Hirano, Toshio

A point mutation of Tyr-759 in interleukin 6 family cytokine receptor subunit gp130 causes autoimmune arthritis

Atsumi, T., Ishihara, K., Kamimura, D., Ikushima, H., Ohtani, T., Hirota, S., Kobayashi, H., Park, S.-J., Saeki, Y., Kitamura, Y., et al. (2002) · The Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 225

IL-6-STAT3 Controls Intracellular MHC Class II αβ Dimer Level through Cathepsin S Activity in Dendritic Cells

Kitamura, H., Kamon, H., Sawa, S.-I., Park, S.-J., Katunuma, N., Ishihara, K., Murakami, M., & Hirano, T. (2005) · Immunity

Cytokine Signaling Pathways and InteractionsImmunotherapy and Immune Responses

Cited by 223

Inflammation amplifier, a new paradigm in cancer biology

Atsumi, T., Singh, R., Sabharwal, L., Bando, H., Meng, J., Arima, Y., Yamada, M., Harada, M., Jiang, J.-J., Kamimura, D., et al. (2014) · Cancer Research

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 217

Regulation of synthesis and secretion of major rat acute‐phase proteins by recombinant human interleukin‐6 (BSF‐2/1L‐6) in hepatocyte primary cultures

ANDUS, T., GEIGER, T., HIRANO, T., KISHIMOTO, T., TRAN‐THI, T., DECKER, K., & HEINRICH, P. C. (1988) · European Journal of Biochemistry

Cytokine Signaling Pathways and InteractionsLiver physiology and pathology

Cited by 188

Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells

Sawa, S.-I., Kamimura, D., Jin, G.-H., Morikawa, H., Kamon, H., Nishihara, M., Ishihara, K., Murakami, M., & Hirano, T. (2006) · The Journal of Experimental Medicine

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 176

Autoregulation of the Stat3 Gene through Cooperation with a cAMP-responsive Element-binding Protein

Ichiba, M., Nakajima, K., Yamanaka, Y., Kiuchi, N., & Hirano, T. (1998) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsGenomics and Chromatin Dynamics

Cited by 175

Interleukin 6 in autoimmune and inflammatory diseases: a personal memoir

HIRANO, T. (2010) · Proceedings of the Japan Academy, Series B

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 172

Involvement of STAT3 in the Granulocyte Colony-stimulating Factor-induced Differentiation of Myeloid Cells

Shimozaki, K., Nakajima, K., Hirano, T., & Nagata, S. (1997) · Journal of Biological Chemistry

Cytokine Signaling Pathways and InteractionsBlood disorders and treatments

Cited by 169

Molecular basis of the cell specificity of cytokine action

Ishihara, K., & Hirano, T. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 122

Disease-association analysis of an inflammation-related feedback loop

Murakami, M., Harada, M., Kamimura, D., Ogura, H., Okuyama, Y., Kumai, N., Okuyama, A., Singh, R., Jiang, J.-J., Atsumi, T., et al. (2013) · Cell Reports

NF-κB Signaling PathwaysCytokine Signaling Pathways and Interactions

Cited by 110

Local microbleeding facilitates IL-6- and IL-17-dependent arthritis in the absence of tissue antigen recognition by activated T cells

Murakami, M., Okuyama, Y., Ogura, H., Asano, S., Arima, Y., Tsuruoka, M., Harada, M., Kanamoto, M., Sawa, Y., Iwakura, Y., et al. (2011) · Journal of Experimental Medicine

Rheumatoid Arthritis Research and TherapiesT-cell and B-cell Immunology

Cited by 100

A pain-mediated neural signal induces relapse in murine autoimmune encephalomyelitis, a multiple sclerosis model

Arima, Y., Kamimura, D., Atsumi, T., Harada, M., Kawamoto, T., Nishikawa, N., Stofkova, A., Ohki, T., Higuchi, K., Morimoto, Y., et al. (2015) · eLife

Multiple Sclerosis Research StudiesPain Mechanisms and Treatments

Cited by 66

The YXXQ motif in gp 130 is crucial for STAT3 phosphorylation at Ser727 through an H7-sensitive kinase pathway

Abe, K., Hirai, M., Mizuno, K., Higashi, N., Sekimoto, T., Miki, T., Hirano, T., & Nakajima, K. (2001) · Oncogene

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 65

Interleukin-6.

Hirano, T., & Kishimoto, T. (1990) · Handbook of Experimental Pharmacology

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 57

A four-step model for the IL-6 amplifier, a regulator of chronic inflammations in tissue-specific MHC class II-associated autoimmune diseases

Murakami, M., & Hirano, T. (2011) · Frontiers in Immunology

Rheumatoid Arthritis Research and TherapiesCytokine Signaling Pathways and Interactions

Cited by 53

Mast cells play role in wound healing through the ZnT2/GPR39/IL-6 axis

Nishida, K., Hasegawa, A., Yamasaki, S., Uchida, R., Ohashi, W., Kurashima, Y., Kunisawa, J., Kimura, S., Iwanaga, T., Watarai, H., et al. (2019) · Scientific Reports

Wound Healing and TreatmentsTrace Elements in Health

Cited by 53

Renin-angiotensin system inhibitors and the severity of coronavirus disease 2019 in Kanagawa, Japan: a retrospective cohort study

Matsuzawa, Y., Ogawa, H., Kimura, K., Konishi, M., Kirigaya, J., Fukui, K., Tsukahara, K., Shimizu, H., Iwabuchi, K., Yamada, Y., et al. (2020) · Hypertension Research

COVID-19 Clinical Research StudiesRenin-Angiotensin System Studies

Cited by 52

Revival of the autoantibody model in rheumatoid arthritis

Hirano, T. (2002) · Nature Immunology

Rheumatoid Arthritis Research and TherapiesSystemic Lupus Erythematosus Research

Cited by 29