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Cited by 81Exercise and Physiological ResponsesGenetics, Aging, and Longevity in Model OrganismsSingle-cell and spatial transcriptomics

A single-cell transcriptomic atlas of exercise-induced anti-inflammatory and geroprotective effects across the body

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Sun, Shuhui, Ma, Shuai, Cai, Yusheng, Wang, Si, Ren, Jie, Yang, Yuanhan, Ping, Jiale, Wang, Xuebao +10 more·2023·The Innovation
DOI 10.1016/j.xinn.2023.100380PMC PMC9898793
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Abstract

Exercise benefits the whole organism, yet, how tissues across the body orchestrally respond to exercise remains enigmatic. Here, in young and old mice, with or without exercise, and exposed to infectious injury, we characterized the phenotypic and molecular adaptations to a 12-month exercise across 14 tissues/organs at single-cell resolution. Overall, exercise protects tissues from infectious injury, although more effectively in young animals, and benefits aged individuals in terms of inflammaging suppression and tissue rejuvenation, with structural improvement in the central nervous system and systemic vasculature being the most prominent. In vascular endothelial cells, we found that readjusting the rhythmic machinery via the core circadian clock protein BMAL1 delayed senescence and facilitated recovery from infectious damage, recapitulating the beneficial effects of exercise. Our study underscores the effect of exercise in reconstituting the youthful circadian clock network and provides a foundation for further investigating the interplay between exercise, aging, and immune challenges across the whole organism.

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  • Geroprotective strategies such as long-term exercise and exposure to youthful bodily fluids mitigate accumulation of IgG and senescent cells in aging tissues.

    “By contrast, established geroprotective strategies such as long-term exercise and exposure to youthful bodily fluids,17”

    From Spatial transcriptomic landscape unveils immunoglobin-associated senescence as a hallmark of aging (2024) · cites this paper as [47]

    The Introduction describes up to 12 months of exercise in young and aged mice, and the Results report fewer senescence-associated markers in exercised old mice. The Introduction also mentions heterochronic parabiosis as an aging intervention, but our copy does not show that exposure to youthful bodily fluids reduces senescent cells, nor does it report reduced IgG accumulation for either strategy. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Sun, S., Ma, S., Cai, Y., Wang, S., Ren, J., Yang, Y., Ping, J., Wang, X., Zhang, Y., Yan, H., Li, W., Esteban, C. R., Yu, Y., Liu, F., Izpisua Belmonte, J. C., Zhang, W., Qu, J., & Liu, G.-H.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Capital Medical University (CN)
Corresponding author
  • Zhang, Weiqi
  • Qu, Jing
  • Liu, Guang-Hui
ORCID
Venue
The Innovation
Publisher
Elsevier BV
Published
2023-01
Volume
4
Issue
1
Pages
100380
ISSN
2666-6758 (ISSN-L)
DOI
10.1016/j.xinn.2023.100380
PMC
PMC9898793
OpenAlex
W4313556529
Cited by
81
References
14
Citations by year
2026: 11 · 2025: 35 · 2024: 22 · 2023: 13
FWCI
8.92
Type
journal article
Language
en
Update notices
erratum (2025-02-03)
Open access
Licence
Locations
  • The Innovation (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Keywords
physical activity, anti-inflammatory activity, geroprotective effects, inflammaging, tissue rejuvenation, aging, circadian clock, Bmal1, vascular endothelial cells, cellular senescence, central nervous system, vascular system, single-cell transcriptomics, tissue-specific responses

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