Laakso, Markku

Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance

The RISC Investigators, Mari, A., Tura, A., Natali, A., Laville, M., Laakso, M., Gabriel, R., Beck-Nielsen, H., & Ferrannini, E. (2010) · Diabetologia

Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 120

Incidence and predictors of silent myocardial infarction in type 2 diabetes and the effect of fenofibrate: an analysis from the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study

Burgess, D. C., Hunt, D., Li, L., Zannino, D., Williamson, E., Davis, T. M. E., Laakso, M., Kesaniemi, Y. A., Zhang, J., Sy, R. W., et al. (2010) · European Heart Journal

Acute Myocardial Infarction ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 119

A Genome-Wide Association Study of IVGTT-Based Measures of First-Phase Insulin Secretion Refines the Underlying Physiology of Type 2 Diabetes Variants

Wood, A. R., Jonsson, A., Jackson, A. U., Wang, N., van Leewen, N., Palmer, N. D., Kobes, S., Deelen, J., Boquete-Vilarino, L., Paananen, J., et al. (2017) · Diabetes

Genetic Associations and EpidemiologyPancreatic function and diabetes

Cited by 117

Discovery of drug-omics associations in type 2 diabetes with generative deep-learning models

Allesøe, R. L., Lundgaard, A. T., Hernández Medina, R., Aguayo-Orozco, A., Johansen, J., Nissen, J. N., Brorsson, C., Mazzoni, G., Niu, L., Biel, J. H., et al. (2023) · Nature Biotechnology

Bioinformatics and Genomic NetworksComputational Drug Discovery Methods

Cited by 111

Quantifying the impact of rare and ultra-rare coding variation across the phenotypic spectrum

Ganna, A., Satterstrom, F. K., Zekavat, S. M., Das, I., Kurki, M. I., Churchhouse, C., Alfoldi, J., Martin, A. R., Havulinna, A. S., Byrnes, A., et al. (2018) · The American Journal of Human Genetics

Genomics and Rare DiseasesGenetic Associations and Epidemiology

Cited by 110

Electrocardiographic Alterations during Hyperinsulinemic Hypoglycemia in Healthy Subjects

Laitinen, T., Lyyra‐Laitinen, T., Huopio, H., Vauhkonen, I., Halonen, T., Hartikainen, J., Niskanen, L., & Laakso, M. (2008) · Annals of Noninvasive Electrocardiology

Cardiac electrophysiology and arrhythmiasDiabetes Management and Research

Cited by 107

A Common Variant in TFB1M Is Associated with Reduced Insulin Secretion and Increased Future Risk of Type 2 Diabetes

Koeck, T., Olsson, A. H., Nitert, M. D., Sharoyko, V. V., Ladenvall, C., Kotova, O., Reiling, E., Rönn, T., Parikh, H., Taneera, J., et al. (2011) · Cell Metabolism

Pancreatic function and diabetesDiabetes and associated disorders

Cited by 105

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

Rutanen, J., Yaluri, N., Modi, S., Pihlajamäki, J., Vänttinen, M., Itkonen, P., Kainulainen, S., Yamamoto, H., Lagouge, M., Sinclair, D. A., et al. (2010) · Diabetes

Sirtuins and Resveratrol in MedicineAdipose Tissue and Metabolism

Cited by 104

Phenotype-Specific Enrichment of Mendelian Disorder Genes near GWAS Regions across 62 Complex Traits

Freund, M. K., Burch, K. S., Shi, H., Mancuso, N., Kichaev, G., Garske, K. M., Pan, D. Z., Miao, Z., Mohlke, K. L., Laakso, M., et al. (2018) · The American Journal of Human Genetics

Genetic Associations and EpidemiologyBioinformatics and Genomic Networks

Cited by 102

Predicting and elucidating the etiology of fatty liver disease: a machine learning modeling and validation study in the IMI DIRECT cohorts

Atabaki-Pasdar, N., Ohlsson, M., Viñuela, A., Frau, F., Pomares-Millan, H., Haid, M., Jones, A. G., Thomas, E. L., Koivula, R. W., Kurbasic, A., et al. (2020) · PLOS Medicine

Liver Disease Diagnosis and TreatmentAlcohol Consumption and Health Effects

Cited by 97

Link between GIP and osteopontin in adipose tissue and insulin resistance

Ahlqvist, E., Osmark, P., Kuulasmaa, T., Pilgaard, K., Omar, B., Brøns, C., Kotova, O., Zetterqvist, A. V., Stančáková, A., Jonsson, A., et al. (2013) · Diabetes

