Laakso, Markku

Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes

Mahajan, A., Wessel, J., Willems, S. M., Zhao, W., Robertson, N. R., Chu, A. Y., Gan, W., Kitajima, H., Taliun, D., Rayner, N. W., et al. (2018) · Nature Genetics

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 442

Impact of common genetic determinants of hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Wheeler, E., Leong, A., Liu, C.-T., Hivert, M.-F., Strawbridge, R. J., Podmore, C., Li, M., Yao, J., Sim, X., Hong, J., et al. (2017) · PLOS Medicine

Genetic Associations and EpidemiologyGenetic Mapping and Diversity in Plants and Animals

Cited by 408

Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland

Eriksson, J., Lindström, J., Valle, T., Aunola, S., Hämäläinen, H., Ilanne-Parikka, P., Keinänen-Kiukaanniemi, S., Laakso, M., Lauhkonen, M., Lehto, P., et al. (1999) · Diabetologia

Diabetes, Cardiovascular Risks, and LipoproteinsDiabetes Treatment and Management

Cited by 368

Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes

Strawbridge, R. J., Dupuis, J., Prokopenko, I., Barker, A., Ahlqvist, E., Rybin, D., Petrie, J. R., Travers, M. E., Bouatia-Naji, N., Dimas, A. S., et al. (2011) · Diabetes

Genetic Associations and EpidemiologyDiabetes and associated disorders

Cited by 356

Changes in insulin sensitivity and insulin release in relation to glycemia and glucose tolerance in 6,414 Finnish men

Stančáková, A., Javorský, M., Kuulasmaa, T., Haffner, S. M., Kuusisto, J., & Laakso, M. (2009) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 348

Insulin action and age. European Group for the Study of Insulin Resistance (EGIR)

Ferrannini, E., Vichi, S., Beck-Nielsen, H., Laakso, M., Paolisso, G., & Smith, U. (1996) · Diabetes

Diabetes, Cardiovascular Risks, and LipoproteinsPancreatic function and diabetes

Cited by 340

Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile

Kilpeläinen, T. O., Zillikens, M. C., Stančákova, A., Finucane, F. M., Ried, J. S., Langenberg, C., Zhang, W., Beckmann, J. S., Luan, J., Vandenput, L., et al. (2011) · Nature Genetics

Genetic Associations and EpidemiologyAdipokines, Inflammation, and Metabolic Diseases

Cited by 335

Effect of fenofibrate on amputation events in people with type 2 diabetes mellitus (FIELD study): a prespecified analysis of a randomised controlled trial

Rajamani, K., Colman, P. G., Li, L. P., Best, J. D., Voysey, M., D'Emden, M. C., Laakso, M., Baker, J. R., & Keech, A. C. (2009) · The Lancet

Diabetic Foot Ulcer Assessment and ManagementPeripheral Artery Disease Management

Cited by 328

Genetic evidence of assortative mating in humans

Robinson, M. R., Kleinman, A., Graff, M., Vinkhuyzen, A. A. E., Couper, D., Miller, M. B., Peyrot, W. J., Abdellaoui, A., Zietsch, B. P., Nolte, I. M., et al. (2017) · Nature Human Behaviour

Genetic Associations and EpidemiologyGenetic and phenotypic traits in livestock

Cited by 326

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension

CHARGE-Heart Failure Consortium, Surendran, P., EchoGen Consortium, METASTROKE Consortium, GIANT Consortium, EPIC-InterAct Consortium, Study, L. C., Wellcome Trust Case Control Consortium, Understanding Society Scientific Group, EPIC-CVD Consortium, et al. (2016) · Nature Genetics

Genetic Associations and EpidemiologyBlood Pressure and Hypertension Studies

Cited by 312

Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls

Platform, B. G., Flannick, J., DiscovEHR Collaboration, CHARGE, LuCamp, ProDiGY, GoT2D, ESP, SIGMA-T2D, T2D-GENES, et al. (2019) · Nature

Genetic Associations and EpidemiologyGenomics and Rare Diseases

Cited by 304

Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies

Wu, J. H. Y., Marklund, M., Imamura, F., Tintle, N., Ardisson Korat, A. V., de Goede, J., Zhou, X., Yang, W.-S., de Oliveira Otto, M. C., Kröger, J., et al. (2017) · The Lancet Diabetes & Endocrinology

Fatty Acid Research and HealthNutritional Studies and Diet

Cited by 298

Insulin Resistance Syndrome Predicts Coronary Heart Disease Events in Elderly Nondiabetic Men

