Heterochronic parabiosis induces stem cell revitalization and systemic rejuvenation across aged tissues.

Cytoscape: A software Environment for integrated models of biomolecular interaction networks

Shannon, P., Markiel, A., Ozier, O., Baliga, N. S., Wang, J. T., Ramage, D., Amin, N., Schwikowski, B., & Ideker, T. (2003) · Genome Research · doi:10.1101/gr.1239303 · Cited by 51,888 · see citing works

The Hallmarks of Aging

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2013) · Cell · doi:10.1016/j.cell.2013.05.039 · Cited by 14,982 · see citing works

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

Zhou, Y., Zhou, B., Pache, L., Chang, M., Khodabakhshi, A. H., Tanaseichuk, O., Benner, C., & Chanda, S. K. (2019) · Nature Communications · doi:10.1038/s41467-019-09234-6 · Cited by 14,611 · see citing works

ggplot2: Elegant Graphics for Data Analysis

Ginestet, C. E. (2011) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2010.00676_9.x · Cited by 14,484 · see citing works

SCANPY: large-scale single-cell gene expression data analysis

Wolf, F. A., Angerer, P., & Theis, F. J. (2018) · Genome Biology · doi:10.1186/s13059-017-1382-0 · Cited by 8,881 · see citing works

Spatial reconstruction of single-cell gene expression data

Satija, R., Farrell, J. A., Gennert, D., Schier, A. F., & Regev, A. (2015) · Nature Biotechnology · doi:10.1038/nbt.3192 · Cited by 7,055 · see citing works

Scenic: single-cell regulatory network inference and clustering.

Aibar, S., González-Blas, C. B., Moerman, T., Huynh-Thu, V. A., Imrichova, H., Hulselmans, G., Rambow, F., Marine, J.-C., Geurts, P., Aerts, J., et al. (2017) · Nature Methods · doi:10.1038/nmeth.4463 · Cited by 6,520 · see citing works

Reversed graph embedding resolves complex single-cell trajectories

Qiu, X., Mao, Q., Tang, Y., Wang, L., Chawla, R., Pliner, H. A., & Trapnell, C. (2017) · Nature Methods · doi:10.1038/nmeth.4402 · Cited by 5,070 · see citing works

DoubletFinder: Doublet Detection in Single-Cell RNA Sequencing Data Using Artificial Nearest Neighbors

McGinnis, C. S., Murrow, L. M., & Gartner, Z. J. (2019) · Cell Systems · doi:10.1016/j.cels.2019.03.003 · Cited by 4,521 · see citing works

Scrublet: computational identification of cell doublets in single-cell transcriptomic data

Wolock, S. L., Lopez, R., & Klein, A. M. (2018) · doi:10.1101/357368 · Cited by 2,758 · see citing works

Scrublet: computational identification of cell doublets in single-cell transcriptomic data

Wolock, S. L., Lopez, R., & Klein, A. M. (2019) · Cell Systems · doi:10.1016/j.cels.2018.11.005 · Cited by 2,758 · see citing works

Single-cell reconstruction of the early maternal–fetal interface in humans

Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358 · see citing works

Rejuvenation of aged progenitor cells by exposure to a young systemic environment

Conboy, I. M., Conboy, M. J., Wagers, A. J., Girma, E. R., Weissman, I. L., & Rando, T. A. (2005) · Nature · doi:10.1038/nature03260 · Cited by 2,287 · see citing works

The ageing systemic milieu negatively regulates neurogenesis and cognitive function

Villeda, S. A., Luo, J., Mosher, K. I., Zou, B., Britschgi, M., Bieri, G., Stan, T. M., Fainberg, N., Ding, Z., Eggel, A., et al. (2011) · Nature · doi:10.1038/nature10357 · Cited by 1,763 · see citing works

PAGA: graph abstraction reconciles clustering with trajectory inference through a topology preserving map of single cells

Wolf, F. A., Hamey, F. K., Plass, M., Solana, J., Dahlin, J. S., Göttgens, B., Rajewsky, N., Simon, L., & Theis, F. J. (2019) · Genome Biology · doi:10.1186/s13059-019-1663-x · Cited by 1,698 · see citing works

Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis

Brack, A. S., Conboy, M. J., Roy, S., Lee, M., Kuo, C. J., Keller, C., & Rando, T. A. (2007) · Science · doi:10.1126/science.1144090 · Cited by 1,564 · see citing works

The twilight of immunity: emerging concepts in aging of the immune system

Nikolich-Žugich, J. (2018) · Nature Immunology · doi:10.1038/s41590-017-0006-x · Cited by 1,240 · see citing works

Cell intrinsic alterations underlie hematopoietic stem cell aging

Rossi, D. J., Bryder, D., Zahn, J. M., Ahlenius, H., Sonu, R., Wagers, A. J., & Weissman, I. L. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0503280102 · Cited by 1,152 · see citing works

Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age

Rossi, D. J., Bryder, D., Seita, J., Nussenzweig, A., Hoeijmakers, J., & Weissman, I. L. (2007) · Nature · doi:10.1038/nature05862 · Cited by 1,115 · see citing works

Single-cell transcriptome profiling reveals neutrophil heterogeneity in homeostasis and infection

Xie, X., Shi, Q., Wu, P., Zhang, X., Kambara, H., Su, J., Yu, H., Park, S., Guo, R., Ren, Q., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0736-z · Cited by 880 · see citing works

Stem cell aging: mechanisms, regulators and therapeutic opportunities

Oh, J., Lee, Y. D., & Wagers, A. J. (2014) · Nature Medicine · doi:10.1038/nm.3651 · Cited by 796 · see citing works

Age-Associated Characteristics of Murine Hematopoietic Stem Cells

Sudo, K., Ema, H., Morita, Y., & Nakauchi, H. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.9.1273 · Cited by 722 · see citing works

Comprehensive Profiling of an Aging Immune System Reveals Clonal GZMK+ CD8+ T Cells as Conserved Hallmark of Inflammaging

Mogilenko, D. A., Shpynov, O., Andhey, P. S., Arthur, L., Swain, A., Esaulova, E., Brioschi, S., Shchukina, I., Kerndl, M., Bambouskova, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2020.11.005 · Cited by 683 · see citing works