Adipokines, Inflammation, and Metabolic DiseasesBone Metabolism and Diseases

Cited by 96

The relation of proinsulin, insulin, and proinsulin-to-insulin ratio to insulin sensitivity and acute insulin response in normoglycemic subjects

Mykkanen, L., Haffner, S. M., Hales, C. N., Ronnemaa, T., & Laakso, M. (1997) · Diabetes

Pancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 92

Relation of Direct and Surrogate Measures of Insulin Resistance to Cardiovascular Risk Factors in Nondiabetic Finnish Offspring of Type 2 Diabetic Individuals

Lorenzo, C., Haffner, S. M., Stančáková, A., & Laakso, M. (2010) · The Journal of Clinical Endocrinology & Metabolism

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 92

Reactive microglia in aging and dementia: an immunohistochemical study of postmortem human brain tissue

Overmyer, M., Helisalmi, S., Soininen, H., Laakso, M., Riekkinen Sr., P., & Alafuzoff, I. (1999) · Acta Neuropathologica

Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatments

Cited by 91

Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits

Civelek, M., Hagopian, R., Pan, C., Che, N., Yang, W.-P., Kayne, P. S., Saleem, N. K., Cederberg, H., Kuusisto, J., Gargalovic, P. S., et al. (2013) · Human Molecular Genetics

MicroRNA in disease regulationGenetic Associations and Epidemiology

Cited by 89

A Strategy for Discovery of Endocrine Interactions with Application to Whole-Body Metabolism

Seldin, M. M., Koplev, S., Rajbhandari, P., Vergnes, L., Rosenberg, G. M., Meng, Y., Pan, C., Phuong, T. M. N., Gharakhanian, R., Che, N., et al. (2018) · Cell Metabolism

Adipose Tissue and MetabolismBioinformatics and Genomic Networks

Cited by 84

Fgr kinase is required for proinflammatory macrophage activation during diet-induced obesity

Acín-Pérez, R., Iborra, S., Martí-Mateos, Y., Cook, E. C. L., Conde-Garrosa, R., Petcherski, A., Muñoz, M. D. M., Martínez de Mena, R., Krishnan, K. C., Jiménez, C., et al. (2020) · Nature Metabolism

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 83

Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

Xie, W., Wood, A. R., Lyssenko, V., Weedon, M. N., Knowles, J. W., Alkayyali, S., Assimes, T. L., Quertermous, T., Abbasi, F., Paananen, J., et al. (2013) · Diabetes

Genetic Associations and EpidemiologyMetabolomics and Mass Spectrometry Studies

Cited by 83

Statins and risk of type 2 diabetes: mechanism and clinical implications

Laakso, M., & Fernandes Silva, L. (2023) · Frontiers in Endocrinology

Lipoproteins and Cardiovascular HealthDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 82

Detection of Novel Gene Variants Associated with Congenital Hypothyroidism in a Finnish Patient Cohort

Löf, C., Patyra, K., Kuulasmaa, T., Vangipurapu, J., Undeutsch, H., Jaeschke, H., Pajunen, T., Kero, A., Krude, H., Biebermann, H., et al. (2016) · Thyroid®

Thyroid Disorders and TreatmentsGenomics and Rare Diseases

Cited by 81

Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study

on behalf of the RISC Investigators, Ferrannini, E., Natali, A., Muscelli, E., Nilsson, P. M., Golay, A., Laakso, M., Beck-Nielsen, H., & Mari, A. (2011) · Diabetologia

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 80

Risk for non-insulindependent diabetes in the normoglycaemic elderly is associated with impaired cognitive function

Vanhanen, M., Koivisto, K., Karjalainen, L., Helkala, E.-L., Laakso, M., Soininen, H., & Riekkinen, P. (1997) · NeuroReport

Dementia and Cognitive Impairment ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 77

Decreased plasma β‐amyloid in the Alzheimer's disease APP A 673 Tvariant carriers

Martiskainen, H., Herukka, S., Stančáková, A., Paananen, J., Soininen, H., Kuusisto, J., Laakso, M., & Hiltunen, M. (2017) · Annals of Neurology

Alzheimer's disease research and treatmentsDementia and Cognitive Impairment Research

Cited by 64

Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population

Lim, E. T., Würtz, P., Havulinna, A. S., Palta, P., Tukiainen, T., Rehnström, K., Esko, T., Mägi, R., Inouye, M., Lappalainen, T., et al. (2014) · PLoS Genetics

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 49