Lempiäinen, P., Mykkänen, L., Pyörälä, K., Laakso, M., & Kuusisto, J. (1999) · Circulation

Diabetes, Cardiovascular Risks, and LipoproteinsCardiovascular Health and Risk Factors

Cited by 293

The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue

Schugar, R. C., Shih, D. M., Warrier, M., Helsley, R. N., Burrows, A., Ferguson, D., Brown, A. L., Gromovsky, A. D., Heine, M., Chatterjee, A., et al. (2017) · Cell Reports

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 291

Blood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies

Harris, W. S., Tintle, N. L., Imamura, F., Qian, F., Korat, A. V. A., Marklund, M., Djoussé, L., Bassett, J. K., Carmichael, P.-H., Chen, Y.-Y., et al. (2021) · Nature Communications

Fatty Acid Research and HealthNutritional Studies and Diet

Cited by 244

Downregulation of Diacylglycerol Kinase Delta Contributes to Hyperglycemia-Induced Insulin Resistance

Chibalin, A. V., Leng, Y., Vieira, E., Krook, A., Björnholm, M., Long, Y. C., Kotova, O., Zhong, Z., Sakane, F., Steiler, T., et al. (2008) · Cell

Metabolism, Diabetes, and CancerDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 232

Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes

Perry, J. R. B., Weedon, M. N., Langenberg, C., Jackson, A. U., Lyssenko, V., Sparsø, T., Thorleifsson, G., Grallert, H., Ferrucci, L., Maggio, M., et al. (2010) · Human Molecular Genetics

Genetic Associations and EpidemiologyHormonal and reproductive studies

Cited by 217

Retinopathy predicts cardiovascular mortality in type 2 diabetic men and women

Juutilainen, A., Lehto, S., Rönnemaa, T., Pyörälä, K., & Laakso, M. (2007) · Diabetes Care

Retinal Diseases and TreatmentsDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 209

High-Sensitivity C-Reactive Protein and Coronary Heart Disease Mortality in Patients With Type 2 Diabetes

Soinio, M., Marniemi, J., Laakso, M., Lehto, S., & Rönnemaa, T. (2006) · Diabetes Care

Adipokines, Inflammation, and Metabolic DiseasesLipoproteins and Cardiovascular Health

Cited by 186

The STOP-NIDDM Trial: An international study on the efficacy of an α-glucosidase inhibitor to prevent type 2 diabetes in a population with impaired glucose tolerance: rationale, design, and preliminary screening data

Chiasson, J.-L., Gomis, R., Hanefeld, M., Josse, R. G., Karasik, A., Laakso, M., & The Stop-Niddm Trial Research Group (1998) · Diabetes Care

Diabetes Treatment and ManagementDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 182

Regulatory variants at KLF14 influence type 2 diabetes risk via a female-specific effect on adipocyte size and body composition

Small, K. S., Todorčević, M., Civelek, M., El-Sayed Moustafa, J. S., Wang, X., Simon, M. M., Fernandez-Tajes, J., Mahajan, A., Horikoshi, M., Hugill, A., et al. (2018) · Nature Genetics

Adipokines, Inflammation, and Metabolic DiseasesGenetic Associations and Epidemiology

Cited by 168

Conjugated bile acids associate with altered rates of glucose and lipid oxidation after Roux-en-Y gastric bypass

Simonen, M., Dali-Youcef, N., Kaminska, D., Venesmaa, S., Käkelä, P., Pääkkönen, M., Hallikainen, M., Kolehmainen, M., Uusitupa, M., Moilanen, L., et al. (2012) · Obesity Surgery

Bariatric Surgery and OutcomesDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 145

Identification and validation of N-acetyltransferase 2 as an insulin sensitivity gene

Knowles, J. W., Xie, W., Zhang, Z., Chennemsetty, I., Assimes, T. L., Paananen, J., Hansson, O., Pankow, J., Goodarzi, M. O., Carcamo-Orive, I., et al. (2015) · Journal of Clinical Investigation

Genetic Associations and EpidemiologyDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 141

High Serum Levels of Advanced Glycation End Products Predict Increased Coronary Heart Disease Mortality in Nondiabetic Women but not in Nondiabetic Men: A Population-Based 18-Year Follow-Up Study

Kilhovd, B. K., Juutilainen, A., Lehto, S., Rönnemaa, T., Torjesen, P. A., Birkeland, K. I., Berg, T. J., Hanssen, K. F., & Laakso, M. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology

Advanced Glycation End Products researchDiabetes, Cardiovascular Risks, and Lipoproteins

Cited by 122