Single-Cell Transcriptomic Atlas of Primate Ovarian Aging

Wang, S., Zheng, Y., Li, J., Yu, Y., Zhang, W., Song, M., Liu, Z., Min, Z., Hu, H., Jing, Y., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.009 · Cited by 592 · see citing works

The ageing epigenome and its rejuvenation

Zhang, W., Qu, J. T., Liu, G., & Belmonte, J. C. I. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0204-5 · Cited by 472 · see citing works

Using single nuclei for RNA-seq to capture the transcriptome of postmortem neurons

Krishnaswami, S. R., Grindberg, R. V., Novotny, M., Venepally, P., Lacar, B., Bhutani, K., Linker, S. B., Pham, S., Erwin, J. A., Miller, J. A., et al. (2016) · Nature Protocols · doi:10.1038/nprot.2016.015 · Cited by 445 · see citing works

Human umbilical cord plasma proteins revitalize hippocampal function in aged mice

Castellano, J. M., Mosher, K. I., Abbey, R. J., McBride, A. A., James, M. L., Berdnik, D., Shen, J. C., Zou, B., Xie, X. S., Tingle, M., et al. (2017) · Nature · doi:10.1038/nature22067 · Cited by 445 · see citing works

JunB Deficiency Leads to a Myeloproliferative Disorder Arising from Hematopoietic Stem Cells

Passegue, E. A., Wagner, E. F., & Weissman, I. L. (2004) · Cell · doi:10.1016/j.cell.2004.10.010 · Cited by 433 · see citing works

A Single-Cell Transcriptomic Atlas of Human Skin Aging

Zou, Z., Long, X., Zhao, Q., Zheng, Y., Song, M., Ma, S., Jing, Y., Wang, S., He, Y., Esteban, C. R., et al. (2021) · Developmental Cell · doi:10.1016/j.devcel.2020.11.002 · Cited by 402 · see citing works

Elimination of senescent cells by β-galactosidase-targeted prodrug attenuates inflammation and restores physical function in aged mice

Cai, Y., Zhou, H., Zhu, Y., Sun, Q., Ji, Y., Xue, A., Wang, Y., Chen, W., Yu, X., Wang, L., et al. (2020) · Cell Research · doi:10.1038/s41422-020-0314-9 · Cited by 397 · see citing works

TNF-α Coordinates Hematopoietic Stem Cell Survival and Myeloid Regeneration

Yamashita, M., & Passegué, E. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.05.019 · Cited by 387 · see citing works

Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

Grunewald, M., Kumar, S., Sharife, H., Volinsky, E., Gileles‐Hillel, A., Licht, T., Permyakova, A., Hinden, L., Azar, S., Friedmann, Y., et al. (2021) · Science · doi:10.1126/science.abc8479 · Cited by 370 · see citing works

A Differentiation Checkpoint Limits Hematopoietic Stem Cell Self-Renewal in Response to DNA Damage

Wang, J., Sun, Q., Morita, Y., Jiang, H., Groß, A., Lechel, A., Hildner, K., Guachalla, L. M., Gompf, A., Hartmann, D., et al. (2012) · Cell · doi:10.1016/j.cell.2012.01.040 · Cited by 343 · see citing works

Single-cell RNA sequencing reveals molecular and functional platelet bias of aged haematopoietic stem cells

Grover, A., Sanjuán-Pla, A., Thongjuea, S., Carrelha, J., Giustacchini, A., Gambardella, A. R., Macaulay, I. C., Mancini, E., Luis, T. C., Mead, A. J., et al. (2016) · Nature Communications · doi:10.1038/ncomms11075 · Cited by 339 · see citing works

Causes and Consequences of Hematopoietic Stem Cell Heterogeneity

Haas, S. F., Trumpp, A., & Milsom, M. D. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.04.003 · Cited by 330 · see citing works

A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing

Florian, M. C., Nattamai, K. J., Dörr, K., Marka, G., Überle, B., Vas, V., Eckl, C., Andrä, I., Schiemann, M., Oostendorp, R. A. J., et al. (2013) · Nature · doi:10.1038/nature12631 · Cited by 303 · see citing works

Aging Human Hematopoietic Stem Cells Manifest Profound Epigenetic Reprogramming of Enhancers That May Predispose to Leukemia

Adelman, E. R., Huang, H.-T., Roisman, A., Olsson, A., Colaprico, A., Qin, T., Lindsley, R. C., Bejar, R. L., Salomonis, N., Grimes, H. L., et al. (2019) · Cancer Discovery · doi:10.1158/2159-8290.cd-18-1474 · Cited by 222 · see citing works

Exposure to a youthful circulation rejuvenates bone repair through modulation of β-catenin

Baht, G. S., Silkstone, D., Vi, L., Nadesan, P., Amani, Y., Whetstone, H., Wei, Q., & Alman, B. A. (2015) · Nature Communications · doi:10.1038/ncomms8131 · Cited by 211 · see citing works

i-cisTarget: an integrative genomics method for the prediction of regulatory features and cis-regulatory modules

Herrmann, C., de Sande, B. V., Potier, D., & Aerts, S. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks543 · Cited by 202 · see citing works

The aging skin microenvironment dictates stem cell behavior

Ge, Y., Miao, Y., Gur-Cohen, S., Gomez, N., Yang, H., Nikolova, M., Polak, L., Hu, Y., Verma, A., Elemento, O., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1901720117 · Cited by 190 · see citing works

JunB Protects against Myeloid Malignancies by Limiting Hematopoietic Stem Cell Proliferation and Differentiation without Affecting Self-Renewal

Santaguida, M. A., Schepers, K., King, B., Sabnis, A. J., Forsberg, E. C., Attema, J. L., Braun, B. S., & Passegue, E. A. (2009) · Cancer Cell · doi:10.1016/j.ccr.2009.02.016 · Cited by 156 · see citing works

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature · doi:10.1038/s41586-022-04461-2 · Cited by 153 · see citing works

Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing

Valletta, S., Thomas, A., Meng, Y., Ren, X., Drissen, R., Sengül, H., Di Genua, C., & Nerlov, C. (2020) · Nature Communications · doi:10.1038/s41467-020-17942-7 · Cited by 122 · see citing works

Specific factors in blood from young but not old mice directly promote synapse formation and NMDA-receptor recruitment

Gan, K. J., & Südhof, T. C. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902672116 · Cited by 114 · see citing works

