z., Wang, S., Sun, L., Wang, Z., Li, J., Sun, G., et al. (2022) · Developmental Cell

Genomics and Chromatin DynamicsTelomeres, Telomerase, and Senescence

Cited by 109

A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

Sun, S., Ma, S., Cai, Y., Wang, S., Ren, J., Yang, Y., Ping, J., Wang, X., Zhang, Y., Yan, H., et al. (2023) · The Innovation

Exercise and Physiological ResponsesGenetics, Aging, and Longevity in Model Organisms

Cited by 81

Targeting aging and age-related diseases with vaccines

Wu, R., Sun, F., Zhang, W., Ren, J., & Liu, G.-H. (2024) · Nature Aging

Immunotherapy and Immune ResponsesImmune responses and vaccinations

Cited by 66

A framework of biomarkers for vascular aging: a consensus statement by the Aging Biomarker Consortium

Aging Biomarker Consortium, Zhang, L., Guo, J., Liu, Y., Sun, S., Liu, B., Yang, Q., Tao, J., Tian, X.-L., Pu, J., et al. (2023) · Life Medicine

Cardiovascular Health and Disease PreventionNitric Oxide and Endothelin Effects

Cited by 60

Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging

Zhang, Y., Zheng, Y., Wang, S., Fan, Y., Ye, Y., Jing, Y., Liu, Z., Yang, S., Xiong, M., Yang, K., et al. (2022) · Protein & Cell

Single-cell and spatial transcriptomicsCongenital heart defects research

Cited by 45

A review of the biomedical innovations for healthy longevity

Moskalev, A., Anisimov, V., Aliper, A., Artemov, A., Asadullah, K., Belsky, D., Baranova, A., de Grey, A., Dixit, V. D., Debonneuil, E., et al. (2017) · Aging

Genetics, Aging, and Longevity in Model OrganismsTelomeres, Telomerase, and Senescence

Cited by 22

Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells

Liu, X., Jiao, H., Zhang, B., Zhang, S., Yan, K., Qu, J., Zhang, W., Yu, L., & Liu, G.-H. (2023) · Life Medicine

Telomeres, Telomerase, and SenescenceGenetics, Aging, and Longevity in Model Organisms

Cited by 22