Mellon, Synthia H.

Accelerating research on biological aging and mental health: Current challenges and future directions.

Han, L. K. M., Verhoeven, J. E., Tyrka, A. R., Penninx, B. W. J. H., Wolkowitz, O. M., Månsson, K. N. T., Lindqvist, D., Boks, M. P., Révész, D., Mellon, S. H., et al. (2019) · Psychoneuroendocrinology

Genetics, Aging, and Longevity in Model OrganismsAging and Gerontology Research

Cited by 104

Multi-omic biomarker identification and validation for diagnosing warzone-related post-traumatic stress disorder

The PTSD Systems Biology Consortium, Dean, K. R., Hammamieh, R., Mellon, S. H., Abu-Amara, D., Flory, J. D., Guffanti, G., Wang, K., Daigle, B. J., Gautam, A., et al. (2020) · Molecular Psychiatry

Posttraumatic Stress Disorder ResearchTraumatic Brain Injury Research

Cited by 101

Structure and function of the hepatic form of 11 beta-hydroxysteroid dehydrogenase in the squirrel monkey, an animal model of glucocorticoid resistance.

Moore, C. C., Mellon, S. H., Murai, J., Siiteri, P. K., & Miller, W. L. (1993) · Endocrinology

Hormonal Regulation and HypertensionAdrenal Hormones and Disorders

Cited by 93

cAMP regulates P450scc gene expression by a cycloheximide-insensitive mechanism in cultured mouse Leydig MA-10 cells

Mellon, S. H., & Vaisse, C. (1989) · Proceedings of the National Academy of Sciences

Sperm and Testicular FunctionAdrenal Hormones and Disorders

Cited by 89

Basic fibroblast growth factor expression is regulated by corticotropin in the human fetal adrenal: a model for adrenal growth regulation

Mesiano, S., Mellon, S. H., Gospodarowicz, D., Di Blasio, A. M., & Jaffe, R. B. (1991) · Proceedings of the National Academy of Sciences

Fibroblast Growth Factor ResearchAdrenal Hormones and Disorders

Cited by 85

Metabolomic analysis of male combat veterans with post traumatic stress disorder

Mellon, S. H., Bersani, F. S., Lindqvist, D., Hammamieh, R., Donohue, D., Dean, K., Jett, M., Yehuda, R., Flory, J., Reus, V. I., et al. (2019) · PLOS ONE

Posttraumatic Stress Disorder ResearchMetabolomics and Mass Spectrometry Studies

Cited by 85

Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation

Bersani, F. S., Wolkowitz, O. M., Lindqvist, D., Yehuda, R., Flory, J., Bierer, L. M., Makotine, I., Abu-Amara, D., Coy, M., Reus, V. I., et al. (2016) · Brain, Behavior, and Immunity

Posttraumatic Stress Disorder ResearchNitric Oxide and Endothelin Effects

Cited by 84

Novel role for the nuclear phosphoprotein SET in transcriptional activation of P450c17 and initiation of neurosteroidogenesis

Compagnone, N. A., Zhang, P., Vigne, J.-L., & Mellon, S. H. (2000) · Molecular Endocrinology

Estrogen and related hormone effectsNuclear Receptors and Signaling

Cited by 81

Prenatal diagnosis of congenital lipoid adrenal hyperplasia.

Saenger, P., Klonari, Z., Black, S. M., Compagnone, N., Mellon, S. H., Fleischer, A., Abrams, C. A., Shackelton, C. H., & Miller, W. L. (1995) · The Journal of Clinical Endocrinology & Metabolism

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 81

Deletion of the Mouse P450c17 Gene Causes Early Embryonic Lethality

Bair, S. R., & Mellon, S. H. (2004) · Molecular and Cellular Biology

Sexual Differentiation and DisordersAdrenal Hormones and Disorders

Cited by 63

P450c11B3 mRNA, transcribed from a third P450c11 gene, is expressed in a tissue-specific, developmentally and hormonally regulated fashion in the rodent adrenal, and encodes a protein with both 11-hydroxylase and 18-hydroxylase activities

Mellon, S. H., Bair, S. R., & Monis, H. (1995) · Journal of Biological Chemistry

Hormonal Regulation and HypertensionAdrenal Hormones and Disorders

Cited by 63

Evidence for disrupted gray matter structural connectivity in posttraumatic stress disorder

Mueller, S. G., Ng, P., Neylan, T., Mackin, S., Wolkowitz, O., Mellon, S., Yan, X., Flory, J., Yehuda, R., Marmar, C. R., et al. (2015) · Psychiatry Research: Neuroimaging