Limited rejuvenation of aged hematopoietic stem cells in young bone marrow niche

Kuribayashi, W., Oshima, M., Itokawa, N., Koide, S., Nakajima-Takagi, Y., Yamashita, M., Yamazaki, S., Rahmutulla, B., Miura, F., Ito, T., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20192283 · Cited by 111 · see citing works

Aged hematopoietic stem cells are refractory to bloodborne systemic rejuvenation interventions

Ho, T. T., Dellorusso, P. V., Verovskaya, E. V., Bakker, S. T., Flach, J., Smith, L. K., Ventura, P. B., Lansinger, O. M., Hérault, A., Zhang, S. Y., et al. (2021) · Journal of Experimental Medicine · doi:10.1084/jem.20210223 · Cited by 101 · see citing works

Aging in the lympho-hematopoietic stem cell compartment

Geiger, H., & Rudolph, K. L. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.010 · Cited by 97 · see citing works

Aging induces aberrant state transition kinetics in murine muscle stem cells

Kimmel, J. C., Hwang, A. B., Scaramozza, A., Marshall, W. F., & Brack, A. S. (2020) · Development · doi:10.1242/dev.183855 · Cited by 95 · see citing works

Aging-induced IL27Ra signaling impairs hematopoietic stem cells

He, H., Xu, P., Zhang, X., Liao, M., Dong, Q., Cong, T., Tang, B., Yang, X., Ye, M., Chang, Y., et al. (2020) · Blood · doi:10.1182/blood.2019003910 · Cited by 94 · see citing works

Hypoxic induction of vascular endothelial growth factor regulates murine hematopoietic stem cell function in the low-oxygenic niche

Rehn, M., Olsson, A., Reckzeh, K., Diffner, E., Carmeliet, P., Landberg, G., & Cammenga, J. (2011) · Blood · doi:10.1182/blood-2011-01-332890 · Cited by 86 · see citing works

Blood-Borne Revitalization of the Aged Brain

Castellano, J. M., Kirby, E. D., & Wyss-Coray, T. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.1616 · Cited by 83 · see citing works

THE MARROW‐BLOOD BARRIER

Tavassoli, M. (1979) · British Journal of Haematology · doi:10.1111/j.1365-2141.1979.tb05862.x · Cited by 83 · see citing works

ATF4 plays a pivotal role in the development of functional hematopoietic stem cells in mouse fetal liver

Zhao, Y., Zhou, J. R., Liu, D., Dong, F., Cheng, H., Wang, W., Pang, Y., Wang, Y., Mu, X., Ni, Y., et al. (2015) · Blood · doi:10.1182/blood-2015-03-633354 · Cited by 82 · see citing works

A single-cell transcriptomic atlas of primate pancreatic islet aging

Li, J., Zheng, Y., Yan, P., Song, M., Wang, S., Sun, L., Liu, Z., Ma, S., Belmonte, J. C. I., Chan, P., et al. (2020) · National Science Review · doi:10.1093/nsr/nwaa127 · Cited by 76 · see citing works

CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells

Sinclair, A., Park, L., Shah, M., Drotar, M. E., Calaminus, S. D. J., Hopcroft, L. E. M., Kinstrie, R., Guitart, A. V., Dunn, K. M., Abraham, S. A., et al. (2016) · Blood · doi:10.1182/blood-2015-08-661785 · Cited by 71 · see citing works

A revival of parabiosis in biomedical research

Eggel, A., & Wyss-Coray, T. (2014) · Swiss Medical Weekly · doi:10.4414/smw.2014.13914 · Cited by 67 · see citing works

Telomere-dependent and telomere-independent roles of RAP1 in regulating human stem cell homeostasis

Zhang, X., Liu, Z., Liu, X., Wang, S., Zhang, Y., He, X., Sun, S., Ma, S., Shyh‐Chang, N., Liu, F., et al. (2019) · Protein & Cell · doi:10.1007/s13238-019-0610-7 · Cited by 55 · see citing works

The Chemokine CCL3 Regulates Myeloid Differentiation and Hematopoietic Stem Cell Numbers

Staversky, R. J., Byun, D. K., Georger, M. A., Zaffuto, B. J., Goodman, A. N., Becker, M. W., Calvi, L. M., & Frisch, B. J. (2018) · Scientific Reports · doi:10.1038/s41598-018-32978-y · Cited by 51 · see citing works

CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential

Shimazu, T., Iida, R., Zhang, Q., Welner, R. S., Medina, K. L., Alberola‐Ila, J., & Kincade, P. W. (2012) · Blood · doi:10.1182/blood-2011-10-388736 · Cited by 49 · see citing works

CCL4 enhances preosteoclast migration and its receptor CCR5 downregulation by RANKL promotes osteoclastogenesis

Lee, D., Shin, K.-J., Kim, D. W., Yoon, K., Choi, Y., Lee, B. N. R., & Cho, J. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-0562-5 · Cited by 48 · see citing works

A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

Xiong, C., Zhang, Z., Baht, G. S., & Terrando, N. (2018) · Journal of Visualized Experiments · doi:10.3791/56701 · Cited by 41 · see citing works

Circulating plasma factors involved in rejuvenation

Kang, J. S., & Yang, Y. R. (2020) · Aging · doi:10.18632/aging.103933 · Cited by 39 · see citing works

Accelerated Aging versus Rejuvenation of the Immune System in Heterochronic Parabiosis

Pishel, I., Shytikov, D. W., Orlova, T. G., Peregudov, A., Artyuhov, I., & Gm, B. (2012) · Rejuvenation Research · doi:10.1089/rej.2012.1331 · Cited by 35 · see citing works

Loss of ATF4 leads to functional aging-like attrition of adult hematopoietic stem cells

Sun, Y., Lin, X., Liu, B., Zhang, Y.-X., Li, W., Zhang, S., He, F., Tian, H., Zhu, X., Liu, X.-M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abj6877 · Cited by 34 · see citing works

Dissecting the bone marrow HSC niches

Zhao, M. L., & Li, L. (2016) · Cell Research · doi:10.1038/cr.2016.71 · Cited by 28 · see citing works

A20 deficiency in multipotent progenitors perturbs quiescence of hematopoietic stem cells

Nakagawa, M. M., Davis, H., & Rathinam, C. V. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.10.020 · Cited by 14 · see citing works

Heterochronic parabiosis: allowing the dissection of the aged immune system (LYM2P.723)

Davies, J., Pulko, V., Thompson, H. L., & Nikolich‐Žugich, J. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.194.supp.62.4 · Cited by 2 · see citing works

Junb Regulates Hematopoietic Stem Cell Numbers in Normal and Leukemic Mice.

