Hirano, Toshio

Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoglobulin

Hirano, T., Yasukawa, K., Harada, H., Taga, T., Watanabe, Y., Matsuda, T., Kashiwamura, S.-I., Nakajima, K., Koyama, K., Iwamatsu, A., et al. (1986) · Nature

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 2,139

Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas

Kawano, M., Hirano, T., Matsuda, T., Taga, T., Horii, Y., Iwato, K., Asaoku, H., Tang, B., Tanabe, O., Tanaka, H., et al. (1988) · Nature

Multiple Myeloma Research and TreatmentsCytokine Signaling Pathways and Interactions

Cited by 1,633

IL-6 in inflammation, autoimmunity and cancer

Hirano, T. (2021) · International Immunology

Cytokine Signaling Pathways and InteractionsNF-κB Signaling Pathways

Cited by 1,453

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

Taga, T., Hibi, M., Hirata, Y., Yamasaki, K., Yasukawa, K., Matsuda, T., Hirano, T., & Kishimoto, T. (1989) · Cell

Cytokine Signaling Pathways and InteractionsReceptor Mechanisms and Signaling

Cited by 1,396

IL-6 in autoimmune disease and chronic inflammatory proliferative disease

Ishihara, K., & Hirano, T. (2002) · Cytokine & Growth Factor Reviews

Cytokine Signaling Pathways and InteractionsRheumatoid Arthritis Research and Therapies

Cited by 807

Interleukin 6 and its receptor: ten years later

Hirano, T. (1998) · International Reviews of Immunology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 788

Excessive production of interleukin 6/B cell stimulatory factor-2 in rheumatoid arthritis

Hirano, T., Matsuda, T., Turner, M., Miyasaka, N., Buchan, G., Tang, B., Sato, K., Shimi, M., Maid, R., Feldmann, M., et al. (1988) · European Journal of Immunology

Rheumatoid Arthritis Research and TherapiesCytokine Signaling Pathways and Interactions

Cited by 784

The essential role of B cell stimulatory factor 2 (BSF-2/IL-6) for the terminal differentiation of B cells

Muraguchi, A., Hirano, T., Tang, B., Matsuda, T., Horii, Y., Nakajima, K., & Kishimoto, T. (1988) · The Journal of experimental medicine

T-cell and B-cell ImmunologyCytokine Signaling Pathways and Interactions

Cited by 783

COVID-19: a new virus, but a familiar receptor and cytokine release syndrome

Hirano, T., & Murakami, M. (2020) · Immunity

SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies

Cited by 772

IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages

Yasukawa, H., Ohishi, M., Mori, H., Murakami, M., Chinen, T., Aki, D., Hanada, T., Takeda, K., Akira, S., Hoshijima, M., et al. (2003) · Nature Immunology

Cytokine Signaling Pathways and InteractionsAdipokines, Inflammation, and Metabolic Diseases

Cited by 771

IL-6 signal transduction and its physiological roles: the signal orchestration model

Kamimura, D., Ishihara, K., & Hirano, T. (2003) · Reviews of Physiology, Biochemistry and Pharmacology

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 673

How COVID-19 induces cytokine storm with high mortality

Hojyo, S., Uchida, M., Tanaka, K., Hasebe, R., Tanaka, Y., Murakami, M., & Hirano, T. (2020) · Inflammation and Regeneration

COVID-19 Clinical Research StudiesCytokine Signaling Pathways and Interactions

Cited by 663

Two Signals Are Necessary for Cell Proliferation Induced by a Cytokine Receptor gp130: Involvement of STAT3 in Anti-Apoptosis

Fukada, T., Hibi, M., Yamanaka, Y., Takahashi-Tezuka, M., Fujitani, Y., Yamaguchi, T., Nakajima, K., & Hirano, T. (1996) · Immunity

Cytokine Signaling Pathways and InteractionsT-cell and B-cell Immunology

Cited by 652

IgG1 plasmacytosis in interleukin 6 transgenic mice

Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1989) · Proceedings of the National Academy of Sciences

Multiple Myeloma Research and TreatmentsLymphoma Diagnosis and Treatment

Cited by 586

A central role for Stat3 in IL‐6‐induced regulation of growth and differentiation in M1 leukemia cells.