Functional Brain Connectivity StudiesPosttraumatic Stress Disorder Research

Cited by 61

Human proopiomelanocortin (79–96), a proposed androgen stimulatory hormone, does not affect steroidogenesis in cultured human fetal adrenal cells

MELLON, S. H., SHIVELY, J. E., & MILLER, W. L. (1991) · The Journal of Clinical Endocrinology & Metabolism

Adrenal Hormones and DisordersStress Responses and Cortisol

Cited by 61

Whole-genome DNA methylation status associated with clinical PTSD measures of OIF/OEF veterans

Hammamieh, R., Chakraborty, N., Gautam, A., Muhie, S., Yang, R., Donohue, D., Kumar, R., Daigle, B. J., Zhang, Y., Amara, D. A., et al. (2017) · Translational Psychiatry

Posttraumatic Stress Disorder ResearchEpigenetics and DNA Methylation

Cited by 57

Role of enhanced glucocorticoid receptor sensitivity in inflammation in PTSD: insights from computational model for circadian-neuroendocrine-immune interactions

Somvanshi, P. R., Mellon, S. H., Yehuda, R., Flory, J. D., Makotkine, I., Bierer, L., Marmar, C., Jett, M., & Doyle, F. J. (2020) · American Journal of Physiology-Endocrinology and Metabolism

Stress Responses and CortisolPosttraumatic Stress Disorder Research

Cited by 55

Transcriptional regulation of P450scc gene expression in neural and steroidogenic cells: implications for regulation of neurosteroidogenesis

Zhang, P., Rodriguez, H., & Mellon, S. H. (1995) · Molecular Endocrinology

Estrogen and related hormone effectsAdrenal Hormones and Disorders

Cited by 53

Epigenetic biotypes of post-traumatic stress disorder in war-zone exposed veteran and active duty males

Yang, R., Gautam, A., Getnet, D., Daigle, B. J., Miller, S., Misganaw, B., Dean, K. R., Kumar, R., Muhie, S., Wang, K., et al. (2021) · Molecular Psychiatry

Posttraumatic Stress Disorder ResearchEpigenetics and DNA Methylation

Cited by 48

Vitamin D and inflammation in major depressive disorder

Grudet, C., Wolkowitz, O. M., Mellon, S. H., Malm, J., Reus, V. I., Brundin, L., Nier, B. M., Dhabhar, F. S., Hough, C. M., Westrin, Å., et al. (2020) · Journal of Affective Disorders

Vitamin D Research StudiesTryptophan and brain disorders

Cited by 45

Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity

Somvanshi, P. R., Mellon, S. H., Flory, J. D., Abu-Amara, D., PTSD Systems Biology Consortium;, Wolkowitz, O. M., Yehuda, R., Jett, M., Hood, L., Marmar, C., et al. (2019) · American Journal of Physiology-Endocrinology and Metabolism

Posttraumatic Stress Disorder ResearchStress Responses and Cortisol

Cited by 43

Cortisol/DHEA ratio and hippocampal volume: A pilot study in major depression and healthy controls

Jin, R. O., Mason, S., Mellon, S. H., Epel, E. S., Reus, V. I., Mahan, L., Rosser, R. L., Hough, C. M., Burke, H. M., Mueller, S. G., et al. (2016) · Psychoneuroendocrinology

Stress Responses and CortisolTreatment of Major Depression

Cited by 41

Peripheral antioxidant markers are associated with total hippocampal and CA3/dentate gyrus volume in MDD and healthy controls—Preliminary findings

Lindqvist, D., Mueller, S., Mellon, S. H., Su, Y., Epel, E. S., Reus, V. I., Rosser, R., Mahan, L., Mackin, R. S., Yang, T. T., et al. (2014) · Psychiatry Research: Neuroimaging

Treatment of Major DepressionStress Responses and Cortisol

Cited by 33

Artificial mutations in P450c11AS (aldosterone synthase) can increase enzymatic activity: a model for low-renin hypertension?

Fardella, C. E., Rodriguez, H., Hum, D. W., Mellon, S. H., & Miller, W. L. (1995) · The Journal of Clinical Endocrinology & Metabolism

Hormonal Regulation and HypertensionRenin-Angiotensin System Studies

Cited by 31

Serum Brain-Derived Neurotrophic Factor, Val66Met Polymorphism and Open-Label SSRI Treatment Response in Major Depressive Disorder

Smit, A. J. T., Wu, G. W. Y., Rampersaud, R., Reus, V. I., Wolkowitz, O. M., & Mellon, S. H. (2024) · Psychoneuroendocrinology

Treatment of Major DepressionNeurotransmitter Receptor Influence on Behavior

Cited by 9