Passegue, E. A., Wagner, E. F., & Weissman, I. L. (2004) · Blood · doi:10.1182/blood.v104.11.560.560 · Cited by 1 · see citing works

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549 · see citing works

The landscape of aging

Cai, Y., Song, W., Li, J., Jing, Y., Liang, C., Zhang, L., Zhang, X., Zhang, W., Liu, B., An, Y., et al. (2022) · Science China Life Sciences · doi:10.1007/s11427-022-2161-3 · Cited by 436 · see citing works

Biomarkers of aging

Bao, H., Cao, J., Chen, M., Min, C., Chen, W., Chen, X., Chen, Y., Chen, Y., Chen, Y., Chen, Z., et al. (2023) · Science China Life Sciences · doi:10.1007/s11427-023-2305-0 · Cited by 389 · see citing works

Metformin decelerates aging clock in male monkeys

Yang, Y., Lu, X., Liu, N., Ma, S., Zhang, H., Zhang, Z., Yang, K., Jiang, M., Zheng, Z., Qiao, Y., et al. (2024) · Cell · doi:10.1016/j.cell.2024.08.021 · Cited by 227 · see citing works

Cell-type-specific aging clocks to quantify aging and rejuvenation in neurogenic regions of the brain

Buckley, M. T., Sun, E., George, B. M., Liu, L. A., Schaum, N., Xu, L., Reyes, J. M., Goodell, M. A., Weissman, I. L., Wyss‐Coray, T., et al. (2022) · Nature Aging · doi:10.1038/s43587-022-00335-4 · Cited by 189 · see citing works

Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases

Ji, S., Xiong, M., Chen, H., Liu, Y., Zhou, L., Hong, Y., Wang, M., Wang, C., Fu, X., & Sun, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01343-5 · Cited by 166 · see citing works

Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging

Ma, S., Ji, Z., Zhang, B., Geng, L., Cai, Y., Nie, C., Li, J., Zuo, Y., Sun, Y., Xu, G., et al. (2024) · Cell · doi:10.1016/j.cell.2024.10.019 · Cited by 162 · see citing works

Determining a multimodal aging clock in a cohort of Chinese women

Li, J., Xiong, M., Fu, X.-H., Fan, Y., Dong, C., Sun, X., Zheng, F., Wang, S., Liu, L., Xu, M., et al. (2023) · Med · doi:10.1016/j.medj.2023.06.010 · Cited by 148 · see citing works

Harnessing matrix stiffness to engineer a bone marrow niche for hematopoietic stem cell rejuvenation

Zhang, X., Cao, D., Xu, L., Xu, Y., Gao, Z., Pan, Y., Jiang, M. Z., Wei, Y., Wang, L., Liao, Y., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.03.005 · Cited by 140 · see citing works

Stress, epigenetics, and aging: Unraveling the intricate crosstalk

Wu, Z., Qu, J. T., Zhang, W., & Liu, G. (2023) · Molecular Cell · doi:10.1016/j.molcel.2023.10.006 · Cited by 142 · see citing works

Aged bone marrow macrophages drive systemic aging and age-related dysfunction via extracellular vesicle-mediated induction of paracrine senescence

Hou, J., Chen, K., He, C., Li, X., Huang, M., Jiang, Y.-Z., Jiao, Y.-R., Xiao, Q., He, W., Liu, L., et al. (2024) · Nature Aging · doi:10.1038/s43587-024-00694-0 · Cited by 136 · see citing works

Roles of chromatin and genome instability in cellular senescence and their relevance to ageing and related diseases

Wu, Z., Qu, J., & Liu, G.-H. (2024) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-024-00775-3 · Cited by 118 · see citing works

Senescence drives immunotherapy resistance by inducing an immunosuppressive tumor microenvironment

Maggiorani, D., Lê, O., Lisi, V., Landais, S., Moquin‐Beaudry, G., Lavallée, V., Decaluwe, H., & Beausejour, C. M. (2024) · Nature Communications · doi:10.1038/s41467-024-46769-9 · Cited by 123 · see citing works

Exosomes from young healthy human plasma promote functional recovery from intracerebral hemorrhage via counteracting ferroptotic injury

Yang, W., Ding, N., Luo, R., Zhang, Q., Li, Z., Zhao, F., Zhang, S., Zhang, X., Zhou, T., Wang, H., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.03.007 · Cited by 108 · see citing works

A stem cell aging framework, from mechanisms to interventions

Liu, B., Qu, J. T., Zhang, W., Belmonte, J. C. I., & Liu, G. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111451 · Cited by 107 · see citing works

Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells

Bi, Y., Qiao, X., Cai, Z., Zhao, H., Ye, R., Liu, Q., Gao, L., Liu, Y., Liang, B., Liu, Y., et al. (2025) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.013 · Cited by 98 · see citing works

Decoding aging-dependent regenerative decline across tissues at single-cell resolution

Cai, Y., Xiong, M., Xin, Z., Liu, C., Ren, J., Yang, X., Lei, J., Li, W., Liu, F., Chu, Q., et al. (2023) · Cell stem cell · doi:10.1016/j.stem.2023.09.014 · Cited by 91 · see citing works

Energy metabolism as therapeutic target for aged wound repair by engineered extracellular vesicle

Zhuang, Y., Jiang, S., Deng, X., Lao, A., Hua, X., Xie, Y., Jiang, L., Wang, X., & Lin, K. (2024) · Science Advances · doi:10.1126/sciadv.adl0372 · Cited by 91 · see citing works

A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

Sun, S., Ma, S., Cai, Y., Wang, S., Ren, J., Yang, Y., Ping, J., Wang, X., Zhang, Y., Yan, H., et al. (2023) · The Innovation · doi:10.1016/j.xinn.2023.100380 · Cited by 81 · see citing works

Heterochronic parabiosis reprograms the mouse brain transcriptome by shifting aging signatures in multiple cell types

Ximerakis, M., Holton, K. M., Giadone, R. M., Ozek, C., Saxena, M., Santiago, S., Adiconis, X., Dionne, D. A., Nguyễn, L., Shah, K. M., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00373-6 · Cited by 82 · see citing works