Nakajima, K., Yamanaka, Y., Nakae, K., Kojima, H., Ichiba, M., Kiuchi, N., Kitaoka, T., Fukada, T., Hibi, M., & Hirano, T. (1996) · The EMBO Journal

Cytokine Signaling Pathways and InteractionsAcute Myeloid Leukemia Research

Cited by 565

Interleukin-17 promotes autoimmunity by triggering a positive-feedback loop via interleukin-6 induction

Ogura, H., Murakami, M., Okuyama, Y., Tsuruoka, M., Kitabayashi, C., Kanamoto, M., Nishihara, M., Iwakura, Y., & Hirano, T. (2008) · Immunity

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 564

Pleiotropy and specificity: insights from the interleukin 6 family of cytokines

Murakami, M., Kamimura, D., & Hirano, T. (2019) · Immunity

Cytokine Signaling Pathways and InteractionsPsoriasis: Treatment and Pathogenesis

Cited by 533

IL-6 regulates in vivo dendritic cell differentiation through STAT3 activation

Park, S.-J., Nakagawa, T., Kitamura, H., Atsumi, T., Kamon, H., Sawa, S.-I., Kamimura, D., Ueda, N., Iwakura, Y., Ishihara, K., et al. (2004) · The Journal of Immunology

Cytokine Signaling Pathways and InteractionsImmunotherapy and Immune Responses

Cited by 519

Human B-cell differentiation factor defined by an anti-peptide antibody and its possible role in autoantibody production

Hirano, T., Taga, T., Yasukawa, K., Nakajima, K., Nakano, N., Takatsuki, F., Shimizu, M., Murashima, A., Tsunasawa, S., & Sakiyama, F. (1987) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologySystemic Lupus Erythematosus Research

Cited by 351

Regional neural activation defines a gateway for autoreactive T cells to cross the blood-brain barrier

Arima, Y., Harada, M., Kamimura, D., Park, J.-H., Kawano, F., Yull, F. E., Kawamoto, T., Iwakura, Y., Betz, U. A. K., Márquez, G., et al. (2012) · Cell

Multiple Sclerosis Research StudiesNeuroinflammation and Neurodegeneration Mechanisms

Cited by 307

The Zinc Transporter SLC39A13/ZIP13 Is Required for Connective Tissue Development; Its Involvement in BMP/TGF-β Signaling Pathways

Fukada, T., Civic, N., Furuichi, T., Shimoda, S., Mishima, K., Higashiyama, H., Idaira, Y., Asada, Y., Kitamura, H., Yamasaki, S., et al. (2008) · PLoS ONE

Trace Elements in HealthConnective tissue disorders research

Cited by 287

IL-6-gp130-STAT3 in T cells directs the development of IL-17+ Th with a minimum effect on that of Treg in the steady state

Nishihara, M., Ogura, H., Ueda, N., Tsuruoka, M., Kitabayashi, C., Tsuji, F., Aono, H., Ishihara, K., Huseby, E., Betz, U. A. K., et al. (2007) · International Immunology

Psoriasis: Treatment and PathogenesisCytokine Signaling Pathways and Interactions

Cited by 268

STAT3 orchestrates contradictory signals in cytokine-induced G1 to S cell-cycle transition

Fukada, T., Ohtani, T., Yoshida, Y., Shirogane, T., Nishida, K., Nakajima, K., Hibi, M., & Hirano, T. (1998) · The EMBO Journal

Cytokine Signaling Pathways and InteractionsCancer-related Molecular Pathways

Cited by 247

Generation of plasmacytomas with the chromosomal translocation t(12;15) in interleukin 6 transgenic mice

Suematsu, S., Matsusaka, T., Matsuda, T., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1992) · Proceedings of the National Academy of Sciences

Multiple Myeloma Research and TreatmentsLymphoma Diagnosis and Treatment

Cited by 227