Circulating cell-free mitochondrial DNA, but not leukocyte mitochondrial DNA copy number, is elevated in major depressive disorder
Open accessAbstract
Major depressive disorder (MDD) has been linked to mitochondrial defects, which could manifest in mitochondrial DNA (mtDNA) polymorphisms or mutations. Additionally, copy number of mtDNA (mtDNA-cn) can be quantified in peripheral blood mononuclear cells (PBMC)s, indirectly reflecting cellular energetics, or in the circulating cell-free mtDNA (ccf-mtDNA) levels, which may reflect a fraction of the mitochondrial genome released during cellular stress. Few studies have examined ccf-mtDNA in MDD, and no studies have tested its relationship with intracellular mtDNA-cn or with antidepressant treatment response. Here, mtDNA levels were quantified in parallel from: (i) PBMCs and (ii) cell-free plasma of 50 unmedicated MDD subjects and 55 controls, in parallel with PBMC telomere length (TL) and antioxidant enzyme glutathione peroxidase (GpX) activity. MtDNA measures were repeated in 19 MDD subjects after 8 weeks of open-label SSRI treatment. In analyses adjusted for age, sex, BMI, and smoking, MDD subjects had significantly elevated levels of ccf-mtDNA (F = 20.6, p = 0.00002). PBMC mtDNA-cn did not differ between groups (p > 0.4). In preliminary analyses, we found that changes in ccf-mtDNA with SSRI treatment differed between SSRI responders and non-responders (F = 6.47, p = 0.02), with the non-responders showing an increase in ccf-mtDNA and responders not changing. Baseline ccf-mtDNA was positively correlated with GpX (r = 0.32, p = 0.001), and PBMC mtDNA correlated positively with PBMC TL (r = 0.38, p = 0.0001). These data suggest that plasma ccf-mtDNA and PBMC mtDNA-cn reflect different cellular processes and that the former may be more reflective of certain aspects of MDD pathophysiology and of the response to SSRI antidepressants.
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Assessing presence of extracellular mitochondria or their fragments by measuring ccf-mtDNA levels could allow on-flight direct estimation of cellular stress to take preventive measures of cumulative damage.
“Assessing the presence of extracellular mitochondria or their fragments by measuring ccf-mtDNA levels could allow on-flight direct estimation of cellular stress to take preventive measures of cumulative damage196,199–206.”
From Key points for the development of antioxidant cocktails to prevent cellular stress and damage caused by reactive oxygen species (ROS) during manned space missions (2021) · cites this paper as [206]
The Introduction says that measuring circulating cell-free mtDNA may inform on cellular stress, and the Discussion suggests it may be a marker of cellular damage or stress. The paper does not establish that this measurement directly estimates stress during flight, detects extracellular mitochondria themselves, or enables preventive action against cumulative damage. (LLM, conf=0.86)
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Self-citation
- Authors
- Lindqvist, D., Wolkowitz, O. M., Picard, M., Ohlsson, L., Bersani, F. S., Fernström, J., Westrin, Å., Hough, C. M., Lin, J., Reus, V. I., Epel, E. S., & Mellon, S. H.
- Affiliations
- University of California, San Francisco (US)
- Columbia University Irving Medical Center (US)
- Malmö University (SE)
- Lund University (SE)
- University of California, Los Angeles (US)
- Corresponding author
- Lindqvist, Daniel
- ORCID
- Venue
- Neuropsychopharmacology
- Published
- 2018-01-30
- Volume
- 43
- Issue
- 7
- Pages
- 1557-1564
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC5983469
- OpenAlex
- W2789855059
- Cited by
- 188
- References
- 56
- Citations by year
- 2026: 15 · 2025: 18 · 2024: 26 · 2023: 27 · 2022: 23 · 2021: 27 · 2020: 26 · 2019: 20 · 2018: 5
- FWCI
- 6.94
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuropsychopharmacology (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- eScholarship (California Digital Library) (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Lund University Publications (Lund University) (submittedVersion)
- Malmö University Publications (Malmö University) (submittedVersion)
- Funders
- Vetenskapsrådet (2015-00387)
- Svenska Läkaresällskapet
- University of California, San Francisco
- National Institute of Mental Health (MH083784, R01MH083784)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- major depressive disorder, circulating cell-free mitochondrial DNA, mitochondrial DNA copy number, peripheral blood mononuclear cells, telomere length, glutathione peroxidase, oxidative stress, antidepressant non-responders, mitochondrial dysfunction
- MeSH terms
- Cell-Free Nucleic Acids, Adult, Major Depressive Disorder, Depressive Disorder, Major, DNA, Mitochondrial, Female, Glutathione Peroxidase, Humans, Leukocytes, Mononuclear, Male, Case-Control Studies, Treatment Outcome, Selective Serotonin Reuptake Inhibitors, Young Adult, DNA Copy Number Variations, Telomere Homeostasis
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