The connection between aging, cellular senescence and gut microbiome alterations: A comprehensive review

Jang, D. S., Shin, J., Shim, E., Ohtani, N., & Jeon, O. H. (2024) · Aging Cell · doi:10.1111/acel.14315 · Cited by 84 · see citing works

SIRT2 counteracts primate cardiac aging via deacetylation of STAT3 that silences CDKN2B

Ye, Y., Yang, K., Liu, H., Yu, Y., Song, M., Huang, D., Lei, J., Zhang, Y., Liu, Z., Chu, Q., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00486-y · Cited by 80 · see citing works

Emerging epigenetic insights into aging mechanisms and interventions

Wu, Z., Zhang, W., Qu, J. T., & Liu, G. (2024) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2023.12.002 · Cited by 74 · see citing works

Systematic profiling reveals betaine as an exercise mimetic for geroprotection

Geng, L., Ping, J., Wu, R., Yan, H., Zhang, H., Zhuang, Y., Ning, T., Wang, J., Liang, C., Zhang, J., et al. (2025) · Cell · doi:10.1016/j.cell.2025.06.001 · Cited by 73 · see citing works

A single-nucleus transcriptomic atlas of primate liver aging uncovers the pro-senescence role of SREBP2 in hepatocytes

Yang, S., Liu, C., Jiang, M., Liu, X., Geng, L., Zhang, Y., Sun, S., Wang, K., Yin, J. B., Ma, S., et al. (2023) · Protein & Cell · doi:10.1093/procel/pwad039 · Cited by 64 · see citing works

Hallmarks of stem cell aging

Rando, T. A., Brunet, A., & Goodell, M. A. (2025) · Cell stem cell · doi:10.1016/j.stem.2025.06.004 · Cited by 66 · see citing works

Single-nucleus profiling unveils a geroprotective role of the FOXO3 in primate skeletal muscle aging

Jing, Y., Zuo, Y., Yu, Y., Sun, L., Yu, Z., Ma, S., Zhao, Q., Sun, G., Hu, H., Li, J., et al. (2022) · Protein & Cell · doi:10.1093/procel/pwac061 · Cited by 57 · see citing works

Toward precision interventions and metrics of inflammaging

Franceschi, C., Olivieri, F., Moskalev, A., Ivanchenko, M., & Santoro, A. (2025) · Nature Aging · doi:10.1038/s43587-025-00938-7 · Cited by 59 · see citing works

A single-nucleus transcriptomic atlas of primate testicular aging reveals exhaustion of the spermatogonial stem cell reservoir and loss of Sertoli cell homeostasis

Huang, D., Zuo, Y., Zhang, C., Sun, G., Jing, Y., Lei, J., Ma, S., Sun, S., Lu, H., Zhang, X., et al. (2022) · Protein & Cell · doi:10.1093/procel/pwac057 · Cited by 55 · see citing works

Prevalent mesenchymal drift in aging and disease is reversed by partial reprogramming

Lu, J. Y., Tu, W. B., Li, R., Weng, M., Sanketi, B. D., Yuan, B., Reddy, P., Esteban, C. R., & Belmonte, J. C. I. (2025) · Cell · doi:10.1016/j.cell.2025.07.031 · Cited by 67 · see citing works

An aging-related immune landscape in the hematopoietic immune system

Lv, J., Zhang, C., Liu, X., Gu, C., Liu, Y., Gao, Y., Huang, Z., Jiang, Q., Chen, B., He, D., et al. (2024) · Immunity & Ageing · doi:10.1186/s12979-023-00403-2 · Cited by 51 · see citing works

Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age

Konturek-Cieśla, A., Dhapola, P., Zhang, Q., Säwén, P., Wan, H., Karlsson, G., & Bryder, D. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112304 · Cited by 41 · see citing works

Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell

Meng, F., Wang, G., Zhou, F., Li, G., Wang, M., Zhou, Z., Han, Y., Chen, X., Hu, Y., Zhang, Y., et al. (2024) · Composites Part B Engineering · doi:10.1016/j.compositesb.2024.111358 · Cited by 39 · see citing works

Engineering 3D-Printed Strontium-Titanium Scaffold-Integrated Highly Bioactive Serum Exosomes for Critical Bone Defects by Osteogenesis and Angiogenesis

Liu, H., Gu, R., Li, W., Zeng, L., Zhu, Y., Heng, B. C., Liu, Y., & Zhou, Y. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.3c00898 · Cited by 38 · see citing works

Multimodal Omics Approaches to Aging and Age-Related Diseases

Ji, Q., Jiang, X., Wang, M., Xin, Z., Zhang, W., Qu, J. T., & Liu, G. (2024) · Phenomics · doi:10.1007/s43657-023-00125-x · Cited by 39 · see citing works

Decoding Aging Hallmarks at the Single-Cell Level

Ma, S., Chi, X., Cai, Y., Ji, Z., Wang, S., Ren, J., & Liu, G. (2023) · Annual Review of Biomedical Data Science · doi:10.1146/annurev-biodatasci-020722-120642 · Cited by 37 · see citing works

Plasma exosomes improve peripheral neuropathy via miR-20b-3p/Stat3 in type I diabetic rats

Li, J., Wu, G., Li, W., Zhou, X., Li, W., Xu, X., Xu, K., Cao, R., & Cui, S. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02222-5 · Cited by 35 · see citing works

Single-cell profiling reveals a potent role of quercetin in promoting hair regeneration

Zhao, Q., Zheng, Y., Zhao, D., Zhao, L., Geng, L., Ma, S., Cai, Y., Liu, C., Yan, Y., Belmonte, J. C. I., et al. (2022) · Protein & Cell · doi:10.1093/procel/pwac062 · Cited by 34 · see citing works

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Mitchell, W., Goeminne, L. J., Tyshkovskiy, A., Zhang, S., Chen, J. Y., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., et al. (2024) · eLife · doi:10.7554/elife.90579.3 · Cited by 33 · see citing works

Aging insights from heterochronic parabiosis models

Lagunas‐Rangel, F. A. (2024) · npj Aging · doi:10.1038/s41514-024-00166-0 · Cited by 34 · see citing works

Genetic enhancement: an avenue to combat aging-related diseases

Cai, Y., Ji, Z., Wang, S., Zhang, W., Qu, J. T., Belmonte, J. C. I., & Liu, G. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac054 · Cited by 33 · see citing works

Brain aging and rejuvenation at single-cell resolution

Sun, E., Nagvekar, R., Pogson, A. N., & Brunet, A. (2025) · Neuron · doi:10.1016/j.neuron.2024.12.007 · Cited by 33 · see citing works

Unraveling aging from transcriptomics

Huang, Y., Zhu, S., Yao, S., Zhai, H., Liu, C., & Han, J. J. (2024) · Trends in Genetics · doi:10.1016/j.tig.2024.09.006 · Cited by 33 · see citing works

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29 · see citing works

Genetic and epigenetic alterations in aging and rejuvenation of human

Park, K., Jeon, M. C., Lee, D., Kim, J., & Im, S.-W. (2024) · Molecules and Cells · doi:10.1016/j.mocell.2024.100137 · Cited by 28 · see citing works

Aging reshapes the adaptive immune system from healer to saboteur

Delgado-Pulido, S., Yousefzadeh, M. J., & Mittelbrunn, M. (2025) · Nature Aging · doi:10.1038/s43587-025-00906-1 · Cited by 29 · see citing works

Bivalent chromatin instructs lineage specification during hematopoiesis

Yagi, M., Bonilla, G. M., Hoetker, M. S., Tsopoulidis, N., Horng, J. E., Haggerty, C., Meissner, A., Sadreyev, R. I., Hock, H. R., & Hochedlinger, K. (2025) · Cell · doi:10.1016/j.cell.2025.05.011 · Cited by 25 · see citing works

Effects of Ginger (Zingiber officinale) on the Hallmarks of Aging

Matin, M., Joshi, T., Wang, D., Tzvetkov, N. T., Matin, F. B., Wierzbicka, A., Jóźwik, A., Horbańczuk, J. O., & Atanasov, A. G. (2024) · Biomolecules · doi:10.3390/biom14080940 · Cited by 25 · see citing works

Multi-omics characterization of partial chemical reprogramming reveals evidence of cell rejuvenation

Mitchell, W., Goeminne, L. J., Tyshkovskiy, A., Zhang, S., Chen, J. Y., Paulo, J. A., Pierce, K. A., Choy, A. H., Clish, C. B., Gygi, S. P., et al. (2024) · eLife · doi:10.7554/elife.90579 · Cited by 23 · see citing works

How age affects human hematopoietic stem and progenitor cells and the strategies to mitigate aging

Li, X., Wang, J., Hu, L., & Cheng, T. (2025) · Experimental Hematology · doi:10.1016/j.exphem.2025.104711 · Cited by 22 · see citing works

Hepatic adaptation to chronic metabolic stress primes tumorigenesis

Tzouanas, C., Shay, J. E. S., Sherman, M. S., Rubin, A. J., Mead, B. E., Dao, T. T., Tao, J.-Y., Lehrich, B. M., Eng, G., Patterson-Fortin, J., et al. (2025) · Cell · doi:10.1016/j.cell.2025.11.031 · Cited by 22 · see citing works

VEGF-A in serum protects against memory impairment in APP/PS1 transgenic mice by blocking neutrophil infiltration

Qi, F., Zuo, Z., Hu, K., Wang, R., Wu, T., Liu, H., Tang, J., Wang, Q., Xie, Y., Tan, L., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02097-w · Cited by 23 · see citing works

Haematopoietic ageing in health and lifespan

Andersson, R., Mejía-Ramírez, E., & Florian, M. C. (2025) · Nature Cell Biology · doi:10.1038/s41556-025-01739-1 · Cited by 24 · see citing works

Migrasomes trigger innate immune activation and mediate transmission of senescence signals across human cells

Liu, X., Jiao, H., Zhang, B., Zhang, S., Yan, K., Qu, J., Zhang, W., Yu, L., & Liu, G.-H. (2023) · Life Medicine · doi:10.1093/lifemedi/lnad050 · Cited by 22 · see citing works

Signaling mechanisms underlying lymphatic vessel dysfunction in skin aging and possible anti-aging strategies

Yang, Y., Wang, X., & Wang, P. (2023) · Biogerontology · doi:10.1007/s10522-023-10016-3 · Cited by 21 · see citing works

Systemic and local regulation of hematopoietic homeostasis in health and disease

Carpenter, R. S., & Maryanovich, M. (2024) · Nature Cardiovascular Research · doi:10.1038/s44161-024-00482-4 · Cited by 22 · see citing works

Therapeutic Plasma Exchange: Current and Emerging Applications to Mitigate Cellular Signaling in Disease

Rony, R. M. I. K., Shokrani, A., Malhi, N. K., Hussey, D. M., Mooney, R., Chen, Z., Scott, T. A., Han, H., Moore, J., Liu, J., et al. (2025) · Biomolecules · doi:10.3390/biom15071000 · Cited by 19 · see citing works

Regeneration leads to global tissue rejuvenation in aging sexual planarians

Dai, X., Li, X., Tyshkovskiy, A., Zuckerman, C., Cheng, N., Lin, P., Paris, D., Qureshi, S., Kruglyak, L., Mao, X., et al. (2025) · Nature Aging · doi:10.1038/s43587-025-00847-9 · Cited by 19 · see citing works

The emerging importance of lymphangiogenesis in aging and aging-associated diseases

Ji, R. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111975 · Cited by 19 · see citing works

Longevity Humans Have Youthful Erythrocyte Function and Metabolic Signatures

Yu, F., Chen, C., Liu, W., Zhao, Z., Fan, Y., Li, Z., Huang, W., Xie, T., Luo, C., Yao, Z., et al. (2025) · Aging Cell · doi:10.1111/acel.14482 · Cited by 20 · see citing works

Age-associated declining of the regeneration potential of skeletal stem/progenitor cells

Mancinelli, L., & Intini, G. (2023) · Frontiers in Physiology · doi:10.3389/fphys.2023.1087254 · Cited by 18 · see citing works

iPSC-derived exosomes promote angiogenesis in naturally aged mice

Li, X., Zhang, H., Wang, X., Lu, M., Ding, Q., Chen, A. F., Xiang, M., & Chen, S. (2023) · Aging · doi:10.18632/aging.204845 · Cited by 18 · see citing works

Tissue mosaicism following stem cell aging: blood as an exemplar

Kapadia, C. D., & Goodell, M. A. (2024) · Nature Aging · doi:10.1038/s43587-024-00589-0 · Cited by 18 · see citing works

A cellular identity crisis? Plasticity changes during aging and rejuvenationPreprint

Gorelov, R. A., & Hochedlinger, K. (2024) · Genes & Development · doi:10.1101/gad.351728.124 · Cited by 18 · see citing works

Single-nucleus transcriptomics reveals a gatekeeper role for FOXP1 in primate cardiac aging

Zhang, Y., Zheng, Y., Wang, S., Fan, Y., Ye, Y., Jing, Y., Liu, Z., Yang, S., Xiong, M., Yang, K., et al. (2022) · Protein & Cell · doi:10.1093/procel/pwac038 · Cited by 45 · see citing works

Geroprotective interventions converge on gene expression programs of reduced inflammation and restored fatty acid metabolism

Landsberger, T., Amit, I., & Alon, U. S. (2023) · GeroScience · doi:10.1007/s11357-023-00915-1 · Cited by 16 · see citing works

Rejuvenation of young blood on aging organs: Effects, circulating factors, and mechanisms

Liu, M., Lan, Q., Wu, H., & Qiu, C.-W. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32652 · Cited by 16 · see citing works

Multimodal clocks of human aging

Li, J., Jiang, B., Zhang, W., Hao, J., Liu, Z., Ji, Q., Zheng, Y., Lu, X., Zheng, Z., Ma, S., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.025 · Cited by 17 · see citing works

Rejuvenating aged stem cells: therapeutic strategies to extend health and lifespan

Matteini, F., Montserrat‐Vazquez, S., & Florian, M. C. (2024) · FEBS Letters · doi:10.1002/1873-3468.14865 · Cited by 15 · see citing works

The immunosenescence clock: A new method for evaluating biological age and predicting mortality risk

Li, S., Wang, K., Wu, J., & Zhu, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102653 · Cited by 16 · see citing works

Multi-omics analysis in developmental bone biology

Matsushita, Y., Noguchi, A., Ono, W., & Ono, N. (2023) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2023.10.006 · Cited by 15 · see citing works

Polyploidisation pleiotropically buffers ageing in hepatocytes

Yin, K., Büttner, M., Deligiannis, I. K., Strzelecki, M., Zhang, L., Talavera-López, C. N., Theis, F. J., Odom, D. T., & Martinez‐Jimenez, C. P. (2024) · Journal of Hepatology · doi:10.1016/j.jhep.2024.03.043 · Cited by 13 · see citing works

The Quest for Eternal Youth: Hallmarks of Aging and Rejuvenating Therapeutic Strategies

Nunkoo, V. S., Cristian, A., Jurcău, A., Diaconu, R. G., & Jurcău, M. C. (2024) · Biomedicines · doi:10.3390/biomedicines12112540 · Cited by 15 · see citing works

Lineage Landscape: a comprehensive database that records lineage commitment across species

Yan, H., Wang, R., Ma, S., Huang, D., Wang, S., Ren, J., Lu, C., Chen, X., Lu, X., Zheng, Z., et al. (2022) · Nucleic Acids Research · doi:10.1093/nar/gkac951 · Cited by 13 · see citing works

Role of the circulating milieu in age-related arterial dysfunction: a novel ex vivo approach

Mahoney, S. A., VanDongen, N. S., Greenberg, N., Venkatasubramanian, R., Rossman, M. J., Widlansky, M. E., Brunt, V. E., de Quirós, Y. B., Seals, D. R., & Clayton, Z. S. (2024) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00014.2024 · Cited by 12 · see citing works

Young Plasma Rejuvenates Blood DNA Methylation Profile, Extends Mean Lifespan, and Improves Physical Appearance in Old Rats

Chiavellini, P., Lehmann, M., Gallardo, M. D., Canatelli-Mallat, M., Pasquini, D. C., Zoller, J. A., Gordevičius, J., Girard, M., Lacunza, E., Hereñú, C. B., et al. (2024) · The Journals of Gerontology Series A · doi:10.1093/gerona/glae071 · Cited by 13 · see citing works

The secret of youth: how is systemic rejuvenation achieved at the single cell level?

Wang, L., Liu, J., Liu, H., Yazawa, M., & Zhu, F. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac018 · Cited by 11 · see citing works

Aging of the Hematopoietic System: Mechanisms, Consequences, and Systemic Interactions

Miyawaki, M., Hashimoto, S., Ogawa, S., & Kase, Y. (2026) · Aging Cell · doi:10.1111/acel.70385 · Cited by 10 · see citing works

Epigenetic aging of human blood cells is influenced by the age of the host body

Holland, P., Istre, M. S., Ali, M. M., Gedde‐Dahl, T., Buechner, J., Wildhagen, M., Brunvoll, S. H., Horvath, S., Matsuyama, S., Dahl, J. A., et al. (2024) · Aging Cell · doi:10.1111/acel.14112 · Cited by 10 · see citing works

Parabiosis, Assembloids, Organoids (PAO)

Hong, Y., Li, L., Yan, L., Bai, L., Su, J., & Zhang, X. (2025) · Advanced Science · doi:10.1002/advs.202511671 · Cited by 9 · see citing works

Small Extracellular Vesicles From Human Amniotic Membrane Mesenchymal Stem Cells Rejuvenate Senescent β Cells and Cure Age‐Related Diabetes in Mice

Xiao, L., Zhang, Z., Li, T., Jiang, Y., Liu, Y., Lv, T., Qin, L., Zhu, Y., & Tang, W. (2025) · Aging Cell · doi:10.1111/acel.70327 · Cited by 9 · see citing works

Human immune aging clock identifies RUNX1 as a decelerator of T cell senescence

Ping, J., Qiao, Q., Gao, D.-D., Li, Y., Fan, Y., Tian, Y., Xiong, M., Zheng, Q., Jiang, B., Li, J., et al. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.007 · Cited by 8 · see citing works

Biological aging clocks in health and disease

Wyss‐Coray, T., & Topol, E. J. (2026) · Nature Medicine · doi:10.1038/s41591-026-04495-3 · Cited by 9 · see citing works

Aging and immunity: the age-old tangoPreprint

Fernández-Maestre, I., Harris, A. S., & Amor, C. (2025) · Genes & Development · doi:10.1101/gad.352644.125 · Cited by 8 · see citing works

Emerging Therapeutic Strategies in Anti‐Aging Medicine: A Comprehensive Review

Peng, Y., Li, R., Li, H., Zhou, J., Liu, X., Valente, G. T., Melo, T. D. C., Chen, S., & 顾镭 (2026) · Medicine Bulletin · doi:10.1002/mdb2.70021 · Cited by 8 · see citing works

The glycolytic metabolite phosphoenolpyruvate restricts cGAS-driven inflammation to promote healthy aging

Song, Z., Hu, H., Zhang, W., Zheng, X., Liang, L., Zhao, B., Song, G., Li, J., Li, S., Wen, Y., et al. (2026) · Nature Aging · doi:10.1038/s43587-026-01087-1 · Cited by 7 · see citing works

In platelet single donor apheresis, platelet factor 4 levels correlated with donor’s age and decreased during storage

Duchez, A., Heestermans, M., Arthaud, C., Eyraud, M., Portier, M., Prier, A., Hamzeh‐Cognasse, H., & Cognasse, F. (2024) · Scientific Reports · doi:10.1038/s41598-024-56826-4 · Cited by 7 · see citing works

An optimized mouse parabiosis protocol for investigation of aging and rejuvenative mechanisms

Rodriguez, S. L., Carver, C. M., Dosch, A. J., Huffman, D. M., Boynton, F. D. D., Ayasoufi, K., & Schafer, M. J. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.993658 · Cited by 6 · see citing works

β2-microglobulin and cognitive decline: unraveling the mediating role of the Dunedin Pace of Aging methylation

Ke, Y., Chen, P., Wu, C., Wang, Q., Zeng, K., & Liang, M. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1505185 · Cited by 6 · see citing works

Pyrroloquinoline Quinone Reprograms the Single‐Cell Landscape of Immune Aging in Hematopoietic Immune System

Liu, X., Zhang, C., Lv, J., Liu, Y., Gu, C., Gao, Y., Ding, W., Chen, H., Xu, N., Yin, H., et al. (2025) · Aging Cell · doi:10.1111/acel.70050 · Cited by 6 · see citing works

Role of stem cells in ageing and age-related diseases

Chaudhary, J. K., Danga, A. K., Kumari, A., Bhardwaj, A., & Rath, P. C. (2025) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2025.112069 · Cited by 6 · see citing works

Hematopoietic Stem Cell Aging: Mechanisms, Microenvironment Influences, and Rejuvenation Strategies

Cui, J., Li, X., Liu, B., Dong, C., & Chang, Y. (2025) · Bioengineering · doi:10.3390/bioengineering12111166 · Cited by 6 · see citing works

Oral microbiome-SASP-aging axis: mechanisms and targeted intervention strategies for age-related diseases

Wu, E., Li, X., Ni, Z., Zhao, F., & Jia, C. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2616138 · Cited by 7 · see citing works

Mesenchymal drift: A convergent framework for the hallmarks of aging

Lu, J. Y., Tu, W. B., Ma, S., Ma, Z., Imaz-Rosshandler, I., Weng, M., Qu, J., Esteban, C. R., Reddy, P., Liu, G.-H., et al. (2026) · Cell · doi:10.1016/j.cell.2026.04.020 · Cited by 10 · see citing works

Heterochronic Parabiosis Causes Dacryoadenitis in Young Lacrimal Glands

Scholand, K. K., Mack, A. F., Guzman, G. U., Maniskas, M. E., Sampige, R. R., Govindarajan, G., McCullough, L. D., & de Paiva, C. S. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24054897 · Cited by 6 · see citing works

Transcranial Electromagnetic Wave Treatment: A Fountain of Healthy Longevity?

Arendash, G. W., & Cao, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119652 · Cited by 6 · see citing works

Research progress on blood therapy for anti-aging

Liu, S., Wang, S., Dong, Y., Yang, S., & Yao, C. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.039 · Cited by 5 · see citing works

Mechanical Stretch‐Induced Interlayer Coordination between MMP2 and COL17A1 Exacerbates Regenerative Exhaustion in Skin

Sun, Y., Qian, Q., Xu, L., Gao, B., Li, T., Li, Y., Zheng, J., Fu, Q., Cheng, X., Chen, N., et al. (2025) · Advanced Science · doi:10.1002/advs.202511474 · Cited by 5 · see citing works

The secretome atlas of two mouse models of progeria

Quintana‐Torres, D., Valle‐Cao, A., Bousquets‐Muñoz, P., Freitas‐Rodríguez, S., Rodríguez, F. J., Lucía, A., López-Otı́n, C., López‐Soto, A., & Folgueras, A. R. (2023) · Aging Cell · doi:10.1111/acel.13952 · Cited by 4 · see citing works

The disparity of platelet factor 4 and platelets in individuals of different ages

Weng, R., Liu, J., Yu, Q., Yuan, H., Qiu, Y., Liu, H., Wang, L., Mei, Z., & Zhu, F. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e34923 · Cited by 5 · see citing works

Stem Cell Rejuvenation via Heterochronic Parabiosis: A Literature Review and Case Analysis

Dou, H. (2025) · Theoretical and Natural Science · doi:10.54254/2753-8818/2025.au27668

The secret of youth: how is systemic rejuvenation achieved at the single cell level?

Wang, L., Liu, J., Liu, H., Yazawa, M., & Zhu, F. (2022) · Life Medicine · doi:10.1093/lifemedi/lnac018 · Cited by 11 · see citing works

Molecular hallmarks of heterochronic parabiosis at single-cell resolution

Pálovics, R., Keller, A., Schaum, N., Tan, W., Fehlmann, T., Borja, M., Kern, F., Bonanno, L., Calcuttawala, K., Webber, J., et al. (2022) · Nature · doi:10.1038/s41586-022-04461-2 · Cited by 153 · see citing works

PDPDT of lung cancer for optimal PDT

Kato, H. (2009) · Photodiagnosis and Photodynamic Therapy · doi:10.1016/j.pdpdt.2009.07.013

The Fountain of Youth: A tale of parabiosis, stem cells, and rejuvenation

Conese, M., Carbone, A., Beccia, E., & Angiolillo, A. (2017) · Open Medicine · doi:10.1515/med-2017-0053 · Cited by 62 · see citing works